LeishMANIAdb
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Putative vesicular transport protein (CDC48 homologue)

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative vesicular transport protein (CDC48 homologue)
Gene product:
vesicular transport protein (CDC48 homologue), putative
Species:
Leishmania braziliensis
UniProt:
A4HFM9_LEIBR
TriTrypDb:
LbrM.27.1140 , LBRM2903_270017300
Length:
666

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

A4HFM9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFM9

Function

Biological processes
Term Name Level Count
GO:0009889 regulation of biosynthetic process 4 1
GO:0009891 positive regulation of biosynthetic process 5 1
GO:0009893 positive regulation of metabolic process 4 1
GO:0009987 cellular process 1 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0010557 positive regulation of macromolecule biosynthetic process 6 1
GO:0010604 positive regulation of macromolecule metabolic process 5 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0022613 ribonucleoprotein complex biogenesis 4 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031325 positive regulation of cellular metabolic process 5 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0031328 positive regulation of cellular biosynthetic process 6 1
GO:0042254 ribosome biogenesis 5 1
GO:0043085 positive regulation of catalytic activity 4 1
GO:0044085 cellular component biogenesis 3 1
GO:0044093 positive regulation of molecular function 3 1
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 6 1
GO:0048518 positive regulation of biological process 3 1
GO:0048522 positive regulation of cellular process 4 1
GO:0050789 regulation of biological process 2 1
GO:0050790 regulation of catalytic activity 3 1
GO:0050794 regulation of cellular process 3 1
GO:0051052 regulation of DNA metabolic process 5 1
GO:0051054 positive regulation of DNA metabolic process 6 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051173 positive regulation of nitrogen compound metabolic process 5 1
GO:0051338 regulation of transferase activity 4 1
GO:0051347 positive regulation of transferase activity 5 1
GO:0051972 regulation of telomerase activity 5 1
GO:0051973 positive regulation of telomerase activity 6 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0065009 regulation of molecular function 2 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0080090 regulation of primary metabolic process 4 1
GO:2000278 regulation of DNA biosynthetic process 6 1
GO:2000573 positive regulation of DNA biosynthetic process 7 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016462 pyrophosphatase activity 5 12
GO:0016787 hydrolase activity 2 12
GO:0016817 hydrolase activity, acting on acid anhydrides 3 12
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 12
GO:0016887 ATP hydrolysis activity 7 12
GO:0017076 purine nucleotide binding 4 12
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12
GO:0043021 ribonucleoprotein complex binding 3 1
GO:0044877 protein-containing complex binding 2 1
GO:1990275 preribosome binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 473 477 PF00656 0.298
CLV_C14_Caspase3-7 500 504 PF00656 0.298
CLV_MEL_PAP_1 398 404 PF00089 0.434
CLV_NRD_NRD_1 201 203 PF00675 0.286
CLV_NRD_NRD_1 23 25 PF00675 0.764
CLV_NRD_NRD_1 231 233 PF00675 0.193
CLV_NRD_NRD_1 252 254 PF00675 0.298
CLV_NRD_NRD_1 318 320 PF00675 0.314
