Arginine--tRNA ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

arginyl-tRNA synthetase, putative

Species:

Leishmania braziliensis

UniProt:

A4HFQ8_LEIBR

TriTrypDb:

LbrM.27.1450 , LBRM2903_270020100

Length:

692

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 1
Forrest at al. (procyclic)	no	yes: 1
Silverman et al.	no	yes: 1
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 3

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 3

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HFQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFQ8

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006399	tRNA metabolic process	7	12
GO:0006418	tRNA aminoacylation for protein translation	6	12
GO:0006420	arginyl-tRNA aminoacylation	7	12
GO:0006520	amino acid metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0019752	carboxylic acid metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043038	amino acid activation	4	12
GO:0043039	tRNA aminoacylation	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043436	oxoacid metabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044281	small molecule metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004812	aminoacyl-tRNA ligase activity	4	12
GO:0004814	arginine-tRNA ligase activity	5	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016874	ligase activity	2	12
GO:0016875	ligase activity, forming carbon-oxygen bonds	3	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140101	catalytic activity, acting on a tRNA	4	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	288	292	PF00656	0.582
CLV_C14_Caspase3-7	305	309	PF00656	0.385
CLV_C14_Caspase3-7	485	489	PF00656	0.504
CLV_MEL_PAP_1	407	413	PF00089	0.381
CLV_NRD_NRD_1	185	187	PF00675	0.325
CLV_NRD_NRD_1	301	303	PF00675	0.587
CLV_NRD_NRD_1	588	590	PF00675	0.304
CLV_NRD_NRD_1	99	101	PF00675	0.534
CLV_PCSK_KEX2_1	185	187	PF00082	0.294
CLV_PCSK_KEX2_1	588	590	PF00082	0.308
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.304
CLV_PCSK_PC1ET2_1	588	590	PF00082	0.308
CLV_PCSK_SKI1_1	206	210	PF00082	0.306
CLV_PCSK_SKI1_1	310	314	PF00082	0.520
CLV_PCSK_SKI1_1	358	362	PF00082	0.549
CLV_PCSK_SKI1_1	490	494	PF00082	0.304
DEG_APCC_DBOX_1	368	376	PF00400	0.544
DEG_APCC_DBOX_1	665	673	PF00400	0.515
DEG_Nend_UBRbox_1	1	4	PF02207	0.517
DEG_ODPH_VHL_1	379	392	PF01847	0.477
DOC_CKS1_1	606	611	PF01111	0.515
DOC_CYCLIN_RxL_1	152	163	PF00134	0.590
DOC_CYCLIN_RxL_1	273	283	PF00134	0.529
DOC_CYCLIN_RxL_1	674	687	PF00134	0.609
DOC_MAPK_DCC_7	384	392	PF00069	0.590
DOC_MAPK_FxFP_2	411	414	PF00069	0.504
DOC_MAPK_gen_1	122	130	PF00069	0.506
DOC_MAPK_gen_1	364	372	PF00069	0.493
DOC_MAPK_gen_1	384	392	PF00069	0.590
DOC_MAPK_gen_1	678	686	PF00069	0.529
DOC_MAPK_MEF2A_6	122	130	PF00069	0.530
DOC_MAPK_MEF2A_6	92	99	PF00069	0.590
DOC_PP1_RVXF_1	153	160	PF00149	0.590
DOC_PP4_FxxP_1	130	133	PF00568	0.504
DOC_PP4_FxxP_1	269	272	PF00568	0.515
