Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFR3_LEIBR

TriTrypDb:

LbrM.27.1500 , LBRM2903_270020600

Length:

675

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFR3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFR3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	146	148	PF00675	0.468
CLV_NRD_NRD_1	304	306	PF00675	0.479
CLV_NRD_NRD_1	321	323	PF00675	0.444
CLV_NRD_NRD_1	353	355	PF00675	0.524
CLV_NRD_NRD_1	386	388	PF00675	0.500
CLV_NRD_NRD_1	398	400	PF00675	0.510
CLV_NRD_NRD_1	414	416	PF00675	0.516
CLV_NRD_NRD_1	422	424	PF00675	0.469
CLV_NRD_NRD_1	516	518	PF00675	0.585
CLV_NRD_NRD_1	530	532	PF00675	0.484
CLV_NRD_NRD_1	81	83	PF00675	0.676
CLV_PCSK_FUR_1	319	323	PF00082	0.392
CLV_PCSK_FUR_1	79	83	PF00082	0.678
CLV_PCSK_KEX2_1	146	148	PF00082	0.409
CLV_PCSK_KEX2_1	166	168	PF00082	0.316
CLV_PCSK_KEX2_1	304	306	PF00082	0.479
CLV_PCSK_KEX2_1	319	321	PF00082	0.446
CLV_PCSK_KEX2_1	353	355	PF00082	0.597
CLV_PCSK_KEX2_1	398	400	PF00082	0.524
CLV_PCSK_KEX2_1	413	415	PF00082	0.518
CLV_PCSK_KEX2_1	422	424	PF00082	0.462
CLV_PCSK_KEX2_1	515	517	PF00082	0.515
CLV_PCSK_KEX2_1	529	531	PF00082	0.581
CLV_PCSK_KEX2_1	81	83	PF00082	0.676
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.409
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.316
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.542
CLV_PCSK_PC1ET2_1	529	531	PF00082	0.581
CLV_PCSK_SKI1_1	201	205	PF00082	0.485
CLV_PCSK_SKI1_1	239	243	PF00082	0.505
CLV_PCSK_SKI1_1	398	402	PF00082	0.522
CLV_Separin_Metazoa	447	451	PF03568	0.511
DEG_APCC_DBOX_1	398	406	PF00400	0.531
DEG_Nend_Nbox_1	1	3	PF02207	0.635
DEG_SPOP_SBC_1	42	46	PF00917	0.501
DEG_SPOP_SBC_1	552	556	PF00917	0.590
DOC_CYCLIN_yCln2_LP_2	568	574	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.593
DOC_MAPK_gen_1	319	328	PF00069	0.509
DOC_MAPK_MEF2A_6	178	185	PF00069	0.365
DOC_PP1_RVXF_1	199	206	PF00149	0.470
DOC_PP2B_LxvP_1	107	110	PF13499	0.580
DOC_PP2B_LxvP_1	560	563	PF13499	0.593
DOC_PP2B_LxvP_1	568	571	PF13499	0.583
DOC_PP2B_LxvP_1	99	102	PF13499	0.584
DOC_USP7_MATH_1	42	46	PF00917	0.618
DOC_USP7_MATH_1	542	546	PF00917	0.685
DOC_USP7_MATH_1	548	552	PF00917	0.641
DOC_USP7_MATH_1	553	557	PF00917	0.706
DOC_USP7_MATH_1	561	565	PF00917	0.520
DOC_USP7_MATH_1	576	580	PF00917	0.731
DOC_USP7_MATH_1	599	603	PF00917	0.641
DOC_USP7_UBL2_3	343	347	PF12436	0.547
DOC_WW_Pin1_4	1	6	PF00397	0.619
DOC_WW_Pin1_4	171	176	PF00397	0.386
DOC_WW_Pin1_4	207	212	PF00397	0.352
DOC_WW_Pin1_4	257	262	PF00397	0.621
DOC_WW_Pin1_4	296	301	PF00397	0.705
DOC_WW_Pin1_4	555	560	PF00397	0.615
DOC_WW_Pin1_4	662	667	PF00397	0.626
DOC_WW_Pin1_4	80	85	PF00397	0.671
LIG_14-3-3_CanoR_1	178	182	PF00244	0.525
LIG_14-3-3_CanoR_1	456	465	PF00244	0.389
LIG_14-3-3_CanoR_1	8	18	PF00244	0.585
LIG_Actin_WH2_2	20	38	PF00022	0.548
