Putative peptidyl dipeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl dipeptidase, putative

Species:

Leishmania braziliensis

UniProt:

A4HFS8_LEIBR

TriTrypDb:

LbrM.27.1650 , LBRM2903_270035200

Length:

460

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 27

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFS8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0019538	protein metabolic process	3	13
GO:0043170	macromolecule metabolic process	3	13
GO:0044238	primary metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004175	endopeptidase activity	4	13
GO:0004222	metalloendopeptidase activity	5	13
GO:0005488	binding	1	13
GO:0008233	peptidase activity	3	13
GO:0008237	metallopeptidase activity	4	13
GO:0016787	hydrolase activity	2	13
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0140096	catalytic activity, acting on a protein	2	13
GO:0004180	carboxypeptidase activity	5	5
GO:0008238	exopeptidase activity	4	5
GO:0008241	peptidyl-dipeptidase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.374
CLV_NRD_NRD_1	173	175	PF00675	0.372
CLV_NRD_NRD_1	227	229	PF00675	0.277
CLV_NRD_NRD_1	30	32	PF00675	0.360
CLV_NRD_NRD_1	4	6	PF00675	0.558
CLV_NRD_NRD_1	443	445	PF00675	0.374
CLV_NRD_NRD_1	61	63	PF00675	0.414
CLV_PCSK_FUR_1	132	136	PF00082	0.309
CLV_PCSK_FUR_1	59	63	PF00082	0.266
CLV_PCSK_KEX2_1	134	136	PF00082	0.309
CLV_PCSK_KEX2_1	173	175	PF00082	0.370
CLV_PCSK_KEX2_1	210	212	PF00082	0.431
CLV_PCSK_KEX2_1	29	31	PF00082	0.360
CLV_PCSK_KEX2_1	4	6	PF00082	0.558
CLV_PCSK_KEX2_1	61	63	PF00082	0.266
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.431
CLV_PCSK_PC7_1	26	32	PF00082	0.420
CLV_PCSK_SKI1_1	157	161	PF00082	0.400
CLV_PCSK_SKI1_1	245	249	PF00082	0.330
CLV_PCSK_SKI1_1	284	288	PF00082	0.532
CLV_PCSK_SKI1_1	30	34	PF00082	0.420
CLV_PCSK_SKI1_1	449	453	PF00082	0.431
CLV_PCSK_SKI1_1	61	65	PF00082	0.410
DEG_APCC_DBOX_1	133	141	PF00400	0.309
DEG_Nend_UBRbox_1	1	4	PF02207	0.561
DOC_CYCLIN_RxL_1	24	37	PF00134	0.420
DOC_MAPK_gen_1	173	179	PF00069	0.370
DOC_MAPK_gen_1	210	218	PF00069	0.532
DOC_MAPK_RevD_3	56	69	PF00069	0.419
DOC_USP7_MATH_1	96	100	PF00917	0.500
DOC_USP7_UBL2_3	445	449	PF12436	0.532
LIG_14-3-3_CanoR_1	173	180	PF00244	0.370
LIG_14-3-3_CanoR_1	221	226	PF00244	0.468
LIG_14-3-3_CanoR_1	352	359	PF00244	0.450
LIG_14-3-3_CanoR_1	424	429	PF00244	0.277
LIG_14-3-3_CanoR_1	61	66	PF00244	0.383
LIG_Actin_WH2_2	48	63	PF00022	0.429
LIG_BRCT_BRCA1_1	374	378	PF00533	0.403
LIG_FHA_1	215	221	PF00498	0.429
LIG_FHA_1	335	341	PF00498	0.431
LIG_FHA_1	46	52	PF00498	0.521
LIG_Integrin_RGD_1	42	44	PF01839	0.429
LIG_LIR_Gen_1	255	265	PF02991	0.374
LIG_LIR_Gen_1	285	293	PF02991	0.406
LIG_LIR_Gen_1	375	386	PF02991	0.335
LIG_LIR_Gen_1	394	399	PF02991	0.391
LIG_LIR_Nem_3	125	129	PF02991	0.379
LIG_LIR_Nem_3	255	261	PF02991	0.374
LIG_LIR_Nem_3	285	289	PF02991	0.463
LIG_LIR_Nem_3	295	300	PF02991	0.372
LIG_LIR_Nem_3	375	381	PF02991	0.359
LIG_LIR_Nem_3	388	393	PF02991	0.384
LIG_LIR_Nem_3	394	398	PF02991	0.392
LIG_MLH1_MIPbox_1	374	378	PF16413	0.423
LIG_Pex14_1	124	128	PF04695	0.366
LIG_PTB_Apo_2	268	275	PF02174	0.420
LIG_PTB_Phospho_1	268	274	PF10480	0.489
LIG_SH2_CRK	233	237	PF00017	0.521
LIG_SH2_CRK	274	278	PF00017	0.489
LIG_SH2_CRK	300	304	PF00017	0.532
LIG_SH2_NCK_1	205	209	PF00017	0.431
LIG_SH2_STAP1	129	133	PF00017	0.372
LIG_SH2_STAP1	300	304	PF00017	0.388
LIG_SH2_STAP1	307	311	PF00017	0.353
LIG_SH2_STAP1	386	390	PF00017	0.384
LIG_SH2_STAP1	438	442	PF00017	0.532
LIG_SH2_STAT5	148	151	PF00017	0.406
LIG_SH2_STAT5	345	348	PF00017	0.381
LIG_SH2_STAT5	377	380	PF00017	0.375
LIG_SH2_STAT5	391	394	PF00017	0.424
LIG_SH3_3	176	182	PF00018	0.372
LIG_Sin3_3	86	93	PF02671	0.431