DOC_PP4_FxxP_1	411	414	PF00568	0.504
DOC_SPAK_OSR1_1	437	441	PF12202	0.609
DOC_USP7_UBL2_3	357	361	PF12436	0.480
DOC_WW_Pin1_4	129	134	PF00397	0.432
DOC_WW_Pin1_4	605	610	PF00397	0.511
DOC_WW_Pin1_4	63	68	PF00397	0.532
LIG_14-3-3_CanoR_1	410	414	PF00244	0.515
LIG_14-3-3_CanoR_1	555	563	PF00244	0.482
LIG_14-3-3_CanoR_1	620	625	PF00244	0.586
LIG_14-3-3_CanoR_1	674	678	PF00244	0.515
LIG_Actin_WH2_2	132	147	PF00022	0.515
LIG_Actin_WH2_2	536	554	PF00022	0.517
LIG_Actin_WH2_2	612	629	PF00022	0.545
LIG_Actin_WH2_2	663	680	PF00022	0.515
LIG_BRCT_BRCA1_1	648	652	PF00533	0.511
LIG_Clathr_ClatBox_1	683	687	PF01394	0.609
LIG_deltaCOP1_diTrp_1	172	177	PF00928	0.495
LIG_deltaCOP1_diTrp_1	467	476	PF00928	0.505
LIG_FAT_LD_1	372	380	PF03623	0.533
LIG_FHA_1	426	432	PF00498	0.547
LIG_FHA_1	497	503	PF00498	0.515
LIG_FHA_1	5	11	PF00498	0.580
LIG_FHA_1	621	627	PF00498	0.581
LIG_FHA_1	678	684	PF00498	0.590
LIG_FHA_2	259	265	PF00498	0.547
LIG_FHA_2	343	349	PF00498	0.536
LIG_FHA_2	462	468	PF00498	0.590
LIG_FHA_2	483	489	PF00498	0.515
LIG_FHA_2	606	612	PF00498	0.512
LIG_LIR_Apic_2	129	133	PF02991	0.504
LIG_LIR_Apic_2	267	272	PF02991	0.515
LIG_LIR_Gen_1	432	443	PF02991	0.546
LIG_LIR_Gen_1	562	569	PF02991	0.568
LIG_LIR_Gen_1	639	648	PF02991	0.515
LIG_LIR_Gen_1	91	99	PF02991	0.576
LIG_LIR_Nem_3	175	180	PF02991	0.536
LIG_LIR_Nem_3	23	29	PF02991	0.488
LIG_LIR_Nem_3	249	254	PF02991	0.512
LIG_LIR_Nem_3	267	273	PF02991	0.504
LIG_LIR_Nem_3	432	438	PF02991	0.566
LIG_LIR_Nem_3	573	579	PF02991	0.374
LIG_LIR_Nem_3	646	651	PF02991	0.535
LIG_LIR_Nem_3	91	97	PF02991	0.576
LIG_MAD2	125	133	PF02301	0.529
LIG_MLH1_MIPbox_1	648	652	PF16413	0.515
LIG_PDZ_Class_3	687	692	PF00595	0.515
LIG_Pex14_1	173	177	PF04695	0.494
LIG_Pex14_2	391	395	PF04695	0.529
LIG_Pex14_2	648	652	PF04695	0.515
LIG_SH2_CRK	255	259	PF00017	0.545
LIG_SH2_CRK	270	274	PF00017	0.504
LIG_SH2_CRK	581	585	PF00017	0.515
LIG_SH2_SRC	579	582	PF00017	0.504
LIG_SH2_STAP1	559	563	PF00017	0.504
LIG_SH2_STAT3	383	386	PF00017	0.515
LIG_SH2_STAT5	183	186	PF00017	0.529
LIG_SH2_STAT5	191	194	PF00017	0.529
LIG_SH2_STAT5	242	245	PF00017	0.609
LIG_SH2_STAT5	424	427	PF00017	0.578
LIG_SH2_STAT5	448	451	PF00017	0.521
LIG_SH2_STAT5	548	551	PF00017	0.500
LIG_SH3_1	24	30	PF00018	0.590
LIG_SH3_3	24	30	PF00018	0.549
LIG_SH3_3	269	275	PF00018	0.508
LIG_SH3_3	655	661	PF00018	0.482
LIG_SUMO_SIM_anti_2	513	519	PF11976	0.529
LIG_SUMO_SIM_anti_2	680	685	PF11976	0.590
LIG_SUMO_SIM_par_1	668	673	PF11976	0.515
LIG_SUMO_SIM_par_1	682	688	PF11976	0.515
LIG_TRAF2_1	231	234	PF00917	0.529
LIG_TRAF2_1	247	250	PF00917	0.529
LIG_TRAF2_1	298	301	PF00917	0.542
LIG_TRAF2_1	30	33	PF00917	0.609
LIG_TRAF2_1	530	533	PF00917	0.494
LIG_TRAF2_1	594	597	PF00917	0.525
LIG_TRAF2_1	608	611	PF00917	0.471
LIG_TRFH_1	26	30	PF08558	0.609
LIG_TYR_ITAM	252	273	PF00017	0.548
LIG_TYR_ITIM	546	551	PF00017	0.507
LIG_UBA3_1	179	187	PF00899	0.504
