Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFR8_LEIBR

TriTrypDb:

LbrM.27.1550 , LBRM2903_270021100

Length:

378

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFR8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.431
CLV_C14_Caspase3-7	310	314	PF00656	0.285
CLV_NRD_NRD_1	174	176	PF00675	0.330
CLV_NRD_NRD_1	69	71	PF00675	0.422
CLV_PCSK_KEX2_1	69	71	PF00082	0.422
CLV_PCSK_SKI1_1	207	211	PF00082	0.385
CLV_PCSK_SKI1_1	226	230	PF00082	0.256
CLV_PCSK_SKI1_1	352	356	PF00082	0.417
CLV_PCSK_SKI1_1	63	67	PF00082	0.400
DEG_APCC_DBOX_1	351	359	PF00400	0.314
DEG_Nend_UBRbox_2	1	3	PF02207	0.460
DEG_SPOP_SBC_1	129	133	PF00917	0.601
DEG_SPOP_SBC_1	137	141	PF00917	0.560
DOC_ANK_TNKS_1	277	284	PF00023	0.355
DOC_CYCLIN_yCln2_LP_2	94	100	PF00134	0.415
DOC_MAPK_gen_1	157	166	PF00069	0.293
DOC_MAPK_gen_1	175	183	PF00069	0.286
DOC_MAPK_MEF2A_6	175	183	PF00069	0.259
DOC_MAPK_MEF2A_6	345	353	PF00069	0.342
DOC_PP2B_LxvP_1	302	305	PF13499	0.452
DOC_PP4_FxxP_1	31	34	PF00568	0.416
DOC_USP7_MATH_1	136	140	PF00917	0.764
DOC_USP7_MATH_1	243	247	PF00917	0.291
DOC_USP7_UBL2_3	12	16	PF12436	0.312
DOC_USP7_UBL2_3	6	10	PF12436	0.347
DOC_WW_Pin1_4	122	127	PF00397	0.700
DOC_WW_Pin1_4	132	137	PF00397	0.644
DOC_WW_Pin1_4	221	226	PF00397	0.372
DOC_WW_Pin1_4	239	244	PF00397	0.273
DOC_WW_Pin1_4	30	35	PF00397	0.448
DOC_WW_Pin1_4	336	341	PF00397	0.366
DOC_WW_Pin1_4	93	98	PF00397	0.339
LIG_14-3-3_CanoR_1	109	113	PF00244	0.383
LIG_14-3-3_CanoR_1	144	150	PF00244	0.430
LIG_14-3-3_CanoR_1	165	171	PF00244	0.486
LIG_14-3-3_CanoR_1	207	216	PF00244	0.415
LIG_14-3-3_CanoR_1	345	349	PF00244	0.459
LIG_14-3-3_CanoR_1	50	54	PF00244	0.505
LIG_14-3-3_CanoR_1	86	92	PF00244	0.259
LIG_APCC_ABBA_1	231	236	PF00400	0.284
LIG_APCC_ABBA_1	277	282	PF00400	0.532
LIG_BRCT_BRCA1_1	23	27	PF00533	0.482
LIG_FHA_1	194	200	PF00498	0.421
LIG_FHA_1	222	228	PF00498	0.435
LIG_FHA_1	239	245	PF00498	0.349
LIG_FHA_1	252	258	PF00498	0.326
LIG_FHA_1	272	278	PF00498	0.395
LIG_FHA_1	53	59	PF00498	0.623
LIG_FHA_1	60	66	PF00498	0.462
LIG_FHA_2	308	314	PF00498	0.394
LIG_FHA_2	88	94	PF00498	0.317
LIG_LIR_Apic_2	29	34	PF02991	0.415
LIG_LIR_Gen_1	111	117	PF02991	0.542
LIG_LIR_Gen_1	186	195	PF02991	0.370
LIG_LIR_Gen_1	43	51	PF02991	0.389
LIG_LIR_Nem_3	111	116	PF02991	0.535
LIG_LIR_Nem_3	186	191	PF02991	0.346
LIG_LIR_Nem_3	43	47	PF02991	0.350
LIG_Pex14_2	184	188	PF04695	0.417
LIG_Pex14_2	191	195	PF04695	0.468
LIG_Pex14_2	27	31	PF04695	0.410
LIG_SH2_CRK	147	151	PF00017	0.419
LIG_SH2_NCK_1	361	365	PF00017	0.480
LIG_SH2_SRC	36	39	PF00017	0.299
LIG_SH2_SRC	361	364	PF00017	0.483
LIG_SH2_STAT5	13	16	PF00017	0.374
LIG_SH2_STAT5	147	150	PF00017	0.407
LIG_SH2_STAT5	269	272	PF00017	0.343
LIG_SH2_STAT5	368	371	PF00017	0.591
