DUF4042 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Retinoic acid induced 16-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HFP1_LEIBR

TriTrypDb:

LbrM.27.1260 , LBRM2903_270018500

Length:

945

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFP1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	801	805	PF00656	0.540
CLV_C14_Caspase3-7	900	904	PF00656	0.539
CLV_NRD_NRD_1	255	257	PF00675	0.526
CLV_NRD_NRD_1	366	368	PF00675	0.537
CLV_NRD_NRD_1	511	513	PF00675	0.606
CLV_NRD_NRD_1	637	639	PF00675	0.687
CLV_NRD_NRD_1	826	828	PF00675	0.709
CLV_NRD_NRD_1	835	837	PF00675	0.482
CLV_PCSK_KEX2_1	366	368	PF00082	0.472
CLV_PCSK_SKI1_1	107	111	PF00082	0.774
CLV_PCSK_SKI1_1	148	152	PF00082	0.489
CLV_PCSK_SKI1_1	341	345	PF00082	0.519
CLV_PCSK_SKI1_1	371	375	PF00082	0.430
CLV_PCSK_SKI1_1	430	434	PF00082	0.400
CLV_PCSK_SKI1_1	499	503	PF00082	0.444
CLV_PCSK_SKI1_1	504	508	PF00082	0.456
CLV_PCSK_SKI1_1	623	627	PF00082	0.563
CLV_PCSK_SKI1_1	818	822	PF00082	0.550
CLV_PCSK_SKI1_1	827	831	PF00082	0.672
DEG_APCC_DBOX_1	370	378	PF00400	0.459
DEG_APCC_DBOX_1	406	414	PF00400	0.426
DEG_APCC_DBOX_1	425	433	PF00400	0.283
DEG_SCF_FBW7_1	884	890	PF00400	0.731
DEG_SPOP_SBC_1	279	283	PF00917	0.691
DEG_SPOP_SBC_1	720	724	PF00917	0.619
DOC_CDC14_PxL_1	322	330	PF14671	0.431
DOC_CDC14_PxL_1	570	578	PF14671	0.546
DOC_CKS1_1	654	659	PF01111	0.487
DOC_CKS1_1	884	889	PF01111	0.732
DOC_CYCLIN_RxL_1	338	348	PF00134	0.554
DOC_CYCLIN_RxL_1	448	459	PF00134	0.463
DOC_CYCLIN_RxL_1	499	510	PF00134	0.468
DOC_MAPK_gen_1	694	704	PF00069	0.661
DOC_MAPK_gen_1	710	719	PF00069	0.676
DOC_MAPK_JIP1_4	243	249	PF00069	0.561
DOC_MAPK_MEF2A_6	243	251	PF00069	0.551
DOC_MAPK_MEF2A_6	308	315	PF00069	0.389
DOC_MAPK_MEF2A_6	587	595	PF00069	0.478
DOC_MAPK_MEF2A_6	853	861	PF00069	0.547
DOC_PP2B_LxvP_1	141	144	PF13499	0.615
DOC_PP2B_LxvP_1	247	250	PF13499	0.502
DOC_USP7_MATH_1	176	180	PF00917	0.657
DOC_USP7_MATH_1	235	239	PF00917	0.365
DOC_USP7_MATH_1	275	279	PF00917	0.669
DOC_USP7_MATH_1	376	380	PF00917	0.493
DOC_USP7_MATH_1	514	518	PF00917	0.509
DOC_USP7_MATH_1	555	559	PF00917	0.687
DOC_USP7_MATH_1	563	567	PF00917	0.577
DOC_USP7_MATH_1	642	646	PF00917	0.581
DOC_USP7_MATH_1	735	739	PF00917	0.687
DOC_USP7_MATH_1	844	848	PF00917	0.736
DOC_USP7_MATH_1	887	891	PF00917	0.758
DOC_USP7_MATH_1	98	102	PF00917	0.745
DOC_WW_Pin1_4	119	124	PF00397	0.780
DOC_WW_Pin1_4	269	274	PF00397	0.631
DOC_WW_Pin1_4	653	658	PF00397	0.633
DOC_WW_Pin1_4	756	761	PF00397	0.554
