Ubiquitin carboxyl-terminal hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin carboxyl-terminal hydrolase, putative

Species:

Leishmania braziliensis

UniProt:

A4HFQ3_LEIBR

TriTrypDb:

LbrM.27.1390 , LBRM2903_270019700

Length:

574

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFQ3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006511	ubiquitin-dependent protein catabolic process	7	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009057	macromolecule catabolic process	4	11
GO:0009987	cellular process	1	11
GO:0016579	protein deubiquitination	6	11
GO:0019538	protein metabolic process	3	11
GO:0019941	modification-dependent protein catabolic process	6	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0043632	modification-dependent macromolecule catabolic process	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044248	cellular catabolic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044265	obsolete cellular macromolecule catabolic process	4	11
GO:0051603	proteolysis involved in protein catabolic process	5	11
GO:0070646	protein modification by small protein removal	5	11
GO:0070647	protein modification by small protein conjugation or removal	5	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901575	organic substance catabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004843	cysteine-type deubiquitinase activity	5	11
GO:0008233	peptidase activity	3	11
GO:0008234	cysteine-type peptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0019783	ubiquitin-like protein peptidase activity	4	11
GO:0101005	deubiquitinase activity	5	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	332	336	PF00656	0.324
CLV_C14_Caspase3-7	444	448	PF00656	0.262
CLV_C14_Caspase3-7	560	564	PF00656	0.338
CLV_NRD_NRD_1	116	118	PF00675	0.534
CLV_NRD_NRD_1	122	124	PF00675	0.521
CLV_NRD_NRD_1	21	23	PF00675	0.429
CLV_NRD_NRD_1	245	247	PF00675	0.321
CLV_NRD_NRD_1	376	378	PF00675	0.328
CLV_NRD_NRD_1	463	465	PF00675	0.328
CLV_NRD_NRD_1	99	101	PF00675	0.566
CLV_PCSK_KEX2_1	116	118	PF00082	0.534
CLV_PCSK_KEX2_1	121	123	PF00082	0.515
CLV_PCSK_KEX2_1	245	247	PF00082	0.318
CLV_PCSK_KEX2_1	376	378	PF00082	0.385
CLV_PCSK_KEX2_1	481	483	PF00082	0.253
CLV_PCSK_KEX2_1	51	53	PF00082	0.443
CLV_PCSK_KEX2_1	99	101	PF00082	0.566
CLV_PCSK_PC1ET2_1	481	483	PF00082	0.253
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.443
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.330
CLV_PCSK_PC7_1	117	123	PF00082	0.576
CLV_PCSK_SKI1_1	180	184	PF00082	0.735
CLV_PCSK_SKI1_1	185	189	PF00082	0.494
CLV_PCSK_SKI1_1	318	322	PF00082	0.328
CLV_PCSK_SKI1_1	341	345	PF00082	0.324
CLV_PCSK_SKI1_1	465	469	PF00082	0.253
CLV_PCSK_SKI1_1	63	67	PF00082	0.505
CLV_PCSK_SKI1_1	85	89	PF00082	0.462
DEG_APCC_DBOX_1	340	348	PF00400	0.297
DEG_Nend_Nbox_1	1	3	PF02207	0.495
