CBF domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CBF/Mak21 family, putative

Species:

Leishmania braziliensis

UniProt:

A4HFS2_LEIBR

TriTrypDb:

LbrM.27.1590 , LBRM2903_270021500

Length:

855

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005730	nucleolus	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HFS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFS2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.351
CLV_C14_Caspase3-7	626	630	PF00656	0.525
CLV_C14_Caspase3-7	693	697	PF00656	0.712
CLV_C14_Caspase3-7	699	703	PF00656	0.541
CLV_C14_Caspase3-7	710	714	PF00656	0.609
CLV_C14_Caspase3-7	722	726	PF00656	0.706
CLV_MEL_PAP_1	836	842	PF00089	0.692
CLV_NRD_NRD_1	148	150	PF00675	0.433
CLV_NRD_NRD_1	184	186	PF00675	0.354
CLV_NRD_NRD_1	277	279	PF00675	0.417
CLV_NRD_NRD_1	314	316	PF00675	0.378
CLV_NRD_NRD_1	614	616	PF00675	0.462
CLV_NRD_NRD_1	678	680	PF00675	0.733
CLV_NRD_NRD_1	792	794	PF00675	0.580
CLV_NRD_NRD_1	851	853	PF00675	0.579
CLV_PCSK_KEX2_1	132	134	PF00082	0.417
CLV_PCSK_KEX2_1	163	165	PF00082	0.355
CLV_PCSK_KEX2_1	184	186	PF00082	0.356
CLV_PCSK_KEX2_1	314	316	PF00082	0.378
CLV_PCSK_KEX2_1	613	615	PF00082	0.322
CLV_PCSK_KEX2_1	678	680	PF00082	0.748
CLV_PCSK_KEX2_1	791	793	PF00082	0.554
CLV_PCSK_KEX2_1	851	853	PF00082	0.691
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.406
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.355
CLV_PCSK_PC1ET2_1	791	793	PF00082	0.562
CLV_PCSK_PC7_1	180	186	PF00082	0.407
CLV_PCSK_SKI1_1	116	120	PF00082	0.434
CLV_PCSK_SKI1_1	129	133	PF00082	0.354
CLV_PCSK_SKI1_1	249	253	PF00082	0.405
CLV_PCSK_SKI1_1	279	283	PF00082	0.398
CLV_PCSK_SKI1_1	314	318	PF00082	0.382
CLV_PCSK_SKI1_1	346	350	PF00082	0.334
CLV_PCSK_SKI1_1	421	425	PF00082	0.362
CLV_PCSK_SKI1_1	448	452	PF00082	0.390
CLV_PCSK_SKI1_1	614	618	PF00082	0.331
CLV_PCSK_SKI1_1	679	683	PF00082	0.769
DEG_APCC_DBOX_1	613	621	PF00400	0.336
DEG_MDM2_SWIB_1	366	374	PF02201	0.305
DEG_Nend_UBRbox_1	1	4	PF02207	0.438
DEG_SPOP_SBC_1	479	483	PF00917	0.339
DEG_SPOP_SBC_1	658	662	PF00917	0.613
DOC_CYCLIN_RxL_1	416	427	PF00134	0.220
DOC_CYCLIN_yCln2_LP_2	125	128	PF00134	0.461
DOC_MAPK_gen_1	11	18	PF00069	0.523
DOC_MAPK_gen_1	369	379	PF00069	0.321
DOC_MAPK_MEF2A_6	11	20	PF00069	0.526
DOC_MAPK_MEF2A_6	519	526	PF00069	0.390
DOC_MAPK_NFAT4_5	519	527	PF00069	0.489
DOC_MAPK_RevD_3	599	615	PF00069	0.303
DOC_PP1_RVXF_1	419	426	PF00149	0.305
DOC_PP2B_LxvP_1	125	128	PF13499	0.461
