SPX domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HFR1_LEIBR

TriTrypDb:

LbrM.27.1480 , LBRM2903_270020400

Length:

396

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFR1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.600
CLV_NRD_NRD_1	349	351	PF00675	0.739
CLV_PCSK_KEX2_1	32	34	PF00082	0.478
CLV_PCSK_KEX2_1	349	351	PF00082	0.856
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.478
CLV_PCSK_SKI1_1	196	200	PF00082	0.466
CLV_PCSK_SKI1_1	32	36	PF00082	0.674
CLV_PCSK_SKI1_1	360	364	PF00082	0.709
CLV_PCSK_SKI1_1	392	396	PF00082	0.678
CLV_PCSK_SKI1_1	71	75	PF00082	0.576
DEG_APCC_DBOX_1	190	198	PF00400	0.573
DEG_SCF_FBW7_1	113	120	PF00400	0.774
DOC_CYCLIN_RxL_1	191	203	PF00134	0.416
DOC_CYCLIN_RxL_1	260	271	PF00134	0.482
DOC_CYCLIN_RxL_1	27	40	PF00134	0.447
DOC_CYCLIN_yClb1_LxF_4	150	156	PF00134	0.461
DOC_CYCLIN_yCln2_LP_2	69	75	PF00134	0.684
DOC_MAPK_gen_1	191	199	PF00069	0.502
DOC_MAPK_gen_1	32	38	PF00069	0.572
DOC_MAPK_gen_1	375	384	PF00069	0.664
DOC_MAPK_MEF2A_6	193	201	PF00069	0.672
DOC_PP1_RVXF_1	214	221	PF00149	0.647
DOC_PP2B_LxvP_1	62	65	PF13499	0.515
DOC_PP2B_LxvP_1	67	70	PF13499	0.503
DOC_SPAK_OSR1_1	207	211	PF12202	0.563
DOC_SPAK_OSR1_1	252	256	PF12202	0.401
DOC_USP7_MATH_1	106	110	PF00917	0.597
DOC_USP7_MATH_1	117	121	PF00917	0.591
DOC_USP7_MATH_1	189	193	PF00917	0.413
DOC_USP7_UBL2_3	357	361	PF12436	0.584
DOC_USP7_UBL2_3	8	12	PF12436	0.472
DOC_USP7_UBL2_3	83	87	PF12436	0.787
DOC_WW_Pin1_4	113	118	PF00397	0.777
DOC_WW_Pin1_4	124	129	PF00397	0.582
DOC_WW_Pin1_4	164	169	PF00397	0.575
LIG_14-3-3_CanoR_1	196	202	PF00244	0.545
LIG_14-3-3_CanoR_1	242	250	PF00244	0.522
LIG_14-3-3_CanoR_1	285	293	PF00244	0.430
LIG_APCC_ABBA_1	371	376	PF00400	0.470
LIG_BIR_II_1	1	5	PF00653	0.504
LIG_BRCT_BRCA1_1	275	279	PF00533	0.374
LIG_BRCT_BRCA1_1	306	310	PF00533	0.497
LIG_deltaCOP1_diTrp_1	376	384	PF00928	0.464
LIG_FHA_1	244	250	PF00498	0.542
LIG_FHA_1	269	275	PF00498	0.377
LIG_FHA_1	285	291	PF00498	0.450
LIG_FHA_1	74	80	PF00498	0.791
LIG_FHA_2	198	204	PF00498	0.560
LIG_FHA_2	384	390	PF00498	0.707
LIG_Integrin_RGD_1	343	345	PF01839	0.605
LIG_LIR_Gen_1	206	214	PF02991	0.512
LIG_LIR_Gen_1	247	258	PF02991	0.611
LIG_LIR_Gen_1	376	385	PF02991	0.467
LIG_LIR_Nem_3	125	129	PF02991	0.548
LIG_LIR_Nem_3	212	217	PF02991	0.578
LIG_LIR_Nem_3	247	253	PF02991	0.594
LIG_LIR_Nem_3	376	381	PF02991	0.459
LIG_NRBOX	193	199	PF00104	0.574
LIG_Pex14_2	155	159	PF04695	0.586
LIG_PTAP_UEV_1	333	338	PF05743	0.587
LIG_RPA_C_Fungi	338	350	PF08784	0.597
