CCT-beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

CCT-beta

Gene product:

T-complex protein 1, beta subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HFQ1_LEIBR

TriTrypDb:

LbrM.27.1370 , LBRM2903_270019600

Length:

529

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005832	chaperonin-containing T-complex	4	12
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	12
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

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Expansion

Sequence features

A4HFQ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFQ1

Function

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Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0005524	ATP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	207	211	PF00656	0.391
CLV_C14_Caspase3-7	93	97	PF00656	0.356
CLV_PCSK_SKI1_1	160	164	PF00082	0.363
CLV_PCSK_SKI1_1	169	173	PF00082	0.345
CLV_PCSK_SKI1_1	277	281	PF00082	0.372
CLV_PCSK_SKI1_1	321	325	PF00082	0.356
CLV_PCSK_SKI1_1	379	383	PF00082	0.441
CLV_PCSK_SKI1_1	404	408	PF00082	0.356
CLV_PCSK_SKI1_1	71	75	PF00082	0.356
CLV_Separin_Metazoa	107	111	PF03568	0.356

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U4	Leptomonas seymouri	32%	97%
A0A0N1HUM6	Leptomonas seymouri	92%	100%
A0A0N1HUW6	Leptomonas seymouri	33%	96%
A0A0N1HXN1	Leptomonas seymouri	26%	98%
A0A0N1I104	Leptomonas seymouri	34%	93%
A0A0N1I2L2	Leptomonas seymouri	33%	98%
A0A0N1II94	Leptomonas seymouri	32%	97%
A0A0N1IM41	Leptomonas seymouri	28%	99%
A0A0S4ITK5	Bodo saltans	24%	77%
A0A0S4IWM5	Bodo saltans	33%	96%

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