Polyprenol reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFS9_LEIBR

TriTrypDb:

LbrM.27.1660 , LBRM2903_270022100

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	9
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	9
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HFS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFS9

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	10
GO:0006488	dolichol-linked oligosaccharide biosynthetic process	5	10
GO:0006490	oligosaccharide-lipid intermediate biosynthetic process	4	10
GO:0006629	lipid metabolic process	3	10
GO:0006720	isoprenoid metabolic process	4	10
GO:0008152	metabolic process	1	10
GO:0008300	isoprenoid catabolic process	5	10
GO:0009056	catabolic process	2	10
GO:0009058	biosynthetic process	2	10
GO:0009987	cellular process	1	10
GO:0016042	lipid catabolic process	4	10
GO:0016093	polyprenol metabolic process	4	10
GO:0016095	polyprenol catabolic process	5	10
GO:0019348	dolichol metabolic process	5	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044242	cellular lipid catabolic process	4	10
GO:0044248	cellular catabolic process	3	10
GO:0044255	cellular lipid metabolic process	3	10
GO:0044281	small molecule metabolic process	2	10
GO:0044282	small molecule catabolic process	3	10
GO:0046164	alcohol catabolic process	4	10
GO:0071704	organic substance metabolic process	2	10
GO:1901135	carbohydrate derivative metabolic process	3	10
GO:1901137	carbohydrate derivative biosynthetic process	4	10
GO:1901575	organic substance catabolic process	3	10
GO:1901576	organic substance biosynthetic process	3	10
GO:1901615	organic hydroxy compound metabolic process	3	10
GO:1901616	organic hydroxy compound catabolic process	4	10
GO:0008299	isoprenoid biosynthetic process	4	1
GO:0008610	lipid biosynthetic process	4	1
GO:0016094	polyprenol biosynthetic process	5	1
GO:0019408	dolichol biosynthetic process	6	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046165	alcohol biosynthetic process	4	1
GO:1901617	organic hydroxy compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	5	10
GO:0016229	steroid dehydrogenase activity	3	10
GO:0016491	oxidoreductase activity	2	10
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	10
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	9
GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors	4	10
GO:0102389	polyprenol reductase activity	5	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	442	446	PF00656	0.521
CLV_NRD_NRD_1	255	257	PF00675	0.458
CLV_NRD_NRD_1	269	271	PF00675	0.483
CLV_NRD_NRD_1	300	302	PF00675	0.425
CLV_NRD_NRD_1	413	415	PF00675	0.300
CLV_NRD_NRD_1	95	97	PF00675	0.274
CLV_PCSK_KEX2_1	269	271	PF00082	0.472
CLV_PCSK_KEX2_1	300	302	PF00082	0.412
CLV_PCSK_KEX2_1	413	415	PF00082	0.300
CLV_PCSK_SKI1_1	12	16	PF00082	0.320
CLV_PCSK_SKI1_1	217	221	PF00082	0.434
CLV_PCSK_SKI1_1	274	278	PF00082	0.435
