LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HFM8_LEIBR
TriTrypDb:
LbrM.27.1130 , LBRM2903_270017200
Length:
146

Annotations

LeishMANIAdb annotations

This small membrane protein has a very long, basic N-terminus that might indicate a putative mitochondrial transit signal.. The protein is conserved in all KInetoplastids, but not seen outside this group.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9
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Expansion

Sequence features

A4HFM8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFM8

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 134 136 PF00675 0.570
CLV_NRD_NRD_1 18 20 PF00675 0.450
CLV_NRD_NRD_1 21 23 PF00675 0.464
CLV_NRD_NRD_1 3 5 PF00675 0.444
CLV_NRD_NRD_1 36 38 PF00675 0.371
CLV_PCSK_FUR_1 131 135 PF00082 0.611
CLV_PCSK_FUR_1 18 22 PF00082 0.430
CLV_PCSK_KEX2_1 130 132 PF00082 0.573
CLV_PCSK_KEX2_1 133 135 PF00082 0.577
CLV_PCSK_KEX2_1 18 20 PF00082 0.449
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1HZT6 Leptomonas seymouri 72% 100%
A0A0S4JFD9 Bodo saltans 47% 100%
A0A1X0P4W3 Trypanosomatidae 52% 100%
A0A3S7X0M9 Leishmania donovani 87% 100%
A0A422MWH1 Trypanosoma rangeli 53% 100%
A4I2Q6 Leishmania infantum 87% 100%
D0A5V7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 57% 100%
E9AD82 Leishmania major 85% 100%
E9AZ06 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS