Pre-rRNA-processing protein TSR2 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFN6_LEIBR

TriTrypDb:

LbrM.27.1210 , LBRM2903_270018000

Length:

224

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFN6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0030490	maturation of SSU-rRNA	9	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.519
CLV_NRD_NRD_1	206	208	PF00675	0.718
CLV_PCSK_FUR_1	206	210	PF00082	0.746
CLV_PCSK_KEX2_1	206	208	PF00082	0.713
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.698
DEG_Nend_UBRbox_3	1	3	PF02207	0.607
DOC_PP2B_LxvP_1	192	195	PF13499	0.546
DOC_USP7_MATH_1	6	10	PF00917	0.620
LIG_14-3-3_CanoR_1	15	19	PF00244	0.567
LIG_14-3-3_CanoR_1	209	215	PF00244	0.690
LIG_APCC_ABBA_1	79	84	PF00400	0.401
LIG_BIR_III_4	153	157	PF00653	0.707
LIG_FHA_1	126	132	PF00498	0.524
LIG_FHA_1	133	139	PF00498	0.586
LIG_FHA_1	30	36	PF00498	0.508
LIG_FHA_2	144	150	PF00498	0.639
LIG_KLC1_Yacidic_2	73	77	PF13176	0.547
LIG_LIR_Gen_1	118	126	PF02991	0.401
LIG_LIR_Gen_1	25	35	PF02991	0.419
LIG_LIR_Gen_1	80	90	PF02991	0.401
LIG_LIR_Nem_3	118	122	PF02991	0.371
LIG_LIR_Nem_3	25	31	PF02991	0.392
LIG_LIR_Nem_3	80	86	PF02991	0.389
LIG_Pex14_2	83	87	PF04695	0.377
LIG_PTB_Apo_2	86	93	PF02174	0.307
LIG_SH2_STAT3	10	13	PF00017	0.621
LIG_SH2_STAT5	111	114	PF00017	0.357
LIG_SH2_STAT5	125	128	PF00017	0.404
LIG_SH2_STAT5	75	78	PF00017	0.528
LIG_SH2_STAT5	82	85	PF00017	0.420
LIG_SH3_3	185	191	PF00018	0.748
LIG_TRAF2_1	99	102	PF00917	0.521
LIG_TYR_ITIM	59	64	PF00017	0.503
LIG_WW_3	194	198	PF00397	0.729
MOD_CK1_1	17	23	PF00069	0.584
MOD_CK1_1	213	219	PF00069	0.686
MOD_CK2_1	117	123	PF00069	0.425
MOD_CK2_1	96	102	PF00069	0.433
MOD_N-GLC_1	210	215	PF02516	0.684
MOD_NEK2_1	14	19	PF00069	0.642
MOD_PIKK_1	182	188	PF00454	0.726
MOD_PK_1	210	216	PF00069	0.675
MOD_PKA_2	14	20	PF00069	0.565
MOD_Plk_1	117	123	PF00069	0.400
MOD_Plk_1	210	216	PF00069	0.675
MOD_Plk_1	96	102	PF00069	0.437
MOD_Plk_2-3	96	102	PF00069	0.449
TRG_DiLeu_BaEn_1	175	180	PF01217	0.537
TRG_ENDOCYTIC_2	61	64	PF00928	0.425
TRG_ER_diArg_1	206	209	PF00400	0.573
TRG_NLS_MonoCore_2	206	211	PF00514	0.700
TRG_NLS_MonoExtN_4	206	212	PF00514	0.643

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL48	Leptomonas seymouri	65%	100%
A0A0S4JFC4	Bodo saltans	39%	99%
A0A1X0P5J5	Trypanosomatidae	46%	100%
A0A3S7X0M3	Leishmania donovani	78%	100%
A0A422N5E3	Trypanosoma rangeli	48%	100%
A4I2R3	Leishmania infantum	78%	100%
D0A5W6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AD90	Leishmania major	76%	99%
E9AZ14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
V5BHP3	Trypanosoma cruzi	55%	100%