C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

KH domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HFQ7_LEIBR

TriTrypDb:

LbrM.27.1440 , LBRM2903_270020000

Length:

529

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFQ7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0005488	binding	1	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003724	RNA helicase activity	3	1
GO:0003824	catalytic activity	1	1
GO:0004386	helicase activity	2	1
GO:0008186	ATP-dependent activity, acting on RNA	2	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:0140657	ATP-dependent activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.792
CLV_NRD_NRD_1	34	36	PF00675	0.557
CLV_NRD_NRD_1	377	379	PF00675	0.399
CLV_NRD_NRD_1	416	418	PF00675	0.474
CLV_NRD_NRD_1	518	520	PF00675	0.499
CLV_NRD_NRD_1	68	70	PF00675	0.834
CLV_PCSK_KEX2_1	157	159	PF00082	0.755
CLV_PCSK_KEX2_1	254	256	PF00082	0.621
CLV_PCSK_KEX2_1	351	353	PF00082	0.470
CLV_PCSK_KEX2_1	377	379	PF00082	0.399
CLV_PCSK_KEX2_1	527	529	PF00082	0.812
CLV_PCSK_KEX2_1	68	70	PF00082	0.774
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.621
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.470
CLV_PCSK_PC1ET2_1	527	529	PF00082	0.812
CLV_PCSK_SKI1_1	133	137	PF00082	0.412
CLV_PCSK_SKI1_1	194	198	PF00082	0.325
CLV_PCSK_SKI1_1	244	248	PF00082	0.352
CLV_PCSK_SKI1_1	52	56	PF00082	0.631
DOC_CKS1_1	500	505	PF01111	0.667
DOC_MAPK_DCC_7	417	426	PF00069	0.433
DOC_MAPK_gen_1	242	251	PF00069	0.593
DOC_MAPK_gen_1	377	388	PF00069	0.370
DOC_MAPK_MEF2A_6	181	188	PF00069	0.634
DOC_MAPK_MEF2A_6	244	253	PF00069	0.641
DOC_MAPK_MEF2A_6	417	426	PF00069	0.433
DOC_PP1_RVXF_1	470	477	PF00149	0.557
DOC_PP4_FxxP_1	308	311	PF00568	0.600
DOC_PP4_FxxP_1	430	433	PF00568	0.467
DOC_USP7_MATH_1	163	167	PF00917	0.739
DOC_USP7_MATH_1	169	173	PF00917	0.707
DOC_USP7_MATH_1	58	62	PF00917	0.733
DOC_USP7_UBL2_3	142	146	PF12436	0.618
DOC_USP7_UBL2_3	414	418	PF12436	0.472
DOC_WD40_RPTOR_TOS_1	182	187	PF00400	0.657
DOC_WW_Pin1_4	499	504	PF00397	0.667
LIG_14-3-3_CanoR_1	133	143	PF00244	0.548
LIG_14-3-3_CanoR_1	148	156	PF00244	0.420
LIG_14-3-3_CanoR_1	292	299	PF00244	0.585
LIG_14-3-3_CanoR_1	30	35	PF00244	0.586
LIG_14-3-3_CanoR_1	300	309	PF00244	0.512
LIG_14-3-3_CanoR_1	417	421	PF00244	0.440
LIG_14-3-3_CanoR_1	486	494	PF00244	0.610
LIG_Actin_WH2_2	27	45	PF00022	0.513
LIG_Actin_WH2_2	325	342	PF00022	0.471
LIG_BIR_II_1	1	5	PF00653	0.678
LIG_BIR_III_2	18	22	PF00653	0.568
LIG_BIR_III_2	497	501	PF00653	0.585
LIG_BIR_III_2	505	509	PF00653	0.526
LIG_BRCT_BRCA1_1	304	308	PF00533	0.619
LIG_EVH1_2	176	180	PF00568	0.735
LIG_EVH1_2	521	525	PF00568	0.546
LIG_FAT_LD_1	7	15	PF03623	0.523
LIG_FHA_1	188	194	PF00498	0.528
LIG_FHA_1	225	231	PF00498	0.579
LIG_FHA_1	289	295	PF00498	0.642
LIG_FHA_2	211	217	PF00498	0.586
LIG_FHA_2	406	412	PF00498	0.430
LIG_FHA_2	486	492	PF00498	0.550
LIG_FHA_2	500	506	PF00498	0.471
LIG_Integrin_RGD_1	102	104	PF01839	0.861
LIG_LIR_Apic_2	155	159	PF02991	0.562
LIG_LIR_Apic_2	305	311	PF02991	0.591
LIG_LIR_Gen_1	216	225	PF02991	0.565
LIG_LIR_Gen_1	304	314	PF02991	0.577
LIG_LIR_Gen_1	410	420	PF02991	0.461
LIG_LIR_Gen_1	455	462	PF02991	0.536
LIG_LIR_Nem_3	216	221	PF02991	0.550
LIG_LIR_Nem_3	304	309	PF02991	0.517
LIG_LIR_Nem_3	410	415	PF02991	0.454
LIG_LIR_Nem_3	436	441	PF02991	0.453
LIG_LIR_Nem_3	455	459	PF02991	0.240
LIG_LIR_Nem_3	464	470	PF02991	0.358
LIG_NRBOX	401	407	PF00104	0.323
LIG_NRP_CendR_1	527	529	PF00754	0.812
