DUF4201 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFP7_LEIBR

TriTrypDb:

LbrM.27.1320 , LBRM2903_270019100

Length:

429

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFP7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.462
CLV_C14_Caspase3-7	310	314	PF00656	0.521
CLV_C14_Caspase3-7	52	56	PF00656	0.533
CLV_NRD_NRD_1	213	215	PF00675	0.494
CLV_NRD_NRD_1	234	236	PF00675	0.461
CLV_NRD_NRD_1	259	261	PF00675	0.423
CLV_NRD_NRD_1	374	376	PF00675	0.420
CLV_NRD_NRD_1	406	408	PF00675	0.510
CLV_NRD_NRD_1	410	412	PF00675	0.594
CLV_PCSK_KEX2_1	234	236	PF00082	0.587
CLV_PCSK_KEX2_1	259	261	PF00082	0.423
CLV_PCSK_KEX2_1	34	36	PF00082	0.529
CLV_PCSK_KEX2_1	374	376	PF00082	0.476
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.565
CLV_PCSK_PC7_1	230	236	PF00082	0.547
CLV_PCSK_PC7_1	370	376	PF00082	0.550
CLV_PCSK_SKI1_1	11	15	PF00082	0.429
CLV_PCSK_SKI1_1	111	115	PF00082	0.487
CLV_PCSK_SKI1_1	185	189	PF00082	0.479
CLV_PCSK_SKI1_1	214	218	PF00082	0.471
CLV_PCSK_SKI1_1	260	264	PF00082	0.510
CLV_PCSK_SKI1_1	393	397	PF00082	0.481
CLV_Separin_Metazoa	106	110	PF03568	0.561
CLV_Separin_Metazoa	186	190	PF03568	0.541
DEG_APCC_DBOX_1	259	267	PF00400	0.479
DEG_APCC_DBOX_1	373	381	PF00400	0.527
DEG_APCC_KENBOX_2	273	277	PF00400	0.314
DOC_CYCLIN_RxL_1	182	192	PF00134	0.365
DOC_CYCLIN_RxL_1	8	18	PF00134	0.339
DOC_MAPK_gen_1	171	180	PF00069	0.546
DOC_MAPK_gen_1	31	39	PF00069	0.503
DOC_MAPK_MEF2A_6	289	296	PF00069	0.315
DOC_MAPK_NFAT4_5	289	297	PF00069	0.317
DOC_USP7_MATH_1	121	125	PF00917	0.521
DOC_USP7_UBL2_3	237	241	PF12436	0.489
DOC_USP7_UBL2_3	408	412	PF12436	0.509
LIG_14-3-3_CanoR_1	230	238	PF00244	0.350
LIG_14-3-3_CanoR_1	243	252	PF00244	0.484
LIG_14-3-3_CanoR_1	407	415	PF00244	0.456
LIG_14-3-3_CanoR_1	71	80	PF00244	0.508
LIG_APCC_ABBA_1	290	295	PF00400	0.315
LIG_APCC_ABBAyCdc20_2	289	295	PF00400	0.314
LIG_BIR_II_1	1	5	PF00653	0.480
LIG_BIR_III_4	199	203	PF00653	0.341
LIG_Clathr_ClatBox_1	13	17	PF01394	0.530
LIG_FHA_1	133	139	PF00498	0.415
LIG_FHA_1	164	170	PF00498	0.492
LIG_FHA_1	52	58	PF00498	0.462
LIG_FHA_1	73	79	PF00498	0.476
LIG_FHA_2	196	202	PF00498	0.624
LIG_FHA_2	245	251	PF00498	0.579
LIG_FHA_2	360	366	PF00498	0.516
LIG_LIR_Gen_1	360	369	PF02991	0.314
LIG_LIR_Nem_3	360	364	PF02991	0.315
LIG_NRBOX	113	119	PF00104	0.354
LIG_PCNA_PIPBox_1	399	408	PF02747	0.330
LIG_PCNA_yPIPBox_3	393	406	PF02747	0.317
LIG_Rb_pABgroove_1	322	330	PF01858	0.514
LIG_SH2_GRB2like	376	379	PF00017	0.358
LIG_SH2_NCK_1	361	365	PF00017	0.527
LIG_SH2_STAP1	328	332	PF00017	0.516
LIG_SH2_STAT5	132	135	PF00017	0.641
LIG_SH2_STAT5	22	25	PF00017	0.464
