Putative proteasome regulatory non-ATP-ase subunit 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome regulatory non-ATP-ase subunit 3, putative

Species:

Leishmania braziliensis

UniProt:

A4HFS3_LEIBR

TriTrypDb:

LbrM.27.1600 , LBRM2903_270021600 , LBRM2903_270021700

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0000502	proteasome complex	3	11
GO:0005737	cytoplasm	2	1
GO:0008541	proteasome regulatory particle, lid subcomplex	2	1
GO:0032991	protein-containing complex	1	12
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	11
GO:1902494	catalytic complex	2	11
GO:1905368	peptidase complex	3	11
GO:1905369	endopeptidase complex	4	11

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Expansion

Sequence features

A4HFS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFS3

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009894	regulation of catabolic process	4	12
GO:0009987	cellular process	1	1
GO:0019222	regulation of metabolic process	3	12
GO:0019538	protein metabolic process	3	1

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Molecular functions
Term	Name	Level	Count
GO:0030234	enzyme regulator activity	2	12
GO:0098772	molecular function regulator activity	1	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.516
CLV_C14_Caspase3-7	282	286	PF00656	0.346
CLV_C14_Caspase3-7	323	327	PF00656	0.607
CLV_C14_Caspase3-7	98	102	PF00656	0.386
CLV_NRD_NRD_1	110	112	PF00675	0.380
CLV_NRD_NRD_1	204	206	PF00675	0.236
CLV_NRD_NRD_1	274	276	PF00675	0.289
CLV_NRD_NRD_1	303	305	PF00675	0.289
CLV_PCSK_KEX2_1	17	19	PF00082	0.550
CLV_PCSK_KEX2_1	204	206	PF00082	0.236

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I651	Leptomonas seymouri	92%	100%
A0A0S4JNS0	Bodo saltans	63%	95%
A0A1X0P493	Trypanosomatidae	71%	100%
A0A3Q8IEE7	Leishmania donovani	97%	100%
A0A3R7N9B6	Trypanosoma rangeli	72%	100%
A4I372	Leishmania infantum	96%	100%
D0A615	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	84%
E9ADC7	Leishmania major	97%	100%
E9AZ51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O42897	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	67%

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