3'-5' exonuclease domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFM6_LEIBR

TriTrypDb:

LbrM.27.1110 , LBRM2903_270017000

Length:

919

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFM6

PDB structure(s): 7am2_BK

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.706
CLV_C14_Caspase3-7	690	694	PF00656	0.411
CLV_NRD_NRD_1	232	234	PF00675	0.463
CLV_NRD_NRD_1	645	647	PF00675	0.498
CLV_NRD_NRD_1	686	688	PF00675	0.412
CLV_NRD_NRD_1	717	719	PF00675	0.549
CLV_NRD_NRD_1	856	858	PF00675	0.483
CLV_PCSK_FUR_1	525	529	PF00082	0.579
CLV_PCSK_KEX2_1	232	234	PF00082	0.518
CLV_PCSK_KEX2_1	527	529	PF00082	0.474
CLV_PCSK_KEX2_1	645	647	PF00082	0.460
CLV_PCSK_KEX2_1	686	688	PF00082	0.412
CLV_PCSK_KEX2_1	716	718	PF00082	0.560
CLV_PCSK_KEX2_1	856	858	PF00082	0.438
CLV_PCSK_PC1ET2_1	527	529	PF00082	0.519
CLV_PCSK_PC1ET2_1	716	718	PF00082	0.606
CLV_PCSK_PC7_1	852	858	PF00082	0.443
CLV_PCSK_SKI1_1	109	113	PF00082	0.666
CLV_PCSK_SKI1_1	219	223	PF00082	0.500
CLV_PCSK_SKI1_1	262	266	PF00082	0.552
CLV_PCSK_SKI1_1	355	359	PF00082	0.505
CLV_PCSK_SKI1_1	692	696	PF00082	0.445
CLV_PCSK_SKI1_1	717	721	PF00082	0.474
CLV_PCSK_SKI1_1	736	740	PF00082	0.205
CLV_PCSK_SKI1_1	824	828	PF00082	0.452
CLV_PCSK_SKI1_1	859	863	PF00082	0.459
DEG_APCC_DBOX_1	354	362	PF00400	0.537
DEG_APCC_DBOX_1	735	743	PF00400	0.451
DEG_SCF_FBW7_2	898	905	PF00400	0.578
DEG_SPOP_SBC_1	47	51	PF00917	0.770
DEG_SPOP_SBC_1	800	804	PF00917	0.628
DOC_ANK_TNKS_1	869	876	PF00023	0.442
DOC_CDC14_PxL_1	505	513	PF14671	0.391
DOC_CKS1_1	738	743	PF01111	0.256
DOC_CKS1_1	890	895	PF01111	0.463
DOC_CKS1_1	899	904	PF01111	0.453
DOC_CYCLIN_RxL_1	350	362	PF00134	0.552
DOC_CYCLIN_yClb1_LxF_4	253	259	PF00134	0.500
DOC_MAPK_gen_1	216	226	PF00069	0.510
DOC_MAPK_gen_1	689	697	PF00069	0.471
DOC_MAPK_MEF2A_6	189	196	PF00069	0.595
DOC_MAPK_MEF2A_6	298	307	PF00069	0.294
DOC_MAPK_MEF2A_6	456	463	PF00069	0.509
DOC_MAPK_MEF2A_6	499	507	PF00069	0.619
DOC_MAPK_MEF2A_6	770	777	PF00069	0.411
DOC_MAPK_NFAT4_5	456	464	PF00069	0.506
DOC_PP1_RVXF_1	438	444	PF00149	0.536
DOC_PP1_RVXF_1	884	891	PF00149	0.582
DOC_PP2B_PxIxI_1	191	197	PF00149	0.334
DOC_PP4_FxxP_1	81	84	PF00568	0.503
DOC_PP4_FxxP_1	890	893	PF00568	0.605
DOC_USP7_MATH_1	160	164	PF00917	0.601
DOC_USP7_MATH_1	172	176	PF00917	0.450
