Putative intraflagellar transport protein IFT88

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

intraflagellar transport protein 88, putative

Species:

Leishmania braziliensis

UniProt:

A4HFN8_LEIBR

TriTrypDb:

LbrM.27.1230 , LBRM2903_270018200

Length:

810

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0031514	motile cilium	5	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0005814	centriole	5	1
GO:0005815	microtubule organizing center	2	1
GO:0030990	intraciliary transport particle	2	1
GO:0032991	protein-containing complex	1	1
GO:0036064	ciliary basal body	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0097546	ciliary base	2	1
GO:0097730	non-motile cilium	5	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HFN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFN8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006996	organelle organization	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0007163	establishment or maintenance of cell polarity	2	1
GO:0008361	regulation of cell size	5	1
GO:0009987	cellular process	1	1
GO:0010970	transport along microtubule	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030010	establishment of cell polarity	3	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0032535	regulation of cellular component size	4	1
GO:0035735	intraciliary transport involved in cilium assembly	4	1
GO:0042073	intraciliary transport	3	1
GO:0044782	cilium organization	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0060271	cilium assembly	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090066	regulation of anatomical structure size	3	1
GO:0099111	microtubule-based transport	4	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1
GO:1905515	non-motile cilium assembly	7	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0019894	kinesin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	330	334	PF00656	0.338
CLV_C14_Caspase3-7	727	731	PF00656	0.681
CLV_C14_Caspase3-7	779	783	PF00656	0.684
CLV_NRD_NRD_1	249	251	PF00675	0.288
CLV_NRD_NRD_1	356	358	PF00675	0.353
CLV_NRD_NRD_1	657	659	PF00675	0.224
CLV_NRD_NRD_1	672	674	PF00675	0.226
CLV_NRD_NRD_1	744	746	PF00675	0.705
CLV_NRD_NRD_1	759	761	PF00675	0.467
CLV_PCSK_KEX2_1	121	123	PF00082	0.521
CLV_PCSK_KEX2_1	174	176	PF00082	0.386
CLV_PCSK_KEX2_1	318	320	PF00082	0.300
CLV_PCSK_KEX2_1	422	424	PF00082	0.369
CLV_PCSK_KEX2_1	535	537	PF00082	0.290
CLV_PCSK_KEX2_1	656	658	PF00082	0.224
CLV_PCSK_KEX2_1	665	667	PF00082	0.224
CLV_PCSK_KEX2_1	743	745	PF00082	0.721
CLV_PCSK_KEX2_1	759	761	PF00082	0.456
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.536
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.386
