Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFR9_LEIBR

TriTrypDb:

LbrM.27.1570 , LBRM2903_270021300

Length:

913

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFR9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.438
CLV_C14_Caspase3-7	513	517	PF00656	0.500
CLV_NRD_NRD_1	143	145	PF00675	0.422
CLV_NRD_NRD_1	278	280	PF00675	0.559
CLV_NRD_NRD_1	315	317	PF00675	0.607
CLV_NRD_NRD_1	395	397	PF00675	0.743
CLV_NRD_NRD_1	470	472	PF00675	0.616
CLV_NRD_NRD_1	906	908	PF00675	0.590
CLV_PCSK_KEX2_1	118	120	PF00082	0.464
CLV_PCSK_KEX2_1	143	145	PF00082	0.422
CLV_PCSK_KEX2_1	278	280	PF00082	0.558
CLV_PCSK_KEX2_1	315	317	PF00082	0.607
CLV_PCSK_KEX2_1	397	399	PF00082	0.779
CLV_PCSK_KEX2_1	831	833	PF00082	0.556
CLV_PCSK_KEX2_1	840	842	PF00082	0.553
CLV_PCSK_KEX2_1	906	908	PF00082	0.590
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.464
CLV_PCSK_PC1ET2_1	397	399	PF00082	0.657
CLV_PCSK_PC1ET2_1	831	833	PF00082	0.556
CLV_PCSK_PC1ET2_1	840	842	PF00082	0.553
CLV_PCSK_SKI1_1	241	245	PF00082	0.529
CLV_PCSK_SKI1_1	278	282	PF00082	0.577
CLV_PCSK_SKI1_1	315	319	PF00082	0.678
CLV_PCSK_SKI1_1	423	427	PF00082	0.568
CLV_PCSK_SKI1_1	633	637	PF00082	0.533
CLV_PCSK_SKI1_1	649	653	PF00082	0.466
CLV_PCSK_SKI1_1	74	78	PF00082	0.488
CLV_PCSK_SKI1_1	841	845	PF00082	0.577
CLV_PCSK_SKI1_1	907	911	PF00082	0.588
CLV_Separin_Metazoa	434	438	PF03568	0.410
DEG_COP1_1	636	645	PF00400	0.528
DEG_Nend_UBRbox_2	1	3	PF02207	0.566
DEG_SPOP_SBC_1	356	360	PF00917	0.432
DEG_SPOP_SBC_1	851	855	PF00917	0.530
DEG_SPOP_SBC_1	858	862	PF00917	0.494
DOC_ANK_TNKS_1	143	150	PF00023	0.439
DOC_CKS1_1	608	613	PF01111	0.518
DOC_CYCLIN_RxL_1	312	321	PF00134	0.674
DOC_CYCLIN_yClb1_LxF_4	284	289	PF00134	0.446
DOC_MAPK_gen_1	118	126	PF00069	0.462
DOC_MAPK_gen_1	54	63	PF00069	0.567
DOC_MAPK_gen_1	684	693	PF00069	0.566
DOC_MAPK_MEF2A_6	119	128	PF00069	0.545
DOC_MAPK_MEF2A_6	54	63	PF00069	0.567
DOC_MAPK_MEF2A_6	686	695	PF00069	0.466
DOC_MAPK_MEF2A_6	755	763	PF00069	0.443
DOC_MAPK_MEF2A_6	90	97	PF00069	0.450
DOC_PP1_RVXF_1	284	290	PF00149	0.446
DOC_PP1_RVXF_1	321	328	PF00149	0.421
DOC_PP1_RVXF_1	797	804	PF00149	0.549
DOC_PP2B_LxvP_1	297	300	PF13499	0.653
DOC_PP4_FxxP_1	281	284	PF00568	0.558
DOC_PP4_FxxP_1	346	349	PF00568	0.524
DOC_USP7_MATH_1	113	117	PF00917	0.701