DOC_USP7_MATH_1	42	46	PF00917	0.797
DOC_USP7_MATH_1	47	51	PF00917	0.664
DOC_USP7_MATH_1	485	489	PF00917	0.681
DOC_USP7_MATH_1	58	62	PF00917	0.713
DOC_USP7_MATH_1	800	804	PF00917	0.626
DOC_USP7_MATH_1	880	884	PF00917	0.525
DOC_USP7_MATH_2	71	77	PF00917	0.641
DOC_WW_Pin1_4	113	118	PF00397	0.478
DOC_WW_Pin1_4	155	160	PF00397	0.712
DOC_WW_Pin1_4	161	166	PF00397	0.711
DOC_WW_Pin1_4	299	304	PF00397	0.472
DOC_WW_Pin1_4	421	426	PF00397	0.533
DOC_WW_Pin1_4	43	48	PF00397	0.571
DOC_WW_Pin1_4	486	491	PF00397	0.723
DOC_WW_Pin1_4	499	504	PF00397	0.624
DOC_WW_Pin1_4	633	638	PF00397	0.512
DOC_WW_Pin1_4	737	742	PF00397	0.253
DOC_WW_Pin1_4	76	81	PF00397	0.377
DOC_WW_Pin1_4	796	801	PF00397	0.599
DOC_WW_Pin1_4	809	814	PF00397	0.567
DOC_WW_Pin1_4	844	849	PF00397	0.545
DOC_WW_Pin1_4	889	894	PF00397	0.460
DOC_WW_Pin1_4	898	903	PF00397	0.445
DOC_WW_Pin1_4	912	917	PF00397	0.675
LIG_14-3-3_CanoR_1	14	22	PF00244	0.581
LIG_14-3-3_CanoR_1	219	224	PF00244	0.510
LIG_14-3-3_CanoR_1	268	273	PF00244	0.496
LIG_14-3-3_CanoR_1	346	352	PF00244	0.339
LIG_14-3-3_CanoR_1	4	10	PF00244	0.555
LIG_14-3-3_CanoR_1	59	63	PF00244	0.652
LIG_14-3-3_CanoR_1	717	725	PF00244	0.533
LIG_14-3-3_CanoR_1	824	832	PF00244	0.496
LIG_14-3-3_CanoR_1	839	844	PF00244	0.396
LIG_Actin_WH2_2	662	678	PF00022	0.500
LIG_Actin_WH2_2	811	826	PF00022	0.440
LIG_BIR_II_1	1	5	PF00653	0.498
LIG_BRCT_BRCA1_1	245	249	PF00533	0.394
LIG_BRCT_BRCA1_1	74	78	PF00533	0.601
LIG_BRCT_BRCA1_1	810	814	PF00533	0.338
LIG_BRCT_BRCA1_1	88	92	PF00533	0.611
LIG_deltaCOP1_diTrp_1	250	258	PF00928	0.541
LIG_deltaCOP1_diTrp_1	432	438	PF00928	0.503
LIG_EH1_1	647	655	PF00400	0.542
LIG_eIF4E_1	243	249	PF01652	0.509
LIG_eIF4E_1	754	760	PF01652	0.384
LIG_FHA_1	156	162	PF00498	0.727
LIG_FHA_1	237	243	PF00498	0.466
LIG_FHA_1	351	357	PF00498	0.531
LIG_FHA_1	500	506	PF00498	0.585
LIG_FHA_1	561	567	PF00498	0.490
LIG_FHA_1	622	628	PF00498	0.540
LIG_FHA_1	634	640	PF00498	0.530
LIG_FHA_1	741	747	PF00498	0.536
LIG_FHA_1	802	808	PF00498	0.502
LIG_FHA_1	810	816	PF00498	0.536
LIG_FHA_2	220	226	PF00498	0.476
LIG_FHA_2	288	294	PF00498	0.452
LIG_FHA_2	751	757	PF00498	0.444
LIG_FHA_2	800	806	PF00498	0.481
LIG_GBD_Chelix_1	426	434	PF00786	0.266
LIG_LIR_Apic_2	337	341	PF02991	0.514
LIG_LIR_Apic_2	79	84	PF02991	0.375
LIG_LIR_Gen_1	138	147	PF02991	0.676
LIG_LIR_Gen_1	277	287	PF02991	0.412
LIG_LIR_Gen_1	455	466	PF02991	0.436
LIG_LIR_Gen_1	518	526	PF02991	0.482
LIG_LIR_Gen_1	582	592	PF02991	0.434
LIG_LIR_Nem_3	138	144	PF02991	0.673
LIG_LIR_Nem_3	277	283	PF02991	0.412
LIG_LIR_Nem_3	455	461	PF02991	0.431
LIG_LIR_Nem_3	518	523	PF02991	0.449
LIG_LIR_Nem_3	582	587	PF02991	0.350
LIG_LIR_Nem_3	608	614	PF02991	0.632
LIG_LIR_Nem_3	61	65	PF02991	0.609
LIG_LIR_Nem_3	636	641	PF02991	0.376
LIG_LIR_Nem_3	75	81	PF02991	0.479
LIG_LIR_Nem_3	89	95	PF02991	0.480
LIG_NRBOX	471	477	PF00104	0.348
LIG_PCNA_yPIPBox_3	201	211	PF02747	0.495
LIG_PCNA_yPIPBox_3	232	242	PF02747	0.545
LIG_Pex14_1	26	30	PF04695	0.691
LIG_Pex14_2	397	401	PF04695	0.584
LIG_SH2_CRK	458	462	PF00017	0.501
LIG_SH2_CRK	62	66	PF00017	0.554
LIG_SH2_CRK	900	904	PF00017	0.462
LIG_SH2_NCK_1	900	904	PF00017	0.421
LIG_SH2_STAP1	730	734	PF00017	0.480
LIG_SH2_STAT5	270	273	PF00017	0.437
LIG_SH2_STAT5	325	328	PF00017	0.533
LIG_SH2_STAT5	638	641	PF00017	0.473
LIG_SH2_STAT5	747	750	PF00017	0.425
LIG_SH2_STAT5	754	757	PF00017	0.355
LIG_SH2_STAT5	767	770	PF00017	0.371
LIG_SH2_STAT5	891	894	PF00017	0.479
LIG_SH2_STAT5	9	12	PF00017	0.499
LIG_SH2_STAT5	900	903	PF00017	0.457
LIG_SH3_1	487	493	PF00018	0.493
LIG_SH3_3	171	177	PF00018	0.669
LIG_SH3_3	32	38	PF00018	0.750
LIG_SH3_3	326	332	PF00018	0.553
LIG_SH3_3	487	493	PF00018	0.493
LIG_SH3_3	607	613	PF00018	0.670
LIG_SH3_3	829	835	PF00018	0.619
LIG_SH3_3	890	896	PF00018	0.477
LIG_SUMO_SIM_anti_2	405	411	PF11976	0.452
LIG_SUMO_SIM_par_1	192	198	PF11976	0.536
LIG_TRFH_1	325	329	PF08558	0.571
LIG_TYR_ITIM	60	65	PF00017	0.570
LIG_TYR_ITIM	898	903	PF00017	0.456
LIG_UBA3_1	315	323	PF00899	0.340
LIG_UBA3_1	565	572	PF00899	0.404
LIG_Vh1_VBS_1	667	685	PF01044	0.381
LIG_WW_3	116	120	PF00397	0.762
LIG_WW_3	56	60	PF00397	0.629
MOD_CDC14_SPxK_1	116	119	PF00782	0.508
MOD_CDC14_SPxK_1	847	850	PF00782	0.331
MOD_CDK_SPxK_1	113	119	PF00069	0.487
MOD_CDK_SPxK_1	844	850	PF00069	0.543
MOD_CK1_1	145	151	PF00069	0.753
MOD_CK1_1	274	280	PF00069	0.438
MOD_CK1_1	45	51	PF00069	0.823
MOD_CK1_1	488	494	PF00069	0.722
MOD_CK1_1	52	58	PF00069	0.750
MOD_CK1_1	521	527	PF00069	0.531
MOD_CK1_1	568	574	PF00069	0.558
MOD_CK1_1	61	67	PF00069	0.607
MOD_CK1_1	76	82	PF00069	0.499
MOD_CK1_1	782	788	PF00069	0.460
MOD_CK1_1	799	805	PF00069	0.492
