LeishMANIAdb
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Putative histone H1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Download

Quick info

Protein:
Putative histone H1
Gene product:
Protein of unknown function (DUF2946), putative
Species:
Leishmania braziliensis
UniProt:
A4HFP4_LEIBR
TriTrypDb:
Length:
112

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 1
NetGPI no yes: 0, no: 1
Cellular components
Term Name Level Count
GO:0000786 nucleosome 3 2
GO:0032991 protein-containing complex 1 2
GO:0032993 protein-DNA complex 2 2
GO:0044815 DNA packaging complex 2 2

Expansion

Sequence features

A4HFP4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFP4

Function

Biological processes
Term Name Level Count
GO:0006325 chromatin organization 4 2
GO:0006334 nucleosome assembly 7 2
GO:0006338 chromatin remodeling 5 2
GO:0009987 cellular process 1 2
GO:0016043 cellular component organization 3 2
GO:0022607 cellular component assembly 4 2
GO:0034728 nucleosome organization 6 2
GO:0043933 protein-containing complex organization 4 2
GO:0065003 protein-containing complex assembly 5 2
GO:0065004 protein-DNA complex assembly 6 2
GO:0071824 protein-DNA complex subunit organization 5 2
GO:0071840 cellular component organization or biogenesis 2 2
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 2
GO:0003677 DNA binding 4 2
GO:0005198 structural molecule activity 1 2
GO:0005488 binding 1 2
GO:0030527 structural constituent of chromatin 2 2
GO:0097159 organic cyclic compound binding 2 2
GO:1901363 heterocyclic compound binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 103 105 PF00082 0.790
CLV_PCSK_KEX2_1 51 53 PF00082 0.833
CLV_PCSK_KEX2_1 71 73 PF00082 0.496
CLV_PCSK_PC1ET2_1 103 105 PF00082 0.790
CLV_PCSK_PC1ET2_1 51 53 PF00082 0.833
CLV_PCSK_PC1ET2_1 71 73 PF00082 0.496
CLV_PCSK_SKI1_1 104 108 PF00082 0.513
CLV_PCSK_SKI1_1 72 76 PF00082 0.845
CLV_PCSK_SKI1_1 81 85 PF00082 0.624
CLV_PCSK_SKI1_1 88 92 PF00082 0.476
CLV_PCSK_SKI1_1 96 100 PF00082 0.503
DEG_Nend_Nbox_1 1 3 PF02207 0.786
DOC_USP7_MATH_1 3 7 PF00917 0.767
DOC_USP7_MATH_1 74 78 PF00917 0.831
DOC_USP7_UBL2_3 103 107 PF12436 0.526
DOC_USP7_UBL2_3 108 112 PF12436 0.471
DOC_USP7_UBL2_3 27 31 PF12436 0.849
DOC_USP7_UBL2_3 32 36 PF12436 0.740
DOC_USP7_UBL2_3 37 41 PF12436 0.643
DOC_USP7_UBL2_3 42 46 PF12436 0.563
DOC_USP7_UBL2_3 47 51 PF12436 0.476
DOC_USP7_UBL2_3 57 61 PF12436 0.490
DOC_USP7_UBL2_3 62 66 PF12436 0.491
DOC_USP7_UBL2_3 67 71 PF12436 0.491
DOC_USP7_UBL2_3 76 80 PF12436 0.512
DOC_USP7_UBL2_3 81 85 PF12436 0.449
DOC_USP7_UBL2_3 88 92 PF12436 0.546
DOC_USP7_UBL2_3 95 99 PF12436 0.431
DOC_WW_Pin1_4 13 18 PF00397 0.835
DOC_WW_Pin1_4 21 26 PF00397 0.716
MOD_CDC14_SPxK_1 16 19 PF00782 0.850
MOD_CDC14_SPxK_1 24 27 PF00782 0.715
MOD_CDK_SPK_2 17 22 PF00069 0.859
MOD_CDK_SPxK_1 13 19 PF00069 0.840
MOD_CDK_SPxK_1 21 27 PF00069 0.717
MOD_GlcNHglycan 5 8 PF01048 0.770
MOD_GlcNHglycan 76 79 PF01048 0.816
MOD_GSK3_1 13 20 PF00069 0.841
MOD_N-GLC_1 3 8 PF02516 0.769
MOD_NEK2_1 2 7 PF00069 0.771
MOD_PKA_1 99 105 PF00069 0.778
MOD_ProDKin_1 13 19 PF00069 0.840
MOD_ProDKin_1 21 27 PF00069 0.717

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS