Leucine-rich repeat protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

predicted leucine-rich repeat protein

Species:

Leishmania braziliensis

UniProt:

A4HFQ6_LEIBR

TriTrypDb:

LbrM.27.1420 , LBRM2903_270019900

Length:

399

Annotations

LeishMANIAdb annotations

Leucine-rich repeat proteins with a hydrophobic terminal helix. Unlike its distant animal relatives, this cytoplasmic sensor protein might be anchored to the membrane.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	14
GO:0042995	cell projection	2	14
GO:0043226	organelle	2	14
GO:0043227	membrane-bounded organelle	3	14
GO:0110165	cellular anatomical entity	1	14
GO:0120025	plasma membrane bounded cell projection	3	14

Expansion

Sequence features

A4HFQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFQ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.325
CLV_C14_Caspase3-7	3	7	PF00656	0.454
CLV_NRD_NRD_1	168	170	PF00675	0.636
CLV_NRD_NRD_1	32	34	PF00675	0.665
CLV_PCSK_KEX2_1	32	34	PF00082	0.668
CLV_PCSK_SKI1_1	195	199	PF00082	0.354
DEG_ODPH_VHL_1	188	199	PF01847	0.477
DOC_CKS1_1	133	138	PF01111	0.463
DOC_CYCLIN_RxL_1	192	201	PF00134	0.352
DOC_MIT_MIM_1	37	49	PF04212	0.602
DOC_PP1_RVXF_1	229	235	PF00149	0.328
DOC_USP7_MATH_1	123	127	PF00917	0.375
DOC_USP7_MATH_1	329	333	PF00917	0.483
DOC_USP7_MATH_1	84	88	PF00917	0.412
DOC_USP7_MATH_1	93	97	PF00917	0.383
DOC_WW_Pin1_4	132	137	PF00397	0.323
LIG_14-3-3_CanoR_1	119	128	PF00244	0.409
LIG_14-3-3_CanoR_1	150	156	PF00244	0.379
LIG_14-3-3_CanoR_1	195	200	PF00244	0.430
LIG_14-3-3_CanoR_1	299	306	PF00244	0.461
LIG_14-3-3_CanoR_1	365	370	PF00244	0.400
LIG_Actin_WH2_2	248	263	PF00022	0.412
LIG_Actin_WH2_2	350	367	PF00022	0.394
LIG_BIR_II_1	1	5	PF00653	0.658
LIG_BIR_III_4	61	65	PF00653	0.482
LIG_BRCT_BRCA1_1	18	22	PF00533	0.442
LIG_FHA_1	119	125	PF00498	0.454
LIG_FHA_1	329	335	PF00498	0.405
LIG_FHA_1	361	367	PF00498	0.466
LIG_FHA_1	388	394	PF00498	0.491
LIG_FHA_1	76	82	PF00498	0.496
LIG_FHA_1	83	89	PF00498	0.438
LIG_FHA_2	1	7	PF00498	0.650
LIG_FHA_2	196	202	PF00498	0.457
LIG_FHA_2	213	219	PF00498	0.499
LIG_FHA_2	276	282	PF00498	0.230
LIG_LIR_Gen_1	226	237	PF02991	0.277
LIG_LIR_Gen_1	66	76	PF02991	0.364
LIG_LIR_Nem_3	100	106	PF02991	0.408
LIG_LIR_Nem_3	226	232	PF02991	0.277
LIG_LIR_Nem_3	256	260	PF02991	0.321
LIG_LIR_Nem_3	66	71	PF02991	0.375
LIG_LRP6_Inhibitor_1	274	280	PF00058	0.322
LIG_LYPXL_SIV_4	67	75	PF13949	0.429
LIG_MAD2	251	259	PF02301	0.463
LIG_PDZ_Class_3	394	399	PF00595	0.528
LIG_SH2_CRK	103	107	PF00017	0.496
LIG_SH2_CRK	148	152	PF00017	0.249
LIG_SH2_CRK	229	233	PF00017	0.409
LIG_SH2_NCK_1	229	233	PF00017	0.362
LIG_SH2_NCK_1	52	56	PF00017	0.546
LIG_SH2_PTP2	133	136	PF00017	0.385
LIG_SH2_SRC	52	55	PF00017	0.501
LIG_SH2_STAP1	148	152	PF00017	0.397
LIG_SH2_STAT5	133	136	PF00017	0.385
LIG_SH2_STAT5	203	206	PF00017	0.479
LIG_SH2_STAT5	266	269	PF00017	0.282
LIG_SH2_STAT5	68	71	PF00017	0.363
LIG_SH3_1	52	58	PF00018	0.650
LIG_SH3_3	52	58	PF00018	0.526
LIG_SH3_3	78	84	PF00018	0.365
LIG_SUMO_SIM_anti_2	126	131	PF11976	0.324
LIG_SUMO_SIM_par_1	335	340	PF11976	0.282
LIG_SUMO_SIM_par_1	95	102	PF11976	0.457
LIG_TRAF2_1	25	28	PF00917	0.561
LIG_TRAF2_1	305	308	PF00917	0.336
LIG_TRAF2_1	35	38	PF00917	0.491
LIG_TYR_ITIM	101	106	PF00017	0.480
LIG_TYR_ITIM	146	151	PF00017	0.245
LIG_TYR_ITIM	227	232	PF00017	0.362
LIG_UBA3_1	151	159	PF00899	0.396
MOD_CK1_1	332	338	PF00069	0.284
MOD_CK1_1	360	366	PF00069	0.477
MOD_CK1_1	387	393	PF00069	0.500
MOD_CK1_1	63	69	PF00069	0.546
MOD_CK2_1	212	218	PF00069	0.517
MOD_CK2_1	275	281	PF00069	0.315
