This small membrane protein has a very long, basic N-terminus that might indicate a putative mitochondrial transit signal.. The protein is conserved in all KInetoplastids, but not seen outside this group.
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 10 |
| NetGPI | no | yes: 0, no: 10 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 9 |
| GO:0110165 | cellular anatomical entity | 1 | 9 |
Related structures:
AlphaFold database: A4HFM8
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 134 | 136 | PF00675 | 0.570 |
| CLV_NRD_NRD_1 | 18 | 20 | PF00675 | 0.450 |
| CLV_NRD_NRD_1 | 21 | 23 | PF00675 | 0.464 |
| CLV_NRD_NRD_1 | 3 | 5 | PF00675 | 0.444 |
| CLV_NRD_NRD_1 | 36 | 38 | PF00675 | 0.371 |
| CLV_PCSK_FUR_1 | 131 | 135 | PF00082 | 0.611 |
| CLV_PCSK_FUR_1 | 18 | 22 | PF00082 | 0.430 |
| CLV_PCSK_KEX2_1 | 130 | 132 | PF00082 | 0.573 |
| CLV_PCSK_KEX2_1 | 133 | 135 | PF00082 | 0.577 |
| CLV_PCSK_KEX2_1 | 18 | 20 | PF00082 | 0.449 |
| CLV_PCSK_KEX2_1 | 21 | 23 | PF00082 | 0.466 |
| CLV_PCSK_KEX2_1 | 3 | 5 | PF00082 | 0.444 |
| CLV_PCSK_KEX2_1 | 36 | 38 | PF00082 | 0.371 |
| CLV_PCSK_PC1ET2_1 | 130 | 132 | PF00082 | 0.568 |
| CLV_PCSK_PC1ET2_1 | 20 | 22 | PF00082 | 0.446 |
| CLV_Separin_Metazoa | 10 | 14 | PF03568 | 0.651 |
| DEG_APCC_DBOX_1 | 2 | 10 | PF00400 | 0.534 |
| DEG_Nend_Nbox_1 | 1 | 3 | PF02207 | 0.630 |
| DOC_MAPK_gen_1 | 111 | 120 | PF00069 | 0.389 |
| DOC_MAPK_gen_1 | 3 | 11 | PF00069 | 0.646 |
| DOC_MAPK_MEF2A_6 | 114 | 122 | PF00069 | 0.428 |
| DOC_MAPK_RevD_3 | 7 | 20 | PF00069 | 0.591 |
| DOC_PP2B_LxvP_1 | 9 | 12 | PF13499 | 0.678 |
| DOC_USP7_MATH_1 | 27 | 31 | PF00917 | 0.586 |
| LIG_14-3-3_CanoR_1 | 68 | 73 | PF00244 | 0.599 |
| LIG_deltaCOP1_diTrp_1 | 66 | 76 | PF00928 | 0.453 |
| LIG_FHA_2 | 94 | 100 | PF00498 | 0.450 |
| LIG_Integrin_RGD_1 | 114 | 116 | PF01839 | 0.562 |
| LIG_LIR_Gen_1 | 105 | 113 | PF02991 | 0.462 |
| LIG_LIR_Gen_1 | 66 | 77 | PF02991 | 0.453 |
| LIG_LIR_Nem_3 | 105 | 110 | PF02991 | 0.433 |
| LIG_LIR_Nem_3 | 119 | 125 | PF02991 | 0.322 |
| LIG_LIR_Nem_3 | 66 | 72 | PF02991 | 0.455 |
| LIG_LIR_Nem_3 | 81 | 86 | PF02991 | 0.294 |
| LIG_REV1ctd_RIR_1 | 90 | 98 | PF16727 | 0.553 |
| LIG_SH2_CRK | 107 | 111 | PF00017 | 0.372 |
| LIG_SH2_STAP1 | 65 | 69 | PF00017 | 0.498 |
| LIG_SH2_STAT3 | 50 | 53 | PF00017 | 0.628 |
| LIG_SH2_STAT5 | 107 | 110 | PF00017 | 0.422 |
| LIG_SH2_STAT5 | 50 | 53 | PF00017 | 0.534 |
| LIG_SH2_STAT5 | 86 | 89 | PF00017 | 0.284 |
| LIG_SH2_STAT5 | 95 | 98 | PF00017 | 0.353 |
| LIG_SH3_2 | 57 | 62 | PF14604 | 0.613 |
| LIG_SH3_3 | 35 | 41 | PF00018 | 0.761 |
| LIG_SH3_3 | 54 | 60 | PF00018 | 0.530 |
| LIG_SH3_3 | 8 | 14 | PF00018 | 0.691 |
| LIG_TYR_ITSM | 103 | 110 | PF00017 | 0.465 |
| MOD_Cter_Amidation | 128 | 131 | PF01082 | 0.627 |
| MOD_GlcNHglycan | 45 | 48 | PF01048 | 0.391 |
| MOD_PIKK_1 | 102 | 108 | PF00454 | 0.464 |
| MOD_PKA_1 | 20 | 26 | PF00069 | 0.651 |
| MOD_PKA_2 | 20 | 26 | PF00069 | 0.707 |
| MOD_PKA_2 | 67 | 73 | PF00069 | 0.620 |
| MOD_Plk_4 | 105 | 111 | PF00069 | 0.382 |
| MOD_Plk_4 | 79 | 85 | PF00069 | 0.339 |
| TRG_DiLeu_BaLyEn_6 | 135 | 140 | PF01217 | 0.413 |
| TRG_ENDOCYTIC_2 | 107 | 110 | PF00928 | 0.292 |
| TRG_ENDOCYTIC_2 | 89 | 92 | PF00928 | 0.351 |
| TRG_ER_diArg_1 | 131 | 134 | PF00400 | 0.388 |
| TRG_ER_diArg_1 | 18 | 21 | PF00400 | 0.624 |
| TRG_ER_diArg_1 | 2 | 4 | PF00400 | 0.647 |
| TRG_ER_diArg_1 | 36 | 38 | PF00400 | 0.731 |
| TRG_NLS_Bipartite_1 | 3 | 24 | PF00514 | 0.663 |
| TRG_NLS_MonoCore_2 | 18 | 23 | PF00514 | 0.652 |
| TRG_NLS_MonoExtC_3 | 129 | 134 | PF00514 | 0.407 |
| TRG_NLS_MonoExtC_3 | 19 | 24 | PF00514 | 0.730 |
| TRG_NLS_MonoExtN_4 | 18 | 24 | PF00514 | 0.663 |
| TRG_Pf-PMV_PEXEL_1 | 138 | 143 | PF00026 | 0.603 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1HZT6 | Leptomonas seymouri | 72% | 100% |
| A0A0S4JFD9 | Bodo saltans | 47% | 100% |
| A0A1X0P4W3 | Trypanosomatidae | 52% | 100% |
| A0A3S7X0M9 | Leishmania donovani | 87% | 100% |
| A0A422MWH1 | Trypanosoma rangeli | 53% | 100% |
| A4I2Q6 | Leishmania infantum | 87% | 100% |
| D0A5V7 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 57% | 100% |
| E9AD82 | Leishmania major | 85% | 100% |
| E9AZ06 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 86% | 100% |