JmjC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

JmjC domain, hydroxylase, putative

Species:

Leishmania braziliensis

UniProt:

A4HFP0_LEIBR

TriTrypDb:

LbrM.27.1250 , LBRM2903_270018400

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFP0

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	1
GO:0006449	regulation of translational termination	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0010629	negative regulation of gene expression	6	1
GO:0018126	protein hydroxylation	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0034250	positive regulation of amide metabolic process	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043243	positive regulation of protein-containing complex disassembly	6	1
GO:0043244	regulation of protein-containing complex disassembly	5	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0045727	positive regulation of translation	7	1
GO:0045905	positive regulation of translational termination	7	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051130	positive regulation of cellular component organization	5	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051247	positive regulation of protein metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	1
GO:0016491	oxidoreductase activity	2	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	1
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	4	1
GO:0043565	sequence-specific DNA binding	5	1
GO:0051213	dioxygenase activity	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.360
CLV_C14_Caspase3-7	33	37	PF00656	0.248
CLV_C14_Caspase3-7	451	455	PF00656	0.474
CLV_NRD_NRD_1	174	176	PF00675	0.418
CLV_NRD_NRD_1	346	348	PF00675	0.598
CLV_NRD_NRD_1	468	470	PF00675	0.419
CLV_NRD_NRD_1	47	49	PF00675	0.404
CLV_PCSK_KEX2_1	173	175	PF00082	0.433
CLV_PCSK_KEX2_1	345	347	PF00082	0.422
CLV_PCSK_KEX2_1	46	48	PF00082	0.468
CLV_PCSK_KEX2_1	468	470	PF00082	0.419
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.313
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.462
CLV_PCSK_SKI1_1	295	299	PF00082	0.310
DEG_Nend_Nbox_1	1	3	PF02207	0.430
DOC_CDC14_PxL_1	312	320	PF14671	0.415
DOC_CKS1_1	288	293	PF01111	0.506
DOC_MAPK_gen_1	345	354	PF00069	0.418
DOC_MAPK_gen_1	468	474	PF00069	0.242
DOC_MAPK_MEF2A_6	110	118	PF00069	0.350
DOC_PP4_FxxP_1	288	291	PF00568	0.515
DOC_USP7_MATH_1	128	132	PF00917	0.591
DOC_USP7_MATH_1	153	157	PF00917	0.511
DOC_USP7_MATH_1	242	246	PF00917	0.470
DOC_USP7_MATH_1	289	293	PF00917	0.502
DOC_USP7_MATH_1	350	354	PF00917	0.706
DOC_WW_Pin1_4	160	165	PF00397	0.401
DOC_WW_Pin1_4	212	217	PF00397	0.665
DOC_WW_Pin1_4	244	249	PF00397	0.417
DOC_WW_Pin1_4	287	292	PF00397	0.506
DOC_WW_Pin1_4	78	83	PF00397	0.650
LIG_APCC_ABBA_1	331	336	PF00400	0.272
LIG_BRCT_BRCA1_1	257	261	PF00533	0.515
LIG_DCNL_PONY_1	1	4	PF03556	0.422
LIG_deltaCOP1_diTrp_1	194	199	PF00928	0.313
LIG_deltaCOP1_diTrp_1	266	271	PF00928	0.424
LIG_eIF4E_1	279	285	PF01652	0.520
LIG_FHA_1	152	158	PF00498	0.548
LIG_FHA_1	280	286	PF00498	0.389
LIG_FHA_1	339	345	PF00498	0.566
LIG_FHA_1	366	372	PF00498	0.392
LIG_FHA_1	399	405	PF00498	0.409
LIG_FHA_1	70	76	PF00498	0.606
LIG_FHA_1	8	14	PF00498	0.465
LIG_FHA_2	288	294	PF00498	0.458
LIG_FHA_2	296	302	PF00498	0.415
LIG_FHA_2	454	460	PF00498	0.507
LIG_FHA_2	93	99	PF00498	0.698
LIG_LIR_Apic_2	182	188	PF02991	0.370
LIG_LIR_Apic_2	266	272	PF02991	0.424
LIG_LIR_Gen_1	234	243	PF02991	0.250
