RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RING-H2 zinc finger, putative

Species:

Leishmania braziliensis

UniProt:

A4HFP6_LEIBR

TriTrypDb:

LbrM.27.1300 , LBRM2903_270018900

Length:

421

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFP6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.478
CLV_C14_Caspase3-7	288	292	PF00656	0.372
CLV_C14_Caspase3-7	3	7	PF00656	0.665
CLV_NRD_NRD_1	113	115	PF00675	0.522
CLV_NRD_NRD_1	132	134	PF00675	0.484
CLV_NRD_NRD_1	160	162	PF00675	0.699
CLV_NRD_NRD_1	20	22	PF00675	0.642
CLV_NRD_NRD_1	308	310	PF00675	0.477
CLV_NRD_NRD_1	408	410	PF00675	0.726
CLV_NRD_NRD_1	75	77	PF00675	0.609
CLV_NRD_NRD_1	95	97	PF00675	0.675
CLV_NRD_NRD_1	98	100	PF00675	0.704
CLV_PCSK_FUR_1	73	77	PF00082	0.548
CLV_PCSK_FUR_1	96	100	PF00082	0.701
CLV_PCSK_KEX2_1	132	134	PF00082	0.536
CLV_PCSK_KEX2_1	155	157	PF00082	0.685
CLV_PCSK_KEX2_1	160	162	PF00082	0.684
CLV_PCSK_KEX2_1	20	22	PF00082	0.668
CLV_PCSK_KEX2_1	308	310	PF00082	0.477
CLV_PCSK_KEX2_1	408	410	PF00082	0.726
CLV_PCSK_KEX2_1	75	77	PF00082	0.708
CLV_PCSK_KEX2_1	95	97	PF00082	0.675
CLV_PCSK_KEX2_1	98	100	PF00082	0.704
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.606
CLV_PCSK_PC7_1	156	162	PF00082	0.534
CLV_PCSK_PC7_1	304	310	PF00082	0.440
CLV_PCSK_SKI1_1	139	143	PF00082	0.586
DEG_APCC_DBOX_1	248	256	PF00400	0.420
DEG_APCC_DBOX_1	373	381	PF00400	0.560
DEG_COP1_1	174	185	PF00400	0.556
DEG_Nend_Nbox_1	1	3	PF02207	0.711
DOC_CYCLIN_RxL_1	112	123	PF00134	0.528
DOC_MAPK_gen_1	139	149	PF00069	0.555
DOC_MAPK_gen_1	160	168	PF00069	0.643
DOC_MAPK_gen_1	408	416	PF00069	0.537
DOC_MAPK_MEF2A_6	363	372	PF00069	0.547
DOC_PP4_FxxP_1	238	241	PF00568	0.490
DOC_USP7_MATH_1	103	107	PF00917	0.580
DOC_USP7_MATH_1	172	176	PF00917	0.618
DOC_USP7_MATH_1	185	189	PF00917	0.675
DOC_USP7_MATH_1	270	274	PF00917	0.510
DOC_USP7_MATH_1	275	279	PF00917	0.451
DOC_USP7_MATH_1	30	34	PF00917	0.553
DOC_USP7_MATH_1	320	324	PF00917	0.723
DOC_USP7_MATH_1	391	395	PF00917	0.601
DOC_USP7_MATH_1	407	411	PF00917	0.564
DOC_USP7_MATH_1	48	52	PF00917	0.655
DOC_USP7_MATH_1	64	68	PF00917	0.581
DOC_USP7_MATH_1	69	73	PF00917	0.631
DOC_WW_Pin1_4	11	16	PF00397	0.749
DOC_WW_Pin1_4	149	154	PF00397	0.706
DOC_WW_Pin1_4	181	186	PF00397	0.706
DOC_WW_Pin1_4	193	198	PF00397	0.510
DOC_WW_Pin1_4	26	31	PF00397	0.555
DOC_WW_Pin1_4	327	332	PF00397	0.760
DOC_WW_Pin1_4	89	94	PF00397	0.703
