Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFT0_LEIBR

TriTrypDb:

LbrM.27.1670 , LBRM2903_270022200

Length:

744

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFT0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	584	588	PF00656	0.607
CLV_MEL_PAP_1	116	122	PF00089	0.492
CLV_NRD_NRD_1	332	334	PF00675	0.737
CLV_NRD_NRD_1	577	579	PF00675	0.590
CLV_NRD_NRD_1	636	638	PF00675	0.555
CLV_NRD_NRD_1	677	679	PF00675	0.540
CLV_PCSK_FUR_1	329	333	PF00082	0.729
CLV_PCSK_FUR_1	342	346	PF00082	0.483
CLV_PCSK_KEX2_1	331	333	PF00082	0.740
CLV_PCSK_KEX2_1	339	341	PF00082	0.725
CLV_PCSK_KEX2_1	344	346	PF00082	0.732
CLV_PCSK_KEX2_1	576	578	PF00082	0.457
CLV_PCSK_KEX2_1	636	638	PF00082	0.423
CLV_PCSK_KEX2_1	677	679	PF00082	0.540
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.764
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.779
CLV_PCSK_PC7_1	340	346	PF00082	0.607
CLV_PCSK_SKI1_1	152	156	PF00082	0.499
CLV_PCSK_SKI1_1	33	37	PF00082	0.427
CLV_PCSK_SKI1_1	45	49	PF00082	0.384
CLV_PCSK_SKI1_1	531	535	PF00082	0.443
CLV_PCSK_SKI1_1	691	695	PF00082	0.479
CLV_PCSK_SKI1_1	725	729	PF00082	0.475
CLV_PCSK_SKI1_1	74	78	PF00082	0.331
DEG_APCC_DBOX_1	690	698	PF00400	0.475
DEG_APCC_DBOX_1	724	732	PF00400	0.502
DEG_APCC_DBOX_1	73	81	PF00400	0.355
DEG_ODPH_VHL_1	128	140	PF01847	0.430
DEG_SCF_TRCP1_1	320	325	PF00400	0.527
DEG_SPOP_SBC_1	371	375	PF00917	0.600
DEG_SPOP_SBC_1	454	458	PF00917	0.612
DOC_CKS1_1	219	224	PF01111	0.469
DOC_CKS1_1	433	438	PF01111	0.526
DOC_CKS1_1	464	469	PF01111	0.526
DOC_CKS1_1	553	558	PF01111	0.501
DOC_CYCLIN_yCln2_LP_2	150	156	PF00134	0.416
DOC_CYCLIN_yCln2_LP_2	433	439	PF00134	0.319
DOC_CYCLIN_yCln2_LP_2	644	650	PF00134	0.507
DOC_MAPK_gen_1	528	538	PF00069	0.443
DOC_MAPK_gen_1	636	644	PF00069	0.580
DOC_MAPK_MEF2A_6	303	312	PF00069	0.401
DOC_MAPK_MEF2A_6	531	540	PF00069	0.432
DOC_MAPK_MEF2A_6	651	659	PF00069	0.373
DOC_PP2B_LxvP_1	127	130	PF13499	0.377
DOC_PP4_MxPP_1	193	196	PF00568	0.536
DOC_USP7_MATH_1	189	193	PF00917	0.548
DOC_USP7_MATH_1	203	207	PF00917	0.506
DOC_USP7_MATH_1	3	7	PF00917	0.579
DOC_USP7_MATH_1	311	315	PF00917	0.684
DOC_USP7_MATH_1	371	375	PF00917	0.645
DOC_USP7_MATH_1	393	397	PF00917	0.636
DOC_USP7_MATH_1	455	459	PF00917	0.707
DOC_USP7_MATH_1	549	553	PF00917	0.522
DOC_USP7_MATH_1	615	619	PF00917	0.467
DOC_USP7_MATH_2	519	525	PF00917	0.513
DOC_WW_Pin1_4	17	22	PF00397	0.387
DOC_WW_Pin1_4	180	185	PF00397	0.558
DOC_WW_Pin1_4	218	223	PF00397	0.459
DOC_WW_Pin1_4	23	28	PF00397	0.408
DOC_WW_Pin1_4	243	248	PF00397	0.595
DOC_WW_Pin1_4	260	265	PF00397	0.414
DOC_WW_Pin1_4	377	382	PF00397	0.747
DOC_WW_Pin1_4	415	420	PF00397	0.581
DOC_WW_Pin1_4	432	437	PF00397	0.524
DOC_WW_Pin1_4	463	468	PF00397	0.769
DOC_WW_Pin1_4	515	520	PF00397	0.454
DOC_WW_Pin1_4	552	557	PF00397	0.504
DOC_WW_Pin1_4	592	597	PF00397	0.674
DOC_WW_Pin1_4	631	636	PF00397	0.481
DOC_WW_Pin1_4	662	667	PF00397	0.428
LIG_14-3-3_CanoR_1	119	128	PF00244	0.397
LIG_14-3-3_CanoR_1	132	141	PF00244	0.386
LIG_14-3-3_CanoR_1	19	29	PF00244	0.447
LIG_14-3-3_CanoR_1	270	278	PF00244	0.479
LIG_14-3-3_CanoR_1	303	309	PF00244	0.622
LIG_14-3-3_CanoR_1	331	336	PF00244	0.622
LIG_14-3-3_CanoR_1	345	354	PF00244	0.483
LIG_14-3-3_CanoR_1	646	655	PF00244	0.445
LIG_14-3-3_CanoR_1	678	688	PF00244	0.357
LIG_EH1_1	649	657	PF00400	0.391
LIG_FHA_1	122	128	PF00498	0.428
LIG_FHA_1	196	202	PF00498	0.594
LIG_FHA_1	248	254	PF00498	0.398
LIG_FHA_1	261	267	PF00498	0.422
LIG_FHA_1	279	285	PF00498	0.477
LIG_FHA_1	305	311	PF00498	0.554
LIG_FHA_1	323	329	PF00498	0.706
LIG_FHA_1	389	395	PF00498	0.595
LIG_FHA_1	403	409	PF00498	0.531
LIG_FHA_1	438	444	PF00498	0.530
LIG_FHA_1	473	479	PF00498	0.583
LIG_FHA_1	593	599	PF00498	0.641
LIG_FHA_1	63	69	PF00498	0.412
LIG_FHA_1	685	691	PF00498	0.428
LIG_FHA_2	134	140	PF00498	0.485
LIG_FHA_2	295	301	PF00498	0.476
LIG_FHA_2	516	522	PF00498	0.530
LIG_FHA_2	7	13	PF00498	0.421
LIG_LIR_Gen_1	298	309	PF02991	0.559
LIG_LIR_Gen_1	407	417	PF02991	0.502
LIG_LIR_Gen_1	558	567	PF02991	0.454
LIG_LIR_Gen_1	9	17	PF02991	0.402
LIG_LIR_Nem_3	298	304	PF02991	0.556
LIG_LIR_Nem_3	71	76	PF02991	0.385
LIG_LIR_Nem_3	9	13	PF02991	0.407
LIG_NRBOX	252	258	PF00104	0.487
LIG_NRBOX	486	492	PF00104	0.292
LIG_SH2_CRK	64	68	PF00017	0.444
LIG_SH2_CRK	699	703	PF00017	0.459
LIG_SH2_CRK	73	77	PF00017	0.337
LIG_SH2_STAP1	675	679	PF00017	0.424
LIG_SH2_STAT3	63	66	PF00017	0.416
LIG_SH2_STAT3	695	698	PF00017	0.478
LIG_SH2_STAT5	252	255	PF00017	0.366
LIG_SH2_STAT5	64	67	PF00017	0.460
LIG_SH2_STAT5	695	698	PF00017	0.389
LIG_SH2_STAT5	8	11	PF00017	0.412
LIG_SH3_3	216	222	PF00018	0.442
LIG_SH3_3	241	247	PF00018	0.330
LIG_SH3_3	305	311	PF00018	0.671
LIG_SH3_3	34	40	PF00018	0.524
LIG_SH3_3	383	389	PF00018	0.671
LIG_SH3_3	632	638	PF00018	0.512
LIG_SUMO_SIM_anti_2	136	142	PF11976	0.486
LIG_SUMO_SIM_par_1	46	51	PF11976	0.453
LIG_SUMO_SIM_par_1	640	645	PF11976	0.547
LIG_UBA3_1	425	432	PF00899	0.456
LIG_UBA3_1	526	534	PF00899	0.309
LIG_UBA3_1	727	735	PF00899	0.464
MOD_CDK_SPK_2	592	597	PF00069	0.674
MOD_CDK_SPK_2	631	636	PF00069	0.504
MOD_CDK_SPxK_1	631	637	PF00069	0.436
MOD_CDK_SPxxK_3	260	267	PF00069	0.515
MOD_CK1_1	115	121	PF00069	0.460
MOD_CK1_1	20	26	PF00069	0.372
MOD_CK1_1	251	257	PF00069	0.391
MOD_CK1_1	288	294	PF00069	0.588
MOD_CK1_1	321	327	PF00069	0.560
MOD_CK1_1	349	355	PF00069	0.690
MOD_CK1_1	373	379	PF00069	0.773
MOD_CK1_1	418	424	PF00069	0.480
MOD_CK1_1	453	459	PF00069	0.526
MOD_CK1_1	471	477	PF00069	0.520
MOD_CK1_1	552	558	PF00069	0.498
MOD_CK1_1	582	588	PF00069	0.650
MOD_CK1_1	589	595	PF00069	0.666
MOD_CK1_1	6	12	PF00069	0.436
MOD_CK1_1	605	611	PF00069	0.387
MOD_CK2_1	294	300	PF00069	0.606
MOD_CK2_1	456	462	PF00069	0.504
MOD_CK2_1	515	521	PF00069	0.546
MOD_DYRK1A_RPxSP_1	218	222	PF00069	0.366
MOD_GlcNHglycan	164	167	PF01048	0.503
MOD_GlcNHglycan	205	208	PF01048	0.579
MOD_GlcNHglycan	313	316	PF01048	0.689
MOD_GlcNHglycan	320	323	PF01048	0.675
MOD_GlcNHglycan	335	338	PF01048	0.667
MOD_GlcNHglycan	348	351	PF01048	0.675
MOD_GlcNHglycan	458	461	PF01048	0.747
MOD_GlcNHglycan	5	8	PF01048	0.494
MOD_GlcNHglycan	510	514	PF01048	0.567
MOD_GlcNHglycan	581	584	PF01048	0.620
MOD_GlcNHglycan	587	591	PF01048	0.702
MOD_GlcNHglycan	598	601	PF01048	0.441
MOD_GlcNHglycan	604	607	PF01048	0.385
MOD_GSK3_1	111	118	PF00069	0.536
MOD_GSK3_1	195	202	PF00069	0.481
MOD_GSK3_1	243	250	PF00069	0.382
MOD_GSK3_1	256	263	PF00069	0.368
MOD_GSK3_1	318	325	PF00069	0.676
MOD_GSK3_1	345	352	PF00069	0.746
MOD_GSK3_1	371	378	PF00069	0.706
MOD_GSK3_1	384	391	PF00069	0.587
MOD_GSK3_1	450	457	PF00069	0.457
MOD_GSK3_1	468	475	PF00069	0.744
MOD_GSK3_1	582	589	PF00069	0.732
MOD_GSK3_1	592	599	PF00069	0.613
MOD_GSK3_1	605	612	PF00069	0.495
MOD_GSK3_1	627	634	PF00069	0.547
MOD_LATS_1	83	89	PF00433	0.513
MOD_N-GLC_1	322	327	PF02516	0.621
MOD_N-GLC_1	679	684	PF02516	0.524
MOD_N-GLC_2	658	660	PF02516	0.461
MOD_NEK2_1	248	253	PF00069	0.378
MOD_NEK2_1	256	261	PF00069	0.403
MOD_NEK2_1	318	323	PF00069	0.567
MOD_NEK2_1	372	377	PF00069	0.709
MOD_NEK2_1	442	447	PF00069	0.534
MOD_NEK2_1	450	455	PF00069	0.635
MOD_NEK2_1	468	473	PF00069	0.565
MOD_NEK2_1	509	514	PF00069	0.511
MOD_NEK2_1	522	527	PF00069	0.478