CLV_NRD_NRD_1 481 483 PF00675 0.298
CLV_NRD_NRD_1 507 509 PF00675 0.419
CLV_NRD_NRD_1 555 557 PF00675 0.476
CLV_PCSK_KEX2_1 201 203 PF00082 0.286
CLV_PCSK_KEX2_1 252 254 PF00082 0.298
CLV_PCSK_KEX2_1 318 320 PF00082 0.314
CLV_PCSK_KEX2_1 353 355 PF00082 0.315
CLV_PCSK_KEX2_1 45 47 PF00082 0.674
CLV_PCSK_KEX2_1 481 483 PF00082 0.298
CLV_PCSK_PC1ET2_1 353 355 PF00082 0.327
CLV_PCSK_PC1ET2_1 45 47 PF00082 0.716
CLV_PCSK_SKI1_1 176 180 PF00082 0.298
CLV_PCSK_SKI1_1 349 353 PF00082 0.453
CLV_PCSK_SKI1_1 456 460 PF00082 0.298
CLV_PCSK_SKI1_1 568 572 PF00082 0.193
CLV_PCSK_SKI1_1 612 616 PF00082 0.582
DOC_ANK_TNKS_1 326 333 PF00023 0.368
DOC_CYCLIN_RxL_1 173 181 PF00134 0.298
DOC_CYCLIN_yCln2_LP_2 151 157 PF00134 0.298
DOC_CYCLIN_yCln2_LP_2 404 410 PF00134 0.418
DOC_MAPK_gen_1 229 237 PF00069 0.193
DOC_MAPK_gen_1 252 263 PF00069 0.298
DOC_MAPK_gen_1 529 539 PF00069 0.298
DOC_MAPK_MEF2A_6 106 115 PF00069 0.404
DOC_MAPK_MEF2A_6 256 265 PF00069 0.298
DOC_MAPK_MEF2A_6 463 471 PF00069 0.298
DOC_MAPK_MEF2A_6 532 541 PF00069 0.298
DOC_MAPK_NFAT4_5 106 114 PF00069 0.402
DOC_MAPK_RevD_3 187 202 PF00069 0.298
DOC_MAPK_RevD_3 303 319 PF00069 0.314
DOC_PP2B_LxvP_1 151 154 PF13499 0.314
DOC_PP2B_LxvP_1 263 266 PF13499 0.378
DOC_PP2B_LxvP_1 537 540 PF13499 0.298
DOC_USP7_MATH_1 185 189 PF00917 0.314
DOC_USP7_MATH_1 368 372 PF00917 0.496
DOC_USP7_MATH_1 428 432 PF00917 0.298
DOC_USP7_MATH_1 487 491 PF00917 0.298
DOC_USP7_MATH_1 540 544 PF00917 0.287
DOC_USP7_MATH_1 641 645 PF00917 0.448
DOC_USP7_UBL2_3 349 353 PF12436 0.311
DOC_USP7_UBL2_3 69 73 PF12436 0.789
DOC_USP7_UBL2_3 9 13 PF12436 0.700
DOC_WW_Pin1_4 16 21 PF00397 0.704
DOC_WW_Pin1_4 183 188 PF00397 0.193
DOC_WW_Pin1_4 294 299 PF00397 0.298
LIG_14-3-3_CanoR_1 461 467 PF00244 0.298
LIG_14-3-3_CanoR_1 659 665 PF00244 0.655
LIG_Actin_WH2_2 580 598 PF00022 0.355
LIG_BIR_II_1 1 5 PF00653 0.559
LIG_BRCT_BRCA1_1 187 191 PF00533 0.298
LIG_DLG_GKlike_1 588 595 PF00625 0.298
LIG_EH1_1 405 413 PF00400 0.406
LIG_FHA_1 139 145 PF00498 0.298
LIG_FHA_1 333 339 PF00498 0.582
LIG_FHA_1 350 356 PF00498 0.297
LIG_FHA_1 385 391 PF00498 0.379
LIG_FHA_1 619 625 PF00498 0.633
LIG_FHA_2 217 223 PF00498 0.333
LIG_FHA_2 342 348 PF00498 0.409
LIG_FHA_2 498 504 PF00498 0.298
LIG_FHA_2 601 607 PF00498 0.335
LIG_FHA_2 88 94 PF00498 0.433
LIG_GBD_Chelix_1 143 151 PF00786 0.298
LIG_GBD_Chelix_1 213 221 PF00786 0.298
LIG_GBD_Chelix_1 494 502 PF00786 0.298
LIG_LIR_Gen_1 362 370 PF02991 0.495
LIG_LIR_Gen_1 371 378 PF02991 0.395
LIG_LIR_Nem_3 287 293 PF02991 0.293
LIG_LIR_Nem_3 344 348 PF02991 0.446
LIG_LIR_Nem_3 362 367 PF02991 0.325
LIG_LIR_Nem_3 371 375 PF02991 0.400
LIG_NRBOX 532 538 PF00104 0.314
LIG_Pex14_2 341 345 PF04695 0.389
LIG_SH2_CRK 413 417 PF00017 0.298
LIG_SH2_PTP2 538 541 PF00017 0.298
LIG_SH2_SRC 512 515 PF00017 0.298
LIG_SH2_STAT3 23 26 PF00017 0.726
LIG_SH2_STAT5 121 124 PF00017 0.334
LIG_SH2_STAT5 300 303 PF00017 0.298
LIG_SH2_STAT5 512 515 PF00017 0.298
LIG_SH2_STAT5 538 541 PF00017 0.298
LIG_SH3_3 155 161 PF00018 0.298
LIG_SH3_3 536 542 PF00018 0.298
LIG_TYR_ITIM 536 541 PF00017 0.314
LIG_UBA3_1 274 281 PF00899 0.375
LIG_UBA3_1 389 397 PF00899 0.438
MOD_CK1_1 165 171 PF00069 0.310
MOD_CK1_1 2 8 PF00069 0.624
MOD_CK1_1 451 457 PF00069 0.298
MOD_CK1_1 58 64 PF00069 0.754
MOD_CK1_1 618 624 PF00069 0.569
MOD_CK2_1 156 162 PF00069 0.268
MOD_CK2_1 264 270 PF00069 0.384
MOD_CK2_1 341 347 PF00069 0.410
MOD_CK2_1 600 606 PF00069 0.318