DOC_PP4_FxxP_1	14	17	PF00568	0.528
DOC_PP4_FxxP_1	292	295	PF00568	0.269
DOC_USP7_MATH_1	217	221	PF00917	0.480
DOC_USP7_MATH_1	404	408	PF00917	0.422
DOC_USP7_MATH_1	458	462	PF00917	0.453
DOC_USP7_MATH_1	470	474	PF00917	0.423
DOC_USP7_MATH_1	479	483	PF00917	0.418
DOC_USP7_MATH_1	584	588	PF00917	0.489
DOC_USP7_MATH_1	664	668	PF00917	0.665
DOC_USP7_MATH_1	721	725	PF00917	0.755
DOC_USP7_MATH_1	766	770	PF00917	0.490
DOC_USP7_MATH_1	804	808	PF00917	0.738
DOC_USP7_MATH_2	657	663	PF00917	0.472
DOC_USP7_UBL2_3	275	279	PF12436	0.432
DOC_USP7_UBL2_3	786	790	PF12436	0.563
DOC_WW_Pin1_4	378	383	PF00397	0.320
DOC_WW_Pin1_4	538	543	PF00397	0.533
DOC_WW_Pin1_4	550	555	PF00397	0.559
DOC_WW_Pin1_4	592	597	PF00397	0.438
DOC_WW_Pin1_4	673	678	PF00397	0.498
DOC_WW_Pin1_4	826	831	PF00397	0.715
LIG_14-3-3_CanoR_1	133	142	PF00244	0.411
LIG_14-3-3_CanoR_1	149	154	PF00244	0.369
LIG_14-3-3_CanoR_1	2	7	PF00244	0.590
LIG_14-3-3_CanoR_1	203	211	PF00244	0.443
LIG_14-3-3_CanoR_1	21	26	PF00244	0.449
LIG_14-3-3_CanoR_1	346	351	PF00244	0.305
LIG_14-3-3_CanoR_1	369	375	PF00244	0.390
LIG_14-3-3_CanoR_1	511	515	PF00244	0.340
LIG_14-3-3_CanoR_1	62	69	PF00244	0.512
LIG_14-3-3_CanoR_1	624	628	PF00244	0.531
LIG_14-3-3_CanoR_1	639	644	PF00244	0.471
LIG_14-3-3_CanoR_1	71	78	PF00244	0.403
LIG_Actin_WH2_2	298	316	PF00022	0.407
LIG_APCC_ABBA_1	523	528	PF00400	0.385
LIG_APCC_ABBA_1	546	551	PF00400	0.458
LIG_BIR_III_2	551	555	PF00653	0.416
LIG_BIR_III_4	190	194	PF00653	0.362
LIG_BIR_III_4	629	633	PF00653	0.475
LIG_BRCT_BRCA1_1	135	139	PF00533	0.440
LIG_BRCT_BRCA1_1	240	244	PF00533	0.490
LIG_BRCT_BRCA1_1	601	605	PF00533	0.338
LIG_BRCT_BRCA1_1	64	68	PF00533	0.613
LIG_Clathr_ClatBox_1	716	720	PF01394	0.517
LIG_DLG_GKlike_1	639	647	PF00625	0.397
LIG_FHA_1	142	148	PF00498	0.442
LIG_FHA_1	149	155	PF00498	0.345
LIG_FHA_1	20	26	PF00498	0.566
LIG_FHA_1	28	34	PF00498	0.582
LIG_FHA_1	296	302	PF00498	0.471
LIG_FHA_1	304	310	PF00498	0.329
LIG_FHA_1	347	353	PF00498	0.313
LIG_FHA_1	503	509	PF00498	0.250
LIG_FHA_1	551	557	PF00498	0.540
LIG_FHA_1	566	572	PF00498	0.668
LIG_FHA_1	762	768	PF00498	0.647
LIG_FHA_1	783	789	PF00498	0.417
LIG_FHA_2	185	191	PF00498	0.489
LIG_FHA_2	243	249	PF00498	0.451
LIG_FHA_2	624	630	PF00498	0.555
LIG_FHA_2	639	645	PF00498	0.477
LIG_FHA_2	651	657	PF00498	0.616
LIG_FHA_2	702	708	PF00498	0.729
LIG_FHA_2	71	77	PF00498	0.421
LIG_FHA_2	738	744	PF00498	0.670
LIG_FXI_DFP_1	716	720	PF00024	0.743
LIG_LIR_Apic_2	290	295	PF02991	0.258
