START domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFS5_LEIBR

TriTrypDb:

LbrM.27.1620 , LBRM2903_270021900

Length:

690

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFS5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	314	318	PF00656	0.793
CLV_C14_Caspase3-7	637	641	PF00656	0.704
CLV_NRD_NRD_1	351	353	PF00675	0.756
CLV_NRD_NRD_1	361	363	PF00675	0.732
CLV_NRD_NRD_1	369	371	PF00675	0.718
CLV_NRD_NRD_1	445	447	PF00675	0.570
CLV_NRD_NRD_1	456	458	PF00675	0.561
CLV_NRD_NRD_1	466	468	PF00675	0.593
CLV_NRD_NRD_1	612	614	PF00675	0.629
CLV_PCSK_FUR_1	367	371	PF00082	0.594
CLV_PCSK_KEX2_1	351	353	PF00082	0.683
CLV_PCSK_KEX2_1	360	362	PF00082	0.695
CLV_PCSK_KEX2_1	369	371	PF00082	0.706
CLV_PCSK_KEX2_1	445	447	PF00082	0.554
CLV_PCSK_KEX2_1	455	457	PF00082	0.574
CLV_PCSK_KEX2_1	686	688	PF00082	0.531
CLV_PCSK_PC1ET2_1	686	688	PF00082	0.531
CLV_PCSK_PC7_1	347	353	PF00082	0.593
CLV_PCSK_PC7_1	356	362	PF00082	0.762
CLV_PCSK_SKI1_1	137	141	PF00082	0.328
CLV_PCSK_SKI1_1	283	287	PF00082	0.630
CLV_PCSK_SKI1_1	295	299	PF00082	0.723
CLV_PCSK_SKI1_1	446	450	PF00082	0.551
CLV_PCSK_SKI1_1	526	530	PF00082	0.592
CLV_PCSK_SKI1_1	674	678	PF00082	0.685
DEG_APCC_DBOX_1	202	210	PF00400	0.545
DEG_APCC_DBOX_1	437	445	PF00400	0.538
DEG_SCF_FBW7_1	385	392	PF00400	0.592
DEG_SPOP_SBC_1	389	393	PF00917	0.593
DOC_CKS1_1	386	391	PF01111	0.592
DOC_CKS1_1	632	637	PF01111	0.826
DOC_MAPK_gen_1	228	237	PF00069	0.819
DOC_MAPK_MEF2A_6	231	239	PF00069	0.813
DOC_MAPK_MEF2A_6	485	493	PF00069	0.518
DOC_PP2B_LxvP_1	209	212	PF13499	0.638
DOC_PP2B_LxvP_1	299	302	PF13499	0.740
DOC_USP7_MATH_1	159	163	PF00917	0.552
DOC_USP7_MATH_1	16	20	PF00917	0.574
DOC_USP7_MATH_1	174	178	PF00917	0.628
DOC_USP7_MATH_1	183	187	PF00917	0.530
DOC_USP7_MATH_1	197	201	PF00917	0.572
DOC_USP7_MATH_1	220	224	PF00917	0.583
DOC_USP7_MATH_1	293	297	PF00917	0.687
DOC_USP7_MATH_1	306	310	PF00917	0.780
DOC_USP7_MATH_1	316	320	PF00917	0.618
DOC_USP7_MATH_1	379	383	PF00917	0.650
DOC_USP7_MATH_1	404	408	PF00917	0.541
DOC_USP7_MATH_1	604	608	PF00917	0.559
DOC_USP7_MATH_2	262	268	PF00917	0.553
DOC_USP7_UBL2_3	526	530	PF12436	0.550
DOC_WW_Pin1_4	170	175	PF00397	0.667
DOC_WW_Pin1_4	184	189	PF00397	0.672
DOC_WW_Pin1_4	201	206	PF00397	0.661
DOC_WW_Pin1_4	221	226	PF00397	0.804
DOC_WW_Pin1_4	258	263	PF00397	0.780
DOC_WW_Pin1_4	289	294	PF00397	0.759
DOC_WW_Pin1_4	381	386	PF00397	0.676
DOC_WW_Pin1_4	390	395	PF00397	0.613
DOC_WW_Pin1_4	582	587	PF00397	0.759
DOC_WW_Pin1_4	593	598	PF00397	0.548
DOC_WW_Pin1_4	623	628	PF00397	0.692
DOC_WW_Pin1_4	631	636	PF00397	0.615
DOC_WW_Pin1_4	83	88	PF00397	0.602
LIG_14-3-3_CanoR_1	158	164	PF00244	0.513
LIG_14-3-3_CanoR_1	228	238	PF00244	0.566
LIG_14-3-3_CanoR_1	270	278	PF00244	0.539
LIG_14-3-3_CanoR_1	467	476	PF00244	0.476
LIG_14-3-3_CanoR_1	497	505	PF00244	0.649
LIG_14-3-3_CanoR_1	560	568	PF00244	0.468
LIG_14-3-3_CterR_2	687	690	PF00244	0.529
LIG_Actin_WH2_2	271	288	PF00022	0.605
LIG_BIR_II_1	1	5	PF00653	0.539
LIG_FHA_1	211	217	PF00498	0.812
LIG_FHA_1	49	55	PF00498	0.474
LIG_FHA_1	87	93	PF00498	0.361
LIG_FHA_2	635	641	PF00498	0.609
LIG_HCF-1_HBM_1	116	119	PF13415	0.604
LIG_Integrin_RGD_1	249	251	PF01839	0.566
LIG_Integrin_RGD_1	324	326	PF01839	0.587
LIG_LIR_Apic_2	104	110	PF02991	0.511
LIG_LIR_Apic_2	147	152	PF02991	0.504
LIG_LIR_Gen_1	662	670	PF02991	0.781
LIG_LIR_Nem_3	116	122	PF02991	0.487
LIG_MAD2	137	145	PF02301	0.355
LIG_MYND_1	207	211	PF01753	0.539
LIG_SH2_CRK	149	153	PF00017	0.628
LIG_SH2_CRK	632	636	PF00017	0.825
LIG_SH2_GRB2like	134	137	PF00017	0.479
LIG_SH2_SRC	515	518	PF00017	0.651
LIG_SH2_STAT5	119	122	PF00017	0.574
LIG_SH2_STAT5	515	518	PF00017	0.566
LIG_SH2_STAT5	53	56	PF00017	0.441
LIG_SH2_STAT5	663	666	PF00017	0.785
LIG_SH2_STAT5	72	75	PF00017	0.587
LIG_SH3_3	299	305	PF00018	0.589
LIG_SH3_3	400	406	PF00018	0.731
LIG_SH3_3	488	494	PF00018	0.676
LIG_SH3_3	502	508	PF00018	0.620
LIG_SH3_3	569	575	PF00018	0.621
LIG_SUMO_SIM_anti_2	91	96	PF11976	0.347
LIG_SUMO_SIM_par_1	137	142	PF11976	0.550
LIG_SUMO_SIM_par_1	77	83	PF11976	0.482
LIG_TRAF2_1	7	10	PF00917	0.604
LIG_UBA3_1	274	283	PF00899	0.633
LIG_UBA3_1	284	289	PF00899	0.592
LIG_UBA3_1	535	541	PF00899	0.566
LIG_WRC_WIRS_1	125	130	PF05994	0.497
MOD_CDC14_SPxK_1	292	295	PF00782	0.766
MOD_CDK_SPK_2	170	175	PF00069	0.552
MOD_CDK_SPK_2	223	228	PF00069	0.603
MOD_CDK_SPK_2	623	628	PF00069	0.627
MOD_CDK_SPxK_1	289	295	PF00069	0.758
MOD_CDK_SPxxK_3	201	208	PF00069	0.716
MOD_CDK_SPxxK_3	221	228	PF00069	0.576
MOD_CDK_SPxxK_3	631	638	PF00069	0.826
MOD_CK1_1	177	183	PF00069	0.645
MOD_CK1_1	187	193	PF00069	0.608
MOD_CK1_1	223	229	PF00069	0.723
MOD_CK1_1	241	247	PF00069	0.547
MOD_CK1_1	269	275	PF00069	0.661
MOD_CK1_1	27	33	PF00069	0.517
MOD_CK1_1	309	315	PF00069	0.781
MOD_CK1_1	414	420	PF00069	0.420
MOD_CK1_1	553	559	PF00069	0.457
MOD_CK1_1	564	570	PF00069	0.723
MOD_CK1_1	607	613	PF00069	0.691
MOD_CK1_1	622	628	PF00069	0.705
MOD_CK1_1	83	89	PF00069	0.477
MOD_CK2_1	258	264	PF00069	0.680
MOD_CK2_1	309	315	PF00069	0.812
MOD_CK2_1	405	411	PF00069	0.606
MOD_CMANNOS	66	69	PF00535	0.572
MOD_Cter_Amidation	367	370	PF01082	0.594
MOD_Cter_Amidation	611	614	PF01082	0.625
MOD_GlcNHglycan	1	4	PF01048	0.528
MOD_GlcNHglycan	176	179	PF01048	0.576
MOD_GlcNHglycan	189	192	PF01048	0.569
MOD_GlcNHglycan	231	234	PF01048	0.682
MOD_GlcNHglycan	240	243	PF01048	0.597
MOD_GlcNHglycan	255	258	PF01048	0.598
MOD_GlcNHglycan	311	314	PF01048	0.796
MOD_GlcNHglycan	317	321	PF01048	0.713
MOD_GlcNHglycan	375	378	PF01048	0.774
MOD_GlcNHglycan	407	410	PF01048	0.602