LIG_SUMO_SIM_par_1	336	341	PF11976	0.277
LIG_TRAF2_1	353	356	PF00917	0.348
LIG_TRAF2_2	290	295	PF00917	0.245
LIG_TRFH_1	119	123	PF08558	0.426
LIG_TYR_ITIM	231	236	PF00017	0.521
LIG_TYR_ITIM	272	277	PF00017	0.417
LIG_UBA3_1	89	95	PF00899	0.350
LIG_WW_1	370	373	PF00397	0.372
LIG_WW_3	369	373	PF00397	0.372
MOD_CK1_1	275	281	PF00069	0.532
MOD_CK1_1	99	105	PF00069	0.277
MOD_CK2_1	67	73	PF00069	0.381
MOD_Cter_Amidation	208	211	PF01082	0.277
MOD_Cter_Amidation	226	229	PF01082	0.210
MOD_Cter_Amidation	442	445	PF01082	0.366
MOD_Cter_Amidation	66	69	PF01082	0.429
MOD_GlcNHglycan	277	280	PF01048	0.532
MOD_GlcNHglycan	374	377	PF01048	0.403
MOD_GlcNHglycan	409	412	PF01048	0.484
MOD_GlcNHglycan	84	87	PF01048	0.532
MOD_GSK3_1	273	280	PF00069	0.381
MOD_GSK3_1	407	414	PF00069	0.457
MOD_GSK3_1	424	431	PF00069	0.345
MOD_GSK3_1	45	52	PF00069	0.317
MOD_N-GLC_1	12	17	PF02516	0.489
MOD_N-GLC_1	252	257	PF02516	0.309
MOD_N-GLC_1	45	50	PF02516	0.370
MOD_NEK2_1	11	16	PF00069	0.540
MOD_NEK2_1	19	24	PF00069	0.384
MOD_NEK2_1	272	277	PF00069	0.387
MOD_NEK2_1	407	412	PF00069	0.309
MOD_PIKK_1	12	18	PF00454	0.496
MOD_PIKK_1	288	294	PF00454	0.372
MOD_PK_1	424	430	PF00069	0.277
MOD_PKA_1	61	67	PF00069	0.277
MOD_PKA_2	172	178	PF00069	0.372
MOD_PKA_2	25	31	PF00069	0.429
MOD_PKA_2	351	357	PF00069	0.450
MOD_PKA_2	61	67	PF00069	0.381
MOD_PKB_1	422	430	PF00069	0.277
MOD_PKB_1	59	67	PF00069	0.277
MOD_Plk_1	252	258	PF00069	0.431
MOD_Plk_2-3	183	189	PF00069	0.431
MOD_Plk_4	214	220	PF00069	0.532
MOD_Plk_4	221	227	PF00069	0.416
MOD_Plk_4	253	259	PF00069	0.398
MOD_Plk_4	61	67	PF00069	0.277
MOD_SUMO_rev_2	139	147	PF00179	0.437
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.628
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.314
TRG_ENDOCYTIC_2	148	151	PF00928	0.431
TRG_ENDOCYTIC_2	233	236	PF00928	0.521
TRG_ENDOCYTIC_2	274	277	PF00928	0.391
TRG_ENDOCYTIC_2	300	303	PF00928	0.505
TRG_ENDOCYTIC_2	345	348	PF00928	0.431
TRG_ENDOCYTIC_2	438	441	PF00928	0.372
TRG_ER_diArg_1	132	135	PF00400	0.309
TRG_ER_diArg_1	23	26	PF00400	0.372
TRG_ER_diArg_1	29	31	PF00400	0.353
TRG_ER_diArg_1	4	6	PF00400	0.818
TRG_ER_diArg_1	421	424	PF00400	0.277
TRG_ER_diArg_1	58	61	PF00400	0.323
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.309
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	397	402	PF00026	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT30	Leptomonas seymouri	75%	68%
A0A0N1PBM8	Leptomonas seymouri	28%	67%
A0A0N1PDB7	Leptomonas seymouri	54%	68%
A0A0S4JRG5	Bodo saltans	26%	68%
A0A0S4JWM4	Bodo saltans	25%	69%
A0A1X0NTS0	Trypanosomatidae	26%	67%
A0A3S5H4X4	Leishmania donovani	79%	100%
A0A3S5H518	Leishmania donovani	85%	68%
A0A3S7WZY5	Leishmania donovani	26%	67%
A0A422MUB5	Trypanosoma rangeli	26%	67%
A4HF12	Leishmania braziliensis	27%	100%
A4HFS7	Leishmania braziliensis	99%	100%
A4HG35	Leishmania braziliensis	92%	68%
A4HG37	Leishmania braziliensis	99%	93%
A4HRR9	Leishmania infantum	85%	68%
A4I291	Leishmania infantum	26%	67%
E9AC74	Leishmania major	82%	100%
E9ACE8	Leishmania major	84%	100%
E9AJN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	68%
E9AYD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	67%
P24155	Rattus norvegicus	30%	67%
P24171	Escherichia coli (strain K12)	46%	68%
P27236	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	45%	68%
P27237	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	35%	68%
P27298	Escherichia coli (strain K12)	35%	68%
P44573	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	31%	68%
P47788	Sus scrofa	31%	67%
P52888	Homo sapiens	30%	67%
Q1JPJ8	Bos taurus	32%	67%
Q4Q937	Leishmania major	26%	100%
Q54DD2	Dictyostelium discoideum	30%	68%
Q8C1A5	Mus musculus	31%	67%
V5B1A3	Trypanosoma cruzi	26%	100%