GTD-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFQ4_LEIBR

TriTrypDb:

LbrM.27.1400

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFQ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.439
CLV_C14_Caspase3-7	241	245	PF00656	0.336
CLV_NRD_NRD_1	220	222	PF00675	0.417
CLV_NRD_NRD_1	231	233	PF00675	0.395
CLV_NRD_NRD_1	255	257	PF00675	0.374
CLV_NRD_NRD_1	297	299	PF00675	0.482
CLV_PCSK_KEX2_1	106	108	PF00082	0.566
CLV_PCSK_KEX2_1	220	222	PF00082	0.417
CLV_PCSK_KEX2_1	224	226	PF00082	0.417
CLV_PCSK_KEX2_1	231	233	PF00082	0.395
CLV_PCSK_KEX2_1	255	257	PF00082	0.374
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.566
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.440
CLV_PCSK_PC7_1	220	226	PF00082	0.473
CLV_PCSK_SKI1_1	136	140	PF00082	0.580
CLV_PCSK_SKI1_1	178	182	PF00082	0.453
CLV_PCSK_SKI1_1	186	190	PF00082	0.365
CLV_PCSK_SKI1_1	220	224	PF00082	0.496
CLV_PCSK_SKI1_1	23	27	PF00082	0.534
CLV_PCSK_SKI1_1	231	235	PF00082	0.342
CLV_PCSK_SKI1_1	345	349	PF00082	0.470
CLV_PCSK_SKI1_1	408	412	PF00082	0.569
CLV_PCSK_SKI1_1	415	419	PF00082	0.546
DEG_Nend_UBRbox_3	1	3	PF02207	0.624
DEG_SPOP_SBC_1	91	95	PF00917	0.485
DOC_MAPK_gen_1	228	238	PF00069	0.453
DOC_MAPK_gen_1	403	412	PF00069	0.565
DOC_MAPK_MEF2A_6	231	238	PF00069	0.384
DOC_MAPK_NFAT4_5	231	239	PF00069	0.320
DOC_PP1_RVXF_1	176	182	PF00149	0.383
DOC_PP1_RVXF_1	233	239	PF00149	0.323
DOC_PP2B_LxvP_1	410	413	PF13499	0.554
DOC_PP2B_LxvP_1	80	83	PF13499	0.508
DOC_PP4_FxxP_1	356	359	PF00568	0.476
DOC_USP7_MATH_1	119	123	PF00917	0.503
DOC_USP7_MATH_1	188	192	PF00917	0.430
DOC_USP7_MATH_1	19	23	PF00917	0.523
DOC_USP7_MATH_1	269	273	PF00917	0.510
DOC_USP7_MATH_1	30	34	PF00917	0.540
DOC_USP7_MATH_1	314	318	PF00917	0.578
DOC_USP7_MATH_1	332	336	PF00917	0.448
DOC_USP7_MATH_1	349	353	PF00917	0.670
DOC_USP7_MATH_1	35	39	PF00917	0.547
DOC_WW_Pin1_4	106	111	PF00397	0.520
DOC_WW_Pin1_4	141	146	PF00397	0.518
DOC_WW_Pin1_4	265	270	PF00397	0.503
DOC_WW_Pin1_4	291	296	PF00397	0.526
DOC_WW_Pin1_4	328	333	PF00397	0.568
DOC_WW_Pin1_4	359	364	PF00397	0.551
DOC_WW_Pin1_4	64	69	PF00397	0.683
DOC_WW_Pin1_4	78	83	PF00397	0.584
LIG_14-3-3_CanoR_1	278	287	PF00244	0.527
LIG_14-3-3_CanoR_1	389	394	PF00244	0.547
LIG_14-3-3_CanoR_1	39	43	PF00244	0.550
LIG_14-3-3_CanoR_1	406	411	PF00244	0.469
LIG_Actin_WH2_2	101	117	PF00022	0.730
LIG_Clathr_ClatBox_1	167	171	PF01394	0.447
LIG_FHA_1	103	109	PF00498	0.705
LIG_FHA_1	342	348	PF00498	0.478
LIG_FHA_1	407	413	PF00498	0.550
LIG_FHA_2	396	402	PF00498	0.363
LIG_FHA_2	7	13	PF00498	0.508
LIG_LIR_Apic_2	354	359	PF02991	0.476
LIG_LIR_Gen_1	187	196	PF02991	0.409
LIG_LIR_Nem_3	187	192	PF02991	0.406
LIG_LIR_Nem_3	316	321	PF02991	0.476
LIG_LIR_Nem_3	377	382	PF02991	0.504
LIG_LIR_Nem_3	391	396	PF02991	0.445
LIG_Pex14_2	318	322	PF04695	0.475
LIG_SH2_PTP2	312	315	PF00017	0.478
LIG_SH2_STAP1	49	53	PF00017	0.501
LIG_SH2_STAT5	312	315	PF00017	0.478
LIG_SH2_STAT5	355	358	PF00017	0.627
LIG_SH2_STAT5	51	54	PF00017	0.738
LIG_SH2_STAT5	7	10	PF00017	0.599
LIG_SH2_STAT5	99	102	PF00017	0.565
LIG_SH3_3	357	363	PF00018	0.534
LIG_SH3_3	97	103	PF00018	0.575