LIG_14-3-3_CanoR_1	114	118	PF00244	0.537
LIG_14-3-3_CanoR_1	132	141	PF00244	0.584
LIG_14-3-3_CanoR_1	160	168	PF00244	0.689
LIG_14-3-3_CanoR_1	249	253	PF00244	0.420
LIG_14-3-3_CanoR_1	374	378	PF00244	0.568
LIG_14-3-3_CanoR_1	73	79	PF00244	0.732
LIG_14-3-3_CanoR_1	8	13	PF00244	0.597
LIG_14-3-3_CanoR_1	98	107	PF00244	0.735
LIG_Actin_WH2_2	291	306	PF00022	0.399
LIG_BIR_III_4	102	106	PF00653	0.561
LIG_CtBP_PxDLS_1	54	58	PF00389	0.518
LIG_FHA_1	142	148	PF00498	0.606
LIG_FHA_1	184	190	PF00498	0.558
LIG_FHA_2	286	292	PF00498	0.408
LIG_FHA_2	78	84	PF00498	0.656
LIG_PTB_Apo_2	224	231	PF02174	0.420
LIG_SH2_STAT5	22	25	PF00017	0.589
LIG_SH2_STAT5	302	305	PF00017	0.604
LIG_SH2_STAT5	348	351	PF00017	0.663
LIG_SH3_3	179	185	PF00018	0.615
LIG_SH3_3	311	317	PF00018	0.532
LIG_SH3_3	365	371	PF00018	0.586
LIG_SH3_3	396	402	PF00018	0.599
LIG_SH3_3	9	15	PF00018	0.678
LIG_SUMO_SIM_par_1	37	45	PF11976	0.590
LIG_SUMO_SIM_par_1	51	60	PF11976	0.483
LIG_TRAF2_1	177	180	PF00917	0.727
LIG_TRAF2_1	210	213	PF00917	0.451
LIG_TRAF2_1	379	382	PF00917	0.558
LIG_TRAF2_1	80	83	PF00917	0.656
LIG_WRC_WIRS_1	88	93	PF05994	0.558
MOD_CAAXbox	418	421	PF01239	0.686
MOD_CDC14_SPxK_1	152	155	PF00782	0.521
MOD_CDC14_SPxK_1	29	32	PF00782	0.503
MOD_CDK_SPK_2	327	332	PF00069	0.556
MOD_CDK_SPxK_1	149	155	PF00069	0.536
MOD_CDK_SPxK_1	26	32	PF00069	0.510
MOD_CDK_SPxK_1	89	95	PF00069	0.557
MOD_CDK_SPxxK_3	149	156	PF00069	0.705
MOD_CDK_SPxxK_3	89	96	PF00069	0.727
MOD_CK1_1	101	107	PF00069	0.620
MOD_CK1_1	109	115	PF00069	0.680
MOD_CK1_1	121	127	PF00069	0.623
MOD_CK1_1	14	20	PF00069	0.714
MOD_CK1_1	164	170	PF00069	0.643
MOD_CK1_1	171	177	PF00069	0.576
MOD_CK1_1	181	187	PF00069	0.707
MOD_CK1_1	188	194	PF00069	0.622
MOD_CK1_1	26	32	PF00069	0.508
MOD_CK1_1	355	361	PF00069	0.585
MOD_CK1_1	373	379	PF00069	0.511
MOD_CK1_1	56	62	PF00069	0.660
MOD_CK1_1	67	73	PF00069	0.572
MOD_CK2_1	207	213	PF00069	0.516
MOD_CK2_1	77	83	PF00069	0.658
MOD_Cter_Amidation	18	21	PF01082	0.530
MOD_GlcNHglycan	102	106	PF01048	0.660
MOD_GlcNHglycan	109	112	PF01048	0.692
MOD_GlcNHglycan	134	137	PF01048	0.615
MOD_GlcNHglycan	16	19	PF01048	0.600
MOD_GlcNHglycan	169	173	PF01048	0.549
MOD_GlcNHglycan	2	5	PF01048	0.671
MOD_GlcNHglycan	25	28	PF01048	0.513
MOD_GlcNHglycan	273	276	PF01048	0.562
MOD_GlcNHglycan	277	280	PF01048	0.473
MOD_GlcNHglycan	318	321	PF01048	0.707
MOD_GlcNHglycan	327	330	PF01048	0.721
MOD_GlcNHglycan	59	62	PF01048	0.607
MOD_GlcNHglycan	66	69	PF01048	0.671
MOD_GSK3_1	101	108	PF00069	0.692
MOD_GSK3_1	109	116	PF00069	0.628
MOD_GSK3_1	137	144	PF00069	0.625
MOD_GSK3_1	164	171	PF00069	0.693
MOD_GSK3_1	181	188	PF00069	0.725
MOD_GSK3_1	191	198	PF00069	0.551
MOD_GSK3_1	199	206	PF00069	0.626
MOD_GSK3_1	26	33	PF00069	0.558
MOD_GSK3_1	271	278	PF00069	0.515
MOD_GSK3_1	316	323	PF00069	0.677
MOD_GSK3_1	348	355	PF00069	0.591
MOD_GSK3_1	358	365	PF00069	0.518
MOD_GSK3_1	49	56	PF00069	0.692
MOD_GSK3_1	7	14	PF00069	0.737
MOD_GSK3_1	74	81	PF00069	0.617
MOD_LATS_1	201	207	PF00433	0.517
MOD_N-GLC_1	78	83	PF02516	0.561
MOD_NEK2_1	107	112	PF00069	0.683
MOD_NEK2_1	119	124	PF00069	0.572
MOD_NEK2_1	141	146	PF00069	0.549
MOD_NEK2_1	154	159	PF00069	0.572
MOD_NEK2_1	168	173	PF00069	0.680
MOD_NEK2_1	349	354	PF00069	0.616
MOD_NEK2_1	372	377	PF00069	0.656
MOD_NEK2_1	55	60	PF00069	0.567
MOD_NEK2_1	74	79	PF00069	0.527
MOD_NEK2_2	185	190	PF00069	0.537
MOD_NEK2_2	257	262	PF00069	0.556
MOD_PIKK_1	358	364	PF00454	0.573
MOD_PIKK_1	49	55	PF00454	0.684
MOD_PK_1	203	209	PF00069	0.590
MOD_PKA_1	132	138	PF00069	0.530
MOD_PKA_1	98	104	PF00069	0.703
MOD_PKA_2	113	119	PF00069	0.567
MOD_PKA_2	132	138	PF00069	0.577
MOD_PKA_2	162	168	PF00069	0.707
MOD_PKA_2	175	181	PF00069	0.585
MOD_PKA_2	248	254	PF00069	0.420
MOD_PKA_2	362	368	PF00069	0.568
MOD_PKA_2	373	379	PF00069	0.606
MOD_PKA_2	407	413	PF00069	0.817
MOD_PKA_2	7	13	PF00069	0.555
MOD_PKA_2	74	80	PF00069	0.640
MOD_PKA_2	98	104	PF00069	0.715
MOD_PKB_1	96	104	PF00069	0.724
MOD_Plk_1	178	184	PF00069	0.609
MOD_Plk_1	355	361	PF00069	0.544
MOD_Plk_1	84	90	PF00069	0.555
MOD_Plk_2-3	221	227	PF00069	0.251
MOD_Plk_4	195	201	PF00069	0.519
MOD_ProDKin_1	11	17	PF00069	0.747
MOD_ProDKin_1	149	155	PF00069	0.705
MOD_ProDKin_1	181	187	PF00069	0.705
MOD_ProDKin_1	193	199	PF00069	0.510
MOD_ProDKin_1	26	32	PF00069	0.554
MOD_ProDKin_1	327	333	PF00069	0.760
MOD_ProDKin_1	89	95	PF00069	0.706
TRG_ER_diArg_1	132	134	PF00400	0.536
TRG_ER_diArg_1	160	163	PF00400	0.640
TRG_ER_diArg_1	20	22	PF00400	0.642
TRG_ER_diArg_1	408	411	PF00400	0.723
TRG_ER_diArg_1	73	76	PF00400	0.603
TRG_ER_diArg_1	95	98	PF00400	0.694

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X0M5	Leishmania donovani	52%	100%
E9AD98	Leishmania major	49%	98%
E9AHF8	Leishmania infantum	52%	100%
E9AZ23	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%