S1-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFP2_LEIBR

TriTrypDb:

LbrM.27.1270 , LBRM2903_270018600

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFP2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.759
CLV_NRD_NRD_1	104	106	PF00675	0.621
CLV_NRD_NRD_1	5	7	PF00675	0.652
CLV_PCSK_SKI1_1	11	15	PF00082	0.611
CLV_PCSK_SKI1_1	162	166	PF00082	0.763
CLV_PCSK_SKI1_1	219	223	PF00082	0.700
CLV_PCSK_SKI1_1	45	49	PF00082	0.593
DEG_APCC_DBOX_1	161	169	PF00400	0.767
DEG_SPOP_SBC_1	175	179	PF00917	0.657
DEG_SPOP_SBC_1	50	54	PF00917	0.558
DOC_ANK_TNKS_1	191	198	PF00023	0.544
DOC_CYCLIN_RxL_1	40	53	PF00134	0.536
DOC_MAPK_gen_1	105	115	PF00069	0.587
DOC_MAPK_MEF2A_6	106	115	PF00069	0.580
DOC_MAPK_MEF2A_6	27	36	PF00069	0.680
DOC_PP1_RVXF_1	107	113	PF00149	0.587
DOC_PP2B_LxvP_1	36	39	PF13499	0.682
DOC_USP7_MATH_1	50	54	PF00917	0.585
DOC_USP7_MATH_1	66	70	PF00917	0.722
DOC_USP7_MATH_1	78	82	PF00917	0.567
DOC_USP7_MATH_1	83	87	PF00917	0.708
DOC_USP7_UBL2_3	7	11	PF12436	0.657
DOC_WW_Pin1_4	128	133	PF00397	0.590
DOC_WW_Pin1_4	85	90	PF00397	0.688
LIG_14-3-3_CanoR_1	176	182	PF00244	0.722
LIG_BIR_II_1	1	5	PF00653	0.671
LIG_FHA_1	176	182	PF00498	0.638
LIG_LIR_Apic_2	20	26	PF02991	0.614
LIG_LIR_Gen_1	91	101	PF02991	0.511
LIG_LIR_Nem_3	91	97	PF02991	0.509
LIG_SH2_STAP1	171	175	PF00017	0.688
LIG_SH2_STAT5	17	20	PF00017	0.690
LIG_SH3_3	210	216	PF00018	0.651
LIG_SH3_3	98	104	PF00018	0.647
LIG_SUMO_SIM_anti_2	117	123	PF11976	0.574
LIG_SUMO_SIM_par_1	117	123	PF11976	0.574
LIG_TRAF2_1	235	238	PF00917	0.636
MOD_CK1_1	180	186	PF00069	0.761
MOD_CK1_1	61	67	PF00069	0.685
MOD_CK1_1	88	94	PF00069	0.717
MOD_CK2_1	203	209	PF00069	0.757
MOD_CK2_1	232	238	PF00069	0.635
MOD_Cter_Amidation	4	7	PF01082	0.656
MOD_GlcNHglycan	1	4	PF01048	0.653
MOD_GlcNHglycan	171	174	PF01048	0.648
MOD_GlcNHglycan	188	191	PF01048	0.706
MOD_GlcNHglycan	19	23	PF01048	0.573
MOD_GlcNHglycan	53	56	PF01048	0.663
MOD_GlcNHglycan	85	88	PF01048	0.724
MOD_GSK3_1	124	131	PF00069	0.689
MOD_GSK3_1	171	178	PF00069	0.656
MOD_GSK3_1	83	90	PF00069	0.603
MOD_N-GLC_1	83	88	PF02516	0.772
MOD_NEK2_1	18	23	PF00069	0.652
MOD_NEK2_1	49	54	PF00069	0.488
MOD_NEK2_2	124	129	PF00069	0.611
MOD_PIKK_1	11	17	PF00454	0.753
MOD_PKA_2	175	181	PF00069	0.719
MOD_Plk_1	61	67	PF00069	0.696
MOD_Plk_2-3	196	202	PF00069	0.553
MOD_Plk_4	177	183	PF00069	0.636
MOD_ProDKin_1	128	134	PF00069	0.590
MOD_ProDKin_1	85	91	PF00069	0.686

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I4	Leptomonas seymouri	58%	97%
A0A3Q8IEC6	Leishmania donovani	80%	100%
A0A3R7MDN0	Trypanosoma rangeli	43%	100%
A4I2R8	Leishmania infantum	80%	100%
D0A5X3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AD95	Leishmania major	82%	100%
E9AZ20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
V5B8N2	Trypanosoma cruzi	43%	100%