DOC_WW_Pin1_4	76	81	PF00397	0.747
DOC_WW_Pin1_4	772	777	PF00397	0.441
DOC_WW_Pin1_4	830	835	PF00397	0.759
DOC_WW_Pin1_4	880	885	PF00397	0.758
DOC_WW_Pin1_4	90	95	PF00397	0.711
LIG_14-3-3_CanoR_1	227	231	PF00244	0.670
LIG_14-3-3_CanoR_1	28	32	PF00244	0.607
LIG_14-3-3_CanoR_1	371	380	PF00244	0.410
LIG_14-3-3_CanoR_1	407	411	PF00244	0.442
LIG_14-3-3_CanoR_1	434	440	PF00244	0.415
LIG_14-3-3_CanoR_1	53	57	PF00244	0.551
LIG_14-3-3_CanoR_1	599	607	PF00244	0.613
LIG_14-3-3_CanoR_1	71	75	PF00244	0.499
LIG_14-3-3_CanoR_1	712	720	PF00244	0.660
LIG_14-3-3_CanoR_1	797	803	PF00244	0.469
LIG_14-3-3_CanoR_1	827	832	PF00244	0.727
LIG_14-3-3_CanoR_1	846	855	PF00244	0.488
LIG_14-3-3_CanoR_1	889	898	PF00244	0.700
LIG_Actin_WH2_2	610	625	PF00022	0.597
LIG_AP2alpha_2	385	387	PF02296	0.540
LIG_BIR_III_2	744	748	PF00653	0.476
LIG_BRCT_BRCA1_1	748	752	PF00533	0.606
LIG_BRCT_BRCA1_1	857	861	PF00533	0.609
LIG_Clathr_ClatBox_1	695	699	PF01394	0.560
LIG_deltaCOP1_diTrp_1	7	16	PF00928	0.442
LIG_EH1_1	776	784	PF00400	0.544
LIG_eIF4E_1	777	783	PF01652	0.616
LIG_FHA_1	307	313	PF00498	0.495
LIG_FHA_1	394	400	PF00498	0.459
LIG_FHA_1	406	412	PF00498	0.453
LIG_FHA_1	422	428	PF00498	0.488
LIG_FHA_1	447	453	PF00498	0.558
LIG_FHA_1	567	573	PF00498	0.554
LIG_FHA_1	604	610	PF00498	0.523
LIG_FHA_1	756	762	PF00498	0.584
LIG_FHA_2	22	28	PF00498	0.622
LIG_FHA_2	315	321	PF00498	0.464
LIG_FHA_2	610	616	PF00498	0.641
LIG_FHA_2	729	735	PF00498	0.631
LIG_FHA_2	799	805	PF00498	0.472
LIG_FHA_2	82	88	PF00498	0.556
LIG_FHA_2	873	879	PF00498	0.450
LIG_GBD_Chelix_1	483	491	PF00786	0.564
LIG_GBD_Chelix_1	782	790	PF00786	0.428
LIG_GSK3_LRP6_1	94	100	PF00069	0.544
LIG_LIR_Apic_2	179	183	PF02991	0.587
LIG_LIR_Apic_2	569	574	PF02991	0.620
LIG_LIR_Gen_1	287	297	PF02991	0.445
LIG_LIR_Gen_1	459	469	PF02991	0.407
LIG_LIR_Gen_1	523	533	PF02991	0.448
LIG_LIR_Gen_1	656	667	PF02991	0.572
LIG_LIR_Gen_1	7	16	PF02991	0.444
LIG_LIR_Gen_1	895	905	PF02991	0.419
LIG_LIR_Gen_1	910	921	PF02991	0.277
LIG_LIR_LC3C_4	785	788	PF02991	0.572
LIG_LIR_Nem_3	14	19	PF02991	0.432
LIG_LIR_Nem_3	287	293	PF02991	0.445
LIG_LIR_Nem_3	459	465	PF02991	0.398
LIG_LIR_Nem_3	523	528	PF02991	0.528
LIG_LIR_Nem_3	564	570	PF02991	0.505
LIG_LIR_Nem_3	649	654	PF02991	0.655
LIG_LIR_Nem_3	656	662	PF02991	0.551
LIG_LIR_Nem_3	7	12	PF02991	0.420
LIG_LIR_Nem_3	895	901	PF02991	0.439
LIG_LIR_Nem_3	910	916	PF02991	0.270
LIG_LYPXL_SIV_4	289	297	PF13949	0.446
LIG_NRBOX	213	219	PF00104	0.466
LIG_NRBOX	45	51	PF00104	0.553
