Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFN4_LEIBR

TriTrypDb:

LbrM.27.1190 , LBRM2903_270017800

Length:

660

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFN4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.487
CLV_C14_Caspase3-7	411	415	PF00656	0.638
CLV_C14_Caspase3-7	93	97	PF00656	0.455
CLV_MEL_PAP_1	517	523	PF00089	0.468
CLV_NRD_NRD_1	190	192	PF00675	0.389
CLV_NRD_NRD_1	268	270	PF00675	0.477
CLV_NRD_NRD_1	550	552	PF00675	0.558
CLV_NRD_NRD_1	606	608	PF00675	0.722
CLV_NRD_NRD_1	625	627	PF00675	0.525
CLV_NRD_NRD_1	628	630	PF00675	0.627
CLV_NRD_NRD_1	634	636	PF00675	0.620
CLV_NRD_NRD_1	75	77	PF00675	0.322
CLV_PCSK_KEX2_1	105	107	PF00082	0.483
CLV_PCSK_KEX2_1	172	174	PF00082	0.502
CLV_PCSK_KEX2_1	550	552	PF00082	0.558
CLV_PCSK_KEX2_1	608	610	PF00082	0.663
CLV_PCSK_KEX2_1	625	627	PF00082	0.546
CLV_PCSK_KEX2_1	634	636	PF00082	0.620
CLV_PCSK_KEX2_1	66	68	PF00082	0.518
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.483
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.502
CLV_PCSK_PC1ET2_1	608	610	PF00082	0.663
CLV_PCSK_PC1ET2_1	625	627	PF00082	0.546
CLV_PCSK_PC1ET2_1	634	636	PF00082	0.620
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.494
CLV_PCSK_SKI1_1	124	128	PF00082	0.383
CLV_PCSK_SKI1_1	169	173	PF00082	0.497
CLV_PCSK_SKI1_1	191	195	PF00082	0.420
CLV_PCSK_SKI1_1	239	243	PF00082	0.307
CLV_PCSK_SKI1_1	32	36	PF00082	0.541
CLV_PCSK_SKI1_1	50	54	PF00082	0.466
CLV_PCSK_SKI1_1	622	626	PF00082	0.685
DEG_APCC_DBOX_1	75	83	PF00400	0.509
DEG_Nend_UBRbox_1	1	4	PF02207	0.613
DEG_SPOP_SBC_1	163	167	PF00917	0.617
DEG_SPOP_SBC_1	424	428	PF00917	0.633
DEG_SPOP_SBC_1	429	433	PF00917	0.602
DEG_SPOP_SBC_1	637	641	PF00917	0.633
DEG_SPOP_SBC_1	655	659	PF00917	0.476
DOC_ANK_TNKS_1	550	557	PF00023	0.549
DOC_CKS1_1	114	119	PF01111	0.390
DOC_CKS1_1	27	32	PF01111	0.489
DOC_CKS1_1	39	44	PF01111	0.357
DOC_CKS1_1	418	423	PF01111	0.563
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.465
DOC_MAPK_gen_1	151	158	PF00069	0.418
DOC_MAPK_gen_1	169	178	PF00069	0.556
DOC_MAPK_gen_1	66	75	PF00069	0.472
DOC_MAPK_JIP1_4	67	73	PF00069	0.475
DOC_MAPK_MEF2A_6	66	75	PF00069	0.472
DOC_PP1_RVXF_1	56	62	PF00149	0.371
DOC_PP4_FxxP_1	126	129	PF00568	0.382
DOC_USP7_MATH_1	152	156	PF00917	0.498
DOC_USP7_MATH_1	164	168	PF00917	0.513