LIG_SH3_3	123	129	PF00018	0.597
LIG_SH3_3	302	308	PF00018	0.251
LIG_SUMO_SIM_par_1	89	96	PF11976	0.474
LIG_TRAF2_1	169	172	PF00917	0.331
LIG_TRAF2_1	249	252	PF00917	0.371
LIG_TYR_ITIM	260	265	PF00017	0.370
LIG_WRC_WIRS_1	146	151	PF05994	0.413
LIG_WRC_WIRS_1	185	190	PF05994	0.405
MOD_CDK_SPK_2	221	226	PF00069	0.265
MOD_CK1_1	118	124	PF00069	0.667
MOD_CK1_1	128	134	PF00069	0.653
MOD_CK1_1	193	199	PF00069	0.315
MOD_CK1_1	21	27	PF00069	0.531
MOD_CK1_1	221	227	PF00069	0.518
MOD_CK1_1	246	252	PF00069	0.365
MOD_CK1_1	59	65	PF00069	0.495
MOD_CK1_1	96	102	PF00069	0.352
MOD_CK2_1	165	171	PF00069	0.356
MOD_CK2_1	246	252	PF00069	0.380
MOD_CK2_1	315	321	PF00069	0.433
MOD_CK2_1	344	350	PF00069	0.365
MOD_CK2_1	87	93	PF00069	0.376
MOD_GlcNHglycan	121	124	PF01048	0.581
MOD_GlcNHglycan	176	179	PF01048	0.413
MOD_GlcNHglycan	23	26	PF01048	0.614
MOD_GlcNHglycan	79	82	PF01048	0.573
MOD_GSK3_1	115	122	PF00069	0.591
MOD_GSK3_1	125	132	PF00069	0.640
MOD_GSK3_1	17	24	PF00069	0.595
MOD_GSK3_1	239	246	PF00069	0.277
MOD_GSK3_1	52	59	PF00069	0.561
MOD_N-GLC_2	85	87	PF02516	0.328
MOD_NEK2_1	116	121	PF00069	0.520
MOD_NEK2_1	174	179	PF00069	0.407
MOD_NEK2_1	183	188	PF00069	0.290
MOD_NEK2_1	199	204	PF00069	0.247
MOD_NEK2_1	315	320	PF00069	0.567
MOD_NEK2_1	369	374	PF00069	0.672
MOD_NEK2_1	42	47	PF00069	0.344
MOD_NEK2_2	155	160	PF00069	0.386
MOD_PIKK_1	49	55	PF00454	0.396
MOD_PKA_2	108	114	PF00069	0.384
MOD_PKA_2	174	180	PF00069	0.486
MOD_PKA_2	344	350	PF00069	0.459
MOD_PKA_2	49	55	PF00069	0.592
MOD_Plk_1	17	23	PF00069	0.598
MOD_Plk_1	251	257	PF00069	0.332
MOD_Plk_1	42	48	PF00069	0.370
MOD_Plk_4	108	114	PF00069	0.419
MOD_Plk_4	145	151	PF00069	0.563
MOD_Plk_4	184	190	PF00069	0.323
MOD_Plk_4	56	62	PF00069	0.486
MOD_Plk_4	87	93	PF00069	0.374
MOD_ProDKin_1	122	128	PF00069	0.704
MOD_ProDKin_1	132	138	PF00069	0.643
MOD_ProDKin_1	221	227	PF00069	0.375
MOD_ProDKin_1	239	245	PF00069	0.281
MOD_ProDKin_1	30	36	PF00069	0.444
MOD_ProDKin_1	336	342	PF00069	0.369
MOD_ProDKin_1	93	99	PF00069	0.341
MOD_SUMO_rev_2	89	97	PF00179	0.322
TRG_DiLeu_BaEn_1	252	257	PF01217	0.232
TRG_DiLeu_BaEn_1	322	327	PF01217	0.483
TRG_ENDOCYTIC_2	147	150	PF00928	0.415
TRG_ENDOCYTIC_2	262	265	PF00928	0.344
TRG_ENDOCYTIC_2	361	364	PF00928	0.429
TRG_ER_diArg_1	68	70	PF00400	0.411
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R9	Leptomonas seymouri	57%	97%
A0A0S4JR94	Bodo saltans	28%	100%
A0A3Q8IDF7	Leishmania donovani	78%	100%
A0A422NFS8	Trypanosoma rangeli	36%	100%
A4I2U3	Leishmania infantum	78%	100%
D0A609	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ADC2	Leishmania major	79%	99%
E9AZ46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
V5B0Z1	Trypanosoma cruzi	35%	100%