DEG_SPOP_SBC_1	425	429	PF00917	0.260
DOC_CKS1_1	211	216	PF01111	0.472
DOC_CYCLIN_RxL_1	338	345	PF00134	0.186
DOC_CYCLIN_RxL_1	460	471	PF00134	0.255
DOC_CYCLIN_RxL_1	60	71	PF00134	0.467
DOC_CYCLIN_yClb5_NLxxxL_5	561	570	PF00134	0.328
DOC_MAPK_gen_1	22	28	PF00069	0.345
DOC_MAPK_gen_1	245	251	PF00069	0.284
DOC_MAPK_gen_1	517	525	PF00069	0.385
DOC_MAPK_gen_1	97	105	PF00069	0.566
DOC_MAPK_MEF2A_6	412	420	PF00069	0.272
DOC_PP1_RVXF_1	168	174	PF00149	0.504
DOC_PP1_RVXF_1	356	362	PF00149	0.385
DOC_PP1_RVXF_1	463	470	PF00149	0.307
DOC_PP1_RVXF_1	61	68	PF00149	0.438
DOC_PP4_FxxP_1	188	191	PF00568	0.766
DOC_USP7_MATH_1	425	429	PF00917	0.289
DOC_USP7_UBL2_3	23	27	PF12436	0.312
DOC_USP7_UBL2_3	3	7	PF12436	0.428
DOC_USP7_UBL2_3	97	101	PF12436	0.538
DOC_WW_Pin1_4	203	208	PF00397	0.774
DOC_WW_Pin1_4	210	215	PF00397	0.650
DOC_WW_Pin1_4	312	317	PF00397	0.286
LIG_14-3-3_CanoR_1	170	179	PF00244	0.679
LIG_14-3-3_CanoR_1	180	188	PF00244	0.600
LIG_14-3-3_CanoR_1	291	297	PF00244	0.256
LIG_14-3-3_CanoR_1	356	362	PF00244	0.271
LIG_APCC_ABBAyCdc20_2	63	69	PF00400	0.454
LIG_BIR_III_4	540	544	PF00653	0.385
LIG_BRCT_BRCA1_1	294	298	PF00533	0.332
LIG_BRCT_BRCA1_1	410	414	PF00533	0.253
LIG_BRCT_BRCA1_1	496	500	PF00533	0.388
LIG_Clathr_ClatBox_1	65	69	PF01394	0.466
LIG_deltaCOP1_diTrp_1	545	551	PF00928	0.297
LIG_eIF4E_1	60	66	PF01652	0.429
LIG_EVH1_1	211	215	PF00568	0.469
LIG_EVH1_2	473	477	PF00568	0.385
LIG_FAT_LD_1	164	172	PF03623	0.620
LIG_FHA_1	194	200	PF00498	0.704
LIG_FHA_1	228	234	PF00498	0.719
LIG_FHA_1	288	294	PF00498	0.318
LIG_FHA_1	502	508	PF00498	0.432
LIG_FHA_1	82	88	PF00498	0.525
LIG_FHA_2	211	217	PF00498	0.591
LIG_FHA_2	358	364	PF00498	0.249
LIG_FHA_2	368	374	PF00498	0.305
LIG_FHA_2	555	561	PF00498	0.385
LIG_FHA_2	76	82	PF00498	0.582
LIG_LIR_Apic_2	186	191	PF02991	0.513
LIG_LIR_Apic_2	450	455	PF02991	0.253
LIG_LIR_Gen_1	106	114	PF02991	0.384
LIG_LIR_Gen_1	295	303	PF02991	0.271
LIG_LIR_Gen_1	338	347	PF02991	0.320
LIG_LIR_Gen_1	392	401	PF02991	0.328
LIG_LIR_Gen_1	518	526	PF02991	0.284
LIG_LIR_Gen_1	545	556	PF02991	0.332
LIG_LIR_Gen_1	9	18	PF02991	0.382
LIG_LIR_Nem_3	295	299	PF02991	0.268
LIG_LIR_Nem_3	323	328	PF02991	0.262
LIG_LIR_Nem_3	338	342	PF02991	0.210
LIG_LIR_Nem_3	360	364	PF02991	0.358
LIG_LIR_Nem_3	392	396	PF02991	0.423
LIG_LIR_Nem_3	434	440	PF02991	0.385
LIG_LIR_Nem_3	518	523	PF02991	0.263
LIG_LIR_Nem_3	545	551	PF02991	0.270
LIG_LIR_Nem_3	9	13	PF02991	0.342
LIG_LYPXL_SIV_4	57	65	PF13949	0.423
LIG_NRBOX	339	345	PF00104	0.173
LIG_Pex14_1	379	383	PF04695	0.385
LIG_PTB_Apo_2	250	257	PF02174	0.253
LIG_PTB_Apo_2	53	60	PF02174	0.438
LIG_PTB_Phospho_1	250	256	PF10480	0.253
LIG_PTB_Phospho_1	53	59	PF10480	0.438
LIG_REV1ctd_RIR_1	498	507	PF16727	0.385
LIG_REV1ctd_RIR_1	65	73	PF16727	0.509
LIG_SH2_CRK	452	456	PF00017	0.253
LIG_SH2_CRK	470	474	PF00017	0.253
LIG_SH2_CRK	520	524	PF00017	0.253
