Putative ethanolamine kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ethanolamine kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HFS0_LEIBR

TriTrypDb:

LbrM.27.1560 , LBRM2903_270021200

Length:

642

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFS0

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016310	phosphorylation	5	8
GO:0044237	cellular metabolic process	2	8
GO:0006629	lipid metabolic process	3	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006646	phosphatidylethanolamine biosynthetic process	6	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006656	phosphatidylcholine biosynthetic process	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008610	lipid biosynthetic process	4	1
GO:0008654	phospholipid biosynthetic process	5	1
GO:0009058	biosynthetic process	2	1
GO:0019637	organophosphate metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046337	phosphatidylethanolamine metabolic process	6	1
GO:0046470	phosphatidylcholine metabolic process	4	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004103	choline kinase activity	5	5
GO:0016301	kinase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	5
GO:0004305	ethanolamine kinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.424
CLV_C14_Caspase3-7	8	12	PF00656	0.340
CLV_NRD_NRD_1	434	436	PF00675	0.203
CLV_NRD_NRD_1	482	484	PF00675	0.312
CLV_NRD_NRD_1	535	537	PF00675	0.391
CLV_PCSK_KEX2_1	261	263	PF00082	0.474
CLV_PCSK_KEX2_1	434	436	PF00082	0.280
CLV_PCSK_KEX2_1	457	459	PF00082	0.203
CLV_PCSK_KEX2_1	495	497	PF00082	0.271
CLV_PCSK_KEX2_1	535	537	PF00082	0.464
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.474
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.203
CLV_PCSK_PC1ET2_1	495	497	PF00082	0.259
CLV_PCSK_SKI1_1	130	134	PF00082	0.680
CLV_PCSK_SKI1_1	356	360	PF00082	0.447
CLV_PCSK_SKI1_1	496	500	PF00082	0.302
CLV_PCSK_SKI1_1	539	543	PF00082	0.405
CLV_PCSK_SKI1_1	570	574	PF00082	0.437
CLV_PCSK_SKI1_1	593	597	PF00082	0.354
DOC_AGCK_PIF_2	319	324	PF00069	0.395
DOC_CKS1_1	108	113	PF01111	0.692
DOC_CYCLIN_RxL_1	587	599	PF00134	0.322
DOC_MAPK_gen_1	481	491	PF00069	0.508
DOC_MAPK_gen_1	627	636	PF00069	0.299
DOC_MAPK_MEF2A_6	16	25	PF00069	0.461
DOC_MAPK_MEF2A_6	251	260	PF00069	0.371
DOC_MAPK_MEF2A_6	627	636	PF00069	0.272
DOC_PP1_RVXF_1	485	492	PF00149	0.459
DOC_PP1_RVXF_1	568	575	PF00149	0.435
DOC_PP2B_LxvP_1	308	311	PF13499	0.402
DOC_USP7_MATH_1	101	105	PF00917	0.642
DOC_USP7_MATH_1	158	162	PF00917	0.508
DOC_USP7_MATH_1	203	207	PF00917	0.587
DOC_USP7_MATH_1	223	227	PF00917	0.636
DOC_USP7_MATH_1	280	284	PF00917	0.473
DOC_USP7_MATH_1	525	529	PF00917	0.418
DOC_USP7_MATH_1	547	551	PF00917	0.560
DOC_USP7_MATH_1	80	84	PF00917	0.658
DOC_USP7_UBL2_3	37	41	PF12436	0.388
DOC_USP7_UBL2_3	373	377	PF12436	0.532
DOC_WW_Pin1_4	107	112	PF00397	0.727