CLV_PCSK_SKI1_1	421	425	PF00082	0.433
DEG_APCC_DBOX_1	461	469	PF00400	0.526
DEG_Nend_UBRbox_1	1	4	PF02207	0.276
DEG_SCF_TRCP1_1	123	128	PF00400	0.321
DEG_SPOP_SBC_1	305	309	PF00917	0.451
DEG_SPOP_SBC_1	340	344	PF00917	0.307
DOC_CDC14_PxL_1	145	153	PF14671	0.181
DOC_CYCLIN_yCln2_LP_2	136	142	PF00134	0.366
DOC_CYCLIN_yCln2_LP_2	289	295	PF00134	0.528
DOC_MAPK_gen_1	169	178	PF00069	0.512
DOC_MAPK_gen_1	93	103	PF00069	0.475
DOC_PP2B_LxvP_1	289	292	PF13499	0.537
DOC_USP7_MATH_1	192	196	PF00917	0.277
DOC_USP7_MATH_1	204	208	PF00917	0.307
DOC_USP7_MATH_1	250	254	PF00917	0.711
DOC_USP7_MATH_1	276	280	PF00917	0.562
DOC_USP7_MATH_1	305	309	PF00917	0.513
DOC_USP7_MATH_1	372	376	PF00917	0.427
DOC_USP7_MATH_1	431	435	PF00917	0.612
DOC_WW_Pin1_4	127	132	PF00397	0.453
DOC_WW_Pin1_4	135	140	PF00397	0.554
DOC_WW_Pin1_4	244	249	PF00397	0.627
DOC_WW_Pin1_4	341	346	PF00397	0.382
LIG_14-3-3_CanoR_1	160	167	PF00244	0.490
LIG_14-3-3_CanoR_1	205	213	PF00244	0.331
LIG_14-3-3_CanoR_1	360	368	PF00244	0.369
LIG_14-3-3_CanoR_1	96	101	PF00244	0.485
LIG_BRCT_BRCA1_1	18	22	PF00533	0.429
LIG_BRCT_BRCA1_1	308	312	PF00533	0.542
LIG_deltaCOP1_diTrp_1	262	268	PF00928	0.478
LIG_EH1_1	102	110	PF00400	0.311
LIG_EH1_1	326	334	PF00400	0.285
LIG_FHA_1	104	110	PF00498	0.300
LIG_FHA_1	156	162	PF00498	0.306
LIG_FHA_1	173	179	PF00498	0.438
LIG_FHA_1	18	24	PF00498	0.238
LIG_FHA_1	235	241	PF00498	0.585
LIG_FHA_1	253	259	PF00498	0.538
LIG_FHA_1	319	325	PF00498	0.475
LIG_FHA_1	329	335	PF00498	0.291
LIG_FHA_1	410	416	PF00498	0.600
LIG_FHA_2	360	366	PF00498	0.367
LIG_FHA_2	396	402	PF00498	0.513
LIG_FHA_2	420	426	PF00498	0.487
LIG_GBD_Chelix_1	415	423	PF00786	0.294
LIG_LIR_Gen_1	177	187	PF02991	0.263
LIG_LIR_Gen_1	19	30	PF02991	0.342
LIG_LIR_Gen_1	199	204	PF02991	0.286
LIG_LIR_Gen_1	309	320	PF02991	0.447
LIG_LIR_Gen_1	33	40	PF02991	0.483
LIG_LIR_Gen_1	375	385	PF02991	0.420
LIG_LIR_Gen_1	99	108	PF02991	0.288
LIG_LIR_Nem_3	177	182	PF02991	0.263
LIG_LIR_Nem_3	19	25	PF02991	0.323
LIG_LIR_Nem_3	199	203	PF02991	0.344
LIG_LIR_Nem_3	265	271	PF02991	0.637
LIG_LIR_Nem_3	296	302	PF02991	0.475
LIG_LIR_Nem_3	309	315	PF02991	0.534
LIG_LIR_Nem_3	33	37	PF02991	0.521
LIG_LIR_Nem_3	365	371	PF02991	0.395
LIG_LIR_Nem_3	375	381	PF02991	0.452
LIG_LIR_Nem_3	99	103	PF02991	0.288
LIG_Pex14_1	18	22	PF04695	0.364
LIG_Pex14_1	209	213	PF04695	0.249
LIG_Pex14_2	115	119	PF04695	0.384
LIG_Pex14_2	30	34	PF04695	0.582
LIG_Pex14_2	466	470	PF04695	0.580
LIG_Rb_LxCxE_1	1	20	PF01857	0.229
LIG_SH2_CRK	302	306	PF00017	0.498
LIG_SH2_NCK_1	200	204	PF00017	0.414
LIG_SH2_STAP1	306	310	PF00017	0.538
LIG_SH2_STAP1	320	324	PF00017	0.434
LIG_SH2_STAT5	104	107	PF00017	0.247
LIG_SH2_STAT5	188	191	PF00017	0.247
LIG_SH2_STAT5	200	203	PF00017	0.339
LIG_SH2_STAT5	320	323	PF00017	0.455
LIG_SH3_3	136	142	PF00018	0.387
LIG_SH3_3	312	318	PF00018	0.467
LIG_SUMO_SIM_anti_2	19	27	PF11976	0.295
LIG_SUMO_SIM_anti_2	331	338	PF11976	0.346