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.300
CLV_PCSK_PC1ET2_1	422	424	PF00082	0.369
CLV_PCSK_PC1ET2_1	535	537	PF00082	0.290
CLV_PCSK_PC1ET2_1	665	667	PF00082	0.214
CLV_PCSK_SKI1_1	250	254	PF00082	0.263
CLV_PCSK_SKI1_1	319	323	PF00082	0.376
CLV_PCSK_SKI1_1	345	349	PF00082	0.434
CLV_PCSK_SKI1_1	363	367	PF00082	0.301
CLV_PCSK_SKI1_1	444	448	PF00082	0.238
CLV_PCSK_SKI1_1	532	536	PF00082	0.224
CLV_PCSK_SKI1_1	703	707	PF00082	0.283
CLV_PCSK_SKI1_1	78	82	PF00082	0.517
CLV_PCSK_SKI1_1	791	795	PF00082	0.595
DEG_Kelch_Keap1_1	458	463	PF01344	0.224
DEG_Nend_UBRbox_3	1	3	PF02207	0.576
DEG_SCF_TRCP1_1	460	466	PF00400	0.252
DEG_SPOP_SBC_1	21	25	PF00917	0.633
DOC_CDC14_PxL_1	113	121	PF14671	0.528
DOC_CKS1_1	12	17	PF01111	0.622
DOC_CYCLIN_RxL_1	519	529	PF00134	0.224
DOC_CYCLIN_yCln2_LP_2	374	380	PF00134	0.417
DOC_PP1_RVXF_1	216	223	PF00149	0.340
DOC_PP1_RVXF_1	627	634	PF00149	0.298
DOC_PP1_RVXF_1	82	89	PF00149	0.540
DOC_PP2B_LxvP_1	374	377	PF13499	0.261
DOC_PP4_FxxP_1	12	15	PF00568	0.607
DOC_PP4_FxxP_1	29	32	PF00568	0.682
DOC_USP7_MATH_1	284	288	PF00917	0.239
DOC_USP7_MATH_1	79	83	PF00917	0.517
DOC_USP7_MATH_2	33	39	PF00917	0.497
DOC_USP7_UBL2_3	136	140	PF12436	0.349
DOC_USP7_UBL2_3	162	166	PF12436	0.315
DOC_USP7_UBL2_3	247	251	PF12436	0.288
DOC_USP7_UBL2_3	432	436	PF12436	0.224
DOC_USP7_UBL2_3	491	495	PF12436	0.369
DOC_USP7_UBL2_3	703	707	PF12436	0.374
DOC_USP7_UBL2_3	791	795	PF12436	0.622
DOC_WW_Pin1_4	11	16	PF00397	0.557
DOC_WW_Pin1_4	253	258	PF00397	0.372
LIG_14-3-3_CanoR_1	636	642	PF00244	0.321
LIG_14-3-3_CanoR_1	743	752	PF00244	0.682
LIG_14-3-3_CanoR_1	78	86	PF00244	0.539
LIG_APCC_ABBA_1	524	529	PF00400	0.224
LIG_APCC_ABBAyCdc20_2	523	529	PF00400	0.239
LIG_EH_1	26	30	PF12763	0.670
LIG_eIF4E_1	475	481	PF01652	0.247
LIG_FHA_1	12	18	PF00498	0.548
LIG_FHA_1	187	193	PF00498	0.284
LIG_FHA_1	205	211	PF00498	0.296
LIG_FHA_1	299	305	PF00498	0.369
LIG_FHA_1	401	407	PF00498	0.483
LIG_FHA_2	288	294	PF00498	0.369
LIG_FHA_2	328	334	PF00498	0.433
LIG_Integrin_RGD_1	658	660	PF01839	0.283
LIG_LIR_Apic_2	26	32	PF02991	0.598
LIG_LIR_Apic_2	57	62	PF02991	0.541
LIG_LIR_Gen_1	212	220	PF02991	0.305
LIG_LIR_Gen_1	287	292	PF02991	0.226
LIG_LIR_Gen_1	301	310	PF02991	0.233
LIG_LIR_Gen_1	320	329	PF02991	0.215
LIG_LIR_Gen_1	463	472	PF02991	0.224
LIG_LIR_Gen_1	564	574	PF02991	0.352
LIG_LIR_Gen_1	6	17	PF02991	0.481
LIG_LIR_Gen_1	644	652	PF02991	0.235
LIG_LIR_Nem_3	176	181	PF02991	0.267
LIG_LIR_Nem_3	212	216	PF02991	0.283
LIG_LIR_Nem_3	287	291	PF02991	0.226
LIG_LIR_Nem_3	301	305	PF02991	0.233
LIG_LIR_Nem_3	320	324	PF02991	0.194
LIG_LIR_Nem_3	341	347	PF02991	0.570
LIG_LIR_Nem_3	463	468	PF02991	0.288
LIG_LIR_Nem_3	564	569	PF02991	0.343