DOC_WW_Pin1_4	205	210	PF00397	0.591
DOC_WW_Pin1_4	338	343	PF00397	0.276
LIG_14-3-3_CanoR_1	443	453	PF00244	0.508
LIG_14-3-3_CanoR_1	587	595	PF00244	0.244
LIG_APCC_ABBA_1	272	277	PF00400	0.435
LIG_BIR_II_1	1	5	PF00653	0.378
LIG_BRCT_BRCA1_1	300	304	PF00533	0.412
LIG_CtBP_PxDLS_1	68	72	PF00389	0.529
LIG_FHA_1	139	145	PF00498	0.507
LIG_FHA_1	248	254	PF00498	0.718
LIG_FHA_1	266	272	PF00498	0.286
LIG_FHA_1	280	286	PF00498	0.390
LIG_FHA_1	291	297	PF00498	0.419
LIG_FHA_1	413	419	PF00498	0.456
LIG_FHA_1	87	93	PF00498	0.514
LIG_LIR_Apic_2	326	332	PF02991	0.405
LIG_LIR_Gen_1	302	313	PF02991	0.339
LIG_LIR_Gen_1	330	340	PF02991	0.429
LIG_LIR_Gen_1	415	422	PF02991	0.459
LIG_LIR_Gen_1	604	613	PF02991	0.374
LIG_LIR_Nem_3	270	275	PF02991	0.437
LIG_LIR_Nem_3	302	308	PF02991	0.395
LIG_LIR_Nem_3	317	322	PF02991	0.334
LIG_LIR_Nem_3	326	331	PF02991	0.236
LIG_LIR_Nem_3	374	379	PF02991	0.547
LIG_LIR_Nem_3	415	420	PF02991	0.502
LIG_LIR_Nem_3	509	513	PF02991	0.527
LIG_LIR_Nem_3	514	520	PF02991	0.481
LIG_LIR_Nem_3	604	609	PF02991	0.345
LIG_LIR_Nem_3	617	623	PF02991	0.317
LIG_LYPXL_yS_3	180	183	PF13949	0.630
LIG_MYND_1	13	17	PF01753	0.334
LIG_NRBOX	49	55	PF00104	0.452
LIG_NRBOX	590	596	PF00104	0.375
LIG_PTB_Apo_2	266	273	PF02174	0.405
LIG_SH2_CRK	305	309	PF00017	0.337
LIG_SH2_CRK	329	333	PF00017	0.395
LIG_SH2_NCK_1	329	333	PF00017	0.407
LIG_SH2_NCK_1	501	505	PF00017	0.502
LIG_SH2_SRC	409	412	PF00017	0.492
LIG_SH2_STAP1	517	521	PF00017	0.459
LIG_SH2_STAT5	216	219	PF00017	0.473
LIG_SH2_STAT5	313	316	PF00017	0.331
LIG_SH2_STAT5	329	332	PF00017	0.420
LIG_SH2_STAT5	409	412	PF00017	0.459
LIG_SH2_STAT5	493	496	PF00017	0.459
LIG_SH2_STAT5	520	523	PF00017	0.403
LIG_SH2_STAT5	631	634	PF00017	0.348
LIG_SH3_1	251	257	PF00018	0.394
LIG_SH3_2	125	130	PF14604	0.536
LIG_SH3_2	77	82	PF14604	0.550
LIG_SH3_3	100	106	PF00018	0.678
LIG_SH3_3	108	114	PF00018	0.696
LIG_SH3_3	119	125	PF00018	0.653
LIG_SH3_3	187	193	PF00018	0.606
LIG_SH3_3	251	257	PF00018	0.518
LIG_SH3_3	74	80	PF00018	0.665
LIG_SUMO_SIM_anti_2	581	586	PF11976	0.284
LIG_SUMO_SIM_par_1	16	22	PF11976	0.288
LIG_SUMO_SIM_par_1	593	599	PF11976	0.305
LIG_SUMO_SIM_par_1	67	72	PF11976	0.530
LIG_TRAF2_1	332	335	PF00917	0.301
LIG_TRAF2_1	96	99	PF00917	0.518
LIG_TYR_ITIM	303	308	PF00017	0.341
LIG_TYR_ITIM	320	325	PF00017	0.329
LIG_UBA3_1	410	416	PF00899	0.502
MOD_CDK_SPxxK_3	338	345	PF00069	0.271
MOD_CK1_1	148	154	PF00069	0.520
MOD_CK1_1	161	167	PF00069	0.724
MOD_CK1_1	170	176	PF00069	0.703
MOD_CK1_1	226	232	PF00069	0.540
MOD_CK1_1	245	251	PF00069	0.479
MOD_CK1_1	298	304	PF00069	0.352
MOD_CK1_1	389	395	PF00069	0.656
MOD_CK1_1	444	450	PF00069	0.594
MOD_CK1_1	550	556	PF00069	0.635
MOD_CK1_1	599	605	PF00069	0.303
MOD_CK2_1	434	440	PF00069	0.541
MOD_CK2_1	542	548	PF00069	0.330
MOD_CK2_1	572	578	PF00069	0.449
MOD_CMANNOS	603	606	PF00535	0.310
MOD_GlcNHglycan	225	228	PF01048	0.632
MOD_GlcNHglycan	263	266	PF01048	0.417
MOD_GlcNHglycan	446	449	PF01048	0.361
MOD_GlcNHglycan	473	476	PF01048	0.259
MOD_GlcNHglycan	509	513	PF01048	0.203
MOD_GlcNHglycan	527	530	PF01048	0.384
MOD_GlcNHglycan	613	616	PF01048	0.466
MOD_GlcNHglycan	637	641	PF01048	0.362
MOD_GlcNHglycan	70	74	PF01048	0.667
MOD_GlcNHglycan	99	102	PF01048	0.703
MOD_GSK3_1	148	155	PF00069	0.707
MOD_GSK3_1	158	165	PF00069	0.642
MOD_GSK3_1	166	173	PF00069	0.670
MOD_GSK3_1	222	229	PF00069	0.639
MOD_GSK3_1	261	268	PF00069	0.436
MOD_GSK3_1	386	393	PF00069	0.583
MOD_GSK3_1	434	441	PF00069	0.480
MOD_GSK3_1	516	523	PF00069	0.504
MOD_GSK3_1	553	560	PF00069	0.444
MOD_GSK3_1	88	95	PF00069	0.531
MOD_GSK3_1	97	104	PF00069	0.537
MOD_N-GLC_1	161	166	PF02516	0.499
MOD_N-GLC_1	5	10	PF02516	0.346
MOD_NEK2_1	166	171	PF00069	0.681
MOD_NEK2_1	304	309	PF00069	0.340
MOD_NEK2_1	367	372	PF00069	0.560
MOD_NEK2_1	410	415	PF00069	0.502
MOD_NEK2_1	438	443	PF00069	0.499
MOD_NEK2_1	491	496	PF00069	0.575
MOD_NEK2_1	53	58	PF00069	0.467
MOD_NEK2_1	542	547	PF00069	0.289
MOD_NEK2_1	601	606	PF00069	0.355
MOD_NEK2_1	69	74	PF00069	0.529
MOD_PIKK_1	101	107	PF00454	0.577
MOD_PIKK_1	115	121	PF00454	0.667
MOD_PIKK_1	367	373	PF00454	0.546
MOD_PIKK_1	586	592	PF00454	0.256
MOD_PIKK_1	71	77	PF00454	0.690
MOD_PIKK_1	80	86	PF00454	0.599
MOD_PKA_1	261	267	PF00069	0.497
MOD_PKA_1	434	440	PF00069	0.468
MOD_PKA_2	167	173	PF00069	0.523
MOD_PKA_2	261	267	PF00069	0.438
MOD_PKA_2	298	304	PF00069	0.352
MOD_PKA_2	352	358	PF00069	0.340
MOD_PKA_2	367	373	PF00069	0.487
MOD_PKA_2	393	399	PF00069	0.383
MOD_PKA_2	404	410	PF00069	0.547
MOD_PKA_2	434	440	PF00069	0.508
MOD_PKA_2	586	592	PF00069	0.256
MOD_Plk_1	161	167	PF00069	0.499
MOD_Plk_1	5	11	PF00069	0.349
MOD_Plk_1	542	548	PF00069	0.297
MOD_Plk_4	232	238	PF00069	0.525
MOD_Plk_4	280	286	PF00069	0.449
MOD_Plk_4	304	310	PF00069	0.336
MOD_Plk_4	434	440	PF00069	0.591
MOD_Plk_4	451	457	PF00069	0.406
MOD_Plk_4	458	464	PF00069	0.502
MOD_Plk_4	516	522	PF00069	0.502
MOD_Plk_4	547	553	PF00069	0.373
MOD_ProDKin_1	107	113	PF00069	0.725
MOD_ProDKin_1	205	211	PF00069	0.586
MOD_ProDKin_1	338	344	PF00069	0.269
TRG_DiLeu_BaEn_1	239	244	PF01217	0.486
TRG_DiLeu_BaEn_1	406	411	PF01217	0.502
TRG_DiLeu_BaLyEn_6	362	367	PF01217	0.446
TRG_ENDOCYTIC_2	180	183	PF00928	0.630
TRG_ENDOCYTIC_2	305	308	PF00928	0.339
TRG_ENDOCYTIC_2	322	325	PF00928	0.340
TRG_ENDOCYTIC_2	328	331	PF00928	0.352
TRG_ENDOCYTIC_2	333	336	PF00928	0.374
TRG_ENDOCYTIC_2	510	513	PF00928	0.492
TRG_ENDOCYTIC_2	631	634	PF00928	0.437
TRG_ER_diArg_1	534	536	PF00400	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5C8	Leptomonas seymouri	55%	100%
A0A1X0P4H9	Trypanosomatidae	46%	100%
A0A3Q8IPY5	Leishmania donovani	74%	100%
A4I2U4	Leishmania infantum	74%	100%
E9ADC3	Leishmania major	73%	100%
E9AZ47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%