CFAP91 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFP8_LEIBR

TriTrypDb:

LbrM.27.1330 , LBRM2903_270019200

Length:

518

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFP8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	473	477	PF00656	0.658
CLV_C14_Caspase3-7	84	88	PF00656	0.551
CLV_NRD_NRD_1	132	134	PF00675	0.527
CLV_NRD_NRD_1	185	187	PF00675	0.524
CLV_NRD_NRD_1	237	239	PF00675	0.562
CLV_NRD_NRD_1	255	257	PF00675	0.530
CLV_NRD_NRD_1	281	283	PF00675	0.551
CLV_NRD_NRD_1	319	321	PF00675	0.528
CLV_NRD_NRD_1	345	347	PF00675	0.571
CLV_NRD_NRD_1	428	430	PF00675	0.733
CLV_NRD_NRD_1	483	485	PF00675	0.677
CLV_PCSK_FUR_1	234	238	PF00082	0.645
CLV_PCSK_FUR_1	317	321	PF00082	0.537
CLV_PCSK_KEX2_1	236	238	PF00082	0.553
CLV_PCSK_KEX2_1	240	242	PF00082	0.463
CLV_PCSK_KEX2_1	255	257	PF00082	0.505
CLV_PCSK_KEX2_1	319	321	PF00082	0.528
CLV_PCSK_KEX2_1	322	324	PF00082	0.550
CLV_PCSK_KEX2_1	428	430	PF00082	0.660
CLV_PCSK_KEX2_1	469	471	PF00082	0.724
CLV_PCSK_KEX2_1	483	485	PF00082	0.613
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.553
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.463
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.585
CLV_PCSK_PC1ET2_1	469	471	PF00082	0.780
CLV_PCSK_PC7_1	424	430	PF00082	0.772
CLV_PCSK_SKI1_1	125	129	PF00082	0.491
CLV_PCSK_SKI1_1	148	152	PF00082	0.516
CLV_PCSK_SKI1_1	283	287	PF00082	0.473
CLV_PCSK_SKI1_1	31	35	PF00082	0.660
CLV_PCSK_SKI1_1	319	323	PF00082	0.571
CLV_PCSK_SKI1_1	366	370	PF00082	0.573
CLV_Separin_Metazoa	159	163	PF03568	0.559
CLV_Separin_Metazoa	197	201	PF03568	0.486
DEG_APCC_DBOX_1	147	155	PF00400	0.501
DOC_CYCLIN_RxL_1	280	290	PF00134	0.473
DOC_MAPK_FxFP_2	408	411	PF00069	0.629
DOC_MAPK_JIP1_4	275	281	PF00069	0.587
DOC_PP1_RVXF_1	308	315	PF00149	0.607
DOC_PP4_FxxP_1	33	36	PF00568	0.572
DOC_PP4_FxxP_1	368	371	PF00568	0.560
DOC_PP4_FxxP_1	408	411	PF00568	0.629
DOC_USP7_MATH_1	243	247	PF00917	0.623
DOC_USP7_MATH_1	454	458	PF00917	0.780
DOC_USP7_MATH_1	468	472	PF00917	0.765
DOC_USP7_MATH_1	479	483	PF00917	0.612
DOC_USP7_MATH_1	496	500	PF00917	0.813
DOC_USP7_UBL2_3	236	240	PF12436	0.545
DOC_USP7_UBL2_3	31	35	PF12436	0.653
DOC_WW_Pin1_4	497	502	PF00397	0.722
LIG_14-3-3_CanoR_1	470	478	PF00244	0.770
LIG_Actin_WH2_2	112	127	PF00022	0.537
LIG_APCC_ABBA_1	331	336	PF00400	0.558
LIG_APCC_ABBA_1	395	400	PF00400	0.645
LIG_APCC_ABBAyCdc20_2	125	131	PF00400	0.381
LIG_Clathr_ClatBox_1	442	446	PF01394	0.775
LIG_Clathr_ClatBox_1	55	59	PF01394	0.637
LIG_FHA_1	155	161	PF00498	0.532
LIG_FHA_1	316	322	PF00498	0.539
LIG_FHA_1	498	504	PF00498	0.559
LIG_FHA_1	50	56	PF00498	0.623
LIG_FHA_1	68	74	PF00498	0.526
LIG_FHA_2	142	148	PF00498	0.481
LIG_FHA_2	203	209	PF00498	0.562
LIG_FHA_2	391	397	PF00498	0.741
LIG_FHA_2	43	49	PF00498	0.682
LIG_FHA_2	509	515	PF00498	0.797
LIG_FHA_2	58	64	PF00498	0.550
LIG_FHA_2	79	85	PF00498	0.572
LIG_LIR_Apic_2	30	36	PF02991	0.579
LIG_LIR_Gen_1	110	119	PF02991	0.553
LIG_LIR_Gen_1	376	382	PF02991	0.537
LIG_LIR_Gen_1	487	496	PF02991	0.679