MOD_CK2_1 87 93 PF00069 0.411
MOD_Cter_Amidation 199 202 PF01082 0.298
MOD_Cter_Amidation 43 46 PF01082 0.686
MOD_Cter_Amidation 506 509 PF01082 0.419
MOD_GlcNHglycan 158 161 PF01048 0.304
MOD_GlcNHglycan 164 167 PF01048 0.313
MOD_GlcNHglycan 29 32 PF01048 0.700
MOD_GlcNHglycan 336 341 PF01048 0.499
MOD_GlcNHglycan 357 360 PF01048 0.443
MOD_GlcNHglycan 430 433 PF01048 0.298
MOD_GlcNHglycan 464 467 PF01048 0.298
MOD_GlcNHglycan 542 545 PF01048 0.453
MOD_GlcNHglycan 578 581 PF01048 0.298
MOD_GlcNHglycan 617 620 PF01048 0.579
MOD_GlcNHglycan 643 646 PF01048 0.472
MOD_GlcNHglycan 66 69 PF01048 0.752
MOD_GlcNHglycan 660 663 PF01048 0.405
MOD_GSK3_1 332 339 PF00069 0.496
MOD_GSK3_1 546 553 PF00069 0.392
MOD_GSK3_1 55 62 PF00069 0.811
MOD_N-GLC_1 282 287 PF02516 0.471
MOD_N-GLC_1 294 299 PF02516 0.222
MOD_N-GLC_1 368 373 PF02516 0.415
MOD_N-GLC_1 428 433 PF02516 0.298
MOD_N-GLC_1 73 78 PF02516 0.515
MOD_NEK2_1 156 161 PF00069 0.268
MOD_NEK2_1 238 243 PF00069 0.298
MOD_NEK2_1 341 346 PF00069 0.354
MOD_NEK2_1 385 390 PF00069 0.388
MOD_NEK2_1 632 637 PF00069 0.426
MOD_NEK2_1 658 663 PF00069 0.370
MOD_PIKK_1 222 228 PF00454 0.383
MOD_PKA_1 481 487 PF00069 0.298
MOD_PKA_2 270 276 PF00069 0.356
MOD_PKA_2 462 468 PF00069 0.298
MOD_PKA_2 481 487 PF00069 0.298
MOD_PKA_2 546 552 PF00069 0.389
MOD_PKA_2 658 664 PF00069 0.620
MOD_Plk_1 368 374 PF00069 0.415
MOD_Plk_1 451 457 PF00069 0.298
MOD_Plk_1 588 594 PF00069 0.298
MOD_Plk_1 632 638 PF00069 0.443
MOD_Plk_2-3 652 658 PF00069 0.539
MOD_Plk_4 185 191 PF00069 0.296
MOD_Plk_4 270 276 PF00069 0.356
MOD_Plk_4 385 391 PF00069 0.395
MOD_Plk_4 418 424 PF00069 0.298
MOD_Plk_4 546 552 PF00069 0.389
MOD_ProDKin_1 16 22 PF00069 0.704
MOD_ProDKin_1 183 189 PF00069 0.193
MOD_ProDKin_1 294 300 PF00069 0.298
MOD_SUMO_for_1 333 336 PF00179 0.518
MOD_SUMO_rev_2 168 175 PF00179 0.298
MOD_SUMO_rev_2 51 61 PF00179 0.543
TRG_ENDOCYTIC_2 321 324 PF00928 0.355
TRG_ENDOCYTIC_2 538 541 PF00928 0.298
TRG_ENDOCYTIC_2 651 654 PF00928 0.427
TRG_ER_diArg_1 251 253 PF00400 0.298
TRG_ER_diArg_1 317 319 PF00400 0.314
TRG_ER_diArg_1 480 482 PF00400 0.298
TRG_NES_CRM1_1 93 107 PF08389 0.502
TRG_NLS_MonoExtC_3 23 28 PF00514 0.761
TRG_Pf-PMV_PEXEL_1 176 181 PF00026 0.298
TRG_Pf-PMV_PEXEL_1 322 326 PF00026 0.445

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2H1 Leptomonas seymouri 32% 72%
A0A0N0P3G0 Leptomonas seymouri 45% 84%
A0A0N0P640 Leptomonas seymouri 26% 90%
A0A0N0P6J4 Leptomonas seymouri 86% 100%
A0A0N0P7Z4 Leptomonas seymouri 34% 69%
A0A0N1I568 Leptomonas seymouri 31% 69%
A0A0S4IMC7 Bodo saltans 45% 100%
A0A0S4JAU3 Bodo saltans 70% 100%
A0A0S4JI00 Bodo saltans 41% 90%
A0A0S4KLG9 Bodo saltans 35% 100%
A0A1X0NXH5 Trypanosomatidae 26% 94%
A0A1X0NXR8 Trypanosomatidae 27% 92%
A0A1X0P1J4 Trypanosomatidae 32% 85%
A0A1X0P433 Trypanosomatidae 75% 100%
A0A1X0P870 Trypanosomatidae 46% 85%
A0A1X0PA10 Trypanosomatidae 32% 73%
A0A3Q8IIU8 Leishmania donovani 31% 70%
A0A3Q8IKK0 Leishmania donovani 26% 90%
A0A3Q8IQP5 Leishmania donovani 45% 85%
A0A3Q8IS46 Leishmania donovani 32% 69%
A0A3R7L6R6 Trypanosoma rangeli 29% 100%
A0A3R7M308 Trypanosoma rangeli 32% 85%
A0A3R7M9L0 Trypanosoma rangeli 45% 85%
A0A3R7MK02 Trypanosoma rangeli 31% 86%
A0A3S5H6W4 Leishmania donovani 36% 69%
A0A3S7X0L3 Leishmania donovani 92% 100%
A0A422MWE3 Trypanosoma rangeli 78% 100%
A0A7N9VSG0 Mus musculus 39% 89%
A4HII5 Leishmania braziliensis 32% 71%
