Putative translation initiation factor eIF2B subunit-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation initiation factor eIF2B delta subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HFP5_LEIBR

TriTrypDb:

LbrM.27.1310 , LBRM2903_270019000

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFP5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003743	translation initiation factor activity	4	11
GO:0005488	binding	1	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	235	237	PF00675	0.441
CLV_NRD_NRD_1	253	255	PF00675	0.272
CLV_NRD_NRD_1	337	339	PF00675	0.180
CLV_NRD_NRD_1	415	417	PF00675	0.257
CLV_NRD_NRD_1	43	45	PF00675	0.497
CLV_PCSK_FUR_1	235	239	PF00082	0.517
CLV_PCSK_KEX2_1	143	145	PF00082	0.634
CLV_PCSK_KEX2_1	235	237	PF00082	0.438
CLV_PCSK_KEX2_1	253	255	PF00082	0.277
CLV_PCSK_KEX2_1	341	343	PF00082	0.328
CLV_PCSK_KEX2_1	39	41	PF00082	0.475
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.634
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.535
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.331
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.475
CLV_PCSK_SKI1_1	131	135	PF00082	0.698
CLV_PCSK_SKI1_1	245	249	PF00082	0.414
CLV_PCSK_SKI1_1	280	284	PF00082	0.480
CLV_PCSK_SKI1_1	34	38	PF00082	0.482
CLV_PCSK_SKI1_1	40	44	PF00082	0.467
CLV_PCSK_SKI1_1	417	421	PF00082	0.249
CLV_PCSK_SKI1_1	48	52	PF00082	0.512
CLV_PCSK_SKI1_1	8	12	PF00082	0.626
DEG_APCC_DBOX_1	39	47	PF00400	0.593
DEG_COP1_1	207	215	PF00400	0.526
DEG_COP1_1	423	432	PF00400	0.510
DEG_SPOP_SBC_1	95	99	PF00917	0.683
DOC_CKS1_1	465	470	PF01111	0.568
DOC_CKS1_1	482	487	PF01111	0.439
DOC_MAPK_gen_1	338	346	PF00069	0.537
DOC_MAPK_gen_1	413	422	PF00069	0.457
DOC_MAPK_gen_1	8	18	PF00069	0.641
DOC_MAPK_MEF2A_6	173	181	PF00069	0.494
DOC_MAPK_MEF2A_6	413	422	PF00069	0.457
DOC_MAPK_MEF2A_6	427	434	PF00069	0.488
DOC_MIT_MIM_1	249	259	PF04212	0.476
DOC_PP2B_LxvP_1	161	164	PF13499	0.438
DOC_PP2B_LxvP_1	210	213	PF13499	0.500
DOC_PP2B_LxvP_1	466	469	PF13499	0.539
DOC_PP2B_LxvP_1	471	474	PF13499	0.535
DOC_PP4_FxxP_1	415	418	PF00568	0.488
DOC_USP7_MATH_1	123	127	PF00917	0.738
DOC_USP7_MATH_1	211	215	PF00917	0.549
DOC_USP7_MATH_1	240	244	PF00917	0.406
DOC_USP7_MATH_1	308	312	PF00917	0.537
DOC_USP7_MATH_1	485	489	PF00917	0.481
DOC_USP7_MATH_1	52	56	PF00917	0.422
DOC_USP7_MATH_1	57	61	PF00917	0.373
DOC_USP7_UBL2_3	295	299	PF12436	0.492
DOC_USP7_UBL2_3	413	417	PF12436	0.457
DOC_USP7_UBL2_3	45	49	PF12436	0.532
DOC_USP7_UBL2_3	8	12	PF12436	0.657
DOC_WW_Pin1_4	103	108	PF00397	0.745
DOC_WW_Pin1_4	458	463	PF00397	0.450
DOC_WW_Pin1_4	464	469	PF00397	0.442
DOC_WW_Pin1_4	481	486	PF00397	0.482
DOC_WW_Pin1_4	512	517	PF00397	0.457
DOC_WW_Pin1_4	96	101	PF00397	0.713
LIG_14-3-3_CanoR_1	138	145	PF00244	0.650
LIG_14-3-3_CanoR_1	157	165	PF00244	0.434
LIG_14-3-3_CanoR_1	205	210	PF00244	0.516
