Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFS6_LEIBR

TriTrypDb:

LbrM.27.1630 , LBRM2903_270022000

Length:

157

Annotations

LeishMANIAdb annotations

No signal peptide, but transit signal possible

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HFS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFS6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.344
CLV_NRD_NRD_1	10	12	PF00675	0.436
CLV_NRD_NRD_1	14	16	PF00675	0.447
CLV_NRD_NRD_1	146	148	PF00675	0.491
CLV_NRD_NRD_1	4	6	PF00675	0.438
CLV_PCSK_KEX2_1	10	12	PF00082	0.436
CLV_PCSK_KEX2_1	14	16	PF00082	0.447
CLV_PCSK_KEX2_1	146	148	PF00082	0.489
CLV_PCSK_KEX2_1	4	6	PF00082	0.438
CLV_PCSK_KEX2_1	86	88	PF00082	0.418
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.435
CLV_PCSK_PC7_1	10	16	PF00082	0.505
DEG_Nend_UBRbox_3	1	3	PF02207	0.645
DOC_CYCLIN_RxL_1	93	104	PF00134	0.696
DOC_MAPK_gen_1	49	58	PF00069	0.355
DOC_USP7_MATH_1	88	92	PF00917	0.699
LIG_FHA_1	126	132	PF00498	0.622
LIG_FHA_1	68	74	PF00498	0.279
LIG_LIR_Gen_1	53	63	PF02991	0.189
LIG_LIR_Nem_3	53	58	PF02991	0.384
LIG_Pex14_1	41	45	PF04695	0.433
LIG_Pex14_2	55	59	PF04695	0.366
LIG_Pex14_2	63	67	PF04695	0.300
LIG_Pex14_2	71	75	PF04695	0.235
LIG_SH2_CRK	16	20	PF00017	0.654
LIG_SH2_NCK_1	16	20	PF00017	0.654
LIG_SH2_STAT3	134	137	PF00017	0.714
LIG_SH2_STAT5	134	137	PF00017	0.636
LIG_SH3_3	135	141	PF00018	0.627
LIG_SH3_3	27	33	PF00018	0.275
LIG_TYR_ITIM	107	112	PF00017	0.624
LIG_WRC_WIRS_1	68	73	PF05994	0.289
LIG_WW_1	29	32	PF00397	0.203
MOD_Cter_Amidation	84	87	PF01082	0.406
MOD_GSK3_1	67	74	PF00069	0.279
MOD_NEK2_1	130	135	PF00069	0.629
MOD_NEK2_1	71	76	PF00069	0.524
MOD_PIKK_1	50	56	PF00454	0.483
MOD_Plk_1	71	77	PF00069	0.522
MOD_Plk_4	130	136	PF00069	0.629
MOD_SUMO_for_1	107	110	PF00179	0.643
MOD_SUMO_rev_2	115	121	PF00179	0.639
TRG_ENDOCYTIC_2	109	112	PF00928	0.682
TRG_ENDOCYTIC_2	16	19	PF00928	0.657
TRG_ENDOCYTIC_2	68	71	PF00928	0.328
TRG_ER_diArg_1	14	16	PF00400	0.713
TRG_ER_diArg_1	145	147	PF00400	0.682
TRG_ER_diArg_1	78	81	PF00400	0.614
TRG_ER_diArg_1	9	11	PF00400	0.706
TRG_Pf-PMV_PEXEL_1	96	101	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5S2	Leptomonas seymouri	86%	100%
A0A0S4JKA8	Bodo saltans	57%	100%
A0A1X0P4E7	Trypanosomatidae	76%	100%
A0A3S7X0S8	Leishmania donovani	90%	100%
A4I366	Leishmania infantum	90%	100%
D0A618	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	100%
E9ADC9	Leishmania major	90%	100%
E9AZ54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%