LIG_SH2_STAT5	251	254	PF00017	0.529
LIG_SH2_STAT5	29	32	PF00017	0.516
LIG_SH2_STAT5	331	334	PF00017	0.295
LIG_SH2_STAT5	361	364	PF00017	0.489
LIG_SH2_STAT5	376	379	PF00017	0.424
LIG_SUMO_SIM_par_1	5	10	PF11976	0.544
LIG_TRAF2_1	128	131	PF00917	0.490
LIG_UBA3_1	13	21	PF00899	0.411
LIG_UBA3_1	6	11	PF00899	0.438
MOD_CK1_1	100	106	PF00069	0.637
MOD_CK1_1	143	149	PF00069	0.502
MOD_CK1_1	2	8	PF00069	0.450
MOD_CK1_1	40	46	PF00069	0.559
MOD_CK1_1	53	59	PF00069	0.679
MOD_CK1_1	62	68	PF00069	0.594
MOD_CK1_1	72	78	PF00069	0.555
MOD_CK2_1	100	106	PF00069	0.453
MOD_CK2_1	131	137	PF00069	0.475
MOD_CK2_1	195	201	PF00069	0.595
MOD_CK2_1	2	8	PF00069	0.575
MOD_CK2_1	22	28	PF00069	0.431
MOD_CK2_1	359	365	PF00069	0.485
MOD_GlcNHglycan	148	151	PF01048	0.667
MOD_GlcNHglycan	2	5	PF01048	0.414
MOD_GlcNHglycan	352	355	PF01048	0.598
MOD_GlcNHglycan	387	391	PF01048	0.308
MOD_GlcNHglycan	408	411	PF01048	0.597
MOD_GlcNHglycan	71	74	PF01048	0.655
MOD_GSK3_1	140	147	PF00069	0.548
MOD_GSK3_1	29	36	PF00069	0.505
MOD_GSK3_1	53	60	PF00069	0.624
MOD_GSK3_1	62	69	PF00069	0.616
MOD_NEK2_1	163	168	PF00069	0.361
MOD_NEK2_1	285	290	PF00069	0.428
MOD_NEK2_1	30	35	PF00069	0.446
MOD_NEK2_1	327	332	PF00069	0.429
MOD_NEK2_1	7	12	PF00069	0.567
MOD_PIKK_1	15	21	PF00454	0.395
MOD_PIKK_1	40	46	PF00454	0.450
MOD_PIKK_1	59	65	PF00454	0.669
MOD_PIKK_1	66	72	PF00454	0.550
MOD_PKA_2	229	235	PF00069	0.396
MOD_PKA_2	252	258	PF00069	0.481
MOD_PKA_2	30	36	PF00069	0.571
MOD_PKA_2	350	356	PF00069	0.413
MOD_PKA_2	406	412	PF00069	0.587
MOD_PKA_2	50	56	PF00069	0.667
MOD_PKA_2	65	71	PF00069	0.714
MOD_PKB_1	64	72	PF00069	0.613
MOD_Plk_1	239	245	PF00069	0.523
MOD_Plk_1	359	365	PF00069	0.481
MOD_Plk_1	97	103	PF00069	0.530
MOD_Plk_4	189	195	PF00069	0.388
MOD_Plk_4	2	8	PF00069	0.602
MOD_Plk_4	327	333	PF00069	0.497
MOD_Plk_4	359	365	PF00069	0.603
MOD_SUMO_for_1	119	122	PF00179	0.605
MOD_SUMO_rev_2	209	216	PF00179	0.464
MOD_SUMO_rev_2	72	81	PF00179	0.584
TRG_ENDOCYTIC_2	282	285	PF00928	0.546
TRG_ENDOCYTIC_2	361	364	PF00928	0.527
TRG_ER_diArg_1	170	173	PF00400	0.406
TRG_ER_diArg_1	259	261	PF00400	0.439
TRG_ER_diArg_1	374	376	PF00400	0.509
TRG_Pf-PMV_PEXEL_1	375	379	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHJ5	Leptomonas seymouri	59%	100%
A0A1X0P450	Trypanosomatidae	29%	100%
A0A3R7M124	Trypanosoma rangeli	26%	100%
A0A3S7X0N0	Leishmania donovani	72%	100%
A4I2S2	Leishmania infantum	72%	100%
D0A5Y0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9ADA0	Leishmania major	70%	100%
E9AZ25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
V5AT73	Trypanosoma cruzi	26%	100%