LIG_LIR_Gen_1	136	147	PF02991	0.418
LIG_LIR_Gen_1	165	172	PF02991	0.370
LIG_LIR_Gen_1	241	252	PF02991	0.460
LIG_LIR_Gen_1	287	296	PF02991	0.372
LIG_LIR_Gen_1	392	402	PF02991	0.339
LIG_LIR_Gen_1	95	104	PF02991	0.396
LIG_LIR_Nem_3	119	125	PF02991	0.487
LIG_LIR_Nem_3	136	142	PF02991	0.349
LIG_LIR_Nem_3	152	158	PF02991	0.324
LIG_LIR_Nem_3	165	169	PF02991	0.274
LIG_LIR_Nem_3	241	247	PF02991	0.456
LIG_LIR_Nem_3	287	291	PF02991	0.350
LIG_LIR_Nem_3	373	378	PF02991	0.366
LIG_LIR_Nem_3	392	398	PF02991	0.155
LIG_LIR_Nem_3	684	689	PF02991	0.525
LIG_LIR_Nem_3	775	780	PF02991	0.585
LIG_LIR_Nem_3	87	93	PF02991	0.382
LIG_LIR_Nem_3	95	100	PF02991	0.364
LIG_MLH1_MIPbox_1	135	139	PF16413	0.440
LIG_MYND_1	123	127	PF01753	0.408
LIG_NBox_RRM_1	425	435	PF00076	0.200
LIG_NRBOX	228	234	PF00104	0.387
LIG_NRBOX	351	357	PF00104	0.426
LIG_NRBOX	373	379	PF00104	0.321
LIG_NRBOX	519	525	PF00104	0.489
LIG_OCRL_FandH_1	394	406	PF00620	0.321
LIG_Pex14_2	366	370	PF04695	0.305
LIG_Pex14_2	545	549	PF04695	0.449
LIG_Pex14_2	97	101	PF04695	0.372
LIG_PTB_Apo_2	365	372	PF02174	0.321
LIG_PTB_Phospho_1	365	371	PF10480	0.321
LIG_RPA_C_Fungi	603	615	PF08784	0.296
LIG_SH2_CRK	371	375	PF00017	0.308
LIG_SH2_SRC	42	45	PF00017	0.512
LIG_SH2_SRC	93	96	PF00017	0.494
LIG_SH2_STAP1	111	115	PF00017	0.381
LIG_SH2_STAP1	166	170	PF00017	0.368
LIG_SH2_STAP1	263	267	PF00017	0.365
LIG_SH2_STAP1	64	68	PF00017	0.613
LIG_SH2_STAP1	738	742	PF00017	0.715
LIG_SH2_STAT3	609	612	PF00017	0.378
LIG_SH2_STAT3	64	67	PF00017	0.481
LIG_SH2_STAT5	138	141	PF00017	0.509
LIG_SH2_STAT5	157	160	PF00017	0.170
LIG_SH2_STAT5	161	164	PF00017	0.353
LIG_SH2_STAT5	288	291	PF00017	0.378
LIG_SH2_STAT5	590	593	PF00017	0.463
LIG_SH2_STAT5	93	96	PF00017	0.494
LIG_SH3_1	124	130	PF00018	0.390
LIG_SH3_2	127	132	PF14604	0.394
LIG_SH3_3	124	130	PF00018	0.401
LIG_SH3_3	13	19	PF00018	0.520
LIG_SH3_3	454	460	PF00018	0.406
LIG_SUMO_SIM_anti_2	349	354	PF11976	0.322
LIG_SUMO_SIM_anti_2	521	526	PF11976	0.489
LIG_SUMO_SIM_par_1	376	381	PF11976	0.321
LIG_SUMO_SIM_par_1	433	439	PF11976	0.305
LIG_TRAF2_1	274	277	PF00917	0.513
LIG_TRAF2_1	326	329	PF00917	0.463
LIG_TRAF2_1	690	693	PF00917	0.694
LIG_TYR_ITIM	153	158	PF00017	0.334
LIG_UBA3_1	243	249	PF00899	0.366
LIG_UBA3_1	352	360	PF00899	0.305
LIG_UBA3_1	377	383	PF00899	0.319
LIG_UBA3_1	780	786	PF00899	0.409
LIG_WW_3	126	130	PF00397	0.479
MOD_CDK_SPK_2	378	383	PF00069	0.305
MOD_CDK_SPK_2	673	678	PF00069	0.498
MOD_CDK_SPxK_1	673	679	PF00069	0.500
