JmjC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cupin-like domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HFQ9_LEIBR

TriTrypDb:

LbrM.27.1460 , LBRM2903_270020200

Length:

594

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFQ9

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018195	peptidyl-arginine modification	6	1
GO:0018216	peptidyl-arginine methylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034969	histone arginine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0043985	histone H4-R3 methylation	7	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000976	transcription cis-regulatory region binding	5	1
GO:0000987	cis-regulatory region sequence-specific DNA binding	6	1
GO:0001067	transcription regulatory region nucleic acid binding	4	1
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0005488	binding	1	1
GO:0043565	sequence-specific DNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:1990837	sequence-specific double-stranded DNA binding	6	1
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.735
CLV_C14_Caspase3-7	241	245	PF00656	0.736
CLV_C14_Caspase3-7	306	310	PF00656	0.285
CLV_NRD_NRD_1	224	226	PF00675	0.690
CLV_NRD_NRD_1	262	264	PF00675	0.451
CLV_NRD_NRD_1	382	384	PF00675	0.327
CLV_NRD_NRD_1	416	418	PF00675	0.296
CLV_NRD_NRD_1	575	577	PF00675	0.485
CLV_PCSK_FUR_1	572	576	PF00082	0.537
CLV_PCSK_KEX2_1	144	146	PF00082	0.612
CLV_PCSK_KEX2_1	20	22	PF00082	0.599
CLV_PCSK_KEX2_1	224	226	PF00082	0.711
CLV_PCSK_KEX2_1	262	264	PF00082	0.454
CLV_PCSK_KEX2_1	382	384	PF00082	0.364
CLV_PCSK_KEX2_1	418	420	PF00082	0.279
CLV_PCSK_KEX2_1	537	539	PF00082	0.420
CLV_PCSK_KEX2_1	574	576	PF00082	0.472
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.643
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.694
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.271
CLV_PCSK_PC1ET2_1	537	539	PF00082	0.432
CLV_PCSK_PC1ET2_1	574	576	PF00082	0.514
CLV_PCSK_PC7_1	258	264	PF00082	0.278
CLV_PCSK_SKI1_1	419	423	PF00082	0.271
CLV_PCSK_SKI1_1	514	518	PF00082	0.454
CLV_PCSK_SKI1_1	579	583	PF00082	0.486
DEG_APCC_DBOX_1	502	510	PF00400	0.423
DEG_Nend_UBRbox_3	1	3	PF02207	0.618
DEG_SPOP_SBC_1	124	128	PF00917	0.678
DEG_SPOP_SBC_1	233	237	PF00917	0.615
DEG_SPOP_SBC_1	527	531	PF00917	0.399
DOC_CDC14_PxL_1	60	68	PF14671	0.582
DOC_CKS1_1	441	446	PF01111	0.286
DOC_MAPK_gen_1	262	268	PF00069	0.319
DOC_MAPK_gen_1	417	423	PF00069	0.295
DOC_MAPK_gen_1	572	582	PF00069	0.488
DOC_MAPK_MEF2A_6	277	284	PF00069	0.337
DOC_MIT_MIM_1	294	304	PF04212	0.365
DOC_PP1_RVXF_1	417	424	PF00149	0.286
DOC_PP2B_LxvP_1	422	425	PF13499	0.271
DOC_PP2B_LxvP_1	61	64	PF13499	0.588
DOC_PP4_FxxP_1	275	278	PF00568	0.306
DOC_USP7_MATH_1	124	128	PF00917	0.753
DOC_USP7_MATH_1	157	161	PF00917	0.608
DOC_USP7_MATH_1	200	204	PF00917	0.635
DOC_USP7_MATH_1	245	249	PF00917	0.638
DOC_USP7_MATH_1	393	397	PF00917	0.415
DOC_USP7_MATH_1	527	531	PF00917	0.492
DOC_USP7_MATH_2	259	265	PF00917	0.502
DOC_WW_Pin1_4	129	134	PF00397	0.654
DOC_WW_Pin1_4	151	156	PF00397	0.637
DOC_WW_Pin1_4	159	164	PF00397	0.559
DOC_WW_Pin1_4	247	252	PF00397	0.592
DOC_WW_Pin1_4	317	322	PF00397	0.371
DOC_WW_Pin1_4	425	430	PF00397	0.311
DOC_WW_Pin1_4	440	445	PF00397	0.209
DOC_WW_Pin1_4	91	96	PF00397	0.504
LIG_14-3-3_CanoR_1	145	151	PF00244	0.670
LIG_14-3-3_CanoR_1	224	232	PF00244	0.571
LIG_14-3-3_CanoR_1	262	268	PF00244	0.451
LIG_14-3-3_CanoR_1	362	367	PF00244	0.192
LIG_14-3-3_CanoR_1	395	401	PF00244	0.286
LIG_14-3-3_CanoR_1	68	78	PF00244	0.439
LIG_BIR_III_2	121	125	PF00653	0.480
LIG_BRCT_BRCA1_1	200	204	PF00533	0.473
LIG_BRCT_BRCA1_1	21	25	PF00533	0.589
LIG_BRCT_BRCA1_1	586	590	PF00533	0.522
LIG_Clathr_ClatBox_1	580	584	PF01394	0.415
LIG_CtBP_PxDLS_1	444	448	PF00389	0.286
LIG_deltaCOP1_diTrp_1	290	294	PF00928	0.365
LIG_FHA_1	234	240	PF00498	0.577
LIG_FHA_1	28	34	PF00498	0.588
LIG_FHA_1	317	323	PF00498	0.325
LIG_FHA_1	446	452	PF00498	0.290
LIG_FHA_1	508	514	PF00498	0.260
LIG_FHA_2	190	196	PF00498	0.493
LIG_FHA_2	224	230	PF00498	0.607
LIG_FHA_2	36	42	PF00498	0.661
LIG_FHA_2	456	462	PF00498	0.192
LIG_FHA_2	527	533	PF00498	0.645
LIG_LIR_Apic_2	273	278	PF02991	0.331
LIG_LIR_Apic_2	3	7	PF02991	0.512
LIG_LIR_Apic_2	361	367	PF02991	0.271
LIG_LIR_Gen_1	22	33	PF02991	0.633
LIG_LIR_Gen_1	373	384	PF02991	0.359
LIG_LIR_Gen_1	47	58	PF02991	0.476
LIG_LIR_Gen_1	74	85	PF02991	0.473
LIG_LIR_Gen_1	88	98	PF02991	0.454
LIG_LIR_Nem_3	22	28	PF02991	0.591
LIG_LIR_Nem_3	255	260	PF02991	0.438
LIG_LIR_Nem_3	289	294	PF02991	0.286
LIG_LIR_Nem_3	332	337	PF02991	0.273
LIG_LIR_Nem_3	351	357	PF02991	0.421
LIG_LIR_Nem_3	373	379	PF02991	0.286
LIG_LIR_Nem_3	47	53	PF02991	0.500
LIG_LIR_Nem_3	74	80	PF02991	0.495
LIG_LIR_Nem_3	88	93	PF02991	0.446
LIG_LIR_Nem_3	94	100	PF02991	0.329
LIG_PCNA_yPIPBox_3	323	335	PF02747	0.378
LIG_PDZ_Class_2	589	594	PF00595	0.516
LIG_Pex14_1	450	454	PF04695	0.331
LIG_Pex14_2	100	104	PF04695	0.408
LIG_Pex14_2	271	275	PF04695	0.286
LIG_Pex14_2	350	354	PF04695	0.271
LIG_Pex14_2	542	546	PF04695	0.351
LIG_Pex14_2	590	594	PF04695	0.521
LIG_SH2_CRK	364	368	PF00017	0.343
LIG_SH2_CRK	90	94	PF00017	0.512
LIG_SH2_GRB2like	406	409	PF00017	0.306
LIG_SH2_NCK_1	364	368	PF00017	0.286
LIG_SH2_PTP2	77	80	PF00017	0.549
LIG_SH2_STAP1	406	410	PF00017	0.286
LIG_SH2_STAP1	455	459	PF00017	0.279
LIG_SH2_STAT5	112	115	PF00017	0.501
LIG_SH2_STAT5	253	256	PF00017	0.496
LIG_SH2_STAT5	334	337	PF00017	0.277
LIG_SH2_STAT5	364	367	PF00017	0.365
LIG_SH2_STAT5	406	409	PF00017	0.286
LIG_SH2_STAT5	486	489	PF00017	0.338
LIG_SH2_STAT5	50	53	PF00017	0.609
LIG_SH2_STAT5	500	503	PF00017	0.334
LIG_SH2_STAT5	77	80	PF00017	0.420
LIG_SH2_STAT5	90	93	PF00017	0.459
LIG_SH2_STAT5	97	100	PF00017	0.311
LIG_SH3_3	275	281	PF00018	0.328
LIG_SH3_3	315	321	PF00018	0.374
LIG_SH3_3	438	444	PF00018	0.286
LIG_SH3_3	549	555	PF00018	0.394
LIG_SUMO_SIM_par_1	280	286	PF11976	0.271
LIG_SUMO_SIM_par_1	29	36	PF11976	0.580
LIG_SUMO_SIM_par_1	356	361	PF11976	0.192
LIG_SUMO_SIM_par_1	443	449	PF11976	0.289
LIG_TRAF2_1	458	461	PF00917	0.385
LIG_TRAF2_1	530	533	PF00917	0.539
LIG_WW_1	185	188	PF00397	0.512
MOD_CDC14_SPxK_1	320	323	PF00782	0.343
MOD_CDK_SPxK_1	129	135	PF00069	0.653
MOD_CDK_SPxK_1	317	323	PF00069	0.415
MOD_CDK_SPxxK_3	129	136	PF00069	0.654
MOD_CK1_1	202	208	PF00069	0.706
MOD_CK1_1	264	270	PF00069	0.371
MOD_CK1_1	32	38	PF00069	0.587
MOD_CK1_1	396	402	PF00069	0.343
MOD_CK2_1	100	106	PF00069	0.455
MOD_CK2_1	134	140	PF00069	0.781
MOD_CK2_1	189	195	PF00069	0.475
MOD_CK2_1	264	270	PF00069	0.372
MOD_CK2_1	443	449	PF00069	0.271
MOD_CK2_1	455	461	PF00069	0.271
MOD_CK2_1	526	532	PF00069	0.530
MOD_Cter_Amidation	142	145	PF01082	0.630
MOD_Cter_Amidation	222	225	PF01082	0.586
MOD_Cter_Amidation	415	418	PF01082	0.286
MOD_GlcNHglycan	207	210	PF01048	0.712
MOD_GlcNHglycan	313	316	PF01048	0.437
MOD_GlcNHglycan	395	398	PF01048	0.364
MOD_GlcNHglycan	434	437	PF01048	0.407
MOD_GlcNHglycan	520	523	PF01048	0.391
MOD_GSK3_1	100	107	PF00069	0.448
MOD_GSK3_1	125	132	PF00069	0.642
MOD_GSK3_1	134	141	PF00069	0.559
MOD_GSK3_1	198	205	PF00069	0.662
MOD_GSK3_1	239	246	PF00069	0.631
MOD_GSK3_1	282	289	PF00069	0.306
MOD_GSK3_1	29	36	PF00069	0.608
MOD_GSK3_1	307	314	PF00069	0.418
MOD_GSK3_1	490	497	PF00069	0.271