LIG_14-3-3_CanoR_1	321	325	PF00244	0.471
LIG_Actin_WH2_2	279	297	PF00022	0.439
LIG_BIR_II_1	1	5	PF00653	0.654
LIG_BRCT_BRCA1_1	424	428	PF00533	0.488
LIG_BRCT_BRCA1_1	487	491	PF00533	0.366
LIG_BRCT_BRCA1_1	499	503	PF00533	0.380
LIG_FHA_1	205	211	PF00498	0.430
LIG_FHA_1	281	287	PF00498	0.458
LIG_FHA_1	313	319	PF00498	0.459
LIG_FHA_1	367	373	PF00498	0.461
LIG_FHA_1	530	536	PF00498	0.507
LIG_FHA_1	545	551	PF00498	0.477
LIG_FHA_1	86	92	PF00498	0.766
LIG_FHA_2	132	138	PF00498	0.637
LIG_FHA_2	219	225	PF00498	0.477
LIG_LIR_Apic_2	479	485	PF02991	0.537
LIG_LIR_Gen_1	220	231	PF02991	0.372
LIG_LIR_Nem_3	198	203	PF02991	0.415
LIG_LIR_Nem_3	220	226	PF02991	0.382
LIG_LIR_Nem_3	297	301	PF02991	0.422
LIG_LIR_Nem_3	326	330	PF02991	0.537
LIG_LIR_Nem_3	369	373	PF02991	0.459
LIG_LIR_Nem_3	423	429	PF02991	0.472
LIG_MYND_1	469	473	PF01753	0.533
LIG_PTAP_UEV_1	82	87	PF05743	0.654
LIG_REV1ctd_RIR_1	489	498	PF16727	0.456
LIG_SH2_CRK	370	374	PF00017	0.457
LIG_SH2_CRK	426	430	PF00017	0.537
LIG_SH2_PTP2	327	330	PF00017	0.537
LIG_SH2_STAT5	309	312	PF00017	0.509
LIG_SH2_STAT5	327	330	PF00017	0.509
LIG_SH2_STAT5	465	468	PF00017	0.380
LIG_SH2_STAT5	510	513	PF00017	0.457
LIG_SH3_3	101	107	PF00018	0.734
LIG_SH3_3	166	172	PF00018	0.579
LIG_SH3_3	259	265	PF00018	0.531
LIG_SH3_3	80	86	PF00018	0.556
LIG_SUMO_SIM_anti_2	176	182	PF11976	0.396
LIG_SUMO_SIM_par_1	207	214	PF11976	0.524
LIG_SUMO_SIM_par_1	285	291	PF11976	0.411
LIG_SUMO_SIM_par_1	342	348	PF11976	0.457
LIG_TRAF2_1	134	137	PF00917	0.666
LIG_TRAF2_1	4	7	PF00917	0.533
LIG_TRAF2_1	62	65	PF00917	0.474
LIG_TRFH_1	512	516	PF08558	0.457
LIG_TYR_ITIM	325	330	PF00017	0.537
LIG_TYR_ITIM	368	373	PF00017	0.457
LIG_UBA3_1	286	295	PF00899	0.505
MOD_CDK_SPxK_1	481	487	PF00069	0.534
MOD_CK1_1	204	210	PF00069	0.451
MOD_CK1_1	297	303	PF00069	0.310
MOD_CK1_1	502	508	PF00069	0.401
MOD_CK1_1	60	66	PF00069	0.478
MOD_CK1_1	84	90	PF00069	0.702
MOD_CK2_1	1	7	PF00069	0.639
MOD_CK2_1	131	137	PF00069	0.671
MOD_CK2_1	18	24	PF00069	0.437
MOD_CK2_1	211	217	PF00069	0.543
MOD_CK2_1	218	224	PF00069	0.492
MOD_CK2_1	297	303	PF00069	0.310
MOD_CK2_1	320	326	PF00069	0.457
MOD_GlcNHglycan	125	128	PF01048	0.696
MOD_GlcNHglycan	140	143	PF01048	0.550
MOD_GlcNHglycan	189	192	PF01048	0.431
MOD_GlcNHglycan	197	200	PF01048	0.376
MOD_GlcNHglycan	239	243	PF01048	0.387
MOD_GlcNHglycan	3	6	PF01048	0.600
MOD_GlcNHglycan	347	350	PF01048	0.295
MOD_GlcNHglycan	362	365	PF01048	0.192
MOD_GlcNHglycan	390	393	PF01048	0.335
MOD_GlcNHglycan	478	481	PF01048	0.314
MOD_GlcNHglycan	487	490	PF01048	0.293
MOD_GlcNHglycan	494	497	PF01048	0.267
MOD_GlcNHglycan	499	502	PF01048	0.206
MOD_GlcNHglycan	505	508	PF01048	0.274
MOD_GlcNHglycan	532	535	PF01048	0.379
MOD_GlcNHglycan	59	62	PF01048	0.440
MOD_GlcNHglycan	79	82	PF01048	0.651
MOD_GlcNHglycan	83	86	PF01048	0.703
MOD_GlcNHglycan	92	95	PF01048	0.641
MOD_GSK3_1	201	208	PF00069	0.414
MOD_GSK3_1	308	315	PF00069	0.457
MOD_GSK3_1	371	378	PF00069	0.480
MOD_GSK3_1	452	459	PF00069	0.510
MOD_GSK3_1	481	488	PF00069	0.441
MOD_GSK3_1	497	504	PF00069	0.456
MOD_GSK3_1	52	59	PF00069	0.415
MOD_GSK3_1	77	84	PF00069	0.616
MOD_GSK3_1	90	97	PF00069	0.635
MOD_GSK3_1	99	106	PF00069	0.669
MOD_N-GLC_1	57	62	PF02516	0.628
MOD_NEK2_1	294	299	PF00069	0.392
MOD_NEK2_1	319	324	PF00069	0.457
MOD_NEK2_1	388	393	PF00069	0.502
MOD_NEK2_1	422	427	PF00069	0.457
MOD_NEK2_1	476	481	PF00069	0.560
MOD_NEK2_1	492	497	PF00069	0.372
MOD_NEK2_1	503	508	PF00069	0.561
MOD_NEK2_1	530	535	PF00069	0.504
MOD_NEK2_2	240	245	PF00069	0.251
MOD_PIKK_1	545	551	PF00454	0.589
MOD_PKA_2	116	122	PF00069	0.502
MOD_PKA_2	156	162	PF00069	0.590
MOD_PKA_2	204	210	PF00069	0.488
MOD_PKA_2	320	326	PF00069	0.457
MOD_PKA_2	476	482	PF00069	0.526
MOD_PKA_2	544	550	PF00069	0.591
MOD_PKB_1	236	244	PF00069	0.377
MOD_Plk_1	218	224	PF00069	0.492
MOD_Plk_1	280	286	PF00069	0.429
MOD_Plk_1	303	309	PF00069	0.470
MOD_Plk_1	545	551	PF00069	0.572
MOD_Plk_4	205	211	PF00069	0.466
MOD_Plk_4	297	303	PF00069	0.310
MOD_Plk_4	312	318	PF00069	0.457
MOD_Plk_4	320	326	PF00069	0.457
MOD_Plk_4	375	381	PF00069	0.457
MOD_ProDKin_1	103	109	PF00069	0.745
MOD_ProDKin_1	458	464	PF00069	0.450
MOD_ProDKin_1	469	475	PF00069	0.438
MOD_ProDKin_1	481	487	PF00069	0.488
MOD_ProDKin_1	512	518	PF00069	0.457
MOD_ProDKin_1	96	102	PF00069	0.712
MOD_SUMO_rev_2	2	10	PF00179	0.536
MOD_SUMO_rev_2	288	297	PF00179	0.480
TRG_DiLeu_BaEn_1	176	181	PF01217	0.450
TRG_DiLeu_BaEn_1	182	187	PF01217	0.465
TRG_DiLeu_BaEn_1	65	70	PF01217	0.405
TRG_DiLeu_BaEn_2	423	429	PF01217	0.457
TRG_ENDOCYTIC_2	327	330	PF00928	0.537
TRG_ENDOCYTIC_2	370	373	PF00928	0.457
TRG_ENDOCYTIC_2	426	429	PF00928	0.537
TRG_ER_diArg_1	234	236	PF00400	0.416
TRG_ER_diArg_1	252	254	PF00400	0.279
TRG_NLS_Bipartite_1	37	52	PF00514	0.571
TRG_NLS_MonoCore_2	337	342	PF00514	0.380
TRG_NLS_MonoExtC_3	337	342	PF00514	0.380
TRG_NLS_MonoExtN_4	336	342	PF00514	0.380
TRG_NLS_MonoExtN_4	45	52	PF00514	0.583
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1D4	Leptomonas seymouri	71%	82%
A0A1X0P4F2	Trypanosomatidae	44%	95%
A0A3Q8IE91	Leishmania donovani	87%	83%
A0A422MX80	Trypanosoma rangeli	42%	91%
A4I2S1	Leishmania infantum	87%	83%
D0A5X8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	89%
E9AD99	Leishmania major	89%	100%
E9AZ24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
P12754	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	85%
P41111	Oryctolagus cuniculus	28%	100%
Q09924	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q3T058	Bos taurus	27%	100%
Q54FM3	Dictyostelium discoideum	25%	90%
Q61749	Mus musculus	27%	100%
Q63186	Rattus norvegicus	25%	100%
Q9UI10	Homo sapiens	26%	100%
V5BHQ4	Trypanosoma cruzi	52%	100%