Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFM7_LEIBR

TriTrypDb:

LbrM.27.1120 , LBRM2903_270017100

Length:

420

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HFM7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFM7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.601
CLV_C14_Caspase3-7	326	330	PF00656	0.616
CLV_NRD_NRD_1	143	145	PF00675	0.597
CLV_NRD_NRD_1	176	178	PF00675	0.403
CLV_NRD_NRD_1	354	356	PF00675	0.470
CLV_NRD_NRD_1	360	362	PF00675	0.481
CLV_NRD_NRD_1	60	62	PF00675	0.646
CLV_PCSK_KEX2_1	176	178	PF00082	0.403
CLV_PCSK_KEX2_1	201	203	PF00082	0.417
CLV_PCSK_KEX2_1	354	356	PF00082	0.470
CLV_PCSK_KEX2_1	360	362	PF00082	0.481
CLV_PCSK_KEX2_1	60	62	PF00082	0.646
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.376
CLV_PCSK_SKI1_1	213	217	PF00082	0.462
CLV_PCSK_SKI1_1	244	248	PF00082	0.360
CLV_PCSK_SKI1_1	389	393	PF00082	0.425
DEG_APCC_KENBOX_2	324	328	PF00400	0.620
DEG_Nend_UBRbox_3	1	3	PF02207	0.541
DOC_ANK_TNKS_1	298	305	PF00023	0.632
DOC_MAPK_gen_1	389	397	PF00069	0.586
DOC_MAPK_gen_1	400	409	PF00069	0.230
DOC_MAPK_gen_1	60	68	PF00069	0.441
DOC_MAPK_HePTP_8	399	411	PF00069	0.314
DOC_MAPK_MEF2A_6	390	399	PF00069	0.567
DOC_MAPK_MEF2A_6	402	411	PF00069	0.288
DOC_MAPK_MEF2A_6	60	69	PF00069	0.447
DOC_PP1_RVXF_1	242	248	PF00149	0.551
DOC_PP1_RVXF_1	400	407	PF00149	0.304
DOC_PP4_FxxP_1	44	47	PF00568	0.425
DOC_USP7_MATH_1	123	127	PF00917	0.428
DOC_USP7_MATH_1	131	135	PF00917	0.480
DOC_USP7_MATH_1	295	299	PF00917	0.644
DOC_USP7_MATH_1	349	353	PF00917	0.663
LIG_14-3-3_CanoR_1	195	204	PF00244	0.524
LIG_14-3-3_CanoR_1	354	358	PF00244	0.616
LIG_14-3-3_CanoR_1	380	384	PF00244	0.594
LIG_14-3-3_CanoR_1	81	86	PF00244	0.521
LIG_Actin_WH2_2	402	420	PF00022	0.313
LIG_FHA_1	18	24	PF00498	0.503
LIG_FHA_1	189	195	PF00498	0.618
LIG_FHA_1	277	283	PF00498	0.591
LIG_FHA_1	366	372	PF00498	0.612
LIG_FHA_1	380	386	PF00498	0.604
LIG_FHA_2	261	267	PF00498	0.622
LIG_FHA_2	32	38	PF00498	0.449
LIG_GBD_Chelix_1	404	412	PF00786	0.404
LIG_LIR_Apic_2	41	47	PF02991	0.420
LIG_LIR_Nem_3	252	258	PF02991	0.519
LIG_NBox_RRM_1	381	391	PF00076	0.577
LIG_NRBOX	391	397	PF00104	0.555
LIG_PCNA_yPIPBox_3	168	179	PF02747	0.617
LIG_SH2_GRB2like	92	95	PF00017	0.426
LIG_SH2_STAP1	264	268	PF00017	0.554
LIG_SH2_STAT5	156	159	PF00017	0.304
LIG_SH2_STAT5	362	365	PF00017	0.603
LIG_SH3_3	20	26	PF00018	0.435