MOD_CK1_1	817	823	PF00069	0.460
MOD_CK2_1	160	166	PF00069	0.744
MOD_CK2_1	231	237	PF00069	0.417
MOD_CK2_1	244	250	PF00069	0.383
MOD_CK2_1	287	293	PF00069	0.486
MOD_CK2_1	558	564	PF00069	0.432
MOD_CMANNOS	435	438	PF00535	0.507
MOD_Cter_Amidation	643	646	PF01082	0.587
MOD_GlcNHglycan	137	140	PF01048	0.692
MOD_GlcNHglycan	142	147	PF01048	0.707
MOD_GlcNHglycan	15	18	PF01048	0.631
MOD_GlcNHglycan	347	350	PF01048	0.487
MOD_GlcNHglycan	366	369	PF01048	0.383
MOD_GlcNHglycan	413	416	PF01048	0.439
MOD_GlcNHglycan	520	523	PF01048	0.490
MOD_GlcNHglycan	54	57	PF01048	0.789
MOD_GlcNHglycan	560	563	PF01048	0.423
MOD_GlcNHglycan	616	619	PF01048	0.641
MOD_GlcNHglycan	671	674	PF01048	0.423
MOD_GlcNHglycan	689	692	PF01048	0.313
MOD_GlcNHglycan	784	787	PF01048	0.486
MOD_GSK3_1	142	149	PF00069	0.666
MOD_GSK3_1	266	273	PF00069	0.490
MOD_GSK3_1	391	398	PF00069	0.641
MOD_GSK3_1	42	49	PF00069	0.790
MOD_GSK3_1	485	492	PF00069	0.730
MOD_GSK3_1	499	506	PF00069	0.381
MOD_GSK3_1	5	12	PF00069	0.738
MOD_GSK3_1	61	68	PF00069	0.668
MOD_GSK3_1	629	636	PF00069	0.462
MOD_GSK3_1	72	79	PF00069	0.603
MOD_GSK3_1	776	783	PF00069	0.421
MOD_GSK3_1	796	803	PF00069	0.330
MOD_N-GLC_1	120	125	PF02516	0.536
MOD_N-GLC_1	344	349	PF02516	0.485
MOD_N-GLC_1	808	813	PF02516	0.606
MOD_N-GLC_1	844	849	PF02516	0.337
MOD_NEK2_1	20	25	PF00069	0.607
MOD_NEK2_1	226	231	PF00069	0.403
MOD_NEK2_1	287	292	PF00069	0.468
MOD_NEK2_1	364	369	PF00069	0.556
MOD_NEK2_1	384	389	PF00069	0.419
MOD_NEK2_1	436	441	PF00069	0.545
MOD_NEK2_1	511	516	PF00069	0.545
MOD_NEK2_1	538	543	PF00069	0.501
MOD_NEK2_1	558	563	PF00069	0.221
MOD_NEK2_1	565	570	PF00069	0.392
MOD_NEK2_1	614	619	PF00069	0.601
MOD_NEK2_1	668	673	PF00069	0.353
MOD_NEK2_1	695	700	PF00069	0.351
MOD_NEK2_1	760	765	PF00069	0.381
MOD_NEK2_1	814	819	PF00069	0.455
MOD_NEK2_2	146	151	PF00069	0.505
MOD_NEK2_2	629	634	PF00069	0.475
MOD_NEK2_2	790	795	PF00069	0.525
MOD_NEK2_2	9	14	PF00069	0.500
MOD_PIKK_1	121	127	PF00454	0.759
MOD_PIKK_1	20	26	PF00454	0.556
MOD_PIKK_1	874	880	PF00454	0.556
MOD_PKA_1	717	723	PF00069	0.563
MOD_PKA_2	13	19	PF00069	0.634
MOD_PKA_2	172	178	PF00069	0.667
MOD_PKA_2	231	237	PF00069	0.564
MOD_PKA_2	345	351	PF00069	0.478
MOD_PKA_2	395	401	PF00069	0.542
MOD_PKA_2	436	442	PF00069	0.565
MOD_PKA_2	58	64	PF00069	0.682