A4HNZ5 Leishmania braziliensis 45% 85%
A4HYS3 Leishmania infantum 26% 90%
A4I2Q7 Leishmania infantum 92% 100%
A4IAB8 Leishmania infantum 31% 70%
A4ICJ9 Leishmania infantum 44% 97%
A7YSY2 Bos taurus 39% 87%
C9ZIP1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 93%
C9ZLX8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 73%
C9ZR48 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 84%
D0A2X0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 85%
D0A5V8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 80% 94%
D4A2B7 Rattus norvegicus 39% 89%
E9AD83 Leishmania major 92% 100%
E9AID2 Leishmania braziliensis 26% 90%
E9AQG2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 69%
E9ASQ6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 85%
E9AUL9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 90%
E9AZ07 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9B124 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 85%
E9B5E1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 70%
O05209 Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) 44% 89%
O13764 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 35% 70%
O14325 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 51% 85%
O15381 Homo sapiens 48% 78%
O28972 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 47% 91%
O60058 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 44% 82%
O74941 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 71%
P03974 Sus scrofa 46% 83%
P23787 Xenopus laevis 45% 83%
P25694 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 44% 80%
P32794 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 42% 85%
P46462 Rattus norvegicus 46% 83%
P54609 Arabidopsis thaliana 44% 82%
P54774 Glycine max 46% 83%
P54777 Rattus norvegicus 37% 68%
P54811 Caenorhabditis elegans 45% 82%
P54812 Caenorhabditis elegans 46% 82%
P55072 Homo sapiens 46% 83%
Q01853 Mus musculus 46% 83%
Q07590 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 43% 85%
Q07844 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 47% 80%
Q13608 Homo sapiens 36% 68%
Q21222 Caenorhabditis elegans 33% 92%
Q3UMC0 Mus musculus 45% 75%
Q3ZBT1 Bos taurus 46% 83%
Q4Q1T9 Leishmania major 45% 100%
Q4Q2J2 Leishmania major 32% 70%
Q4Q741 Leishmania major 32% 83%
Q4QCW5 Leishmania major 25% 90%
Q4QF14 Leishmania major 36% 69%
Q54SY2 Dictyostelium discoideum 47% 77%
Q58556 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 50% 74%
Q5AWS6 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 44% 81%
Q6CPV1 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 30% 67%
Q6GL04 Xenopus tropicalis 46% 83%
Q7KN62 Drosophila melanogaster 44% 83%
Q7ZU99 Danio rerio 45% 83%
Q8NB90 Homo sapiens 45% 75%
Q8RY16 Arabidopsis thaliana 32% 71%
Q8SSJ5 Encephalitozoon cuniculi (strain GB-M1) 43% 85%
Q96372 Capsicum annuum 45% 83%
Q99LC9 Mus musculus 37% 68%
Q9BVQ7 Homo sapiens 41% 88%
Q9DBY8 Mus musculus 49% 78%
Q9HPF0 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 49% 90%
Q9LZF6 Arabidopsis thaliana 45% 82%
Q9NAG4 Caenorhabditis elegans 44% 82%
Q9P3A7 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 45% 82%
Q9SCN8 Arabidopsis thaliana 45% 82%
Q9SS94 Arabidopsis thaliana 47% 81%
Q9ZPR1 Arabidopsis thaliana 38% 100%
V5AUZ1 Trypanosoma cruzi 33% 85%
V5BCV9 Trypanosoma cruzi 25% 100%
V5BD45 Trypanosoma cruzi 74% 100%
V5BKY8 Trypanosoma cruzi 30% 86%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS