Putative proteasome regulatory non-ATP-ase subunit 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome regulatory non-ATP-ase subunit 3, putative

Species:

Leishmania braziliensis

UniProt:

A4HFS3_LEIBR

TriTrypDb:

LbrM.27.1600 , LBRM2903_270021600 , LBRM2903_270021700

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000502	proteasome complex	3	11
GO:0032991	protein-containing complex	1	12
GO:0140535	intracellular protein-containing complex	2	11
GO:1902494	catalytic complex	2	11
GO:1905368	peptidase complex	3	11
GO:1905369	endopeptidase complex	4	11
GO:0005737	cytoplasm	2	1
GO:0008541	proteasome regulatory particle, lid subcomplex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFS3

Function

Biological processes
Term	Name	Level	Count
GO:0009894	regulation of catabolic process	4	12
GO:0019222	regulation of metabolic process	3	12
GO:0042176	regulation of protein catabolic process	5	12
GO:0050789	regulation of biological process	2	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0051246	regulation of protein metabolic process	5	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0080090	regulation of primary metabolic process	4	12
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0030234	enzyme regulator activity	2	12
GO:0098772	molecular function regulator activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.516
CLV_C14_Caspase3-7	282	286	PF00656	0.346
CLV_C14_Caspase3-7	323	327	PF00656	0.607
CLV_C14_Caspase3-7	98	102	PF00656	0.386
CLV_NRD_NRD_1	110	112	PF00675	0.380
CLV_NRD_NRD_1	204	206	PF00675	0.236
CLV_NRD_NRD_1	274	276	PF00675	0.289
CLV_NRD_NRD_1	303	305	PF00675	0.289
CLV_PCSK_KEX2_1	17	19	PF00082	0.550
CLV_PCSK_KEX2_1	204	206	PF00082	0.236
CLV_PCSK_KEX2_1	25	27	PF00082	0.475
CLV_PCSK_KEX2_1	274	276	PF00082	0.289
CLV_PCSK_KEX2_1	287	289	PF00082	0.289
CLV_PCSK_KEX2_1	303	305	PF00082	0.289
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.583
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.508
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.289
CLV_PCSK_SKI1_1	121	125	PF00082	0.313
CLV_PCSK_SKI1_1	170	174	PF00082	0.274
CLV_PCSK_SKI1_1	305	309	PF00082	0.377
DEG_ODPH_VHL_1	153	165	PF01847	0.435
DEG_SPOP_SBC_1	262	266	PF00917	0.296
DEG_SPOP_SBC_1	6	10	PF00917	0.397
DOC_CYCLIN_RxL_1	90	101	PF00134	0.361
DOC_MAPK_gen_1	274	281	PF00069	0.323
DOC_MAPK_MEF2A_6	126	135	PF00069	0.320
DOC_MAPK_MEF2A_6	150	159	PF00069	0.357
DOC_MAPK_MEF2A_6	186	194	PF00069	0.436
DOC_PP1_RVXF_1	272	279	PF00149	0.305
DOC_USP7_MATH_1	6	10	PF00917	0.553
LIG_14-3-3_CanoR_1	121	130	PF00244	0.204
LIG_14-3-3_CanoR_1	170	175	PF00244	0.497
LIG_14-3-3_CanoR_1	186	191	PF00244	0.356
LIG_14-3-3_CanoR_1	212	222	PF00244	0.470
LIG_Actin_WH2_2	191	206	PF00022	0.436
LIG_CSK_EPIYA_1	267	271	PF00017	0.374
LIG_FHA_1	122	128	PF00498	0.204
LIG_FHA_1	185	191	PF00498	0.448
LIG_FHA_1	67	73	PF00498	0.442
LIG_FHA_1	90	96	PF00498	0.347
LIG_FHA_2	280	286	PF00498	0.289