LIG_NRBOX	691	697	PF00104	0.551
LIG_NRBOX	798	804	PF00104	0.576
LIG_NRBOX	816	822	PF00104	0.595
LIG_PTB_Apo_2	518	525	PF02174	0.508
LIG_Rb_pABgroove_1	857	865	PF01858	0.571
LIG_REV1ctd_RIR_1	499	508	PF16727	0.330
LIG_SH2_CRK	147	151	PF00017	0.508
LIG_SH2_CRK	462	466	PF00017	0.306
LIG_SH2_CRK	863	867	PF00017	0.573
LIG_SH2_CRK	913	917	PF00017	0.590
LIG_SH2_CRK	931	935	PF00017	0.456
LIG_SH2_GRB2like	659	662	PF00017	0.453
LIG_SH2_NCK_1	180	184	PF00017	0.437
LIG_SH2_PTP2	571	574	PF00017	0.555
LIG_SH2_SRC	180	183	PF00017	0.446
LIG_SH2_SRC	659	662	PF00017	0.575
LIG_SH2_STAP1	25	29	PF00017	0.380
LIG_SH2_STAP1	525	529	PF00017	0.664
LIG_SH2_STAP1	863	867	PF00017	0.502
LIG_SH2_STAP1	913	917	PF00017	0.559
LIG_SH2_STAT3	197	200	PF00017	0.518
LIG_SH2_STAT5	15	18	PF00017	0.428
LIG_SH2_STAT5	353	356	PF00017	0.442
LIG_SH2_STAT5	428	431	PF00017	0.425
LIG_SH2_STAT5	571	574	PF00017	0.555
LIG_SH2_STAT5	659	662	PF00017	0.529
LIG_SH2_STAT5	777	780	PF00017	0.620
LIG_SH2_STAT5	800	803	PF00017	0.472
LIG_SH2_STAT5	931	934	PF00017	0.636
LIG_SH2_STAT5	940	943	PF00017	0.416
LIG_SH3_1	881	887	PF00018	0.512
LIG_SH3_2	884	889	PF14604	0.518
LIG_SH3_3	154	160	PF00018	0.708
LIG_SH3_3	526	532	PF00018	0.659
LIG_SH3_3	644	650	PF00018	0.728
LIG_SH3_3	652	658	PF00018	0.612
LIG_SH3_3	77	83	PF00018	0.726
LIG_SH3_3	826	832	PF00018	0.467
LIG_SH3_3	854	860	PF00018	0.642
LIG_SH3_3	881	887	PF00018	0.726
LIG_SH3_3	92	98	PF00018	0.674
LIG_Sin3_3	784	791	PF02671	0.547
LIG_SUMO_SIM_anti_2	245	250	PF11976	0.398
LIG_SUMO_SIM_anti_2	26	34	PF11976	0.540
LIG_SUMO_SIM_anti_2	606	612	PF11976	0.630
LIG_SUMO_SIM_anti_2	789	795	PF11976	0.636
LIG_SUMO_SIM_par_1	1	7	PF11976	0.486
LIG_SUMO_SIM_par_1	606	612	PF11976	0.609
LIG_SUMO_SIM_par_1	853	858	PF11976	0.651
LIG_TYR_ITIM	798	803	PF00017	0.569
LIG_TYR_ITIM	911	916	PF00017	0.594
LIG_TYR_ITIM	929	934	PF00017	0.516
LIG_TYR_ITIM	938	943	PF00017	0.667
LIG_UBA3_1	191	199	PF00899	0.424
LIG_UBA3_1	251	257	PF00899	0.468
LIG_UBA3_1	410	415	PF00899	0.470
LIG_UBA3_1	45	51	PF00899	0.476
LIG_UBA3_1	938	942	PF00899	0.629
LIG_WW_1	144	147	PF00397	0.452
MOD_CDC14_SPxK_1	833	836	PF00782	0.774
MOD_CDK_SPxK_1	830	836	PF00069	0.762
MOD_CDK_SPxK_1	883	889	PF00069	0.517
MOD_CDK_SPxxK_3	830	837	PF00069	0.764
MOD_CK1_1	122	128	PF00069	0.715
MOD_CK1_1	278	284	PF00069	0.617
MOD_CK1_1	566	572	PF00069	0.540
MOD_CK1_1	715	721	PF00069	0.605
MOD_CK1_1	73	79	PF00069	0.627
MOD_CK1_1	775	781	PF00069	0.501
MOD_CK1_1	847	853	PF00069	0.708