LIG_SH2_GRB2like	256	259	PF00017	0.253
LIG_SH2_GRB2like	54	57	PF00017	0.437
LIG_SH2_GRB2like	60	63	PF00017	0.423
LIG_SH2_NCK_1	470	474	PF00017	0.361
LIG_SH2_NCK_1	520	524	PF00017	0.173
LIG_SH2_NCK_1	54	58	PF00017	0.378
LIG_SH2_SRC	54	57	PF00017	0.437
LIG_SH2_STAP1	10	14	PF00017	0.399
LIG_SH2_STAP1	229	233	PF00017	0.646
LIG_SH2_STAP1	24	28	PF00017	0.497
LIG_SH2_STAP1	537	541	PF00017	0.332
LIG_SH2_STAP1	54	58	PF00017	0.332
LIG_SH2_STAT3	181	184	PF00017	0.470
LIG_SH2_STAT3	378	381	PF00017	0.281
LIG_SH2_STAT5	181	184	PF00017	0.566
LIG_SH2_STAT5	229	232	PF00017	0.556
LIG_SH2_STAT5	272	275	PF00017	0.385
LIG_SH2_STAT5	278	281	PF00017	0.253
LIG_SH2_STAT5	393	396	PF00017	0.392
LIG_SH2_STAT5	440	443	PF00017	0.253
LIG_SH2_STAT5	537	540	PF00017	0.289
LIG_SH2_STAT5	568	571	PF00017	0.253
LIG_SH2_STAT5	60	63	PF00017	0.310
LIG_SH3_2	212	217	PF14604	0.467
LIG_SH3_3	188	194	PF00018	0.712
LIG_SH3_3	206	212	PF00018	0.634
LIG_SH3_3	25	31	PF00018	0.565
LIG_SH3_3	356	362	PF00018	0.170
LIG_TRAF2_1	395	398	PF00917	0.272
LIG_TRAF2_1	45	48	PF00917	0.261
LIG_TYR_ITSM	516	523	PF00017	0.272
LIG_UBA3_1	1	7	PF00899	0.300
LIG_UBA3_1	476	481	PF00899	0.262
LIG_WRC_WIRS_1	293	298	PF05994	0.299
MOD_CAAXbox	571	574	PF01239	0.416
MOD_CDC14_SPxK_1	315	318	PF00782	0.332
MOD_CDK_SPxK_1	312	318	PF00069	0.332
MOD_CDK_SPxxK_3	210	217	PF00069	0.469
MOD_CK1_1	131	137	PF00069	0.562
MOD_CK1_1	158	164	PF00069	0.672
MOD_CK1_1	203	209	PF00069	0.579
MOD_CK1_1	227	233	PF00069	0.625
MOD_CK1_1	280	286	PF00069	0.377
MOD_CK1_1	367	373	PF00069	0.380
MOD_CK1_1	429	435	PF00069	0.385
MOD_CK1_1	513	519	PF00069	0.375
MOD_CK1_1	80	86	PF00069	0.538
MOD_CK2_1	160	166	PF00069	0.664
MOD_CK2_1	198	204	PF00069	0.743
MOD_CK2_1	357	363	PF00069	0.314
MOD_CK2_1	367	373	PF00069	0.286
MOD_CK2_1	6	12	PF00069	0.419
MOD_GlcNHglycan	200	203	PF01048	0.498
MOD_GlcNHglycan	237	240	PF01048	0.535
MOD_GlcNHglycan	312	315	PF01048	0.469
MOD_GlcNHglycan	348	351	PF01048	0.188
MOD_GlcNHglycan	398	402	PF01048	0.328
MOD_GlcNHglycan	490	493	PF01048	0.170
MOD_GSK3_1	156	163	PF00069	0.557
MOD_GSK3_1	235	242	PF00069	0.438
MOD_GSK3_1	308	315	PF00069	0.339
MOD_GSK3_1	410	417	PF00069	0.287
MOD_GSK3_1	425	432	PF00069	0.234
MOD_GSK3_1	490	497	PF00069	0.452
MOD_GSK3_1	499	506	PF00069	0.308
MOD_GSK3_1	77	84	PF00069	0.413
MOD_N-GLC_1	227	232	PF02516	0.572
MOD_N-GLC_1	234	239	PF02516	0.574
MOD_N-GLC_1	264	269	PF02516	0.385
MOD_N-GLC_1	308	313	PF02516	0.288
MOD_N-GLC_1	329	334	PF02516	0.385
MOD_N-GLC_1	385	390	PF02516	0.270
MOD_N-GLC_1	414	419	PF02516	0.328
MOD_N-GLC_1	447	452	PF02516	0.392
MOD_N-GLC_1	495	500	PF02516	0.385
MOD_N-GLC_1	75	80	PF02516	0.364
MOD_N-GLC_2	253	255	PF02516	0.253
MOD_N-GLC_2	62	64	PF02516	0.424
MOD_NEK2_1	13	18	PF00069	0.399
MOD_NEK2_1	171	176	PF00069	0.467
MOD_NEK2_1	234	239	PF00069	0.479
MOD_NEK2_1	251	256	PF00069	0.270