DOC_USP7_MATH_1	171	175	PF00917	0.454
DOC_USP7_MATH_1	330	334	PF00917	0.562
DOC_USP7_MATH_1	355	359	PF00917	0.551
DOC_USP7_MATH_1	362	366	PF00917	0.525
DOC_USP7_MATH_1	369	373	PF00917	0.544
DOC_USP7_MATH_1	410	414	PF00917	0.576
DOC_USP7_MATH_1	416	420	PF00917	0.837
DOC_USP7_MATH_1	425	429	PF00917	0.500
DOC_USP7_MATH_1	488	492	PF00917	0.647
DOC_USP7_MATH_1	509	513	PF00917	0.541
DOC_USP7_MATH_1	568	572	PF00917	0.623
DOC_USP7_MATH_1	582	586	PF00917	0.620
DOC_USP7_MATH_1	637	641	PF00917	0.706
DOC_USP7_MATH_1	84	88	PF00917	0.475
DOC_USP7_MATH_2	582	588	PF00917	0.643
DOC_USP7_UBL2_3	604	608	PF12436	0.723
DOC_USP7_UBL2_3	621	625	PF12436	0.546
DOC_USP7_UBL2_3	630	634	PF12436	0.682
DOC_WW_Pin1_4	113	118	PF00397	0.413
DOC_WW_Pin1_4	26	31	PF00397	0.331
DOC_WW_Pin1_4	308	313	PF00397	0.551
DOC_WW_Pin1_4	38	43	PF00397	0.326
DOC_WW_Pin1_4	414	419	PF00397	0.721
DOC_WW_Pin1_4	50	55	PF00397	0.451
DOC_WW_Pin1_4	6	11	PF00397	0.666
LIG_14-3-3_CanoR_1	151	157	PF00244	0.554
LIG_14-3-3_CanoR_1	273	278	PF00244	0.578
LIG_14-3-3_CanoR_1	291	296	PF00244	0.671
LIG_14-3-3_CanoR_1	297	305	PF00244	0.558
LIG_14-3-3_CanoR_1	443	449	PF00244	0.657
LIG_14-3-3_CanoR_1	520	524	PF00244	0.558
LIG_14-3-3_CanoR_1	609	618	PF00244	0.558
LIG_14-3-3_CanoR_1	635	645	PF00244	0.626
LIG_Actin_WH2_2	228	245	PF00022	0.425
LIG_APCC_ABBA_1	250	255	PF00400	0.284
LIG_BRCT_BRCA1_1	258	262	PF00533	0.389
LIG_BRCT_BRCA1_1	364	368	PF00533	0.546
LIG_Clathr_ClatBox_1	261	265	PF01394	0.497
LIG_EH1_1	129	137	PF00400	0.364
LIG_eIF4E_1	120	126	PF01652	0.353
LIG_eIF4E_1	130	136	PF01652	0.409
LIG_FHA_1	105	111	PF00498	0.649
LIG_FHA_1	12	18	PF00498	0.473
LIG_FHA_1	184	190	PF00498	0.352
LIG_FHA_1	235	241	PF00498	0.403
LIG_FHA_1	249	255	PF00498	0.425
LIG_FHA_1	431	437	PF00498	0.672
LIG_FHA_1	559	565	PF00498	0.636
LIG_FHA_2	114	120	PF00498	0.380
LIG_FHA_2	203	209	PF00498	0.611
LIG_FHA_2	219	225	PF00498	0.507
LIG_FHA_2	390	396	PF00498	0.610
LIG_FHA_2	490	496	PF00498	0.509
LIG_FHA_2	526	532	PF00498	0.619
LIG_KLC1_Yacidic_2	227	232	PF13176	0.527
LIG_LIR_Nem_3	119	125	PF02991	0.403
LIG_LIR_Nem_3	522	526	PF02991	0.567
LIG_MLH1_MIPbox_1	364	368	PF16413	0.552
LIG_PDZ_Class_1	655	660	PF00595	0.513
LIG_SH2_CRK	122	126	PF00017	0.387
LIG_SH2_NCK_1	130	134	PF00017	0.368
LIG_SH2_SRC	230	233	PF00017	0.447
LIG_SH2_SRC	454	457	PF00017	0.626
LIG_SH2_STAP1	23	27	PF00017	0.515
LIG_SH2_STAP1	267	271	PF00017	0.372
LIG_SH2_STAT5	230	233	PF00017	0.523
LIG_SH2_STAT5	305	308	PF00017	0.725
LIG_SH2_STAT5	310	313	PF00017	0.689
LIG_SH2_STAT5	435	438	PF00017	0.666
LIG_SH3_3	111	117	PF00018	0.440
LIG_SH3_3	146	152	PF00018	0.500
LIG_SH3_3	415	421	PF00018	0.566
LIG_SH3_3	72	78	PF00018	0.455
LIG_SH3_4	604	611	PF00018	0.660
LIG_SUMO_SIM_par_1	40	48	PF11976	0.325
LIG_SUMO_SIM_par_1	561	567	PF11976	0.636
LIG_SxIP_EBH_1	540	552	PF03271	0.611
LIG_TRAF2_1	220	223	PF00917	0.452
LIG_TRAF2_1	90	93	PF00917	0.472
LIG_WRC_WIRS_1	292	297	PF05994	0.515
LIG_WW_1	302	305	PF00397	0.524
MOD_CDK_SPxK_1	26	32	PF00069	0.511
MOD_CDK_SPxxK_3	308	315	PF00069	0.552
MOD_CK1_1	154	160	PF00069	0.412
MOD_CK1_1	214	220	PF00069	0.459
MOD_CK1_1	256	262	PF00069	0.381
MOD_CK1_1	279	285	PF00069	0.637
MOD_CK1_1	428	434	PF00069	0.661
MOD_CK1_1	48	54	PF00069	0.629
MOD_CK1_1	527	533	PF00069	0.536
MOD_CK1_1	534	540	PF00069	0.577
MOD_CK1_1	571	577	PF00069	0.635
MOD_CK1_1	612	618	PF00069	0.556
MOD_CK1_1	638	644	PF00069	0.624
MOD_CK1_1	648	654	PF00069	0.507
MOD_CK2_1	202	208	PF00069	0.505
MOD_CK2_1	525	531	PF00069	0.624
MOD_CK2_1	92	98	PF00069	0.566
MOD_Cter_Amidation	618	621	PF01082	0.635
MOD_DYRK1A_RPxSP_1	50	54	PF00069	0.446
MOD_GlcNHglycan	158	161	PF01048	0.493
MOD_GlcNHglycan	166	169	PF01048	0.564
MOD_GlcNHglycan	194	197	PF01048	0.575
MOD_GlcNHglycan	200	203	PF01048	0.589
MOD_GlcNHglycan	213	216	PF01048	0.459
MOD_GlcNHglycan	298	301	PF01048	0.673
MOD_GlcNHglycan	357	360	PF01048	0.605
MOD_GlcNHglycan	371	374	PF01048	0.545
MOD_GlcNHglycan	427	430	PF01048	0.814
MOD_GlcNHglycan	511	514	PF01048	0.614
MOD_GlcNHglycan	533	536	PF01048	0.481
MOD_GlcNHglycan	573	576	PF01048	0.692
MOD_GlcNHglycan	645	648	PF01048	0.723
MOD_GSK3_1	152	159	PF00069	0.547
MOD_GSK3_1	183	190	PF00069	0.564
MOD_GSK3_1	194	201	PF00069	0.557
MOD_GSK3_1	214	221	PF00069	0.475
MOD_GSK3_1	291	298	PF00069	0.588
MOD_GSK3_1	304	311	PF00069	0.513
MOD_GSK3_1	330	337	PF00069	0.711
MOD_GSK3_1	37	44	PF00069	0.481
MOD_GSK3_1	410	417	PF00069	0.665
MOD_GSK3_1	424	431	PF00069	0.651
MOD_GSK3_1	444	451	PF00069	0.472
MOD_GSK3_1	461	468	PF00069	0.627
MOD_GSK3_1	497	504	PF00069	0.569
MOD_GSK3_1	511	518	PF00069	0.542
MOD_GSK3_1	525	532	PF00069	0.488
MOD_GSK3_1	560	567	PF00069	0.683
MOD_GSK3_1	609	616	PF00069	0.660