MOD_CK2_1	4	10	PF00069	0.637
MOD_GlcNHglycan	121	124	PF01048	0.467
MOD_GlcNHglycan	136	139	PF01048	0.383
MOD_GlcNHglycan	143	146	PF01048	0.425
MOD_GlcNHglycan	178	181	PF01048	0.479
MOD_GlcNHglycan	331	334	PF01048	0.361
MOD_GlcNHglycan	346	349	PF01048	0.284
MOD_GlcNHglycan	357	360	PF01048	0.422
MOD_GlcNHglycan	387	390	PF01048	0.522
MOD_GlcNHglycan	61	65	PF01048	0.414
MOD_GSK3_1	119	126	PF00069	0.430
MOD_GSK3_1	151	158	PF00069	0.363
MOD_GSK3_1	189	196	PF00069	0.543
MOD_GSK3_1	324	331	PF00069	0.397
MOD_GSK3_1	355	362	PF00069	0.456
MOD_GSK3_1	385	392	PF00069	0.458
MOD_N-GLC_1	155	160	PF02516	0.480
MOD_N-GLC_1	218	223	PF02516	0.362
MOD_N-GLC_1	275	280	PF02516	0.371
MOD_N-GLC_1	282	287	PF02516	0.320
MOD_NEK2_1	118	123	PF00069	0.464
MOD_NEK2_1	155	160	PF00069	0.361
MOD_NEK2_1	16	21	PF00069	0.533
MOD_NEK2_1	212	217	PF00069	0.392
MOD_NEK2_1	225	230	PF00069	0.202
MOD_NEK2_1	357	362	PF00069	0.504
MOD_NEK2_1	4	9	PF00069	0.577
MOD_NEK2_1	75	80	PF00069	0.435
MOD_NEK2_1	99	104	PF00069	0.355
MOD_NEK2_2	190	195	PF00069	0.416
MOD_NEK2_2	389	394	PF00069	0.313
MOD_OFUCOSY	282	287	PF10250	0.444
MOD_PIKK_1	16	22	PF00454	0.606
MOD_PKA_2	118	124	PF00069	0.335
MOD_PKA_2	393	399	PF00069	0.448
MOD_Plk_1	218	224	PF00069	0.292
MOD_Plk_1	225	231	PF00069	0.244
MOD_Plk_1	275	281	PF00069	0.374
MOD_Plk_1	5	11	PF00069	0.533
MOD_Plk_1	99	105	PF00069	0.368
MOD_Plk_2-3	218	224	PF00069	0.327
MOD_Plk_4	123	129	PF00069	0.323
MOD_Plk_4	333	339	PF00069	0.285
MOD_Plk_4	375	381	PF00069	0.368
MOD_ProDKin_1	132	138	PF00069	0.319
TRG_ENDOCYTIC_2	103	106	PF00928	0.490
TRG_ENDOCYTIC_2	148	151	PF00928	0.261
TRG_ENDOCYTIC_2	229	232	PF00928	0.346
TRG_ENDOCYTIC_2	266	269	PF00928	0.337
TRG_ENDOCYTIC_2	68	71	PF00928	0.456
TRG_ER_diArg_1	31	33	PF00400	0.697
TRG_NLS_Bipartite_1	32	52	PF00514	0.387
TRG_Pf-PMV_PEXEL_1	251	256	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	299	303	PF00026	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUH0	Leptomonas seymouri	27%	85%
A0A0N1I317	Leptomonas seymouri	74%	100%
A0A0S4JL85	Bodo saltans	27%	94%
A0A0S4JV86	Bodo saltans	41%	100%
A0A1X0NTY3	Trypanosomatidae	26%	89%
A0A1X0P364	Trypanosomatidae	24%	93%
A0A1X0P4Z4	Trypanosomatidae	50%	100%
A0A3Q8IDE6	Leishmania donovani	85%	100%
A0A3R7L7Y9	Trypanosoma rangeli	25%	90%
A0A3R7NL91	Trypanosoma rangeli	49%	100%
A0A3S5H5G2	Leishmania donovani	27%	90%
A0A3S7WXH1	Leishmania donovani	24%	100%
A0A3S7WZL6	Leishmania donovani	24%	93%
A4H461	Leishmania braziliensis	27%	90%
A4HEQ6	Leishmania braziliensis	25%	100%
A4HSD0	Leishmania infantum	27%	90%
A4I053	Leishmania infantum	24%	100%
A4I1Y5	Leishmania infantum	24%	93%
A4I2T1	Leishmania infantum	85%	100%
C9ZPX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	92%
C9ZS33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	89%
D0A5Z5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	96%
E9ADA9	Leishmania major	87%	100%
E9AKB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	90%
E9AW16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AY32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AZ34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
P10775	Sus scrofa	27%	88%
P13489	Homo sapiens	25%	87%
P29315	Rattus norvegicus	24%	88%
Q0VAA2	Homo sapiens	28%	82%
Q14BP6	Mus musculus	28%	100%
Q4Q9E1	Leishmania major	26%	100%
Q4QJI8	Leishmania major	28%	90%
Q6ZQY2	Homo sapiens	29%	100%
Q8HZP9	Pan troglodytes	26%	87%
Q91VI7	Mus musculus	24%	88%
Q9LE82	Arabidopsis thaliana	26%	75%
Q9M651	Arabidopsis thaliana	26%	73%
V5BPZ7	Trypanosoma cruzi	26%	89%
V5DHF2	Trypanosoma cruzi	49%	100%