DOC_USP7_MATH_1	167	171	PF00917	0.480
DOC_USP7_MATH_1	220	224	PF00917	0.636
DOC_USP7_MATH_1	29	33	PF00917	0.509
DOC_USP7_MATH_1	356	360	PF00917	0.454
DOC_USP7_MATH_1	399	403	PF00917	0.727
DOC_USP7_MATH_1	52	56	PF00917	0.580
DOC_USP7_MATH_1	521	525	PF00917	0.632
DOC_USP7_MATH_1	543	547	PF00917	0.621
DOC_USP7_MATH_1	557	561	PF00917	0.590
DOC_USP7_MATH_1	68	72	PF00917	0.391
DOC_USP7_MATH_1	811	815	PF00917	0.620
DOC_USP7_MATH_1	851	855	PF00917	0.622
DOC_WW_Pin1_4	102	107	PF00397	0.498
DOC_WW_Pin1_4	3	8	PF00397	0.557
DOC_WW_Pin1_4	389	394	PF00397	0.595
DOC_WW_Pin1_4	401	406	PF00397	0.557
DOC_WW_Pin1_4	448	453	PF00397	0.417
DOC_WW_Pin1_4	491	496	PF00397	0.570
DOC_WW_Pin1_4	517	522	PF00397	0.539
DOC_WW_Pin1_4	607	612	PF00397	0.648
DOC_WW_Pin1_4	64	69	PF00397	0.550
DOC_WW_Pin1_4	824	829	PF00397	0.784
LIG_14-3-3_CanoR_1	119	128	PF00244	0.528
LIG_14-3-3_CanoR_1	241	248	PF00244	0.530
LIG_14-3-3_CanoR_1	286	290	PF00244	0.432
LIG_14-3-3_CanoR_1	398	407	PF00244	0.721
LIG_14-3-3_CanoR_1	474	480	PF00244	0.674
LIG_14-3-3_CanoR_1	54	60	PF00244	0.597
LIG_14-3-3_CanoR_1	567	573	PF00244	0.710
LIG_14-3-3_CanoR_1	637	641	PF00244	0.531
LIG_14-3-3_CanoR_1	697	705	PF00244	0.434
LIG_14-3-3_CanoR_1	743	749	PF00244	0.510
LIG_14-3-3_CanoR_1	780	789	PF00244	0.643
LIG_14-3-3_CanoR_1	841	846	PF00244	0.550
LIG_14-3-3_CanoR_1	891	900	PF00244	0.562
LIG_Actin_WH2_2	671	688	PF00022	0.559
LIG_APCC_ABBAyCdc20_2	315	321	PF00400	0.587
LIG_BIR_III_4	114	118	PF00653	0.470
LIG_BIR_III_4	383	387	PF00653	0.586
LIG_BRCT_BRCA1_1	104	108	PF00533	0.446
LIG_BRCT_BRCA1_1	26	30	PF00533	0.510
LIG_BRCT_BRCA1_1	5	9	PF00533	0.464
LIG_BRCT_BRCA1_1	678	682	PF00533	0.648
LIG_BRCT_BRCA1_1	88	92	PF00533	0.490
LIG_BRCT_BRCA1_2	678	684	PF00533	0.648
LIG_Clathr_ClatBox_1	738	742	PF01394	0.449
LIG_FHA_1	11	17	PF00498	0.447
LIG_FHA_1	275	281	PF00498	0.662
LIG_FHA_1	350	356	PF00498	0.444
LIG_FHA_1	449	455	PF00498	0.397
LIG_FHA_1	532	538	PF00498	0.664
LIG_FHA_1	621	627	PF00498	0.530
LIG_FHA_1	637	643	PF00498	0.586
LIG_FHA_1	697	703	PF00498	0.431
LIG_FHA_1	793	799	PF00498	0.644
LIG_FHA_1	853	859	PF00498	0.566
LIG_FHA_1	899	905	PF00498	0.590
LIG_FHA_2	172	178	PF00498	0.579
LIG_FHA_2	211	217	PF00498	0.570
LIG_FHA_2	438	444	PF00498	0.599
LIG_FHA_2	511	517	PF00498	0.492
LIG_FHA_2	569	575	PF00498	0.535
LIG_FHA_2	696	702	PF00498	0.510
LIG_GBD_Chelix_1	904	912	PF00786	0.581
LIG_LIR_Apic_2	250	256	PF02991	0.509
LIG_LIR_Gen_1	288	297	PF02991	0.608
LIG_LIR_Gen_1	335	346	PF02991	0.458
LIG_LIR_Gen_1	571	579	PF02991	0.439
LIG_LIR_Gen_1	591	601	PF02991	0.437
LIG_LIR_Gen_1	668	678	PF02991	0.458
LIG_LIR_Nem_3	288	292	PF02991	0.602
LIG_LIR_Nem_3	326	330	PF02991	0.435
LIG_LIR_Nem_3	335	341	PF02991	0.499
LIG_LIR_Nem_3	571	575	PF02991	0.527
LIG_LIR_Nem_3	591	596	PF02991	0.383
LIG_LIR_Nem_3	668	674	PF02991	0.540
LIG_LIR_Nem_3	679	685	PF02991	0.566
LIG_LIR_Nem_3	89	95	PF02991	0.614
LIG_MAD2	633	641	PF02301	0.530
LIG_MLH1_MIPbox_1	5	9	PF16413	0.434
LIG_PCNA_yPIPBox_3	231	243	PF02747	0.515
LIG_Pex14_2	879	883	PF04695	0.475
LIG_SH2_CRK	338	342	PF00017	0.425
LIG_SH2_CRK	671	675	PF00017	0.540
LIG_SH2_PTP2	340	343	PF00017	0.419
LIG_SH2_SRC	338	341	PF00017	0.427
LIG_SH2_STAP1	191	195	PF00017	0.536
LIG_SH2_STAP1	334	338	PF00017	0.468
LIG_SH2_STAP1	496	500	PF00017	0.627
LIG_SH2_STAP1	506	510	PF00017	0.499
LIG_SH2_STAP1	597	601	PF00017	0.611
LIG_SH2_STAT5	100	103	PF00017	0.486
LIG_SH2_STAT5	274	277	PF00017	0.499
LIG_SH2_STAT5	334	337	PF00017	0.466
LIG_SH2_STAT5	340	343	PF00017	0.441
LIG_SH2_STAT5	345	348	PF00017	0.518
LIG_SH2_STAT5	463	466	PF00017	0.623
LIG_SH3_3	103	109	PF00018	0.463
LIG_SH3_3	154	160	PF00018	0.507
LIG_SH3_3	688	694	PF00018	0.524
LIG_SUMO_SIM_anti_2	55	61	PF11976	0.403
LIG_SUMO_SIM_par_1	216	223	PF11976	0.469
LIG_SUMO_SIM_par_1	864	871	PF11976	0.466
LIG_SxIP_EBH_1	604	614	PF03271	0.506
LIG_TRAF2_1	227	230	PF00917	0.551
LIG_TRAF2_1	412	415	PF00917	0.682
LIG_TYR_ITIM	669	674	PF00017	0.499
LIG_WRC_WIRS_1	363	368	PF05994	0.525
LIG_WRC_WIRS_1	569	574	PF05994	0.445
LIG_WRC_WIRS_1	880	885	PF05994	0.480
MOD_CDK_SPxxK_3	389	396	PF00069	0.598
MOD_CDK_SPxxK_3	824	831	PF00069	0.533
MOD_CK1_1	210	216	PF00069	0.668
MOD_CK1_1	259	265	PF00069	0.627
MOD_CK1_1	306	312	PF00069	0.554
MOD_CK1_1	365	371	PF00069	0.491
MOD_CK1_1	392	398	PF00069	0.670
MOD_CK1_1	517	523	PF00069	0.670
MOD_CK1_1	524	530	PF00069	0.565
MOD_CK1_1	55	61	PF00069	0.542
MOD_CK1_1	672	678	PF00069	0.459
MOD_CK1_1	814	820	PF00069	0.644
MOD_CK2_1	205	211	PF00069	0.599
MOD_CK2_1	409	415	PF00069	0.676
MOD_CK2_1	437	443	PF00069	0.600
MOD_CK2_1	814	820	PF00069	0.541
MOD_Cter_Amidation	116	119	PF01082	0.469
MOD_GlcNHglycan	114	118	PF01048	0.671
MOD_GlcNHglycan	132	135	PF01048	0.330
MOD_GlcNHglycan	207	210	PF01048	0.661
MOD_GlcNHglycan	297	300	PF01048	0.702
MOD_GlcNHglycan	308	311	PF01048	0.580
MOD_GlcNHglycan	31	34	PF01048	0.584
MOD_GlcNHglycan	401	404	PF01048	0.709
MOD_GlcNHglycan	516	520	PF01048	0.618
MOD_GlcNHglycan	523	526	PF01048	0.593
MOD_GlcNHglycan	554	557	PF01048	0.629
MOD_GlcNHglycan	627	630	PF01048	0.606
MOD_GlcNHglycan	671	674	PF01048	0.453
MOD_GlcNHglycan	724	727	PF01048	0.607
MOD_GlcNHglycan	784	787	PF01048	0.532
MOD_GlcNHglycan	813	816	PF01048	0.613
MOD_GlcNHglycan	841	844	PF01048	0.580
MOD_GSK3_1	167	174	PF00069	0.477
MOD_GSK3_1	201	208	PF00069	0.687
MOD_GSK3_1	210	217	PF00069	0.567
MOD_GSK3_1	258	265	PF00069	0.546
MOD_GSK3_1	295	302	PF00069	0.619
MOD_GSK3_1	409	416	PF00069	0.549
MOD_GSK3_1	43	50	PF00069	0.543
MOD_GSK3_1	510	517	PF00069	0.635
MOD_GSK3_1	519	526	PF00069	0.642
MOD_GSK3_1	527	534	PF00069	0.551
MOD_GSK3_1	543	550	PF00069	0.524
MOD_GSK3_1	557	564	PF00069	0.623
MOD_GSK3_1	603	610	PF00069	0.635
MOD_GSK3_1	620	627	PF00069	0.502
MOD_GSK3_1	64	71	PF00069	0.453
MOD_GSK3_1	672	679	PF00069	0.559
MOD_GSK3_1	841	848	PF00069	0.516
MOD_GSK3_1	894	901	PF00069	0.679
MOD_N-GLC_1	205	210	PF02516	0.521
MOD_N-GLC_1	47	52	PF02516	0.528
MOD_N-GLC_1	514	519	PF02516	0.521
MOD_N-GLC_1	557	562	PF02516	0.628
MOD_N-GLC_1	811	816	PF02516	0.517
MOD_N-GLC_1	823	828	PF02516	0.584
MOD_NEK2_1	124	129	PF00069	0.496
MOD_NEK2_1	16	21	PF00069	0.628
MOD_NEK2_1	171	176	PF00069	0.586
MOD_NEK2_1	24	29	PF00069	0.517
MOD_NEK2_1	285	290	PF00069	0.649
MOD_NEK2_1	475	480	PF00069	0.559
MOD_NEK2_1	514	519	PF00069	0.634
MOD_NEK2_1	603	608	PF00069	0.484
MOD_NEK2_1	674	679	PF00069	0.638
MOD_NEK2_1	744	749	PF00069	0.453
MOD_NEK2_1	782	787	PF00069	0.574
MOD_NEK2_1	879	884	PF00069	0.568
MOD_NEK2_2	167	172	PF00069	0.479
MOD_NEK2_2	750	755	PF00069	0.383
MOD_PIKK_1	220	226	PF00454	0.516
MOD_PIKK_1	47	53	PF00454	0.524
MOD_PIKK_1	727	733	PF00454	0.746
MOD_PKA_2	285	291	PF00069	0.611
MOD_PKA_2	399	405	PF00069	0.724
MOD_PKA_2	510	516	PF00069	0.690
MOD_PKA_2	55	61	PF00069	0.572
MOD_PKA_2	579	585	PF00069	0.542
MOD_PKA_2	603	609	PF00069	0.491
MOD_PKA_2	636	642	PF00069	0.543
MOD_PKA_2	696	702	PF00069	0.423
MOD_PKA_2	744	750	PF00069	0.458
MOD_PKA_2	782	788	PF00069	0.548
MOD_PKB_1	396	404	PF00069	0.616
MOD_Plk_1	191	197	PF00069	0.548
MOD_Plk_1	210	216	PF00069	0.586
MOD_Plk_1	557	563	PF00069	0.625
MOD_Plk_1	643	649	PF00069	0.521
MOD_Plk_2-3	547	553	PF00069	0.543
MOD_Plk_4	171	177	PF00069	0.449
MOD_Plk_4	210	216	PF00069	0.499
MOD_Plk_4	496	502	PF00069	0.531
MOD_Plk_4	532	538	PF00069	0.574
MOD_Plk_4	55	61	PF00069	0.566
MOD_Plk_4	561	567	PF00069	0.532
MOD_Plk_4	894	900	PF00069	0.574
MOD_ProDKin_1	102	108	PF00069	0.492
MOD_ProDKin_1	3	9	PF00069	0.558
MOD_ProDKin_1	389	395	PF00069	0.597
MOD_ProDKin_1	401	407	PF00069	0.551
MOD_ProDKin_1	448	454	PF00069	0.413
MOD_ProDKin_1	491	497	PF00069	0.564
MOD_ProDKin_1	517	523	PF00069	0.540
MOD_ProDKin_1	607	613	PF00069	0.652
MOD_ProDKin_1	64	70	PF00069	0.557
MOD_ProDKin_1	824	830	PF00069	0.784
MOD_SUMO_for_1	544	547	PF00179	0.529
MOD_SUMO_for_1	856	859	PF00179	0.518
MOD_SUMO_rev_2	223	233	PF00179	0.574
MOD_SUMO_rev_2	706	715	PF00179	0.519
TRG_DiLeu_BaEn_1	326	331	PF01217	0.463
TRG_DiLeu_BaEn_1	659	664	PF01217	0.429
TRG_DiLeu_BaLyEn_6	313	318	PF01217	0.683
TRG_DiLeu_LyEn_5	659	664	PF01217	0.429
TRG_ENDOCYTIC_2	338	341	PF00928	0.427
TRG_ENDOCYTIC_2	671	674	PF00928	0.541
TRG_ENDOCYTIC_2	880	883	PF00928	0.587
TRG_ER_diArg_1	278	280	PF00400	0.563
TRG_ER_diArg_1	314	316	PF00400	0.688
TRG_ER_diArg_1	396	399	PF00400	0.752
TRG_ER_diArg_1	508	511	PF00400	0.450
TRG_ER_diArg_1	54	57	PF00400	0.486
TRG_ER_diArg_1	906	908	PF00400	0.602
TRG_NES_CRM1_1	238	250	PF08389	0.541
TRG_NLS_MonoCore_2	396	401	PF00514	0.747
TRG_NLS_MonoCore_2	470	475	PF00514	0.526
TRG_NLS_MonoExtC_3	395	400	PF00514	0.769
TRG_NLS_MonoExtN_4	393	400	PF00514	0.833
TRG_NLS_MonoExtN_4	469	475	PF00514	0.521
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.658
TRG_Pf-PMV_PEXEL_1	316	321	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	662	666	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	802	806	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWA8	Leptomonas seymouri	48%	98%
A0A381ML15	Leishmania infantum	72%	100%
A0A3S7X0S0	Leishmania donovani	72%	100%
E9ADC4	Leishmania major	71%	99%
E9AZ48	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%