LIG_UBA3_1	334	340	PF00899	0.484
LIG_UBA3_1	35	40	PF00899	0.494
LIG_UBA3_1	375	384	PF00899	0.478
LIG_UBA3_1	540	547	PF00899	0.545
LIG_WRC_WIRS_1	648	653	PF05994	0.429
MOD_CDK_SPxxK_3	605	612	PF00069	0.515
MOD_CK1_1	199	205	PF00069	0.565
MOD_CK1_1	306	312	PF00069	0.342
MOD_CK1_1	496	502	PF00069	0.504
MOD_CK1_1	570	576	PF00069	0.413
MOD_CK1_1	605	611	PF00069	0.590
MOD_CK2_1	244	250	PF00069	0.513
MOD_CK2_1	258	264	PF00069	0.504
MOD_CK2_1	295	301	PF00069	0.625
MOD_CK2_1	342	348	PF00069	0.531
MOD_CK2_1	353	359	PF00069	0.475
MOD_CK2_1	527	533	PF00069	0.494
MOD_CK2_1	605	611	PF00069	0.541
MOD_Cter_Amidation	488	491	PF01082	0.304
MOD_GlcNHglycan	495	498	PF01048	0.314
MOD_GlcNHglycan	568	572	PF01048	0.443
MOD_GSK3_1	306	313	PF00069	0.542
MOD_GSK3_1	321	328	PF00069	0.601
MOD_GSK3_1	349	356	PF00069	0.470
MOD_GSK3_1	422	429	PF00069	0.504
MOD_GSK3_1	523	530	PF00069	0.539
MOD_GSK3_1	59	66	PF00069	0.549
MOD_GSK3_1	643	650	PF00069	0.429
MOD_GSK3_1	673	680	PF00069	0.590
MOD_N-GLC_1	646	651	PF02516	0.409
MOD_N-GLC_1	95	100	PF02516	0.329
MOD_NEK2_1	144	149	PF00069	0.515
MOD_NEK2_1	258	263	PF00069	0.588
MOD_NEK2_1	551	556	PF00069	0.513
MOD_NEK2_1	567	572	PF00069	0.376
MOD_NEK2_1	662	667	PF00069	0.529
MOD_PIKK_1	314	320	PF00454	0.539
MOD_PIKK_1	523	529	PF00454	0.545
MOD_PIKK_1	54	60	PF00454	0.590
MOD_PK_1	583	589	PF00069	0.504
MOD_PKA_2	144	150	PF00069	0.515
MOD_PKA_2	409	415	PF00069	0.515
MOD_PKA_2	554	560	PF00069	0.482
MOD_PKA_2	673	679	PF00069	0.515
MOD_Plk_1	162	168	PF00069	0.525
MOD_Plk_1	199	205	PF00069	0.559
MOD_Plk_1	233	239	PF00069	0.505
MOD_Plk_1	349	355	PF00069	0.499
MOD_Plk_1	510	516	PF00069	0.515
MOD_Plk_1	602	608	PF00069	0.574
MOD_Plk_1	646	652	PF00069	0.429
MOD_Plk_1	670	676	PF00069	0.515
MOD_Plk_1	95	101	PF00069	0.529
MOD_Plk_2-3	472	478	PF00069	0.565
MOD_Plk_4	144	150	PF00069	0.514
MOD_Plk_4	265	271	PF00069	0.504
MOD_Plk_4	349	355	PF00069	0.476
MOD_Plk_4	620	626	PF00069	0.501
MOD_Plk_4	647	653	PF00069	0.429
MOD_ProDKin_1	129	135	PF00069	0.432
MOD_ProDKin_1	605	611	PF00069	0.511
MOD_ProDKin_1	63	69	PF00069	0.532
MOD_SUMO_rev_2	298	304	PF00179	0.414
MOD_SUMO_rev_2	356	362	PF00179	0.471
TRG_DiLeu_BaEn_4	350	356	PF01217	0.562
TRG_DiLeu_BaEn_4	532	538	PF01217	0.494
TRG_DiLeu_BaLyEn_6	152	157	PF01217	0.590
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.545
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.590
TRG_ENDOCYTIC_2	255	258	PF00928	0.504
TRG_ENDOCYTIC_2	270	273	PF00928	0.504
TRG_ENDOCYTIC_2	435	438	PF00928	0.504
TRG_ENDOCYTIC_2	455	458	PF00928	0.519
TRG_ENDOCYTIC_2	548	551	PF00928	0.507
TRG_ENDOCYTIC_2	563	566	PF00928	0.453
TRG_ENDOCYTIC_2	581	584	PF00928	0.504
TRG_ENDOCYTIC_2	642	645	PF00928	0.515
TRG_NES_CRM1_1	151	163	PF08389	0.429
TRG_NES_CRM1_1	504	519	PF08389	0.529
TRG_NLS_MonoExtC_3	184	189	PF00514	0.429
TRG_NLS_MonoExtN_4	119	126	PF00514	0.576
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.243

