Putative cation transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cation transporter, putative

Species:

Leishmania braziliensis

UniProt:

A4HFQ2_LEIBR

TriTrypDb:

LbrM.27.1380

Length:

663

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4HFQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFQ2

Function

Biological processes
Term	Name	Level	Count
GO:0006873	intracellular monoatomic ion homeostasis	4	7
GO:0006875	obsolete intracellular metal ion homeostasis	6	7
GO:0006882	intracellular zinc ion homeostasis	7	7
GO:0009987	cellular process	1	8
GO:0019725	cellular homeostasis	2	7
GO:0030003	intracellular monoatomic cation homeostasis	5	7
GO:0042592	homeostatic process	3	7
GO:0046916	obsolete intracellular transition metal ion homeostasis	7	7
GO:0048878	chemical homeostasis	4	7
GO:0050801	monoatomic ion homeostasis	5	7
GO:0055065	obsolete metal ion homeostasis	7	7
GO:0055069	obsolete zinc ion homeostasis	8	7
GO:0055076	obsolete transition metal ion homeostasis	8	7
GO:0055080	monoatomic cation homeostasis	6	7
GO:0055082	intracellular chemical homeostasis	3	7
GO:0065007	biological regulation	1	7
GO:0065008	regulation of biological quality	2	7
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	7
GO:0072507	obsolete divalent inorganic cation homeostasis	7	7
GO:0098771	inorganic ion homeostasis	6	7
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	2
GO:0006812	monoatomic cation transport	5	2
GO:0030001	metal ion transport	6	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0000041	transition metal ion transport	7	1
GO:0006829	zinc ion transport	8	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0055085	transmembrane transport	2	1
GO:0071577	zinc ion transmembrane transport	6	1
GO:0098655	monoatomic cation transmembrane transport	4	1
GO:0098660	inorganic ion transmembrane transport	4	1
GO:0098662	inorganic cation transmembrane transport	5	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0005385	zinc ion transmembrane transporter activity	7	8
GO:0008324	monoatomic cation transmembrane transporter activity	4	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	8
GO:0022857	transmembrane transporter activity	2	12
GO:0022890	inorganic cation transmembrane transporter activity	4	8
GO:0046873	metal ion transmembrane transporter activity	5	8
GO:0046915	transition metal ion transmembrane transporter activity	6	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	325	329	PF00656	0.637
CLV_NRD_NRD_1	14	16	PF00675	0.360
CLV_NRD_NRD_1	161	163	PF00675	0.397
CLV_NRD_NRD_1	241	243	PF00675	0.556
CLV_NRD_NRD_1	589	591	PF00675	0.264
CLV_PCSK_KEX2_1	14	16	PF00082	0.360
CLV_PCSK_KEX2_1	161	163	PF00082	0.407
CLV_PCSK_SKI1_1	322	326	PF00082	0.426
CLV_PCSK_SKI1_1	572	576	PF00082	0.275
CLV_PCSK_SKI1_1	590	594	PF00082	0.305
CLV_PCSK_SKI1_1	615	619	PF00082	0.298
DEG_Nend_UBRbox_2	1	3	PF02207	0.580
DOC_CYCLIN_RxL_1	319	330	PF00134	0.520
DOC_CYCLIN_RxL_1	569	580	PF00134	0.475
DOC_CYCLIN_RxL_1	588	596	PF00134	0.507
DOC_MAPK_DCC_7	21	31	PF00069	0.561
DOC_MAPK_gen_1	366	376	PF00069	0.422
DOC_MAPK_MEF2A_6	366	374	PF00069	0.425
DOC_PP1_RVXF_1	320	327	PF00149	0.607
DOC_PP1_RVXF_1	99	105	PF00149	0.552
DOC_PP2B_LxvP_1	464	467	PF13499	0.254
DOC_PP2B_LxvP_1	576	579	PF13499	0.524
DOC_PP4_FxxP_1	463	466	PF00568	0.265
DOC_USP7_MATH_1	285	289	PF00917	0.320
DOC_USP7_MATH_1	300	304	PF00917	0.361
DOC_USP7_MATH_1	327	331	PF00917	0.651
DOC_USP7_MATH_1	338	342	PF00917	0.595
DOC_USP7_MATH_1	390	394	PF00917	0.271
DOC_USP7_MATH_1	549	553	PF00917	0.329
DOC_WW_Pin1_4	45	50	PF00397	0.570
DOC_WW_Pin1_4	601	606	PF00397	0.510
LIG_14-3-3_CanoR_1	118	127	PF00244	0.400
LIG_14-3-3_CanoR_1	14	22	PF00244	0.566
LIG_14-3-3_CanoR_1	161	169	PF00244	0.585
LIG_14-3-3_CanoR_1	583	592	PF00244	0.477
LIG_APCC_ABBA_1	658	663	PF00400	0.522
LIG_BIR_III_4	494	498	PF00653	0.406
LIG_BRCT_BRCA1_1	397	401	PF00533	0.251
LIG_CtBP_PxDLS_1	26	30	PF00389	0.551
LIG_EH1_1	255	263	PF00400	0.280
LIG_eIF4E_1	34	40	PF01652	0.550
LIG_FHA_1	131	137	PF00498	0.508
LIG_FHA_1	189	195	PF00498	0.206
LIG_FHA_1	2	8	PF00498	0.571
LIG_FHA_1	219	225	PF00498	0.472
LIG_FHA_1	266	272	PF00498	0.244
LIG_FHA_1	276	282	PF00498	0.399
LIG_FHA_1	375	381	PF00498	0.280
LIG_FHA_1	568	574	PF00498	0.477
LIG_FHA_1	594	600	PF00498	0.504
LIG_FHA_1	638	644	PF00498	0.533
LIG_FHA_1	79	85	PF00498	0.251
LIG_FHA_1	92	98	PF00498	0.369
LIG_FHA_2	106	112	PF00498	0.595
LIG_FHA_2	323	329	PF00498	0.632
LIG_LIR_Gen_1	175	181	PF02991	0.219
LIG_LIR_Gen_1	303	311	PF02991	0.262
LIG_LIR_Gen_1	398	405	PF02991	0.247
LIG_LIR_Gen_1	470	479	PF02991	0.262
LIG_LIR_Gen_1	87	97	PF02991	0.290
LIG_LIR_Nem_3	175	179	PF02991	0.292
LIG_LIR_Nem_3	296	302	PF02991	0.424
LIG_LIR_Nem_3	303	308	PF02991	0.239
LIG_LIR_Nem_3	367	371	PF02991	0.406
LIG_LIR_Nem_3	437	442	PF02991	0.301
LIG_LIR_Nem_3	470	476	PF02991	0.262
LIG_LIR_Nem_3	562	567	PF02991	0.293
LIG_LIR_Nem_3	87	92	PF02991	0.290
LIG_LIR_Nem_3	94	99	PF02991	0.495
LIG_NRBOX	193	199	PF00104	0.212
LIG_NRBOX	522	528	PF00104	0.271
LIG_PCNA_yPIPBox_3	272	281	PF02747	0.556
LIG_PCNA_yPIPBox_3	349	362	PF02747	0.534
LIG_Pex14_1	85	89	PF04695	0.271
LIG_REV1ctd_RIR_1	93	99	PF16727	0.211
LIG_SH2_CRK	195	199	PF00017	0.211
LIG_SH2_PTP2	176	179	PF00017	0.212
LIG_SH2_PTP2	454	457	PF00017	0.271
LIG_SH2_SRC	34	37	PF00017	0.549
LIG_SH2_SRC	519	522	PF00017	0.271
LIG_SH2_STAP1	415	419	PF00017	0.317
LIG_SH2_STAP1	581	585	PF00017	0.532
LIG_SH2_STAT5	176	179	PF00017	0.212
