Mitochondrial RNA binding protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

guide RNA-binding protein of 21 kDa

Species:

Leishmania braziliensis

UniProt:

A4HFN5_LEIBR

TriTrypDb:

LbrM.27.1200 , LBRM2903_270017900

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFN5

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	9
GO:0009889	regulation of biosynthetic process	4	9
GO:0010468	regulation of gene expression	5	9
GO:0010556	regulation of macromolecule biosynthetic process	5	9
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	9
GO:0019222	regulation of metabolic process	3	9
GO:0031323	regulation of cellular metabolic process	4	9
GO:0031326	regulation of cellular biosynthetic process	5	9
GO:0050789	regulation of biological process	2	9
GO:0050794	regulation of cellular process	3	9
GO:0051171	regulation of nitrogen compound metabolic process	4	9
GO:0051252	regulation of RNA metabolic process	5	9
GO:0060255	regulation of macromolecule metabolic process	4	9
GO:0065007	biological regulation	1	9
GO:0080090	regulation of primary metabolic process	4	9
GO:1903506	regulation of nucleic acid-templated transcription	7	9
GO:2001141	regulation of RNA biosynthetic process	6	9

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003677	DNA binding	4	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.371
CLV_NRD_NRD_1	222	224	PF00675	0.688
CLV_NRD_NRD_1	34	36	PF00675	0.407
CLV_NRD_NRD_1	39	41	PF00675	0.361
CLV_PCSK_FUR_1	99	103	PF00082	0.385
CLV_PCSK_KEX2_1	101	103	PF00082	0.291
CLV_PCSK_KEX2_1	221	223	PF00082	0.670
CLV_PCSK_KEX2_1	34	36	PF00082	0.407
CLV_PCSK_KEX2_1	39	41	PF00082	0.361
CLV_PCSK_PC7_1	217	223	PF00082	0.703
CLV_PCSK_PC7_1	35	41	PF00082	0.367
CLV_PCSK_SKI1_1	139	143	PF00082	0.210
CLV_PCSK_SKI1_1	40	44	PF00082	0.325
CLV_PCSK_SKI1_1	73	77	PF00082	0.291
DEG_APCC_DBOX_1	7	15	PF00400	0.564
DEG_Nend_Nbox_1	1	3	PF02207	0.543
DOC_ANK_TNKS_1	66	73	PF00023	0.325
DOC_MAPK_gen_1	99	107	PF00069	0.297
DOC_USP7_MATH_1	15	19	PF00917	0.629
DOC_USP7_MATH_1	25	29	PF00917	0.394
DOC_WW_Pin1_4	21	26	PF00397	0.269
DOC_WW_Pin1_4	91	96	PF00397	0.291
LIG_14-3-3_CanoR_1	101	106	PF00244	0.298
LIG_14-3-3_CanoR_1	152	161	PF00244	0.291
LIG_14-3-3_CanoR_1	20	25	PF00244	0.241
LIG_14-3-3_CanoR_1	3	11	PF00244	0.713
LIG_14-3-3_CanoR_1	39	49	PF00244	0.312
LIG_14-3-3_CanoR_1	67	71	PF00244	0.470
LIG_BRCT_BRCA1_1	103	107	PF00533	0.325
LIG_BRCT_BRCA1_1	17	21	PF00533	0.635
LIG_BRCT_BRCA1_1	183	187	PF00533	0.330
LIG_deltaCOP1_diTrp_1	159	165	PF00928	0.291
LIG_FHA_1	43	49	PF00498	0.389
LIG_Integrin_RGD_1	196	198	PF01839	0.661
LIG_LIR_Nem_3	104	110	PF02991	0.367
LIG_LIR_Nem_3	78	83	PF02991	0.291
LIG_MYND_1	81	85	PF01753	0.291
LIG_Pex14_1	161	165	PF04695	0.291
LIG_Pex14_2	133	137	PF04695	0.367
LIG_Pex14_2	165	169	PF04695	0.291
LIG_PTB_Apo_2	127	134	PF02174	0.385
LIG_SH2_STAT5	144	147	PF00017	0.369
LIG_TRAF2_1	157	160	PF00917	0.375
MOD_CK1_1	179	185	PF00069	0.420
MOD_CK1_1	199	205	PF00069	0.456
MOD_CK1_1	225	231	PF00069	0.646
MOD_CK1_1	24	30	PF00069	0.363
MOD_CK1_1	44	50	PF00069	0.331
MOD_CK2_1	114	120	PF00069	0.394
MOD_GlcNHglycan	178	181	PF01048	0.325
MOD_GlcNHglycan	224	227	PF01048	0.743
MOD_GlcNHglycan	27	30	PF01048	0.380
MOD_GlcNHglycan	5	8	PF01048	0.574
MOD_GSK3_1	20	27	PF00069	0.398
MOD_GSK3_1	40	47	PF00069	0.323
MOD_N-GLC_1	90	95	PF02516	0.406
MOD_NEK2_1	137	142	PF00069	0.385
MOD_NEK2_1	176	181	PF00069	0.331
MOD_NEK2_1	42	47	PF00069	0.343
MOD_NEK2_1	75	80	PF00069	0.331
MOD_NEK2_2	15	20	PF00069	0.498
MOD_PIKK_1	152	158	PF00454	0.291
MOD_PIKK_1	75	81	PF00454	0.291
MOD_PKA_1	101	107	PF00069	0.298
MOD_PKA_1	222	228	PF00069	0.637
MOD_PKA_2	101	107	PF00069	0.307
MOD_PKA_2	222	228	PF00069	0.543
MOD_PKA_2	66	72	PF00069	0.413
MOD_PKB_1	99	107	PF00069	0.385
MOD_Plk_4	114	120	PF00069	0.367
MOD_ProDKin_1	21	27	PF00069	0.269
MOD_ProDKin_1	91	97	PF00069	0.291
MOD_SUMO_for_1	49	52	PF00179	0.291
MOD_SUMO_rev_2	69	75	PF00179	0.385
TRG_ER_diArg_1	101	103	PF00400	0.292
TRG_ER_diArg_1	221	223	PF00400	0.720

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDV2	Leptomonas seymouri	64%	98%
A0A3R7KST0	Trypanosoma rangeli	55%	100%
A0A3S7X0L6	Leishmania donovani	87%	100%
A4I2R2	Leishmania infantum	87%	100%
D0A5W5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AD89	Leishmania major	79%	100%
E9AZ13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%