MOD_GSK3_1	636	643	PF00069	0.749
MOD_N-GLC_1	341	346	PF02516	0.585
MOD_N-GLC_1	48	53	PF02516	0.415
MOD_NEK2_1	156	161	PF00069	0.443
MOD_NEK2_1	194	199	PF00069	0.521
MOD_NEK2_1	295	300	PF00069	0.702
MOD_NEK2_1	368	373	PF00069	0.555
MOD_NEK2_1	45	50	PF00069	0.586
MOD_NEK2_1	482	487	PF00069	0.439
MOD_NEK2_1	611	616	PF00069	0.558
MOD_NEK2_1	654	659	PF00069	0.670
MOD_NEK2_2	497	502	PF00069	0.488
MOD_PIKK_1	276	282	PF00454	0.524
MOD_PIKK_1	645	651	PF00454	0.539
MOD_PK_1	461	467	PF00069	0.595
MOD_PKA_1	620	626	PF00069	0.634
MOD_PKA_1	635	641	PF00069	0.660
MOD_PKA_2	152	158	PF00069	0.492
MOD_PKA_2	187	193	PF00069	0.471
MOD_PKA_2	202	208	PF00069	0.508
MOD_PKA_2	290	296	PF00069	0.594
MOD_PKA_2	519	525	PF00069	0.581
MOD_PKA_2	625	631	PF00069	0.831
MOD_PKB_1	607	615	PF00069	0.720
MOD_Plk_1	471	477	PF00069	0.463
MOD_Plk_1	48	54	PF00069	0.543
MOD_Plk_1	564	570	PF00069	0.692
MOD_Plk_2-3	218	224	PF00069	0.451
MOD_Plk_2-3	92	98	PF00069	0.475
MOD_Plk_4	134	140	PF00069	0.397
MOD_Plk_4	225	231	PF00069	0.424
MOD_Plk_4	253	259	PF00069	0.391
MOD_Plk_4	291	297	PF00069	0.516
MOD_Plk_4	431	437	PF00069	0.672
MOD_ProDKin_1	113	119	PF00069	0.402
MOD_ProDKin_1	26	32	PF00069	0.330
MOD_ProDKin_1	308	314	PF00069	0.551
MOD_ProDKin_1	38	44	PF00069	0.334
MOD_ProDKin_1	414	420	PF00069	0.721
MOD_ProDKin_1	50	56	PF00069	0.447
MOD_ProDKin_1	6	12	PF00069	0.667
MOD_SUMO_rev_2	383	392	PF00179	0.572
MOD_SUMO_rev_2	578	587	PF00179	0.671
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.380
TRG_ENDOCYTIC_2	122	125	PF00928	0.382
TRG_ENDOCYTIC_2	523	526	PF00928	0.559
TRG_ER_diArg_1	178	181	PF00400	0.409
TRG_ER_diArg_1	549	551	PF00400	0.557
TRG_NLS_Bipartite_1	592	611	PF00514	0.661
TRG_NLS_Bipartite_1	620	638	PF00514	0.708
TRG_NLS_MonoCore_2	65	70	PF00514	0.475
TRG_NLS_MonoExtC_3	624	629	PF00514	0.664
TRG_NLS_MonoExtN_4	604	611	PF00514	0.653
TRG_NLS_MonoExtN_4	618	624	PF00514	0.671
TRG_NLS_MonoExtN_4	625	630	PF00514	0.666
TRG_NLS_MonoExtN_4	632	638	PF00514	0.684
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	609	613	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILF9	Leptomonas seymouri	43%	97%
A0A3S7X0L5	Leishmania donovani	69%	100%
A4I2R1	Leishmania infantum	69%	100%
E9AD88	Leishmania major	66%	98%
E9AZ12	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%