MOD_NEK2_2	189	194	PF00069	0.457
MOD_NEK2_2	404	409	PF00069	0.370
MOD_PIKK_1	379	385	PF00454	0.582
MOD_PIKK_1	62	68	PF00454	0.382
MOD_PIKK_1	627	633	PF00454	0.709
MOD_PKA_1	331	337	PF00069	0.575
MOD_PKA_2	118	124	PF00069	0.389
MOD_PKA_2	269	275	PF00069	0.478
MOD_PKA_2	331	337	PF00069	0.575
MOD_PKA_2	596	602	PF00069	0.586
MOD_PKB_1	329	337	PF00069	0.701
MOD_Plk_1	299	305	PF00069	0.607
MOD_Plk_4	226	232	PF00069	0.382
MOD_Plk_4	248	254	PF00069	0.427
MOD_Plk_4	291	297	PF00069	0.451
MOD_Plk_4	304	310	PF00069	0.565
MOD_Plk_4	404	410	PF00069	0.375
MOD_Plk_4	522	528	PF00069	0.495
MOD_Plk_4	549	555	PF00069	0.528
MOD_Plk_4	605	611	PF00069	0.490
MOD_Plk_4	651	657	PF00069	0.364
MOD_ProDKin_1	17	23	PF00069	0.394
MOD_ProDKin_1	180	186	PF00069	0.552
MOD_ProDKin_1	218	224	PF00069	0.452
MOD_ProDKin_1	243	249	PF00069	0.588
MOD_ProDKin_1	260	266	PF00069	0.415
MOD_ProDKin_1	377	383	PF00069	0.748
MOD_ProDKin_1	415	421	PF00069	0.574
MOD_ProDKin_1	432	438	PF00069	0.525
MOD_ProDKin_1	463	469	PF00069	0.770
MOD_ProDKin_1	515	521	PF00069	0.455
MOD_ProDKin_1	552	558	PF00069	0.498
MOD_ProDKin_1	592	598	PF00069	0.658
MOD_ProDKin_1	631	637	PF00069	0.477
MOD_ProDKin_1	662	668	PF00069	0.424
MOD_SUMO_for_1	357	360	PF00179	0.531
MOD_SUMO_rev_2	259	268	PF00179	0.477
MOD_SUMO_rev_2	392	402	PF00179	0.520
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.415
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.520
TRG_DiLeu_BaLyEn_6	538	543	PF01217	0.490
TRG_DiLeu_BaLyEn_6	726	731	PF01217	0.426
TRG_ENDOCYTIC_2	73	76	PF00928	0.377
TRG_ER_diArg_1	328	331	PF00400	0.720
TRG_ER_diArg_1	340	343	PF00400	0.509
TRG_ER_diArg_1	575	578	PF00400	0.600
TRG_ER_diArg_1	635	637	PF00400	0.425
TRG_ER_diArg_1	677	679	PF00400	0.540
TRG_NLS_MonoExtC_3	337	342	PF00514	0.754
TRG_NLS_MonoExtN_4	338	343	PF00514	0.685
TRG_Pf-PMV_PEXEL_1	528	532	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	541	545	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	729	733	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5D1	Leptomonas seymouri	64%	100%
A0A1X0P485	Trypanosomatidae	36%	100%
A0A3S7X0R8	Leishmania donovani	81%	100%
A4I368	Leishmania infantum	81%	100%
D0A620	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ADD1	Leishmania major	79%	100%
E9AZ56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
V5B0Y4	Trypanosoma cruzi	41%	100%