MOD_CDK_SPxxK_3	550	557	PF00069	0.554
MOD_CDK_SPxxK_3	826	833	PF00069	0.714
MOD_CK1_1	234	240	PF00069	0.526
MOD_CK1_1	303	309	PF00069	0.434
MOD_CK1_1	475	481	PF00069	0.400
MOD_CK1_1	510	516	PF00069	0.357
MOD_CK1_1	565	571	PF00069	0.660
MOD_CK1_1	582	588	PF00069	0.552
MOD_CK1_1	642	648	PF00069	0.385
MOD_CK1_1	70	76	PF00069	0.464
MOD_CK2_1	168	174	PF00069	0.247
MOD_CK2_1	195	201	PF00069	0.373
MOD_CK2_1	242	248	PF00069	0.451
MOD_CK2_1	271	277	PF00069	0.462
MOD_CK2_1	323	329	PF00069	0.478
MOD_CK2_1	687	693	PF00069	0.650
MOD_GlcNHglycan	387	390	PF01048	0.368
MOD_GlcNHglycan	477	480	PF01048	0.424
MOD_GlcNHglycan	564	567	PF01048	0.483
MOD_GlcNHglycan	600	604	PF01048	0.552
MOD_GlcNHglycan	629	633	PF01048	0.539
MOD_GlcNHglycan	650	653	PF01048	0.571
MOD_GlcNHglycan	661	664	PF01048	0.613
MOD_GlcNHglycan	79	82	PF01048	0.273
MOD_GlcNHglycan	802	805	PF01048	0.574
MOD_GlcNHglycan	806	809	PF01048	0.604
MOD_GlcNHglycan	845	848	PF01048	0.485
MOD_GSK3_1	168	175	PF00069	0.393
MOD_GSK3_1	231	238	PF00069	0.420
MOD_GSK3_1	27	34	PF00069	0.583
MOD_GSK3_1	300	307	PF00069	0.419
MOD_GSK3_1	385	392	PF00069	0.328
MOD_GSK3_1	471	478	PF00069	0.434
MOD_GSK3_1	562	569	PF00069	0.671
MOD_GSK3_1	579	586	PF00069	0.462
MOD_GSK3_1	618	625	PF00069	0.483
MOD_GSK3_1	63	70	PF00069	0.507
MOD_GSK3_1	638	645	PF00069	0.331
MOD_GSK3_1	697	704	PF00069	0.540
MOD_GSK3_1	782	789	PF00069	0.657
MOD_GSK3_1	800	807	PF00069	0.549
MOD_GSK3_1	822	829	PF00069	0.769
MOD_GSK3_1	839	846	PF00069	0.454
MOD_LATS_1	60	66	PF00433	0.375
MOD_N-GLC_1	475	480	PF02516	0.371
MOD_N-GLC_1	592	597	PF02516	0.478
MOD_NEK2_1	1	6	PF00069	0.623
MOD_NEK2_1	100	105	PF00069	0.359
MOD_NEK2_1	162	167	PF00069	0.351
MOD_NEK2_1	172	177	PF00069	0.358
MOD_NEK2_1	195	200	PF00069	0.373
MOD_NEK2_1	233	238	PF00069	0.411
MOD_NEK2_1	247	252	PF00069	0.373
MOD_NEK2_1	337	342	PF00069	0.395
MOD_NEK2_1	638	643	PF00069	0.609
MOD_NEK2_1	760	765	PF00069	0.701
MOD_NEK2_2	257	262	PF00069	0.382
MOD_NEK2_2	370	375	PF00069	0.390
MOD_PIKK_1	133	139	PF00454	0.415
MOD_PIKK_1	438	444	PF00454	0.452
MOD_PIKK_1	618	624	PF00454	0.501
MOD_PIKK_1	63	69	PF00454	0.534
MOD_PK_1	2	8	PF00069	0.352
MOD_PKA_1	149	155	PF00069	0.465
MOD_PKA_1	184	190	PF00069	0.495
MOD_PKA_2	1	7	PF00069	0.378
MOD_PKA_2	148	154	PF00069	0.413
MOD_PKA_2	184	190	PF00069	0.509
MOD_PKA_2	202	208	PF00069	0.326
MOD_PKA_2	510	516	PF00069	0.355
MOD_PKA_2	623	629	PF00069	0.536
MOD_PKA_2	638	644	PF00069	0.517
MOD_PKA_2	70	76	PF00069	0.429
MOD_PKA_2	838	844	PF00069	0.725