LIG_PCNA_yPIPBox_3	392	406	PF02747	0.359
LIG_PCNA_yPIPBox_3	4	13	PF02747	0.587
LIG_PTB_Apo_2	368	375	PF02174	0.493
LIG_PTB_Apo_2	406	413	PF02174	0.445
LIG_PTB_Phospho_1	406	412	PF10480	0.446
LIG_SH2_CRK	156	160	PF00017	0.577
LIG_SH2_CRK	376	380	PF00017	0.601
LIG_SH2_CRK	412	416	PF00017	0.441
LIG_SH2_GRB2like	423	426	PF00017	0.400
LIG_SH2_PTP2	423	426	PF00017	0.416
LIG_SH2_SRC	462	465	PF00017	0.591
LIG_SH2_STAP1	412	416	PF00017	0.441
LIG_SH2_STAP1	462	466	PF00017	0.589
LIG_SH2_STAP1	494	498	PF00017	0.544
LIG_SH2_STAT3	439	442	PF00017	0.448
LIG_SH2_STAT5	195	198	PF00017	0.570
LIG_SH2_STAT5	320	323	PF00017	0.562
LIG_SH2_STAT5	423	426	PF00017	0.400
LIG_SH2_STAT5	439	442	PF00017	0.433
LIG_SH3_3	183	189	PF00018	0.453
LIG_SH3_3	497	503	PF00018	0.610
LIG_SH3_3	67	73	PF00018	0.798
LIG_SH3_3	74	80	PF00018	0.793
LIG_SUMO_SIM_par_1	382	389	PF11976	0.351
LIG_SxIP_EBH_1	414	427	PF03271	0.481
LIG_TRFH_1	195	199	PF08558	0.457
LIG_TYR_ITAM	409	426	PF00017	0.455
LIG_TYR_ITIM	421	426	PF00017	0.418
LIG_UBA3_1	246	254	PF00899	0.714
LIG_UBA3_1	385	393	PF00899	0.589
LIG_UBA3_1	466	472	PF00899	0.609
LIG_WRC_WIRS_1	303	308	PF05994	0.532
LIG_WW_3	78	82	PF00397	0.702
MOD_CK1_1	493	499	PF00069	0.613
MOD_CK2_1	210	216	PF00069	0.552
MOD_CK2_1	457	463	PF00069	0.485
MOD_CK2_1	485	491	PF00069	0.546
MOD_Cter_Amidation	525	528	PF01082	0.791
MOD_GlcNHglycan	165	168	PF01048	0.807
MOD_GlcNHglycan	81	84	PF01048	0.815
MOD_GlcNHglycan	89	92	PF01048	0.831
MOD_GlcNHglycan	96	99	PF01048	0.840
MOD_GSK3_1	122	129	PF00069	0.621
MOD_GSK3_1	288	295	PF00069	0.681
MOD_GSK3_1	330	337	PF00069	0.516
MOD_GSK3_1	448	455	PF00069	0.531
MOD_N-GLC_1	207	212	PF02516	0.341
MOD_N-GLC_1	428	433	PF02516	0.440
MOD_NEK2_1	247	252	PF00069	0.617
MOD_NEK2_1	294	299	PF00069	0.549
MOD_NEK2_1	319	324	PF00069	0.578
MOD_NEK2_1	457	462	PF00069	0.497
MOD_NEK2_1	485	490	PF00069	0.499
MOD_NEK2_1	87	92	PF00069	0.692
MOD_PIKK_1	334	340	PF00454	0.555
MOD_PIKK_1	357	363	PF00454	0.574
MOD_PIKK_1	440	446	PF00454	0.534
MOD_PKA_1	35	41	PF00069	0.576
MOD_PKA_1	377	383	PF00069	0.389
MOD_PKA_2	117	123	PF00069	0.826
MOD_PKA_2	147	153	PF00069	0.531
MOD_PKA_2	377	383	PF00069	0.551
MOD_PKA_2	416	422	PF00069	0.467
MOD_PKA_2	485	491	PF00069	0.608
MOD_Plk_1	126	132	PF00069	0.592
MOD_Plk_1	224	230	PF00069	0.581
MOD_Plk_1	428	434	PF00069	0.454
MOD_Plk_1	490	496	PF00069	0.571
MOD_Plk_4	294	300	PF00069	0.549
MOD_Plk_4	416	422	PF00069	0.467
MOD_Plk_4	452	458	PF00069	0.483
MOD_ProDKin_1	499	505	PF00069	0.671
MOD_SUMO_for_1	253	256	PF00179	0.603
MOD_SUMO_rev_2	514	522	PF00179	0.652
TRG_DiLeu_BaEn_4	436	442	PF01217	0.452
TRG_DiLeu_BaLyEn_6	401	406	PF01217	0.421
TRG_ENDOCYTIC_2	376	379	PF00928	0.604
TRG_ENDOCYTIC_2	412	415	PF00928	0.444
TRG_ENDOCYTIC_2	423	426	PF00928	0.400
TRG_ENDOCYTIC_2	438	441	PF00928	0.436
TRG_ER_diArg_1	156	158	PF00400	0.778
TRG_ER_diArg_1	376	378	PF00400	0.573
TRG_ER_diArg_1	68	70	PF00400	0.853
TRG_NES_CRM1_1	18	29	PF08389	0.546
TRG_Pf-PMV_PEXEL_1	205	209	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	377	382	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4C0	Leptomonas seymouri	75%	99%
A0A0S4JP69	Bodo saltans	46%	100%
A0A1X0P4C7	Trypanosomatidae	47%	100%
A0A3S5H7H8	Leishmania donovani	88%	100%
A0A422NFN8	Trypanosoma rangeli	48%	100%
A4I2T3	Leishmania infantum	88%	100%
D0A5Z7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9ADB1	Leishmania major	88%	100%
E9AZ36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BGH6	Trypanosoma cruzi	48%	100%