Protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein phosphatase

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFP3_LEIBR

TriTrypDb:

LbrM.27.1280 , LBRM2903_270018700

Length:

423

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFP3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004721	phosphoprotein phosphatase activity	3	8
GO:0004722	protein serine/threonine phosphatase activity	4	8
GO:0005488	binding	1	8
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	8
GO:0016791	phosphatase activity	5	8
GO:0017018	myosin phosphatase activity	5	8
GO:0042578	phosphoric ester hydrolase activity	4	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0140096	catalytic activity, acting on a protein	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.609
CLV_C14_Caspase3-7	212	216	PF00656	0.332
CLV_NRD_NRD_1	3	5	PF00675	0.530
CLV_PCSK_KEX2_1	3	5	PF00082	0.530
CLV_PCSK_SKI1_1	129	133	PF00082	0.290
CLV_PCSK_SKI1_1	194	198	PF00082	0.357
CLV_PCSK_SKI1_1	238	242	PF00082	0.287
CLV_PCSK_SKI1_1	336	340	PF00082	0.417
DEG_APCC_DBOX_1	335	343	PF00400	0.456
DEG_Nend_Nbox_1	1	3	PF02207	0.613
DOC_CYCLIN_yCln2_LP_2	248	254	PF00134	0.451
DOC_MAPK_MEF2A_6	263	272	PF00069	0.427
DOC_MAPK_MEF2A_6	385	393	PF00069	0.398
DOC_PP1_RVXF_1	1	8	PF00149	0.510
DOC_PP1_RVXF_1	9	16	PF00149	0.340
DOC_PP2B_LxvP_1	268	271	PF13499	0.408
DOC_PP4_FxxP_1	415	418	PF00568	0.544
DOC_USP7_MATH_1	149	153	PF00917	0.646
DOC_USP7_MATH_1	160	164	PF00917	0.483
DOC_USP7_MATH_1	181	185	PF00917	0.624
DOC_USP7_MATH_1	369	373	PF00917	0.404
DOC_USP7_MATH_1	85	89	PF00917	0.407
DOC_USP7_UBL2_3	125	129	PF12436	0.336
DOC_USP7_UBL2_3	259	263	PF12436	0.310
DOC_WW_Pin1_4	319	324	PF00397	0.448
DOC_WW_Pin1_4	365	370	PF00397	0.372
LIG_14-3-3_CanoR_1	18	24	PF00244	0.456
LIG_14-3-3_CanoR_1	194	201	PF00244	0.567
LIG_14-3-3_CanoR_1	207	217	PF00244	0.447
LIG_APCC_ABBA_1	298	303	PF00400	0.403
LIG_Clathr_ClatBox_1	269	273	PF01394	0.407
LIG_EH1_1	291	299	PF00400	0.330
LIG_eIF4E_1	75	81	PF01652	0.445
LIG_FAT_LD_1	339	347	PF03623	0.285
LIG_FHA_1	105	111	PF00498	0.375
LIG_FHA_1	196	202	PF00498	0.461
LIG_FHA_1	226	232	PF00498	0.307
LIG_FHA_1	280	286	PF00498	0.383
LIG_FHA_1	388	394	PF00498	0.379
LIG_FHA_2	143	149	PF00498	0.440
LIG_FHA_2	195	201	PF00498	0.431
LIG_FHA_2	335	341	PF00498	0.536
LIG_IRF3_LxIS_1	136	141	PF10401	0.340
LIG_LIR_Apic_2	412	418	PF02991	0.537
LIG_LIR_Gen_1	283	294	PF02991	0.346
LIG_LIR_Gen_1	34	45	PF02991	0.389
LIG_LIR_Nem_3	126	131	PF02991	0.444
LIG_LIR_Nem_3	283	289	PF02991	0.316
LIG_LIR_Nem_3	296	302	PF02991	0.339
LIG_LIR_Nem_3	325	329	PF02991	0.435
LIG_LIR_Nem_3	34	40	PF02991	0.394
LIG_LIR_Nem_3	87	92	PF02991	0.395