MOD_Plk_1	247	253	PF00069	0.419
MOD_Plk_1	301	307	PF00069	0.408
MOD_Plk_1	599	605	PF00069	0.331
MOD_Plk_2-3	323	329	PF00069	0.474
MOD_Plk_4	149	155	PF00069	0.388
MOD_Plk_4	172	178	PF00069	0.487
MOD_Plk_4	184	190	PF00069	0.468
MOD_Plk_4	2	8	PF00069	0.515
MOD_Plk_4	238	244	PF00069	0.483
MOD_Plk_4	247	253	PF00069	0.497
MOD_Plk_4	284	290	PF00069	0.356
MOD_Plk_4	348	354	PF00069	0.319
MOD_Plk_4	362	368	PF00069	0.305
MOD_Plk_4	37	43	PF00069	0.545
MOD_Plk_4	513	519	PF00069	0.365
MOD_ProDKin_1	378	384	PF00069	0.320
MOD_ProDKin_1	538	544	PF00069	0.531
MOD_ProDKin_1	550	556	PF00069	0.562
MOD_ProDKin_1	592	598	PF00069	0.440
MOD_ProDKin_1	673	679	PF00069	0.500
MOD_ProDKin_1	826	832	PF00069	0.715
MOD_SUMO_for_1	556	559	PF00179	0.512
MOD_SUMO_rev_2	274	281	PF00179	0.414
MOD_SUMO_rev_2	50	56	PF00179	0.548
MOD_SUMO_rev_2	555	565	PF00179	0.712
TRG_DiLeu_BaEn_2	247	253	PF01217	0.396
TRG_DiLeu_BaLyEn_6	414	419	PF01217	0.305
TRG_ENDOCYTIC_2	155	158	PF00928	0.335
TRG_ENDOCYTIC_2	166	169	PF00928	0.358
TRG_ENDOCYTIC_2	226	229	PF00928	0.361
TRG_ENDOCYTIC_2	288	291	PF00928	0.353
TRG_ENDOCYTIC_2	319	322	PF00928	0.504
TRG_ENDOCYTIC_2	371	374	PF00928	0.308
TRG_ENDOCYTIC_2	375	378	PF00928	0.302
TRG_ENDOCYTIC_2	686	689	PF00928	0.534
TRG_ER_diArg_1	313	315	PF00400	0.380
TRG_ER_diArg_1	488	491	PF00400	0.275
TRG_ER_diArg_1	613	615	PF00400	0.415
TRG_ER_diArg_1	677	679	PF00400	0.499
TRG_ER_diArg_1	792	794	PF00400	0.544
TRG_ER_diArg_1	833	836	PF00400	0.613
TRG_ER_diArg_1	850	852	PF00400	0.511
TRG_NES_CRM1_1	538	551	PF08389	0.526
TRG_NES_CRM1_1	89	102	PF08389	0.368
TRG_NLS_MonoCore_2	789	794	PF00514	0.591
TRG_NLS_MonoExtC_3	789	795	PF00514	0.535
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	778	782	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	792	797	PF00026	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKJ4	Leptomonas seymouri	78%	100%
A0A0S4JS41	Bodo saltans	52%	100%
A0A1X0P4I0	Trypanosomatidae	61%	100%
A0A3R7MHJ2	Trypanosoma rangeli	60%	100%
A0A3S7X0Q5	Leishmania donovani	85%	100%
A4I371	Leishmania infantum	85%	100%
D0A614	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9ADC6	Leishmania major	85%	100%
E9AZ50	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
G0SEQ5	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	28%	82%
O36021	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	99%
Q12176	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	83%
V5DHD7	Trypanosoma cruzi	58%	100%