LIG_LIR_Gen_1	81	89	PF02991	0.558
LIG_LIR_Nem_3	110	115	PF02991	0.570
LIG_LIR_Nem_3	163	168	PF02991	0.595
LIG_LIR_Nem_3	376	381	PF02991	0.536
LIG_LIR_Nem_3	487	493	PF02991	0.678
LIG_SH2_CRK	112	116	PF00017	0.559
LIG_SH2_GRB2like	78	81	PF00017	0.560
LIG_SH2_STAP1	297	301	PF00017	0.577
LIG_SH2_STAP1	375	379	PF00017	0.586
LIG_SH2_STAT5	16	19	PF00017	0.658
LIG_SH2_STAT5	204	207	PF00017	0.517
LIG_SH2_STAT5	215	218	PF00017	0.483
LIG_SH2_STAT5	57	60	PF00017	0.649
LIG_SH2_STAT5	78	81	PF00017	0.560
LIG_SH2_STAT5	82	85	PF00017	0.563
LIG_SH3_3	124	130	PF00018	0.503
LIG_SH3_3	155	161	PF00018	0.513
LIG_TRAF2_1	205	208	PF00917	0.517
LIG_TRAF2_1	340	343	PF00917	0.564
LIG_UBA3_1	198	206	PF00899	0.383
MOD_CDK_SPxxK_3	497	504	PF00069	0.683
MOD_CK1_1	287	293	PF00069	0.443
MOD_CK1_1	508	514	PF00069	0.738
MOD_CK1_1	61	67	PF00069	0.746
MOD_CK2_1	141	147	PF00069	0.497
MOD_CK2_1	202	208	PF00069	0.495
MOD_CK2_1	229	235	PF00069	0.537
MOD_CK2_1	243	249	PF00069	0.589
MOD_CK2_1	336	342	PF00069	0.580
MOD_CK2_1	390	396	PF00069	0.629
MOD_CK2_1	57	63	PF00069	0.617
MOD_CK2_1	78	84	PF00069	0.630
MOD_GlcNHglycan	338	341	PF01048	0.571
MOD_GlcNHglycan	4	7	PF01048	0.511
MOD_GlcNHglycan	456	459	PF01048	0.685
MOD_GlcNHglycan	472	475	PF01048	0.729
MOD_GlcNHglycan	96	99	PF01048	0.613
MOD_GSK3_1	355	362	PF00069	0.679
MOD_GSK3_1	450	457	PF00069	0.764
MOD_GSK3_1	57	64	PF00069	0.639
MOD_N-GLC_1	355	360	PF02516	0.546
MOD_N-GLC_1	400	405	PF02516	0.602
MOD_NEK2_1	141	146	PF00069	0.528
MOD_NEK2_1	285	290	PF00069	0.454
MOD_NEK2_1	315	320	PF00069	0.515
MOD_NEK2_1	355	360	PF00069	0.514
MOD_NEK2_2	324	329	PF00069	0.566
MOD_NMyristoyl	1	7	PF02799	0.648
MOD_PIKK_1	160	166	PF00454	0.589
MOD_PIKK_1	359	365	PF00454	0.663
MOD_PKA_1	469	475	PF00069	0.749
MOD_PKA_2	336	342	PF00069	0.580
MOD_PKA_2	423	429	PF00069	0.570
MOD_PKA_2	462	468	PF00069	0.767
MOD_PKA_2	469	475	PF00069	0.781
MOD_Plk_1	355	361	PF00069	0.534
MOD_Plk_1	463	469	PF00069	0.549
MOD_Plk_1	91	97	PF00069	0.703
MOD_Plk_4	110	116	PF00069	0.423
MOD_Plk_4	78	84	PF00069	0.560
MOD_Plk_4	91	97	PF00069	0.540
MOD_ProDKin_1	497	503	PF00069	0.724
MOD_SUMO_for_1	210	213	PF00179	0.608
TRG_DiLeu_BaEn_1	110	115	PF01217	0.556
TRG_ENDOCYTIC_2	112	115	PF00928	0.557
TRG_ENDOCYTIC_2	293	296	PF00928	0.572
TRG_ENDOCYTIC_2	375	378	PF00928	0.563
TRG_ENDOCYTIC_2	82	85	PF00928	0.563
TRG_ER_diArg_1	115	118	PF00400	0.569
TRG_ER_diArg_1	255	257	PF00400	0.551
TRG_ER_diArg_1	317	320	PF00400	0.526
TRG_NLS_MonoExtC_3	132	138	PF00514	0.560
TRG_NLS_MonoExtN_4	130	137	PF00514	0.600
TRG_NLS_MonoExtN_4	280	286	PF00514	0.486
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB65	Leptomonas seymouri	77%	100%
A0A0S4IYS9	Bodo saltans	60%	100%
A0A1X0P4B6	Trypanosomatidae	69%	100%
A0A3Q8ICN6	Leishmania donovani	86%	100%
A4I2S3	Leishmania infantum	86%	100%
D0A5Y1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9ADA1	Leishmania major	86%	100%
E9AZ26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5D978	Trypanosoma cruzi	70%	100%