MOD_NEK2_1	264	269	PF00069	0.253
MOD_NEK2_1	292	297	PF00069	0.227
MOD_NEK2_1	310	315	PF00069	0.398
MOD_NEK2_1	328	333	PF00069	0.300
MOD_NEK2_1	414	419	PF00069	0.385
MOD_NEK2_1	468	473	PF00069	0.253
MOD_NEK2_1	476	481	PF00069	0.253
MOD_NEK2_1	501	506	PF00069	0.309
MOD_NEK2_1	515	520	PF00069	0.289
MOD_NEK2_2	510	515	PF00069	0.170
MOD_PIKK_1	180	186	PF00454	0.578
MOD_PIKK_1	264	270	PF00454	0.207
MOD_PIKK_1	329	335	PF00454	0.297
MOD_PIKK_1	75	81	PF00454	0.551
MOD_PK_1	172	178	PF00069	0.571
MOD_PK_1	385	391	PF00069	0.332
MOD_PK_1	503	509	PF00069	0.170
MOD_PKA_2	171	177	PF00069	0.558
MOD_PKA_2	357	363	PF00069	0.281
MOD_PKB_1	170	178	PF00069	0.566
MOD_Plk_1	264	270	PF00069	0.170
MOD_Plk_1	308	314	PF00069	0.268
MOD_Plk_1	385	391	PF00069	0.294
MOD_Plk_1	397	403	PF00069	0.294
MOD_Plk_1	414	420	PF00069	0.243
MOD_Plk_1	447	453	PF00069	0.376
MOD_Plk_1	495	501	PF00069	0.385
MOD_Plk_2-3	160	166	PF00069	0.615
MOD_Plk_4	13	19	PF00069	0.285
MOD_Plk_4	256	262	PF00069	0.332
MOD_Plk_4	385	391	PF00069	0.253
MOD_Plk_4	447	453	PF00069	0.272
MOD_Plk_4	495	501	PF00069	0.392
MOD_Plk_4	510	516	PF00069	0.191
MOD_ProDKin_1	203	209	PF00069	0.774
MOD_ProDKin_1	210	216	PF00069	0.652
MOD_ProDKin_1	312	318	PF00069	0.286
MOD_SUMO_for_1	45	48	PF00179	0.472
MOD_SUMO_rev_2	552	557	PF00179	0.282
MOD_SUMO_rev_2	89	98	PF00179	0.403
TRG_DiLeu_BaLyEn_6	288	293	PF01217	0.385
TRG_ENDOCYTIC_2	10	13	PF00928	0.348
TRG_ENDOCYTIC_2	107	110	PF00928	0.443
TRG_ENDOCYTIC_2	325	328	PF00928	0.297
TRG_ENDOCYTIC_2	393	396	PF00928	0.328
TRG_ENDOCYTIC_2	486	489	PF00928	0.297
TRG_ENDOCYTIC_2	520	523	PF00928	0.253
TRG_ENDOCYTIC_2	58	61	PF00928	0.420
TRG_ER_diArg_1	121	123	PF00400	0.511
TRG_ER_diArg_1	170	173	PF00400	0.558
TRG_ER_diArg_1	356	359	PF00400	0.271
TRG_ER_diArg_1	376	378	PF00400	0.283
TRG_NLS_Bipartite_1	464	485	PF00514	0.385
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.237

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1S4	Leptomonas seymouri	64%	97%
A0A0S4IVV7	Bodo saltans	28%	97%
A0A1X0NIL8	Trypanosomatidae	25%	75%
A0A1X0P5M1	Trypanosomatidae	44%	100%
A0A3Q8IGB5	Leishmania donovani	84%	100%
A0A422NFS3	Trypanosoma rangeli	43%	100%
A4I2S8	Leishmania infantum	84%	100%
B2GUX4	Rattus norvegicus	31%	100%
D0A5Z2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ADA6	Leishmania major	83%	100%
E9AZ31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
O94269	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
P36026	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	80%
Q2KJ72	Bos taurus	30%	100%
Q6NTR6	Xenopus laevis	26%	83%
Q7ZUM8	Danio rerio	28%	83%
Q91W36	Mus musculus	28%	100%
Q9H0E7	Homo sapiens	26%	81%
Q9HFS7	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	27%	72%
Q9QZL6	Mus musculus	30%	100%
Q9Y6I4	Homo sapiens	28%	100%
V5BQL0	Trypanosoma cruzi	44%	100%