MOD_GlcNHglycan	416	419	PF01048	0.569
MOD_GlcNHglycan	469	472	PF01048	0.548
MOD_GlcNHglycan	54	57	PF01048	0.387
MOD_GlcNHglycan	606	609	PF01048	0.611
MOD_GlcNHglycan	640	644	PF01048	0.823
MOD_GlcNHglycan	647	650	PF01048	0.723
MOD_GlcNHglycan	82	85	PF01048	0.455
MOD_GSK3_1	170	177	PF00069	0.758
MOD_GSK3_1	183	190	PF00069	0.639
MOD_GSK3_1	197	204	PF00069	0.596
MOD_GSK3_1	258	265	PF00069	0.698
MOD_GSK3_1	289	296	PF00069	0.634
MOD_GSK3_1	381	388	PF00069	0.616
MOD_GSK3_1	463	470	PF00069	0.510
MOD_GSK3_1	48	55	PF00069	0.425
MOD_GSK3_1	615	622	PF00069	0.662
MOD_GSK3_1	674	681	PF00069	0.564
MOD_LATS_1	354	360	PF00433	0.833
MOD_N-GLC_1	253	258	PF02516	0.737
MOD_NEK2_1	238	243	PF00069	0.600
MOD_NEK2_1	54	59	PF00069	0.341
MOD_NEK2_1	561	566	PF00069	0.670
MOD_PIKK_1	101	107	PF00454	0.495
MOD_PIKK_1	150	156	PF00454	0.523
MOD_PIKK_1	269	275	PF00454	0.598
MOD_PIKK_1	379	385	PF00454	0.626
MOD_PIKK_1	584	590	PF00454	0.790
MOD_PK_1	168	174	PF00069	0.551
MOD_PKA_1	467	473	PF00069	0.466
MOD_PKA_2	174	180	PF00069	0.598
MOD_PKA_2	269	275	PF00069	0.572
MOD_PKA_2	355	361	PF00069	0.692
MOD_PKA_2	368	374	PF00069	0.696
MOD_PKA_2	496	502	PF00069	0.655
MOD_PKA_2	559	565	PF00069	0.450
MOD_Plk_1	439	445	PF00069	0.535
MOD_Plk_4	130	136	PF00069	0.492
MOD_Plk_4	177	183	PF00069	0.711
MOD_Plk_4	211	217	PF00069	0.696
MOD_Plk_4	293	299	PF00069	0.659
MOD_Plk_4	439	445	PF00069	0.535
MOD_Plk_4	48	54	PF00069	0.320
MOD_Plk_4	515	521	PF00069	0.502
MOD_Plk_4	659	665	PF00069	0.784
MOD_Plk_4	678	684	PF00069	0.596
MOD_Plk_4	88	94	PF00069	0.396
MOD_ProDKin_1	170	176	PF00069	0.663
MOD_ProDKin_1	184	190	PF00069	0.672
MOD_ProDKin_1	201	207	PF00069	0.657
MOD_ProDKin_1	221	227	PF00069	0.799
MOD_ProDKin_1	258	264	PF00069	0.778
MOD_ProDKin_1	289	295	PF00069	0.762
MOD_ProDKin_1	381	387	PF00069	0.675
MOD_ProDKin_1	390	396	PF00069	0.612
MOD_ProDKin_1	582	588	PF00069	0.762
MOD_ProDKin_1	593	599	PF00069	0.550
MOD_ProDKin_1	623	629	PF00069	0.693
MOD_ProDKin_1	631	637	PF00069	0.616
MOD_ProDKin_1	83	89	PF00069	0.606
MOD_SUMO_rev_2	277	285	PF00179	0.695
MOD_SUMO_rev_2	337	345	PF00179	0.591
MOD_SUMO_rev_2	481	487	PF00179	0.718
MOD_SUMO_rev_2	517	524	PF00179	0.650
TRG_ENDOCYTIC_2	122	125	PF00928	0.542
TRG_ENDOCYTIC_2	663	666	PF00928	0.785
TRG_ER_diArg_1	360	362	PF00400	0.849
TRG_ER_diArg_1	367	370	PF00400	0.852
TRG_ER_diArg_1	444	446	PF00400	0.584
TRG_ER_diArg_1	455	457	PF00400	0.423
TRG_NES_CRM1_1	439	451	PF08389	0.541
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.679

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5C9	Leptomonas seymouri	43%	100%
A0A3Q8IEB2	Leishmania donovani	65%	99%
A4I365	Leishmania infantum	65%	99%
E9ADC8	Leishmania major	66%	100%
E9AZ53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	98%