LIG_Actin_WH2_2	473	491	PF00022	0.400
LIG_CaM_IQ_9	138	154	PF13499	0.474
LIG_FHA_1	102	108	PF00498	0.497
LIG_FHA_1	241	247	PF00498	0.370
LIG_FHA_1	293	299	PF00498	0.724
LIG_FHA_1	538	544	PF00498	0.594
LIG_FHA_1	555	561	PF00498	0.605
LIG_FHA_1	611	617	PF00498	0.542
LIG_FHA_1	9	15	PF00498	0.598
LIG_FHA_2	191	197	PF00498	0.338
LIG_FHA_2	405	411	PF00498	0.355
LIG_FHA_2	458	464	PF00498	0.402
LIG_LIR_Apic_2	569	575	PF02991	0.573
LIG_LIR_Gen_1	133	144	PF02991	0.413
LIG_LIR_Gen_1	159	168	PF02991	0.356
LIG_LIR_Gen_1	196	206	PF02991	0.471
LIG_LIR_Nem_3	133	139	PF02991	0.420
LIG_LIR_Nem_3	159	165	PF02991	0.352
LIG_LIR_Nem_3	196	202	PF02991	0.487
LIG_LIR_Nem_3	581	586	PF02991	0.550
LIG_LYPXL_SIV_4	131	139	PF13949	0.341
LIG_LYPXL_yS_3	647	650	PF13949	0.631
LIG_SH2_CRK	370	374	PF00017	0.488
LIG_SH2_CRK	612	616	PF00017	0.488
LIG_SH2_GRB2like	612	615	PF00017	0.466
LIG_SH2_NCK_1	132	136	PF00017	0.346
LIG_SH2_PTP2	136	139	PF00017	0.479
LIG_SH2_PTP2	572	575	PF00017	0.464
LIG_SH2_PTP2	583	586	PF00017	0.456
LIG_SH2_SRC	278	281	PF00017	0.665
LIG_SH2_SRC	583	586	PF00017	0.543
LIG_SH2_STAP1	132	136	PF00017	0.503
LIG_SH2_STAP1	199	203	PF00017	0.475
LIG_SH2_STAP1	370	374	PF00017	0.505
LIG_SH2_STAT5	122	125	PF00017	0.471
LIG_SH2_STAT5	136	139	PF00017	0.365
LIG_SH2_STAT5	506	509	PF00017	0.545
LIG_SH2_STAT5	572	575	PF00017	0.593
LIG_SH2_STAT5	583	586	PF00017	0.556
LIG_SH2_STAT5	610	613	PF00017	0.670
LIG_SH2_STAT5	628	631	PF00017	0.559
LIG_SH3_3	102	108	PF00018	0.596
LIG_SH3_3	277	283	PF00018	0.561
LIG_SH3_3	570	576	PF00018	0.591
LIG_SH3_3	582	588	PF00018	0.545
LIG_SH3_3	593	599	PF00018	0.650
LIG_SH3_3	620	626	PF00018	0.563
LIG_SH3_3	645	651	PF00018	0.571
LIG_SH3_3	663	669	PF00018	0.503
LIG_SUMO_SIM_par_1	10	19	PF11976	0.527
LIG_SUMO_SIM_par_1	101	106	PF11976	0.605
LIG_SUMO_SIM_par_1	554	564	PF11976	0.493
LIG_TRAF2_1	194	197	PF00917	0.452
LIG_TRAF2_1	392	395	PF00917	0.585
LIG_TRAF2_1	407	410	PF00917	0.434
LIG_TRAF2_1	425	428	PF00917	0.538
LIG_TRAF2_1	482	485	PF00917	0.614
LIG_TRAF2_1	493	496	PF00917	0.546
LIG_TRAF2_1	72	75	PF00917	0.668
MOD_CDC14_SPxK_1	87	90	PF00782	0.625
MOD_CDK_SPxK_1	84	90	PF00069	0.639
MOD_CDK_SPxxK_3	1	8	PF00069	0.508
MOD_CDK_SPxxK_3	171	178	PF00069	0.380
MOD_CK1_1	256	262	PF00069	0.669
MOD_CK1_1	291	297	PF00069	0.614
MOD_CK1_1	44	50	PF00069	0.636
MOD_CK1_1	551	557	PF00069	0.600
MOD_CK1_1	579	585	PF00069	0.640
MOD_CK2_1	190	196	PF00069	0.377
MOD_CK2_1	296	302	PF00069	0.594
MOD_CK2_1	404	410	PF00069	0.609
MOD_CK2_1	423	429	PF00069	0.498
MOD_CK2_1	457	463	PF00069	0.385
MOD_CK2_1	68	74	PF00069	0.672
MOD_Cter_Amidation	79	82	PF01082	0.682
MOD_GlcNHglycan	254	258	PF01048	0.476
MOD_GlcNHglycan	37	40	PF01048	0.621
MOD_GlcNHglycan	544	547	PF01048	0.676
MOD_GlcNHglycan	563	566	PF01048	0.706
