Mitochondrial RNA binding protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

guide RNA-binding protein of 21 kDa

Species:

Leishmania braziliensis

UniProt:

A4HFN5_LEIBR

TriTrypDb:

LbrM.27.1200 , LBRM2903_270017900

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HFN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFN5

Function

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Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	9
GO:0009889	regulation of biosynthetic process	4	9
GO:0010468	regulation of gene expression	5	9
GO:0010556	regulation of macromolecule biosynthetic process	5	9
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	9
GO:0019222	regulation of metabolic process	3	9
GO:0031323	regulation of cellular metabolic process	4	9
GO:0031326	regulation of cellular biosynthetic process	5	9
GO:0050789	regulation of biological process	2	9
GO:0050794	regulation of cellular process	3	9

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003677	DNA binding	4	9
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.371
CLV_NRD_NRD_1	222	224	PF00675	0.688
CLV_NRD_NRD_1	34	36	PF00675	0.407
CLV_NRD_NRD_1	39	41	PF00675	0.361
CLV_PCSK_FUR_1	99	103	PF00082	0.385
CLV_PCSK_KEX2_1	101	103	PF00082	0.291
CLV_PCSK_KEX2_1	221	223	PF00082	0.670
CLV_PCSK_KEX2_1	34	36	PF00082	0.407
CLV_PCSK_KEX2_1	39	41	PF00082	0.361
CLV_PCSK_PC7_1	217	223	PF00082	0.703

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDV2	Leptomonas seymouri	64%	98%
A0A3R7KST0	Trypanosoma rangeli	55%	100%
A0A3S7X0L6	Leishmania donovani	87%	100%
A4I2R2	Leishmania infantum	87%	100%
D0A5W5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AD89	Leishmania major	79%	100%
E9AZ13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%

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