MOD_CK1_1	890	896	PF00069	0.516
MOD_CK1_1	897	903	PF00069	0.575
MOD_CK1_1	90	96	PF00069	0.611
MOD_CK1_1	97	103	PF00069	0.620
MOD_CK2_1	162	168	PF00069	0.514
MOD_CK2_1	21	27	PF00069	0.619
MOD_CK2_1	314	320	PF00069	0.428
MOD_CK2_1	609	615	PF00069	0.613
MOD_CK2_1	631	637	PF00069	0.478
MOD_GlcNHglycan	277	280	PF01048	0.754
MOD_GlcNHglycan	374	377	PF01048	0.478
MOD_GlcNHglycan	477	480	PF01048	0.490
MOD_GlcNHglycan	600	603	PF01048	0.660
MOD_GlcNHglycan	671	674	PF01048	0.528
MOD_GlcNHglycan	714	717	PF01048	0.673
MOD_GlcNHglycan	723	726	PF01048	0.678
MOD_GlcNHglycan	846	849	PF01048	0.617
MOD_GSK3_1	107	114	PF00069	0.758
MOD_GSK3_1	118	125	PF00069	0.775
MOD_GSK3_1	222	229	PF00069	0.452
MOD_GSK3_1	271	278	PF00069	0.662
MOD_GSK3_1	280	287	PF00069	0.644
MOD_GSK3_1	357	364	PF00069	0.574
MOD_GSK3_1	372	379	PF00069	0.423
MOD_GSK3_1	393	400	PF00069	0.393
MOD_GSK3_1	405	412	PF00069	0.451
MOD_GSK3_1	434	441	PF00069	0.450
MOD_GSK3_1	442	449	PF00069	0.421
MOD_GSK3_1	52	59	PF00069	0.478
MOD_GSK3_1	557	564	PF00069	0.642
MOD_GSK3_1	594	601	PF00069	0.691
MOD_GSK3_1	665	672	PF00069	0.663
MOD_GSK3_1	715	722	PF00069	0.749
MOD_GSK3_1	75	82	PF00069	0.710
MOD_GSK3_1	756	763	PF00069	0.603
MOD_GSK3_1	798	805	PF00069	0.537
MOD_GSK3_1	842	849	PF00069	0.766
MOD_GSK3_1	883	890	PF00069	0.763
MOD_GSK3_1	90	97	PF00069	0.685
MOD_N-GLC_1	514	519	PF02516	0.535
MOD_NEK2_1	126	131	PF00069	0.748
MOD_NEK2_1	190	195	PF00069	0.295
MOD_NEK2_1	314	319	PF00069	0.440
MOD_NEK2_1	372	377	PF00069	0.525
MOD_NEK2_1	435	440	PF00069	0.489
MOD_NEK2_1	506	511	PF00069	0.430
MOD_NEK2_1	557	562	PF00069	0.541
MOD_NEK2_1	56	61	PF00069	0.634
MOD_NEK2_1	593	598	PF00069	0.683
MOD_NEK2_1	609	614	PF00069	0.395
MOD_NEK2_1	628	633	PF00069	0.449
MOD_NEK2_1	666	671	PF00069	0.635
MOD_NEK2_1	70	75	PF00069	0.710
MOD_NEK2_1	786	791	PF00069	0.469
MOD_NEK2_1	802	807	PF00069	0.487
MOD_NEK2_1	855	860	PF00069	0.566
MOD_NEK2_2	563	568	PF00069	0.633
MOD_PIKK_1	306	312	PF00454	0.502
MOD_PIKK_1	335	341	PF00454	0.671
MOD_PIKK_1	421	427	PF00454	0.512
MOD_PIKK_1	932	938	PF00454	0.588
MOD_PKA_1	256	262	PF00069	0.542
MOD_PKA_1	366	372	PF00069	0.487
MOD_PKA_1	827	833	PF00069	0.643
MOD_PKA_2	226	232	PF00069	0.539
MOD_PKA_2	242	248	PF00069	0.494
MOD_PKA_2	27	33	PF00069	0.615
MOD_PKA_2	366	372	PF00069	0.485
MOD_PKA_2	393	399	PF00069	0.413
MOD_PKA_2	406	412	PF00069	0.425
MOD_PKA_2	52	58	PF00069	0.385
MOD_PKA_2	598	604	PF00069	0.625
MOD_PKA_2	70	76	PF00069	0.522
MOD_PKA_2	735	741	PF00069	0.658