LIG_SUMO_SIM_par_1	148	154	PF11976	0.192
LIG_SUMO_SIM_par_1	290	296	PF11976	0.571
LIG_SUMO_SIM_par_1	331	338	PF11976	0.414
MOD_CK1_1	132	138	PF00069	0.658
MOD_CK1_1	359	365	PF00069	0.572
MOD_CK1_1	396	402	PF00069	0.407
MOD_CK1_1	66	72	PF00069	0.411
MOD_CK2_1	395	401	PF00069	0.369
MOD_CMANNOS	89	92	PF00535	0.281
MOD_GlcNHglycan	123	126	PF01048	0.598
MOD_GlcNHglycan	127	130	PF01048	0.655
MOD_GlcNHglycan	131	134	PF01048	0.541
MOD_GlcNHglycan	194	197	PF01048	0.356
MOD_GlcNHglycan	278	281	PF01048	0.645
MOD_GlcNHglycan	362	365	PF01048	0.614
MOD_GlcNHglycan	374	377	PF01048	0.413
MOD_GlcNHglycan	398	401	PF01048	0.414
MOD_GlcNHglycan	43	46	PF01048	0.558
MOD_GlcNHglycan	433	436	PF01048	0.662
MOD_GlcNHglycan	65	68	PF01048	0.622
MOD_GSK3_1	103	110	PF00069	0.242
MOD_GSK3_1	121	128	PF00069	0.372
MOD_GSK3_1	151	158	PF00069	0.181
MOD_GSK3_1	192	199	PF00069	0.403
MOD_GSK3_1	244	251	PF00069	0.581
MOD_GSK3_1	335	342	PF00069	0.526
MOD_GSK3_1	356	363	PF00069	0.619
MOD_GSK3_1	377	384	PF00069	0.385
MOD_GSK3_1	41	48	PF00069	0.447
MOD_GSK3_1	415	422	PF00069	0.448
MOD_GSK3_1	62	69	PF00069	0.476
MOD_GSK3_1	92	99	PF00069	0.336
MOD_N-GLC_1	340	345	PF02516	0.412
MOD_N-GLC_1	393	398	PF02516	0.249
MOD_N-GLC_1	409	414	PF02516	0.325
MOD_NEK2_1	103	108	PF00069	0.259
MOD_NEK2_1	151	156	PF00069	0.286
MOD_NEK2_1	161	166	PF00069	0.389
MOD_NEK2_1	252	257	PF00069	0.702
MOD_NEK2_1	275	280	PF00069	0.617
MOD_NEK2_1	335	340	PF00069	0.190
MOD_NEK2_1	395	400	PF00069	0.400
MOD_NEK2_1	415	420	PF00069	0.363
MOD_NEK2_2	183	188	PF00069	0.263
MOD_NEK2_2	350	355	PF00069	0.446
MOD_PIKK_1	204	210	PF00454	0.396
MOD_PKA_1	96	102	PF00069	0.267
MOD_PKA_2	159	165	PF00069	0.331
MOD_PKA_2	204	210	PF00069	0.412
MOD_PKA_2	359	365	PF00069	0.453
MOD_PKA_2	92	98	PF00069	0.348
MOD_Plk_1	393	399	PF00069	0.231
MOD_Plk_4	174	180	PF00069	0.254
MOD_Plk_4	18	24	PF00069	0.343
MOD_Plk_4	236	242	PF00069	0.438
MOD_Plk_4	328	334	PF00069	0.392
MOD_Plk_4	377	383	PF00069	0.414
MOD_Plk_4	385	391	PF00069	0.401
MOD_Plk_4	415	421	PF00069	0.274
MOD_Plk_4	84	90	PF00069	0.364
MOD_Plk_4	96	102	PF00069	0.243
MOD_ProDKin_1	127	133	PF00069	0.577
MOD_ProDKin_1	135	141	PF00069	0.701
MOD_ProDKin_1	244	250	PF00069	0.545
MOD_ProDKin_1	341	347	PF00069	0.480
MOD_SUMO_rev_2	55	65	PF00179	0.513
TRG_DiLeu_BaLyEn_6	146	151	PF01217	0.295
TRG_ENDOCYTIC_2	200	203	PF00928	0.349
TRG_ER_diArg_1	268	270	PF00400	0.415
TRG_ER_diArg_1	299	301	PF00400	0.398
TRG_ER_diArg_1	413	415	PF00400	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXY2	Leptomonas seymouri	42%	100%
A0A0S4JTN4	Bodo saltans	29%	100%
A0A1X0P483	Trypanosomatidae	30%	100%
A0A3Q8ICQ8	Leishmania donovani	72%	100%
A0A3R7NH72	Trypanosoma rangeli	30%	100%
A4I367	Leishmania infantum	72%	100%
D0A619	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ADD0	Leishmania major	73%	100%
E9AZ55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%