This 4-TM protein belongs to broad Eukaryotic family of primarily ER-associated proteins. This family also encompasses the human Emopamil-binding protein and intracellular sigma receptors.. Might be a sterol isomerase.. Localization: ER (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 9 |
| NetGPI | no | yes: 0, no: 9 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 9 |
| GO:0110165 | cellular anatomical entity | 1 | 9 |
Related structures:
AlphaFold database: A4HFN3
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 181 | 183 | PF00675 | 0.436 |
| CLV_NRD_NRD_1 | 58 | 60 | PF00675 | 0.553 |
| CLV_PCSK_KEX2_1 | 58 | 60 | PF00082 | 0.512 |
| DEG_SIAH_1 | 39 | 47 | PF03145 | 0.332 |
| DOC_CYCLIN_yCln2_LP_2 | 139 | 145 | PF00134 | 0.341 |
| DOC_MAPK_MEF2A_6 | 99 | 106 | PF00069 | 0.347 |
| DOC_PP1_RVXF_1 | 9 | 15 | PF00149 | 0.488 |
| DOC_PP2B_LxvP_1 | 139 | 142 | PF13499 | 0.341 |
| DOC_PP2B_PxIxI_1 | 18 | 24 | PF00149 | 0.199 |
| DOC_USP7_MATH_1 | 164 | 168 | PF00917 | 0.543 |
| LIG_14-3-3_CanoR_1 | 182 | 191 | PF00244 | 0.596 |
| LIG_14-3-3_CanoR_1 | 31 | 36 | PF00244 | 0.345 |
| LIG_Clathr_ClatBox_1 | 20 | 24 | PF01394 | 0.259 |
| LIG_FHA_1 | 125 | 131 | PF00498 | 0.302 |
| LIG_FHA_1 | 135 | 141 | PF00498 | 0.307 |
| LIG_FHA_2 | 129 | 135 | PF00498 | 0.377 |
| LIG_LIR_Gen_1 | 112 | 121 | PF02991 | 0.393 |
| LIG_LIR_Gen_1 | 144 | 154 | PF02991 | 0.301 |
| LIG_LIR_Gen_1 | 64 | 74 | PF02991 | 0.316 |
| LIG_LIR_Nem_3 | 108 | 113 | PF02991 | 0.300 |
| LIG_LIR_Nem_3 | 144 | 149 | PF02991 | 0.335 |
| LIG_LIR_Nem_3 | 51 | 56 | PF02991 | 0.300 |
| LIG_LIR_Nem_3 | 64 | 70 | PF02991 | 0.324 |
| LIG_LIR_Nem_3 | 72 | 76 | PF02991 | 0.255 |
| LIG_NRP_CendR_1 | 193 | 195 | PF00754 | 0.369 |
| LIG_SH2_CRK | 110 | 114 | PF00017 | 0.300 |
| LIG_SH2_STAP1 | 126 | 130 | PF00017 | 0.273 |
| LIG_SH2_STAP1 | 56 | 60 | PF00017 | 0.313 |
| LIG_SH2_STAT5 | 115 | 118 | PF00017 | 0.324 |
| LIG_SH2_STAT5 | 126 | 129 | PF00017 | 0.260 |
| LIG_SH2_STAT5 | 190 | 193 | PF00017 | 0.585 |
| LIG_SH3_3 | 32 | 38 | PF00018 | 0.332 |
| LIG_SUMO_SIM_par_1 | 102 | 108 | PF11976 | 0.227 |
| LIG_SUMO_SIM_par_1 | 116 | 122 | PF11976 | 0.454 |
| LIG_SUMO_SIM_par_1 | 18 | 24 | PF11976 | 0.279 |
| LIG_TYR_ITIM | 113 | 118 | PF00017 | 0.319 |
| LIG_TYR_ITSM | 106 | 113 | PF00017 | 0.300 |
| LIG_UBA3_1 | 106 | 111 | PF00899 | 0.341 |
| LIG_UBA3_1 | 117 | 125 | PF00899 | 0.308 |
| LIG_UBA3_1 | 26 | 33 | PF00899 | 0.438 |
| MOD_CK1_1 | 105 | 111 | PF00069 | 0.205 |
| MOD_CK1_1 | 167 | 173 | PF00069 | 0.607 |
| MOD_CK2_1 | 128 | 134 | PF00069 | 0.345 |
| MOD_Cter_Amidation | 191 | 194 | PF01082 | 0.450 |
| MOD_GlcNHglycan | 166 | 169 | PF01048 | 0.370 |
| MOD_GlcNHglycan | 184 | 187 | PF01048 | 0.389 |
| MOD_GlcNHglycan | 87 | 90 | PF01048 | 0.285 |
| MOD_GSK3_1 | 105 | 112 | PF00069 | 0.320 |
| MOD_GSK3_1 | 124 | 131 | PF00069 | 0.323 |
| MOD_GSK3_1 | 167 | 174 | PF00069 | 0.647 |
| MOD_GSK3_1 | 27 | 34 | PF00069 | 0.456 |
| MOD_N-GLC_1 | 164 | 169 | PF02516 | 0.357 |
| MOD_NEK2_1 | 109 | 114 | PF00069 | 0.307 |
| MOD_NEK2_1 | 27 | 32 | PF00069 | 0.387 |
| MOD_NEK2_1 | 83 | 88 | PF00069 | 0.409 |
| MOD_PK_1 | 31 | 37 | PF00069 | 0.346 |
| MOD_PKA_1 | 182 | 188 | PF00069 | 0.568 |
| MOD_Plk_4 | 102 | 108 | PF00069 | 0.212 |
| MOD_Plk_4 | 109 | 115 | PF00069 | 0.320 |
| MOD_Plk_4 | 134 | 140 | PF00069 | 0.276 |
| MOD_Plk_4 | 141 | 147 | PF00069 | 0.285 |
| MOD_Plk_4 | 69 | 75 | PF00069 | 0.254 |
| TRG_DiLeu_BaLyEn_6 | 16 | 21 | PF01217 | 0.199 |
| TRG_DiLeu_BaLyEn_6 | 4 | 9 | PF01217 | 0.519 |
| TRG_ENDOCYTIC_2 | 110 | 113 | PF00928 | 0.330 |
| TRG_ENDOCYTIC_2 | 115 | 118 | PF00928 | 0.317 |
| TRG_ENDOCYTIC_2 | 155 | 158 | PF00928 | 0.422 |
| TRG_ENDOCYTIC_2 | 49 | 52 | PF00928 | 0.360 |
| TRG_ER_diArg_1 | 58 | 60 | PF00400 | 0.353 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1I830 | Leptomonas seymouri | 52% | 97% |
| A0A0S4JB23 | Bodo saltans | 39% | 100% |
| A0A1X0P436 | Trypanosomatidae | 54% | 100% |
| A0A3Q8IGA5 | Leishmania donovani | 77% | 99% |
| A4I2R0 | Leishmania infantum | 77% | 99% |
| D0A5W3 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 46% | 100% |
| E9AD87 | Leishmania major | 74% | 100% |
| E9AZ11 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 77% | 99% |