LIG_FHA_2	293	299	PF00498	0.351
LIG_FHA_2	321	327	PF00498	0.624
LIG_LIR_Gen_1	169	175	PF02991	0.517
LIG_LIR_LC3C_4	128	131	PF02991	0.369
LIG_LIR_Nem_3	169	174	PF02991	0.517
LIG_PDZ_Class_3	329	334	PF00595	0.590
LIG_PTB_Apo_2	324	331	PF02174	0.643
LIG_SH2_CRK	210	214	PF00017	0.436
LIG_SH2_CRK	31	35	PF00017	0.380
LIG_SH2_NCK_1	210	214	PF00017	0.436
LIG_SH2_PTP2	88	91	PF00017	0.337
LIG_SH2_SRC	99	102	PF00017	0.350
LIG_SH2_STAT3	270	273	PF00017	0.374
LIG_SH2_STAT5	156	159	PF00017	0.427
LIG_SH2_STAT5	232	235	PF00017	0.436
LIG_SH2_STAT5	85	88	PF00017	0.323
LIG_SH2_STAT5	99	102	PF00017	0.350
LIG_SH3_3	291	297	PF00018	0.410
LIG_SUMO_SIM_anti_2	124	131	PF11976	0.314
LIG_SUMO_SIM_anti_2	49	57	PF11976	0.271
LIG_SUMO_SIM_par_1	49	57	PF11976	0.302
LIG_WW_3	138	142	PF00397	0.388
MOD_CK1_1	211	217	PF00069	0.436
MOD_CK1_1	225	231	PF00069	0.436
MOD_CK1_1	256	262	PF00069	0.450
MOD_CK2_1	225	231	PF00069	0.430
MOD_CK2_1	261	267	PF00069	0.303
MOD_CK2_1	292	298	PF00069	0.396
MOD_GSK3_1	121	128	PF00069	0.364
MOD_GSK3_1	213	220	PF00069	0.489
MOD_GSK3_1	6	13	PF00069	0.540
MOD_GSK3_1	66	73	PF00069	0.467
MOD_LATS_1	184	190	PF00433	0.436
MOD_N-GLC_1	10	15	PF02516	0.613
MOD_N-GLC_1	225	230	PF02516	0.244
MOD_N-GLC_1	279	284	PF02516	0.280
MOD_N-GLC_1	70	75	PF02516	0.571
MOD_NEK2_1	149	154	PF00069	0.393
MOD_NEK2_1	222	227	PF00069	0.541
MOD_NEK2_1	279	284	PF00069	0.305
MOD_NEK2_1	53	58	PF00069	0.376
MOD_NEK2_1	66	71	PF00069	0.227
MOD_PKA_2	149	155	PF00069	0.410
MOD_PKA_2	211	217	PF00069	0.429
MOD_Plk_1	70	76	PF00069	0.455
MOD_Plk_4	125	131	PF00069	0.335
MOD_Plk_4	170	176	PF00069	0.436
MOD_Plk_4	186	192	PF00069	0.436
MOD_SUMO_for_1	307	310	PF00179	0.410
MOD_SUMO_rev_2	301	309	PF00179	0.410
TRG_DiLeu_BaEn_1	250	255	PF01217	0.448
TRG_ENDOCYTIC_2	156	159	PF00928	0.436
TRG_ENDOCYTIC_2	210	213	PF00928	0.436
TRG_ENDOCYTIC_2	31	34	PF00928	0.379
TRG_ENDOCYTIC_2	88	91	PF00928	0.337
TRG_ER_diArg_1	203	205	PF00400	0.471
TRG_ER_diArg_1	274	276	PF00400	0.305
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.261
TRG_Pf-PMV_PEXEL_1	316	320	PF00026	0.336
TRG_Pf-PMV_PEXEL_1	93	98	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I651	Leptomonas seymouri	92%	100%
A0A0S4JNS0	Bodo saltans	63%	95%
A0A1X0P493	Trypanosomatidae	71%	100%
A0A3Q8IEE7	Leishmania donovani	97%	100%
A0A3R7N9B6	Trypanosoma rangeli	72%	100%
A4I372	Leishmania infantum	96%	100%
D0A615	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	84%
E9ADC7	Leishmania major	97%	100%
E9AZ51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O42897	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	67%
O61470	Anopheles gambiae	44%	67%
P25161	Drosophila melanogaster	43%	68%
P93768	Nicotiana tabacum	45%	68%
Q04908	Caenorhabditis elegans	43%	66%
Q06364	Daucus carota	44%	68%
Q1ZXD3	Dictyostelium discoideum	39%	66%
Q9LNU4	Arabidopsis thaliana	43%	68%
Q9LQR8	Arabidopsis thaliana	44%	69%
Q9U5Z8	Anopheles stephensi	44%	67%
V5B0Y8	Trypanosoma cruzi	71%	100%