AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFN9_LEIBR

TriTrypDb:

LbrM.27.1240 , LBRM2903_270018300

Length:

554

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFN9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFN9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.455
DEG_COP1_1	399	407	PF00400	0.624
DEG_SCF_FBW7_1	346	353	PF00400	0.599
DEG_SCF_FBW7_1	454	459	PF00400	0.689
DEG_SPOP_SBC_1	277	281	PF00917	0.720
DOC_ANK_TNKS_1	535	542	PF00023	0.797
DOC_CKS1_1	262	267	PF01111	0.712
DOC_CKS1_1	271	276	PF01111	0.797
DOC_CKS1_1	347	352	PF01111	0.601
DOC_CKS1_1	453	458	PF01111	0.791
DOC_PP1_RVXF_1	2	9	PF00149	0.704
DOC_PP2B_LxvP_1	345	348	PF13499	0.693
DOC_PP2B_LxvP_1	542	545	PF13499	0.805
DOC_PP4_FxxP_1	453	456	PF00568	0.576
DOC_PP4_FxxP_1	495	498	PF00568	0.601
DOC_USP7_MATH_1	110	114	PF00917	0.568
DOC_USP7_MATH_1	253	257	PF00917	0.687
DOC_USP7_MATH_1	275	279	PF00917	0.653
DOC_USP7_MATH_1	324	328	PF00917	0.682
DOC_USP7_MATH_1	330	334	PF00917	0.621
DOC_USP7_MATH_1	350	354	PF00917	0.530
DOC_USP7_MATH_1	374	378	PF00917	0.746
DOC_USP7_MATH_1	384	388	PF00917	0.709
DOC_USP7_MATH_1	447	451	PF00917	0.853
DOC_USP7_MATH_1	520	524	PF00917	0.665
DOC_USP7_MATH_1	535	539	PF00917	0.582
DOC_USP7_MATH_1	66	70	PF00917	0.553
DOC_WW_Pin1_4	123	128	PF00397	0.603
DOC_WW_Pin1_4	193	198	PF00397	0.716
DOC_WW_Pin1_4	223	228	PF00397	0.671
DOC_WW_Pin1_4	254	259	PF00397	0.678
DOC_WW_Pin1_4	261	266	PF00397	0.668
DOC_WW_Pin1_4	270	275	PF00397	0.739
DOC_WW_Pin1_4	299	304	PF00397	0.586
DOC_WW_Pin1_4	334	339	PF00397	0.814
DOC_WW_Pin1_4	346	351	PF00397	0.624
DOC_WW_Pin1_4	357	362	PF00397	0.702
DOC_WW_Pin1_4	367	372	PF00397	0.701
DOC_WW_Pin1_4	415	420	PF00397	0.574
DOC_WW_Pin1_4	452	457	PF00397	0.794
DOC_WW_Pin1_4	549	554	PF00397	0.778
LIG_14-3-3_CanoR_1	149	153	PF00244	0.659
LIG_AP2alpha_2	104	106	PF02296	0.780
LIG_BIR_II_1	1	5	PF00653	0.725
LIG_BRCT_BRCA1_1	449	453	PF00533	0.600
LIG_EVH1_1	271	275	PF00568	0.817
LIG_EVH1_1	453	457	PF00568	0.575
LIG_EVH1_1	542	546	PF00568	0.807
LIG_EVH1_2	544	548	PF00568	0.807
LIG_FHA_1	124	130	PF00498	0.540
LIG_FHA_1	31	37	PF00498	0.719
LIG_FHA_1	443	449	PF00498	0.819
LIG_FHA_1	457	463	PF00498	0.592
LIG_FHA_1	485	491	PF00498	0.561
LIG_GSK3_LRP6_1	346	351	PF00069	0.595
LIG_IBAR_NPY_1	478	480	PF08397	0.754
LIG_LIR_Apic_2	377	383	PF02991	0.842
LIG_LIR_Apic_2	450	456	PF02991	0.588
LIG_LIR_Apic_2	477	483	PF02991	0.832
LIG_LIR_Gen_1	163	171	PF02991	0.706
LIG_LIR_Gen_1	391	399	PF02991	0.592
LIG_LIR_Gen_1	526	535	PF02991	0.585
LIG_LIR_Nem_3	137	143	PF02991	0.697
LIG_LIR_Nem_3	163	168	PF02991	0.701
LIG_LIR_Nem_3	321	325	PF02991	0.551
LIG_LIR_Nem_3	391	396	PF02991	0.593
LIG_LIR_Nem_3	526	530	PF02991	0.581
LIG_LIR_Nem_3	547	551	PF02991	0.818
LIG_LYPXL_SIV_4	328	336	PF13949	0.575
LIG_LYPXL_yS_3	322	325	PF13949	0.550
LIG_PROFILIN_1	183	189	PF00235	0.573
LIG_SH2_CRK	359	363	PF00017	0.828
LIG_SH2_CRK	380	384	PF00017	0.834
LIG_SH2_CRK	480	484	PF00017	0.826
LIG_SH2_NCK_1	214	218	PF00017	0.818
LIG_SH2_NCK_1	359	363	PF00017	0.828
LIG_SH2_SRC	310	313	PF00017	0.821
LIG_SH2_SRC	480	483	PF00017	0.829
LIG_SH2_STAP1	143	147	PF00017	0.678
LIG_SH2_STAT3	143	146	PF00017	0.678
LIG_SH2_STAT3	246	249	PF00017	0.578
LIG_SH2_STAT5	219	222	PF00017	0.820
LIG_SH2_STAT5	237	240	PF00017	0.538
LIG_SH2_STAT5	270	273	PF00017	0.583
LIG_SH2_STAT5	310	313	PF00017	0.821
LIG_SH2_STAT5	393	396	PF00017	0.609
LIG_SH3_1	269	275	PF00018	0.717
LIG_SH3_3	178	184	PF00018	0.834
LIG_SH3_3	224	230	PF00018	0.749
LIG_SH3_3	252	258	PF00018	0.741
LIG_SH3_3	262	268	PF00018	0.681
LIG_SH3_3	269	275	PF00018	0.646
LIG_SH3_3	309	315	PF00018	0.671
LIG_SH3_3	317	323	PF00018	0.518
LIG_SH3_3	344	350	PF00018	0.688
LIG_SH3_3	355	361	PF00018	0.738
LIG_SH3_3	368	374	PF00018	0.771
LIG_SH3_3	451	457	PF00018	0.720
LIG_SH3_3	469	475	PF00018	0.759
LIG_SH3_3	496	502	PF00018	0.853
LIG_SH3_3	514	520	PF00018	0.531
LIG_SH3_3	540	546	PF00018	0.815
LIG_SH3_3	547	553	PF00018	0.700
LIG_WRC_WIRS_1	524	529	PF05994	0.837
LIG_WRPW_2	548	551	PF00400	0.817
MOD_CK1_1	256	262	PF00069	0.733
MOD_CK1_1	278	284	PF00069	0.843
MOD_CK1_1	295	301	PF00069	0.561
MOD_CK1_1	306	312	PF00069	0.642
MOD_CK1_1	318	324	PF00069	0.751
MOD_CK1_1	340	346	PF00069	0.765
MOD_CK1_1	406	412	PF00069	0.673
MOD_CK1_1	523	529	PF00069	0.796
MOD_CK1_1	531	537	PF00069	0.671
MOD_CK1_1	69	75	PF00069	0.476
MOD_CK2_1	69	75	PF00069	0.593
MOD_GlcNHglycan	120	123	PF01048	0.599
MOD_GlcNHglycan	130	134	PF01048	0.475
MOD_GlcNHglycan	223	226	PF01048	0.678
MOD_GlcNHglycan	281	284	PF01048	0.860
MOD_GlcNHglycan	294	297	PF01048	0.644
MOD_GlcNHglycan	305	308	PF01048	0.589
MOD_GlcNHglycan	326	329	PF01048	0.666
MOD_GlcNHglycan	332	335	PF01048	0.684
MOD_GlcNHglycan	396	399	PF01048	0.816
MOD_GlcNHglycan	412	415	PF01048	0.541
MOD_GlcNHglycan	430	433	PF01048	0.562
MOD_GlcNHglycan	449	452	PF01048	0.627
MOD_GlcNHglycan	530	533	PF01048	0.699
MOD_GlcNHglycan	537	540	PF01048	0.581
MOD_GlcNHglycan	54	57	PF01048	0.772
MOD_GSK3_1	189	196	PF00069	0.649
MOD_GSK3_1	219	226	PF00069	0.573
MOD_GSK3_1	253	260	PF00069	0.796
MOD_GSK3_1	273	280	PF00069	0.572
MOD_GSK3_1	282	289	PF00069	0.664
MOD_GSK3_1	295	302	PF00069	0.619
MOD_GSK3_1	30	37	PF00069	0.808
MOD_GSK3_1	330	337	PF00069	0.672
MOD_GSK3_1	346	353	PF00069	0.587
MOD_GSK3_1	394	401	PF00069	0.588
MOD_GSK3_1	406	413	PF00069	0.556
MOD_GSK3_1	420	427	PF00069	0.591
MOD_GSK3_1	437	444	PF00069	0.710
MOD_GSK3_1	452	459	PF00069	0.635
MOD_GSK3_1	519	526	PF00069	0.786
MOD_GSK3_1	531	538	PF00069	0.671
MOD_GSK3_1	65	72	PF00069	0.734
MOD_GSK3_1	83	90	PF00069	0.571
MOD_N-GLC_1	34	39	PF02516	0.806
MOD_N-GLC_1	399	404	PF02516	0.723
MOD_N-GLC_1	437	442	PF02516	0.676
MOD_NEK2_1	129	134	PF00069	0.512
MOD_NEK2_1	200	205	PF00069	0.595
MOD_NEK2_1	30	35	PF00069	0.811
MOD_PIKK_1	110	116	PF00454	0.576
MOD_PIKK_1	282	288	PF00454	0.691
MOD_PIKK_1	295	301	PF00454	0.804
MOD_PIKK_1	30	36	PF00454	0.810
MOD_PIKK_1	351	357	PF00454	0.861
MOD_PIKK_1	374	380	PF00454	0.839
MOD_PIKK_1	87	93	PF00454	0.726
MOD_PKA_2	148	154	PF00069	0.674
MOD_PKA_2	535	541	PF00069	0.836
MOD_Plk_1	340	346	PF00069	0.605
MOD_Plk_4	235	241	PF00069	0.575
MOD_Plk_4	257	263	PF00069	0.702
MOD_Plk_4	306	312	PF00069	0.575
MOD_Plk_4	457	463	PF00069	0.712
MOD_ProDKin_1	123	129	PF00069	0.595
MOD_ProDKin_1	193	199	PF00069	0.715
MOD_ProDKin_1	223	229	PF00069	0.671
MOD_ProDKin_1	254	260	PF00069	0.677
MOD_ProDKin_1	261	267	PF00069	0.670
MOD_ProDKin_1	270	276	PF00069	0.741
MOD_ProDKin_1	299	305	PF00069	0.587
MOD_ProDKin_1	334	340	PF00069	0.815
MOD_ProDKin_1	346	352	PF00069	0.627
MOD_ProDKin_1	357	363	PF00069	0.701
MOD_ProDKin_1	367	373	PF00069	0.700
MOD_ProDKin_1	415	421	PF00069	0.577
MOD_ProDKin_1	452	458	PF00069	0.795
MOD_SUMO_rev_2	69	78	PF00179	0.522
TRG_DiLeu_BaLyEn_6	195	200	PF01217	0.851
TRG_ENDOCYTIC_2	165	168	PF00928	0.708
TRG_ENDOCYTIC_2	322	325	PF00928	0.550
TRG_ENDOCYTIC_2	393	396	PF00928	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IPV7	Leishmania donovani	62%	95%
A4I2R5	Leishmania infantum	62%	95%
E9AD92	Leishmania major	61%	100%
E9AZ17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	95%