LIG_LIR_Gen_1	431	439	PF02991	0.438
LIG_LIR_Gen_1	476	482	PF02991	0.474
LIG_LIR_Gen_1	8	19	PF02991	0.292
LIG_LIR_Nem_3	245	249	PF02991	0.435
LIG_LIR_Nem_3	252	257	PF02991	0.479
LIG_LIR_Nem_3	476	481	PF02991	0.474
LIG_LIR_Nem_3	8	14	PF02991	0.320
LIG_LYPXL_S_1	66	70	PF13949	0.243
LIG_Pex14_1	195	199	PF04695	0.309
LIG_Pex14_1	375	379	PF04695	0.424
LIG_SH2_CRK	185	189	PF00017	0.362
LIG_SH2_CRK	239	243	PF00017	0.473
LIG_SH2_CRK	320	324	PF00017	0.480
LIG_SH2_CRK	478	482	PF00017	0.372
LIG_SH2_STAP1	257	261	PF00017	0.424
LIG_SH2_STAP1	478	482	PF00017	0.476
LIG_SH2_STAT5	139	142	PF00017	0.302
LIG_SH2_STAT5	279	282	PF00017	0.467
LIG_SH2_STAT5	441	444	PF00017	0.211
LIG_SH3_3	18	24	PF00018	0.315
LIG_SH3_3	283	289	PF00018	0.529
LIG_SH3_3	303	309	PF00018	0.416
LIG_SH3_3	310	316	PF00018	0.415
LIG_SH3_3	62	68	PF00018	0.445
LIG_SUMO_SIM_anti_2	400	410	PF11976	0.404
LIG_TRAF2_1	340	343	PF00917	0.415
LIG_TYR_ITIM	318	323	PF00017	0.253
LIG_WRC_WIRS_1	196	201	PF05994	0.385
LIG_WRC_WIRS_1	351	356	PF05994	0.415
MOD_CDK_SPxxK_3	78	85	PF00069	0.553
MOD_CK1_1	120	126	PF00069	0.418
MOD_CK1_1	156	162	PF00069	0.571
MOD_CK1_1	166	172	PF00069	0.565
MOD_CK1_1	198	204	PF00069	0.427
MOD_CK1_1	212	218	PF00069	0.448
MOD_CK1_1	353	359	PF00069	0.486
MOD_CK1_1	397	403	PF00069	0.476
MOD_CK1_1	431	437	PF00069	0.389
MOD_CK1_1	57	63	PF00069	0.435
MOD_CK1_1	77	83	PF00069	0.649
MOD_CK2_1	295	301	PF00069	0.273
MOD_CK2_1	453	459	PF00069	0.462
MOD_GlcNHglycan	123	126	PF01048	0.460
MOD_GlcNHglycan	176	179	PF01048	0.469
MOD_GlcNHglycan	326	329	PF01048	0.300
MOD_GlcNHglycan	355	358	PF01048	0.626
MOD_GlcNHglycan	363	366	PF01048	0.540
MOD_GSK3_1	117	124	PF00069	0.446
MOD_GSK3_1	145	152	PF00069	0.348
MOD_GSK3_1	155	162	PF00069	0.467
MOD_GSK3_1	253	260	PF00069	0.284
MOD_GSK3_1	361	368	PF00069	0.487
MOD_GSK3_1	393	400	PF00069	0.422
MOD_GSK3_1	74	81	PF00069	0.575
MOD_N-GLC_1	324	329	PF02516	0.355
MOD_N-GLC_1	425	430	PF02516	0.477
MOD_N-GLC_2	262	264	PF02516	0.284
MOD_N-GLC_2	29	31	PF02516	0.449
MOD_N-GLC_2	374	376	PF02516	0.280
MOD_NEK2_1	149	154	PF00069	0.439
MOD_NEK2_1	4	9	PF00069	0.476
MOD_NEK2_1	54	59	PF00069	0.281
MOD_PIKK_1	130	136	PF00454	0.506
MOD_PIKK_1	163	169	PF00454	0.528
MOD_PKA_1	174	180	PF00069	0.278
MOD_PKA_2	174	180	PF00069	0.505
MOD_Plk_1	428	434	PF00069	0.374
MOD_Plk_4	301	307	PF00069	0.279
MOD_ProDKin_1	160	166	PF00069	0.396
MOD_ProDKin_1	212	218	PF00069	0.662
MOD_ProDKin_1	244	250	PF00069	0.256
MOD_ProDKin_1	287	293	PF00069	0.380
MOD_ProDKin_1	78	84	PF00069	0.647
MOD_SUMO_for_1	96	99	PF00179	0.488
TRG_ENDOCYTIC_2	11	14	PF00928	0.410
TRG_ENDOCYTIC_2	320	323	PF00928	0.344
TRG_ENDOCYTIC_2	478	481	PF00928	0.477
TRG_ENDOCYTIC_2	67	70	PF00928	0.254
TRG_ER_diArg_1	344	347	PF00400	0.418
TRG_ER_diArg_1	467	469	PF00400	0.434
TRG_ER_diArg_1	47	49	PF00400	0.462
TRG_NES_CRM1_1	293	303	PF08389	0.393
TRG_Pf-PMV_PEXEL_1	189	194	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	468	473	PF00026	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I519	Leptomonas seymouri	50%	92%
A0A0S4JI40	Bodo saltans	30%	98%
A0A1X0P4A9	Trypanosomatidae	37%	100%
A0A3R7LP24	Trypanosoma rangeli	38%	100%
A0A3S7X0M0	Leishmania donovani	76%	100%
A4I2R6	Leishmania infantum	76%	100%
D0A5X2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AD93	Leishmania major	77%	100%
E9AZ18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q08BY5	Danio rerio	24%	100%
V5BD54	Trypanosoma cruzi	39%	100%