LIG_Sin3_3	166	173	PF02671	0.418
LIG_SUMO_SIM_anti_2	149	155	PF11976	0.517
LIG_SUMO_SIM_anti_2	190	197	PF11976	0.396
LIG_SUMO_SIM_par_1	166	171	PF11976	0.444
LIG_SUMO_SIM_par_1	190	197	PF11976	0.383
LIG_TRAF2_1	182	185	PF00917	0.309
LIG_TRAF2_1	9	12	PF00917	0.510
LIG_UBA3_1	131	139	PF00899	0.492
LIG_WRC_WIRS_1	315	320	PF05994	0.492
LIG_WRC_WIRS_1	390	395	PF05994	0.411
MOD_CDC14_SPxK_1	67	70	PF00782	0.656
MOD_CDK_SPxK_1	64	70	PF00069	0.662
MOD_CDK_SPxxK_3	291	298	PF00069	0.562
MOD_CK1_1	141	147	PF00069	0.571
MOD_CK1_1	258	264	PF00069	0.563
MOD_CK1_1	294	300	PF00069	0.556
MOD_CK1_1	3	9	PF00069	0.521
MOD_CK1_1	303	309	PF00069	0.574
MOD_CK1_1	331	337	PF00069	0.588
MOD_CK1_1	351	357	PF00069	0.713
MOD_CK1_1	369	375	PF00069	0.529
MOD_CK1_1	38	44	PF00069	0.651
MOD_CK2_1	179	185	PF00069	0.317
MOD_CK2_1	332	338	PF00069	0.485
MOD_CK2_1	395	401	PF00069	0.368
MOD_CK2_1	6	12	PF00069	0.506
MOD_CK2_1	66	72	PF00069	0.530
MOD_DYRK1A_RPxSP_1	78	82	PF00069	0.522
MOD_GlcNHglycan	286	290	PF01048	0.498
MOD_GlcNHglycan	305	308	PF01048	0.559
MOD_GSK3_1	102	109	PF00069	0.590
MOD_GSK3_1	119	126	PF00069	0.470
MOD_GSK3_1	261	268	PF00069	0.575
MOD_GSK3_1	269	276	PF00069	0.596
MOD_GSK3_1	30	37	PF00069	0.588
MOD_GSK3_1	328	335	PF00069	0.496
MOD_GSK3_1	62	69	PF00069	0.672
MOD_GSK3_1	78	85	PF00069	0.643
MOD_GSK3_1	86	93	PF00069	0.607
MOD_N-GLC_1	141	146	PF02516	0.527
MOD_NEK2_1	131	136	PF00069	0.492
MOD_NEK2_1	138	143	PF00069	0.479
MOD_NEK2_1	238	243	PF00069	0.304
MOD_NEK2_1	285	290	PF00069	0.535
MOD_NEK2_1	340	345	PF00069	0.552
MOD_NEK2_1	92	97	PF00069	0.501
MOD_PIKK_1	125	131	PF00454	0.568
MOD_PIKK_1	179	185	PF00454	0.317
MOD_PIKK_1	269	275	PF00454	0.561
MOD_PIKK_1	278	284	PF00454	0.546
MOD_PIKK_1	30	36	PF00454	0.567
MOD_PIKK_1	300	306	PF00454	0.547
MOD_PIKK_1	82	88	PF00454	0.613
MOD_PKA_1	255	261	PF00069	0.353
MOD_PKA_1	62	68	PF00069	0.525
MOD_PKA_2	19	25	PF00069	0.644
MOD_PKA_2	216	222	PF00069	0.416
MOD_PKA_2	255	261	PF00069	0.488
MOD_PKA_2	3	9	PF00069	0.537
MOD_PKA_2	30	36	PF00069	0.538
MOD_PKA_2	323	329	PF00069	0.565
MOD_PKA_2	38	44	PF00069	0.526
MOD_PKA_2	388	394	PF00069	0.528
MOD_Plk_2-3	395	401	PF00069	0.368
MOD_Plk_4	149	155	PF00069	0.499
MOD_Plk_4	188	194	PF00069	0.587
MOD_Plk_4	3	9	PF00069	0.502
MOD_Plk_4	351	357	PF00069	0.479
MOD_Plk_4	406	412	PF00069	0.455
MOD_ProDKin_1	106	112	PF00069	0.518
MOD_ProDKin_1	141	147	PF00069	0.516
MOD_ProDKin_1	265	271	PF00069	0.506
MOD_ProDKin_1	291	297	PF00069	0.527
MOD_ProDKin_1	328	334	PF00069	0.571
MOD_ProDKin_1	359	365	PF00069	0.550
MOD_ProDKin_1	64	70	PF00069	0.686
MOD_ProDKin_1	78	84	PF00069	0.586
MOD_SUMO_rev_2	258	264	PF00179	0.407
TRG_DiLeu_BaLyEn_6	158	163	PF01217	0.415
TRG_ENDOCYTIC_2	312	315	PF00928	0.488
TRG_ER_diArg_1	231	233	PF00400	0.317
TRG_ER_diArg_1	254	256	PF00400	0.471
TRG_ER_diArg_1	96	99	PF00400	0.621
TRG_Pf-PMV_PEXEL_1	221	226	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCB3	Leptomonas seymouri	35%	91%
A0A3S7X0N8	Leishmania donovani	62%	95%
A4I2S9	Leishmania infantum	62%	95%
E9ADA7	Leishmania major	62%	100%
E9AZ32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	95%