LIG_SH2_STAT5	3	6	PF00017	0.569
LIG_SH2_STAT5	34	37	PF00017	0.549
LIG_SH2_STAT5	454	457	PF00017	0.292
LIG_SH2_STAT5	473	476	PF00017	0.271
LIG_SH2_STAT5	519	522	PF00017	0.271
LIG_SH2_STAT5	632	635	PF00017	0.564
LIG_SH3_3	599	605	PF00018	0.505
LIG_SH3_3	94	100	PF00018	0.425
LIG_Sin3_3	556	563	PF02671	0.280
LIG_SUMO_SIM_anti_2	175	184	PF11976	0.212
LIG_SUMO_SIM_anti_2	249	255	PF11976	0.265
LIG_SUMO_SIM_anti_2	28	33	PF11976	0.548
LIG_SUMO_SIM_anti_2	306	313	PF11976	0.310
LIG_SUMO_SIM_anti_2	36	42	PF11976	0.547
LIG_SUMO_SIM_anti_2	377	382	PF11976	0.243
LIG_SUMO_SIM_anti_2	529	537	PF11976	0.271
LIG_SUMO_SIM_anti_2	555	562	PF11976	0.285
LIG_SUMO_SIM_par_1	175	184	PF11976	0.269
LIG_SUMO_SIM_par_1	356	363	PF11976	0.541
LIG_SUMO_SIM_par_1	36	42	PF11976	0.553
LIG_SUMO_SIM_par_1	377	384	PF11976	0.212
LIG_SUMO_SIM_par_1	473	478	PF11976	0.271
LIG_SUMO_SIM_par_1	555	562	PF11976	0.294
LIG_SUMO_SIM_par_1	572	577	PF11976	0.470
LIG_TYR_ITIM	174	179	PF00017	0.305
LIG_TYR_ITIM	32	37	PF00017	0.550
LIG_UBA3_1	236	243	PF00899	0.433
LIG_WRC_WIRS_1	277	282	PF05994	0.406
LIG_WRC_WIRS_1	86	91	PF05994	0.271
LIG_WRC_WIRS_1	92	97	PF05994	0.271
MOD_CDK_SPK_2	601	606	PF00069	0.527
MOD_CK1_1	105	111	PF00069	0.572
MOD_CK1_1	276	282	PF00069	0.424
MOD_CK1_1	288	294	PF00069	0.295
MOD_CK1_1	330	336	PF00069	0.644
MOD_CK1_1	42	48	PF00069	0.570
MOD_CK1_1	552	558	PF00069	0.271
MOD_CK1_1	577	583	PF00069	0.526
MOD_CK1_1	79	85	PF00069	0.265
MOD_CK2_1	207	213	PF00069	0.212
MOD_CK2_1	300	306	PF00069	0.357
MOD_CK2_1	631	637	PF00069	0.506
MOD_GlcNHglycan	120	123	PF01048	0.287
MOD_GlcNHglycan	130	133	PF01048	0.250
MOD_GlcNHglycan	17	20	PF01048	0.366
MOD_GlcNHglycan	202	205	PF01048	0.324
MOD_GlcNHglycan	258	261	PF01048	0.271
MOD_GlcNHglycan	287	290	PF01048	0.269
MOD_GlcNHglycan	312	315	PF01048	0.305
MOD_GlcNHglycan	340	343	PF01048	0.410
MOD_GlcNHglycan	500	503	PF01048	0.237
MOD_GlcNHglycan	551	554	PF01048	0.271
MOD_GlcNHglycan	561	564	PF01048	0.271
MOD_GlcNHglycan	576	579	PF01048	0.352
MOD_GlcNHglycan	633	636	PF01048	0.437
MOD_GlcNHglycan	65	68	PF01048	0.245
MOD_GlcNHglycan	74	77	PF01048	0.576
MOD_GlcNHglycan	78	81	PF01048	0.619
MOD_GSK3_1	114	121	PF00069	0.617
MOD_GSK3_1	130	137	PF00069	0.425
MOD_GSK3_1	160	167	PF00069	0.617
MOD_GSK3_1	300	307	PF00069	0.365
MOD_GSK3_1	353	360	PF00069	0.543
MOD_GSK3_1	38	45	PF00069	0.563
MOD_GSK3_1	528	535	PF00069	0.271
MOD_GSK3_1	627	634	PF00069	0.565
MOD_GSK3_1	637	644	PF00069	0.593
MOD_GSK3_1	72	79	PF00069	0.357
MOD_N-GLC_1	188	193	PF02516	0.552
MOD_N-GLC_1	353	358	PF02516	0.336
MOD_N-GLC_1	583	588	PF02516	0.308
MOD_N-GLC_1	627	632	PF02516	0.367
MOD_N-GLC_1	654	659	PF02516	0.312
MOD_NEK2_1	1	6	PF00069	0.573
MOD_NEK2_1	128	133	PF00069	0.273
MOD_NEK2_1	160	165	PF00069	0.605