LIG_SH3_3	7	13	PF00018	0.521
LIG_SUMO_SIM_anti_2	161	166	PF11976	0.382
LIG_SUMO_SIM_anti_2	182	192	PF11976	0.545
LIG_SUMO_SIM_par_1	161	166	PF11976	0.332
LIG_SUMO_SIM_par_1	182	192	PF11976	0.545
LIG_TRAF2_1	105	108	PF00917	0.427
LIG_TYR_ITIM	154	159	PF00017	0.304
LIG_UBA3_1	395	402	PF00899	0.447
MOD_CK1_1	134	140	PF00069	0.491
MOD_CK1_1	375	381	PF00069	0.664
MOD_CK1_1	80	86	PF00069	0.520
MOD_CK2_1	101	107	PF00069	0.437
MOD_CK2_1	163	169	PF00069	0.508
MOD_CK2_1	260	266	PF00069	0.618
MOD_CK2_1	31	37	PF00069	0.531
MOD_GlcNHglycan	121	124	PF01048	0.576
MOD_GlcNHglycan	125	128	PF01048	0.563
MOD_GlcNHglycan	140	143	PF01048	0.534
MOD_GlcNHglycan	165	168	PF01048	0.508
MOD_GlcNHglycan	290	293	PF01048	0.408
MOD_GlcNHglycan	351	354	PF01048	0.427
MOD_GlcNHglycan	374	377	PF01048	0.573
MOD_GSK3_1	119	126	PF00069	0.537
MOD_GSK3_1	134	141	PF00069	0.500
MOD_GSK3_1	277	284	PF00069	0.580
MOD_GSK3_1	33	40	PF00069	0.453
MOD_GSK3_1	349	356	PF00069	0.723
MOD_GSK3_1	375	382	PF00069	0.621
MOD_GSK3_1	73	80	PF00069	0.472
MOD_N-GLC_1	234	239	PF02516	0.329
MOD_N-GLC_1	73	78	PF02516	0.661
MOD_N-GLC_2	401	403	PF02516	0.222
MOD_NEK2_1	188	193	PF00069	0.563
MOD_NEK2_1	276	281	PF00069	0.555
MOD_NEK2_1	39	44	PF00069	0.448
MOD_NEK2_1	412	417	PF00069	0.326
MOD_PIKK_1	54	60	PF00454	0.401
MOD_PIKK_1	84	90	PF00454	0.479
MOD_PKA_1	360	366	PF00069	0.674
MOD_PKA_2	169	175	PF00069	0.530
MOD_PKA_2	353	359	PF00069	0.660
MOD_PKA_2	360	366	PF00069	0.692
MOD_PKA_2	379	385	PF00069	0.631
MOD_PKA_2	51	57	PF00069	0.516
MOD_PKA_2	80	86	PF00069	0.598
MOD_Plk_1	109	115	PF00069	0.415
MOD_Plk_1	234	240	PF00069	0.534
MOD_Plk_1	259	265	PF00069	0.483
MOD_Plk_2-3	103	109	PF00069	0.526
MOD_Plk_2-3	260	266	PF00069	0.484
MOD_Plk_2-3	319	325	PF00069	0.615
MOD_Plk_4	189	195	PF00069	0.547
MOD_Plk_4	278	284	PF00069	0.586
MOD_Plk_4	412	418	PF00069	0.227
MOD_SUMO_for_1	200	203	PF00179	0.603
MOD_SUMO_for_1	215	218	PF00179	0.535
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.375
TRG_ENDOCYTIC_2	156	159	PF00928	0.304
TRG_ER_diArg_1	175	177	PF00400	0.601
TRG_ER_diArg_1	360	362	PF00400	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCL1	Leptomonas seymouri	43%	98%
A0A3S7X0L7	Leishmania donovani	64%	100%
A4I2Q5	Leishmania infantum	63%	100%
E9AD81	Leishmania major	63%	100%
E9AZ05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%