MOD_GlcNHglycan	568	571	PF01048	0.493
MOD_GlcNHglycan	60	63	PF01048	0.597
MOD_GlcNHglycan	601	604	PF01048	0.647
MOD_GlcNHglycan	656	659	PF01048	0.478
MOD_GSK3_1	253	260	PF00069	0.578
MOD_GSK3_1	288	295	PF00069	0.702
MOD_GSK3_1	400	407	PF00069	0.367
MOD_GSK3_1	41	48	PF00069	0.632
MOD_GSK3_1	537	544	PF00069	0.544
MOD_GSK3_1	548	555	PF00069	0.595
MOD_GSK3_1	610	617	PF00069	0.667
MOD_GSK3_1	667	674	PF00069	0.558
MOD_GSK3_1	80	87	PF00069	0.747
MOD_N-GLC_1	56	61	PF02516	0.725
MOD_NEK2_1	35	40	PF00069	0.584
MOD_NEK2_1	7	12	PF00069	0.590
MOD_PIKK_1	240	246	PF00454	0.372
MOD_PIKK_1	283	289	PF00454	0.678
MOD_PIKK_1	400	406	PF00454	0.446
MOD_PKA_1	423	429	PF00069	0.520
MOD_PKA_2	177	183	PF00069	0.503
MOD_PKA_2	35	41	PF00069	0.578
MOD_PKA_2	431	437	PF00069	0.382
MOD_PKA_2	7	13	PF00069	0.713
MOD_Plk_1	376	382	PF00069	0.481
MOD_Plk_4	579	585	PF00069	0.562
MOD_ProDKin_1	1	7	PF00069	0.619
MOD_ProDKin_1	171	177	PF00069	0.384
MOD_ProDKin_1	207	213	PF00069	0.357
MOD_ProDKin_1	257	263	PF00069	0.624
MOD_ProDKin_1	296	302	PF00069	0.695
MOD_ProDKin_1	555	561	PF00069	0.618
MOD_ProDKin_1	662	668	PF00069	0.625
MOD_ProDKin_1	80	86	PF00069	0.668
MOD_SUMO_rev_2	159	168	PF00179	0.526
MOD_SUMO_rev_2	382	390	PF00179	0.350
MOD_SUMO_rev_2	87	97	PF00179	0.545
TRG_DiLeu_BaEn_1	324	329	PF01217	0.511
TRG_DiLeu_BaEn_1	444	449	PF01217	0.366
TRG_DiLeu_BaEn_4	444	450	PF01217	0.367
TRG_DiLeu_LyEn_5	30	35	PF01217	0.550
TRG_DiLeu_LyEn_5	324	329	PF01217	0.528
TRG_ENDOCYTIC_2	136	139	PF00928	0.420
TRG_ENDOCYTIC_2	199	202	PF00928	0.480
TRG_ENDOCYTIC_2	370	373	PF00928	0.490
TRG_ENDOCYTIC_2	583	586	PF00928	0.555
TRG_ENDOCYTIC_2	592	595	PF00928	0.767
TRG_ENDOCYTIC_2	647	650	PF00928	0.631
TRG_ER_diArg_1	303	305	PF00400	0.483
TRG_ER_diArg_1	318	321	PF00400	0.445
TRG_ER_diArg_1	412	415	PF00400	0.604
TRG_ER_diArg_1	449	452	PF00400	0.456
TRG_ER_diArg_1	516	519	PF00400	0.635
TRG_ER_diArg_1	78	81	PF00400	0.678
TRG_NLS_Bipartite_1	500	519	PF00514	0.642
TRG_NLS_MonoCore_2	144	149	PF00514	0.471
TRG_NLS_MonoExtC_3	145	151	PF00514	0.475
TRG_NLS_MonoExtC_3	165	171	PF00514	0.327
TRG_NLS_MonoExtC_3	514	519	PF00514	0.633
TRG_NLS_MonoExtN_4	145	150	PF00514	0.473
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	309	314	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	327	332	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	414	418	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	516	520	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	521	525	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUL8	Leptomonas seymouri	54%	98%
A0A3Q8ICQ0	Leishmania donovani	73%	98%
A4I2T9	Leishmania infantum	73%	98%
D0A604	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9ADB7	Leishmania major	73%	99%
E9AZ42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	98%