MOD_NEK2_1	235	240	PF00069	0.340
MOD_NEK2_1	256	261	PF00069	0.294
MOD_NEK2_1	273	278	PF00069	0.578
MOD_NEK2_1	310	315	PF00069	0.294
MOD_NEK2_1	345	350	PF00069	0.596
MOD_NEK2_1	374	379	PF00069	0.274
MOD_NEK2_1	39	44	PF00069	0.565
MOD_NEK2_1	405	410	PF00069	0.274
MOD_NEK2_1	456	461	PF00069	0.294
MOD_NEK2_1	475	480	PF00069	0.279
MOD_NEK2_1	526	531	PF00069	0.286
MOD_NEK2_1	567	572	PF00069	0.477
MOD_NEK2_1	574	579	PF00069	0.544
MOD_NEK2_1	593	598	PF00069	0.461
MOD_NEK2_1	609	614	PF00069	0.466
MOD_NEK2_1	63	68	PF00069	0.262
MOD_NEK2_1	69	74	PF00069	0.447
MOD_NEK2_1	78	83	PF00069	0.376
MOD_NEK2_2	91	96	PF00069	0.212
MOD_PIKK_1	160	166	PF00454	0.555
MOD_PKA_2	13	19	PF00069	0.558
MOD_PKA_2	160	166	PF00069	0.614
MOD_PKA_2	76	82	PF00069	0.390
MOD_Plk_1	114	120	PF00069	0.572
MOD_Plk_1	188	194	PF00069	0.206
MOD_Plk_1	327	333	PF00069	0.618
MOD_Plk_1	353	359	PF00069	0.600
MOD_Plk_1	615	621	PF00069	0.496
MOD_Plk_1	654	660	PF00069	0.508
MOD_Plk_4	169	175	PF00069	0.298
MOD_Plk_4	228	234	PF00069	0.321
MOD_Plk_4	27	33	PF00069	0.550
MOD_Plk_4	276	282	PF00069	0.435
MOD_Plk_4	288	294	PF00069	0.359
MOD_Plk_4	327	333	PF00069	0.594
MOD_Plk_4	353	359	PF00069	0.583
MOD_Plk_4	374	380	PF00069	0.329
MOD_Plk_4	406	412	PF00069	0.367
MOD_Plk_4	418	424	PF00069	0.295
MOD_Plk_4	528	534	PF00069	0.290
MOD_Plk_4	654	660	PF00069	0.508
MOD_Plk_4	79	85	PF00069	0.248
MOD_Plk_4	91	97	PF00069	0.271
MOD_ProDKin_1	45	51	PF00069	0.570
MOD_ProDKin_1	601	607	PF00069	0.508
MOD_SUMO_rev_2	363	371	PF00179	0.543
MOD_SUMO_rev_2	421	428	PF00179	0.448
TRG_DiLeu_BaEn_1	115	120	PF01217	0.559
TRG_DiLeu_BaEn_1	247	252	PF01217	0.382
TRG_DiLeu_BaEn_1	306	311	PF01217	0.271
TRG_DiLeu_BaEn_1	470	475	PF01217	0.248
TRG_DiLeu_BaEn_2	366	372	PF01217	0.448
TRG_DiLeu_BaLyEn_6	562	567	PF01217	0.271
TRG_DiLeu_LyEn_5	115	120	PF01217	0.559
TRG_ENDOCYTIC_2	176	179	PF00928	0.305
TRG_ENDOCYTIC_2	195	198	PF00928	0.211
TRG_ENDOCYTIC_2	34	37	PF00928	0.549
TRG_ENDOCYTIC_2	368	371	PF00928	0.406
TRG_ENDOCYTIC_2	436	439	PF00928	0.448
TRG_ENDOCYTIC_2	454	457	PF00928	0.271
TRG_ENDOCYTIC_2	473	476	PF00928	0.271
TRG_ENDOCYTIC_2	519	522	PF00928	0.271
TRG_ER_diArg_1	13	15	PF00400	0.556
TRG_ER_diArg_1	160	162	PF00400	0.606
TRG_Pf-PMV_PEXEL_1	591	595	PF00026	0.269

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB11	Leptomonas seymouri	55%	100%
A0A3Q8IDA3	Leishmania donovani	78%	100%
A0A3Q8IGB8	Leishmania donovani	23%	100%
A4HJM3	Leishmania braziliensis	24%	100%
A4I2S7	Leishmania infantum	77%	100%
A4I745	Leishmania infantum	24%	100%
E9ADA5	Leishmania major	79%	100%
E9AZ30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
E9B239	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4Q622	Leishmania major	24%	100%