LIG_SH2_STAP1	250	254	PF00017	0.552
LIG_SH2_STAT5	181	184	PF00017	0.474
LIG_SH2_STAT5	273	276	PF00017	0.378
LIG_SH3_3	306	312	PF00018	0.609
LIG_SH3_3	331	337	PF00018	0.633
LIG_SH3_3	53	59	PF00018	0.584
LIG_SH3_4	83	90	PF00018	0.750
LIG_SUMO_SIM_par_1	197	203	PF11976	0.664
LIG_UBA3_1	381	387	PF00899	0.508
LIG_WRC_WIRS_1	217	222	PF05994	0.447
MOD_CK1_1	164	170	PF00069	0.658
MOD_CK1_1	325	331	PF00069	0.679
MOD_CK1_1	351	357	PF00069	0.849
MOD_CK1_1	365	371	PF00069	0.576
MOD_CK1_1	85	91	PF00069	0.577
MOD_CK1_1	95	101	PF00069	0.717
MOD_CK2_1	180	186	PF00069	0.483
MOD_CK2_1	197	203	PF00069	0.541
MOD_CK2_1	364	370	PF00069	0.620
MOD_CK2_1	383	389	PF00069	0.741
MOD_GlcNHglycan	107	111	PF01048	0.628
MOD_GlcNHglycan	324	328	PF01048	0.628
MOD_GlcNHglycan	350	353	PF01048	0.801
MOD_GlcNHglycan	84	87	PF01048	0.542
MOD_GlcNHglycan	94	97	PF01048	0.720
MOD_GSK3_1	113	120	PF00069	0.586
MOD_GSK3_1	339	346	PF00069	0.669
MOD_GSK3_1	88	95	PF00069	0.661
MOD_N-GLC_1	322	327	PF02516	0.783
MOD_N-GLC_2	122	124	PF02516	0.518
MOD_NEK2_1	138	143	PF00069	0.629
MOD_NEK2_1	155	160	PF00069	0.439
MOD_NEK2_1	172	177	PF00069	0.441
MOD_NEK2_1	197	202	PF00069	0.527
MOD_NEK2_1	339	344	PF00069	0.597
MOD_NEK2_1	74	79	PF00069	0.538
MOD_NEK2_1	92	97	PF00069	0.677
MOD_PK_1	377	383	PF00069	0.465
MOD_PKA_2	284	290	PF00069	0.596
MOD_PKA_2	332	338	PF00069	0.826
MOD_PKA_2	348	354	PF00069	0.613
MOD_PKB_1	375	383	PF00069	0.464
MOD_Plk_1	189	195	PF00069	0.419
MOD_Plk_1	99	105	PF00069	0.747
MOD_Plk_4	138	144	PF00069	0.656
MOD_Plk_4	155	161	PF00069	0.518
MOD_Plk_4	377	383	PF00069	0.560
MOD_Plk_4	74	80	PF00069	0.538
MOD_Plk_4	88	94	PF00069	0.501
MOD_ProDKin_1	113	119	PF00069	0.776
MOD_ProDKin_1	124	130	PF00069	0.577
MOD_ProDKin_1	164	170	PF00069	0.577
MOD_SUMO_rev_2	162	167	PF00179	0.472
MOD_SUMO_rev_2	212	217	PF00179	0.403
TRG_DiLeu_BaEn_2	212	218	PF01217	0.552
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.427
TRG_ENDOCYTIC_2	214	217	PF00928	0.581
TRG_ENDOCYTIC_2	250	253	PF00928	0.522
TRG_ER_diArg_1	191	194	PF00400	0.646
TRG_NLS_Bipartite_1	349	364	PF00514	0.587
TRG_NLS_MonoExtC_3	359	364	PF00514	0.574
TRG_NLS_MonoExtN_4	357	364	PF00514	0.578
TRG_Pf-PMV_PEXEL_1	233	238	PF00026	0.672
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.350

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAE2	Leptomonas seymouri	40%	82%
A0A3S7X0P6	Leishmania donovani	55%	100%
A4I2T7	Leishmania infantum	55%	100%
E9ADB5	Leishmania major	57%	100%
E9AZ40	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%