MOD_PKA_2	717	723	PF00069	0.504
MOD_PKB_1	837	845	PF00069	0.395
MOD_Plk_1	146	152	PF00069	0.767
MOD_Plk_1	199	205	PF00069	0.435
MOD_Plk_1	236	242	PF00069	0.514
MOD_Plk_1	243	249	PF00069	0.509
MOD_Plk_1	86	92	PF00069	0.571
MOD_Plk_2-3	244	250	PF00069	0.530
MOD_Plk_2-3	399	405	PF00069	0.506
MOD_Plk_2-3	726	732	PF00069	0.465
MOD_Plk_2-3	750	756	PF00069	0.433
MOD_Plk_4	219	225	PF00069	0.510
MOD_Plk_4	244	250	PF00069	0.465
MOD_Plk_4	287	293	PF00069	0.404
MOD_Plk_4	65	71	PF00069	0.617
MOD_Plk_4	776	782	PF00069	0.427
MOD_Plk_4	839	845	PF00069	0.557
MOD_ProDKin_1	113	119	PF00069	0.487
MOD_ProDKin_1	155	161	PF00069	0.710
MOD_ProDKin_1	299	305	PF00069	0.462
MOD_ProDKin_1	421	427	PF00069	0.528
MOD_ProDKin_1	43	49	PF00069	0.570
MOD_ProDKin_1	486	492	PF00069	0.725
MOD_ProDKin_1	499	505	PF00069	0.608
MOD_ProDKin_1	633	639	PF00069	0.507
MOD_ProDKin_1	737	743	PF00069	0.254
MOD_ProDKin_1	76	82	PF00069	0.383
MOD_ProDKin_1	796	802	PF00069	0.592
MOD_ProDKin_1	809	815	PF00069	0.561
MOD_ProDKin_1	844	850	PF00069	0.543
MOD_ProDKin_1	889	895	PF00069	0.461
MOD_ProDKin_1	898	904	PF00069	0.452
MOD_ProDKin_1	912	918	PF00069	0.676
MOD_SUMO_for_1	126	129	PF00179	0.543
MOD_SUMO_for_1	371	374	PF00179	0.481
MOD_SUMO_rev_2	414	423	PF00179	0.553
TRG_DiLeu_BaEn_1	301	306	PF01217	0.530
TRG_DiLeu_BaEn_1	664	669	PF01217	0.465
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.511
TRG_ENDOCYTIC_2	458	461	PF00928	0.448
TRG_ENDOCYTIC_2	62	65	PF00928	0.560
TRG_ENDOCYTIC_2	638	641	PF00928	0.560
TRG_ENDOCYTIC_2	900	903	PF00928	0.452
TRG_ER_diArg_1	107	110	PF00400	0.536
TRG_ER_diArg_1	26	29	PF00400	0.603
TRG_ER_diArg_1	645	647	PF00400	0.490
TRG_ER_diArg_1	686	689	PF00400	0.426
TRG_ER_diArg_1	849	852	PF00400	0.453
TRG_ER_diArg_1	855	857	PF00400	0.445
TRG_ER_diArg_1	95	98	PF00400	0.553
TRG_NES_CRM1_1	453	465	PF08389	0.505
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I525	Leptomonas seymouri	64%	98%
A0A0S4JJP4	Bodo saltans	28%	100%
A0A1X0P5I8	Trypanosomatidae	41%	100%
A0A3S7X0L4	Leishmania donovani	86%	100%
A0A422N2Z0	Trypanosoma rangeli	42%	100%
A4I2Q4	Leishmania infantum	86%	100%
D0A5V6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AD80	Leishmania major	86%	100%
E9AZ04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5B8L6	Trypanosoma cruzi	41%	100%