MOD_GSK3_1	527	534	PF00069	0.622
MOD_GSK3_1	67	74	PF00069	0.426
MOD_N-GLC_1	404	409	PF02516	0.271
MOD_N-GLC_1	412	417	PF02516	0.271
MOD_NEK2_1	100	105	PF00069	0.426
MOD_NEK2_1	204	209	PF00069	0.711
MOD_NEK2_1	311	316	PF00069	0.429
MOD_NEK2_1	33	38	PF00069	0.546
MOD_NEK2_1	490	495	PF00069	0.271
MOD_NEK2_1	516	521	PF00069	0.390
MOD_NEK2_1	53	58	PF00069	0.566
MOD_NEK2_1	69	74	PF00069	0.472
MOD_NEK2_2	29	34	PF00069	0.635
MOD_OFUCOSY	67	73	PF10250	0.460
MOD_PIKK_1	223	229	PF00454	0.556
MOD_PIKK_1	243	249	PF00454	0.465
MOD_PIKK_1	494	500	PF00454	0.271
MOD_PKA_1	307	313	PF00069	0.343
MOD_PKA_2	100	106	PF00069	0.449
MOD_PKA_2	223	229	PF00069	0.694
MOD_PKA_2	261	267	PF00069	0.391
MOD_PKA_2	299	305	PF00069	0.378
MOD_PKA_2	67	73	PF00069	0.426
MOD_Plk_1	455	461	PF00069	0.252
MOD_Plk_1	490	496	PF00069	0.310
MOD_Plk_2-3	353	359	PF00069	0.407
MOD_Plk_2-3	528	534	PF00069	0.549
MOD_Plk_4	146	152	PF00069	0.466
MOD_Plk_4	179	185	PF00069	0.375
MOD_Plk_4	29	35	PF00069	0.493
MOD_Plk_4	307	313	PF00069	0.343
MOD_Plk_4	353	359	PF00069	0.299
MOD_Plk_4	53	59	PF00069	0.361
MOD_Plk_4	93	99	PF00069	0.548
MOD_ProDKin_1	129	135	PF00069	0.654
MOD_ProDKin_1	151	157	PF00069	0.635
MOD_ProDKin_1	159	165	PF00069	0.557
MOD_ProDKin_1	247	253	PF00069	0.579
MOD_ProDKin_1	317	323	PF00069	0.371
MOD_ProDKin_1	425	431	PF00069	0.311
MOD_ProDKin_1	440	446	PF00069	0.209
MOD_ProDKin_1	91	97	PF00069	0.502
TRG_AP2beta_CARGO_1	373	383	PF09066	0.306
TRG_ENDOCYTIC_2	187	190	PF00928	0.415
TRG_ENDOCYTIC_2	467	470	PF00928	0.281
TRG_ENDOCYTIC_2	50	53	PF00928	0.609
TRG_ENDOCYTIC_2	77	80	PF00928	0.405
TRG_ENDOCYTIC_2	90	93	PF00928	0.444
TRG_ENDOCYTIC_2	97	100	PF00928	0.311
TRG_ER_diArg_1	382	384	PF00400	0.322
TRG_ER_diArg_1	417	420	PF00400	0.296
TRG_ER_diArg_1	575	577	PF00400	0.561
TRG_NES_CRM1_1	52	65	PF08389	0.501
TRG_NLS_MonoExtC_3	134	140	PF00514	0.632
TRG_NLS_MonoExtN_4	133	139	PF00514	0.700
TRG_Pf-PMV_PEXEL_1	563	567	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4D1	Leptomonas seymouri	73%	99%
A0A0S4JT19	Bodo saltans	44%	100%
A0A1X0P469	Trypanosomatidae	50%	100%
A0A3Q8IE56	Leishmania donovani	85%	99%
A0A422NFR7	Trypanosoma rangeli	52%	100%
A4I2T5	Leishmania infantum	84%	99%
D0A601	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9ADB3	Leishmania major	84%	100%
E9AZ38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
V5BL30	Trypanosoma cruzi	50%	100%