MOD_PKA_2	888	894	PF00069	0.671
MOD_PKB_1	710	718	PF00069	0.666
MOD_Plk_1	225	231	PF00069	0.692
MOD_Plk_1	628	634	PF00069	0.638
MOD_Plk_1	894	900	PF00069	0.453
MOD_Plk_2-3	34	40	PF00069	0.549
MOD_Plk_2-3	629	635	PF00069	0.655
MOD_Plk_4	122	128	PF00069	0.526
MOD_Plk_4	235	241	PF00069	0.470
MOD_Plk_4	242	248	PF00069	0.399
MOD_Plk_4	27	33	PF00069	0.616
MOD_Plk_4	298	304	PF00069	0.594
MOD_Plk_4	40	46	PF00069	0.471
MOD_Plk_4	406	412	PF00069	0.478
MOD_Plk_4	461	467	PF00069	0.435
MOD_Plk_4	514	520	PF00069	0.499
MOD_Plk_4	52	58	PF00069	0.580
MOD_Plk_4	563	569	PF00069	0.501
MOD_Plk_4	603	609	PF00069	0.487
MOD_Plk_4	650	656	PF00069	0.536
MOD_Plk_4	798	804	PF00069	0.479
MOD_Plk_4	907	913	PF00069	0.347
MOD_ProDKin_1	119	125	PF00069	0.776
MOD_ProDKin_1	269	275	PF00069	0.629
MOD_ProDKin_1	653	659	PF00069	0.633
MOD_ProDKin_1	756	762	PF00069	0.548
MOD_ProDKin_1	76	82	PF00069	0.750
MOD_ProDKin_1	772	778	PF00069	0.445
MOD_ProDKin_1	830	836	PF00069	0.762
MOD_ProDKin_1	880	886	PF00069	0.760
MOD_ProDKin_1	90	96	PF00069	0.711
MOD_SUMO_rev_2	583	589	PF00179	0.723
MOD_SUMO_rev_2	632	641	PF00179	0.678
TRG_DiLeu_BaEn_1	27	32	PF01217	0.609
TRG_DiLeu_BaEn_2	339	345	PF01217	0.479
TRG_DiLeu_BaLyEn_6	213	218	PF01217	0.421
TRG_DiLeu_BaLyEn_6	247	252	PF01217	0.437
TRG_DiLeu_BaLyEn_6	448	453	PF01217	0.571
TRG_DiLeu_BaLyEn_6	464	469	PF01217	0.434
TRG_DiLeu_BaLyEn_6	493	498	PF01217	0.566
TRG_DiLeu_BaLyEn_6	691	696	PF01217	0.550
TRG_DiLeu_BaLyEn_6	757	762	PF01217	0.382
TRG_ENDOCYTIC_2	147	150	PF00928	0.438
TRG_ENDOCYTIC_2	290	293	PF00928	0.452
TRG_ENDOCYTIC_2	462	465	PF00928	0.523
TRG_ENDOCYTIC_2	525	528	PF00928	0.660
TRG_ENDOCYTIC_2	570	573	PF00928	0.522
TRG_ENDOCYTIC_2	659	662	PF00928	0.575
TRG_ENDOCYTIC_2	800	803	PF00928	0.472
TRG_ENDOCYTIC_2	863	866	PF00928	0.476
TRG_ENDOCYTIC_2	913	916	PF00928	0.592
TRG_ENDOCYTIC_2	931	934	PF00928	0.457
TRG_ENDOCYTIC_2	940	943	PF00928	0.631
TRG_ER_diArg_1	707	710	PF00400	0.569
TRG_NES_CRM1_1	241	253	PF08389	0.482
TRG_NES_CRM1_1	34	47	PF08389	0.564
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	694	699	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6X3	Leptomonas seymouri	52%	86%
A0A0S4JF10	Bodo saltans	24%	100%
A0A1X0P440	Trypanosomatidae	31%	92%
A0A3S5H7H7	Leishmania donovani	76%	96%
A0A3S5IQJ7	Trypanosoma rangeli	28%	100%
A4I2R7	Leishmania infantum	76%	96%
E9AD94	Leishmania major	76%	100%
E9AZ19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	94%
V5BHP8	Trypanosoma cruzi	29%	100%