LIG_NRBOX	334	340	PF00104	0.470
LIG_SH2_CRK	128	132	PF00017	0.288
LIG_SH2_GRB2like	96	99	PF00017	0.285
LIG_SH2_STAP1	329	333	PF00017	0.398
LIG_SH2_STAP1	64	68	PF00017	0.338
LIG_SH2_STAT3	250	253	PF00017	0.440
LIG_SH2_STAT5	217	220	PF00017	0.431
LIG_SH2_STAT5	223	226	PF00017	0.353
LIG_SH2_STAT5	239	242	PF00017	0.524
LIG_SH2_STAT5	311	314	PF00017	0.527
LIG_SH2_STAT5	75	78	PF00017	0.434
LIG_SH3_3	133	139	PF00018	0.482
LIG_SH3_3	20	26	PF00018	0.393
LIG_SUMO_SIM_anti_2	276	283	PF11976	0.340
LIG_SUMO_SIM_par_1	107	114	PF11976	0.300
LIG_SUMO_SIM_par_1	129	134	PF11976	0.430
LIG_SUMO_SIM_par_1	387	394	PF11976	0.395
LIG_TRAF2_1	118	121	PF00917	0.511
MOD_CK1_1	141	147	PF00069	0.540
MOD_CK1_1	325	331	PF00069	0.585
MOD_CK1_1	410	416	PF00069	0.429
MOD_CK2_1	173	179	PF00069	0.641
MOD_CK2_1	406	412	PF00069	0.595
MOD_CK2_1	68	74	PF00069	0.280
MOD_Cter_Amidation	9	12	PF01082	0.479
MOD_GlcNHglycan	140	143	PF01048	0.455
MOD_GlcNHglycan	162	165	PF01048	0.595
MOD_GlcNHglycan	176	179	PF01048	0.761
MOD_GlcNHglycan	315	318	PF01048	0.459
MOD_GlcNHglycan	55	58	PF01048	0.479
MOD_GlcNHglycan	64	67	PF01048	0.318
MOD_GSK3_1	134	141	PF00069	0.394
MOD_GSK3_1	181	188	PF00069	0.528
MOD_GSK3_1	192	199	PF00069	0.420
MOD_GSK3_1	365	372	PF00069	0.364
MOD_GSK3_1	387	394	PF00069	0.377
MOD_GSK3_1	406	413	PF00069	0.425
MOD_NEK2_1	104	109	PF00069	0.389
MOD_NEK2_1	111	116	PF00069	0.378
MOD_NEK2_1	150	155	PF00069	0.632
MOD_NEK2_1	38	43	PF00069	0.368
MOD_NEK2_1	391	396	PF00069	0.393
MOD_NEK2_1	68	73	PF00069	0.272
MOD_NEK2_2	85	90	PF00069	0.413
MOD_PKA_1	11	17	PF00069	0.361
MOD_PKA_2	53	59	PF00069	0.380
MOD_PKA_2	99	105	PF00069	0.326
MOD_PKB_1	236	244	PF00069	0.288
MOD_Plk_1	171	177	PF00069	0.644
MOD_Plk_1	225	231	PF00069	0.305
MOD_Plk_1	355	361	PF00069	0.305
MOD_Plk_1	387	393	PF00069	0.330
MOD_Plk_1	411	417	PF00069	0.399
MOD_Plk_4	106	112	PF00069	0.376
MOD_Plk_4	11	17	PF00069	0.271
MOD_Plk_4	225	231	PF00069	0.371
MOD_Plk_4	322	328	PF00069	0.538
MOD_Plk_4	387	393	PF00069	0.330
MOD_Plk_4	48	54	PF00069	0.391
MOD_ProDKin_1	319	325	PF00069	0.448
MOD_ProDKin_1	365	371	PF00069	0.366
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.427
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.399
TRG_ENDOCYTIC_2	128	131	PF00928	0.425
TRG_ER_diArg_1	2	4	PF00400	0.539
TRG_ER_diArg_1	236	239	PF00400	0.283
TRG_Pf-PMV_PEXEL_1	304	308	PF00026	0.294
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC93	Leptomonas seymouri	60%	100%
A0A0S4JF75	Bodo saltans	29%	81%
A0A3S7X0P0	Leishmania donovani	78%	100%
A4I2R9	Leishmania infantum	78%	100%
E9AD96	Leishmania major	76%	100%
E9AZ21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%