LIG_LIR_Nem_3	6	12	PF02991	0.477
LIG_LIR_Nem_3	602	607	PF02991	0.318
LIG_PALB2_WD40_1	561	569	PF16756	0.284
LIG_PCNA_yPIPBox_3	605	617	PF02747	0.278
LIG_Pex14_1	383	387	PF04695	0.267
LIG_Pex14_1	616	620	PF04695	0.258
LIG_PTB_Apo_2	216	223	PF02174	0.325
LIG_PTB_Apo_2	621	628	PF02174	0.294
LIG_PTB_Phospho_1	621	627	PF10480	0.285
LIG_REV1ctd_RIR_1	631	640	PF16727	0.295
LIG_SH2_CRK	213	217	PF00017	0.285
LIG_SH2_CRK	249	253	PF00017	0.288
LIG_SH2_CRK	302	306	PF00017	0.146
LIG_SH2_CRK	387	391	PF00017	0.266
LIG_SH2_GRB2like	200	203	PF00017	0.311
LIG_SH2_SRC	200	203	PF00017	0.311
LIG_SH2_SRC	387	390	PF00017	0.415
LIG_SH2_SRC	424	427	PF00017	0.369
LIG_SH2_SRC	527	530	PF00017	0.224
LIG_SH2_SRC	548	551	PF00017	0.261
LIG_SH2_SRC	600	603	PF00017	0.268
LIG_SH2_STAP1	190	194	PF00017	0.281
LIG_SH2_STAP1	206	210	PF00017	0.289
LIG_SH2_STAP1	288	292	PF00017	0.224
LIG_SH2_STAP1	387	391	PF00017	0.266
LIG_SH2_STAP1	527	531	PF00017	0.224
LIG_SH2_STAP1	627	631	PF00017	0.280
LIG_SH2_STAT3	236	239	PF00017	0.257
LIG_SH2_STAT3	684	687	PF00017	0.429
LIG_SH2_STAT5	206	209	PF00017	0.354
LIG_SH2_STAT5	236	239	PF00017	0.247
LIG_SH2_STAT5	242	245	PF00017	0.201
LIG_SH2_STAT5	364	367	PF00017	0.355
LIG_SH2_STAT5	389	392	PF00017	0.270
LIG_SH2_STAT5	418	421	PF00017	0.239
LIG_SH2_STAT5	451	454	PF00017	0.224
LIG_SH2_STAT5	600	603	PF00017	0.268
LIG_SH2_STAT5	620	623	PF00017	0.333
LIG_SH2_STAT5	661	664	PF00017	0.308
LIG_SH2_STAT5	684	687	PF00017	0.292
LIG_SH3_2	115	120	PF14604	0.528
LIG_SH3_3	112	118	PF00018	0.523
LIG_SH3_3	217	223	PF00018	0.480
LIG_SH3_3	554	560	PF00018	0.318
LIG_SH3_3	571	577	PF00018	0.265
LIG_TRAF2_1	126	129	PF00917	0.437
LIG_TRAF2_1	32	35	PF00917	0.634
LIG_TYR_ITIM	306	311	PF00017	0.257
LIG_TYR_ITIM	385	390	PF00017	0.366
LIG_UBA3_1	147	152	PF00899	0.389
LIG_UBA3_1	243	251	PF00899	0.224
LIG_WRC_WIRS_1	531	536	PF05994	0.146
MOD_CK1_1	123	129	PF00069	0.601
MOD_CK1_1	287	293	PF00069	0.369
MOD_CK1_1	466	472	PF00069	0.239
MOD_CK1_1	715	721	PF00069	0.577
MOD_CK2_1	123	129	PF00069	0.456
MOD_CK2_1	287	293	PF00069	0.295
MOD_CK2_1	405	411	PF00069	0.297
MOD_CK2_1	558	564	PF00069	0.409
MOD_CK2_1	728	734	PF00069	0.724
MOD_CK2_1	798	804	PF00069	0.629
MOD_Cter_Amidation	757	760	PF01082	0.582
MOD_GlcNHglycan	143	147	PF01048	0.318
MOD_GlcNHglycan	37	40	PF01048	0.592
MOD_GlcNHglycan	460	463	PF01048	0.157
MOD_GlcNHglycan	559	563	PF01048	0.356
MOD_GlcNHglycan	56	59	PF01048	0.533
MOD_GlcNHglycan	723	726	PF01048	0.644
MOD_GlcNHglycan	73	76	PF01048	0.505
MOD_GlcNHglycan	746	749	PF01048	0.652
MOD_GSK3_1	16	23	PF00069	0.582
MOD_GSK3_1	327	334	PF00069	0.315
MOD_GSK3_1	401	408	PF00069	0.289
MOD_GSK3_1	712	719	PF00069	0.586
MOD_GSK3_1	769	776	PF00069	0.600
MOD_LATS_1	742	748	PF00433	0.597
MOD_N-GLC_1	109	114	PF02516	0.440
MOD_N-GLC_1	298	303	PF02516	0.288
MOD_N-GLC_1	484	489	PF02516	0.331
MOD_N-GLC_1	787	792	PF02516	0.554
MOD_NEK2_1	167	172	PF00069	0.313
MOD_NEK2_1	317	322	PF00069	0.323
MOD_NEK2_1	650	655	PF00069	0.224
MOD_NEK2_1	88	93	PF00069	0.461
MOD_NEK2_2	530	535	PF00069	0.210
MOD_NEK2_2	701	706	PF00069	0.377
MOD_PIKK_1	123	129	PF00454	0.521
MOD_PIKK_1	389	395	PF00454	0.343
MOD_PIKK_1	45	51	PF00454	0.695
MOD_PKA_1	120	126	PF00069	0.646
MOD_PKA_1	743	749	PF00069	0.751
MOD_PKA_2	106	112	PF00069	0.396
MOD_PKA_2	322	328	PF00069	0.251
MOD_PKA_2	635	641	PF00069	0.320
MOD_PKA_2	743	749	PF00069	0.681
MOD_PKA_2	88	94	PF00069	0.565
MOD_PKB_1	442	450	PF00069	0.224
MOD_Plk_1	109	115	PF00069	0.440
MOD_Plk_1	142	148	PF00069	0.311
MOD_Plk_1	167	173	PF00069	0.506
MOD_Plk_1	186	192	PF00069	0.224
MOD_Plk_1	298	304	PF00069	0.288
MOD_Plk_1	437	443	PF00069	0.288
MOD_Plk_1	466	472	PF00069	0.224
MOD_Plk_1	484	490	PF00069	0.274
MOD_Plk_1	729	735	PF00069	0.751
MOD_Plk_2-3	798	804	PF00069	0.472
MOD_Plk_4	287	293	PF00069	0.369
MOD_Plk_4	582	588	PF00069	0.323
MOD_ProDKin_1	11	17	PF00069	0.561
MOD_ProDKin_1	253	259	PF00069	0.380
MOD_SUMO_for_1	622	625	PF00179	0.302
MOD_SUMO_rev_2	776	785	PF00179	0.707
TRG_DiLeu_BaEn_2	175	181	PF01217	0.259
TRG_DiLeu_BaEn_4	143	149	PF01217	0.310
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.263
TRG_DiLeu_BaLyEn_6	565	570	PF01217	0.319
TRG_ENDOCYTIC_2	178	181	PF00928	0.263
TRG_ENDOCYTIC_2	213	216	PF00928	0.285
TRG_ENDOCYTIC_2	249	252	PF00928	0.413
TRG_ENDOCYTIC_2	288	291	PF00928	0.224
TRG_ENDOCYTIC_2	302	305	PF00928	0.224
TRG_ENDOCYTIC_2	308	311	PF00928	0.102
TRG_ENDOCYTIC_2	387	390	PF00928	0.270
TRG_ENDOCYTIC_2	451	454	PF00928	0.224
TRG_ENDOCYTIC_2	465	468	PF00928	0.224
TRG_ENDOCYTIC_2	606	609	PF00928	0.338
TRG_ENDOCYTIC_2	668	671	PF00928	0.224
TRG_ENDOCYTIC_2	9	12	PF00928	0.458
TRG_ER_diArg_1	227	230	PF00400	0.224
TRG_ER_diArg_1	441	444	PF00400	0.224
TRG_ER_diArg_1	656	658	PF00400	0.239
TRG_ER_diArg_1	743	745	PF00400	0.750
TRG_NES_CRM1_1	187	201	PF08389	0.277
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.288
TRG_Pf-PMV_PEXEL_1	665	669	PF00026	0.224

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBZ3	Leptomonas seymouri	81%	99%
A0A0S4JJR3	Bodo saltans	66%	100%
A0A1X0P453	Trypanosomatidae	66%	100%
A0A3Q8IDD3	Leishmania donovani	93%	100%
A0A3R7M723	Trypanosoma rangeli	66%	100%
A4I2R4	Leishmania infantum	93%	100%
D0A5X0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9AD91	Leishmania major	92%	100%
E9AZ16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q13099	Homo sapiens	43%	98%
Q61371	Mus musculus	43%	98%
V5B8M5	Trypanosoma cruzi	65%	93%