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S4	Leptomonas seymouri	83%	100%
A0A0S4JSY3	Bodo saltans	60%	100%
A0A1X0P461	Trypanosomatidae	68%	100%
A0A3Q8IED7	Leishmania donovani	91%	100%
A0A3R7MEE6	Trypanosoma rangeli	70%	100%
A1AC37	Escherichia coli O1:K1 / APEC	30%	100%
A1RS32	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	24%	100%
A4I2T4	Leishmania infantum	91%	100%
A8A178	Escherichia coli O9:H4 (strain HS)	30%	100%
B1J0L2	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	30%	100%
B1LCZ5	Escherichia coli (strain SMS-3-5 / SECEC)	30%	100%
B1XHE4	Escherichia coli (strain K12 / DH10B)	30%	100%
B2U4X7	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	30%	100%
B6I0S7	Escherichia coli (strain SE11)	30%	100%
B7L7S9	Escherichia coli (strain 55989 / EAEC)	30%	100%
B7LPH0	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	31%	100%
B7M2G7	Escherichia coli O8 (strain IAI1)	30%	100%
B7MBT5	Escherichia coli O45:K1 (strain S88 / ExPEC)	30%	100%
B7MW70	Escherichia coli O81 (strain ED1a)	30%	100%
B7NBM7	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	30%	100%
B7NS42	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	30%	100%
B7USQ3	Escherichia coli O127:H6 (strain E2348/69 / EPEC)	30%	100%
C4ZQG0	Escherichia coli (strain K12 / MC4100 / BW2952)	30%	100%
D0A5Z9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9ADB2	Leishmania major	91%	100%
E9AZ37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P11875	Escherichia coli (strain K12)	30%	100%
Q0T3Q1	Shigella flexneri serotype 5b (strain 8401)	31%	100%
Q0TGV6	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	30%	100%
Q1RAQ8	Escherichia coli (strain UTI89 / UPEC)	30%	100%
Q322J5	Shigella boydii serotype 4 (strain Sb227)	30%	100%
Q32H69	Shigella dysenteriae serotype 1 (strain Sd197)	30%	100%
Q5X3M1	Legionella pneumophila (strain Paris)	22%	100%
Q7URC7	Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)	31%	100%
Q83KQ3	Shigella flexneri	31%	100%
Q8FGQ0	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	30%	100%
Q971X1	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	25%	100%
V5BQK5	Trypanosoma cruzi	69%	100%