Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFM5_LEIBR

TriTrypDb:

LbrM.27.1100 , LBRM2903_270016900

Length:

207

Annotations

LeishMANIAdb annotations

This small family of proteins is restricted to kinetoplastids only.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HFM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFM5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	199	201	PF00675	0.364
CLV_NRD_NRD_1	205	207	PF00675	0.402
CLV_PCSK_KEX2_1	140	142	PF00082	0.446
CLV_PCSK_KEX2_1	199	201	PF00082	0.387
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.443
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.401
CLV_PCSK_SKI1_1	201	205	PF00082	0.460
CLV_PCSK_SKI1_1	29	33	PF00082	0.497
CLV_PCSK_SKI1_1	45	49	PF00082	0.380
CLV_PCSK_SKI1_1	54	58	PF00082	0.365
DEG_COP1_1	143	153	PF00400	0.587
DEG_Nend_Nbox_1	1	3	PF02207	0.619
DOC_USP7_MATH_1	119	123	PF00917	0.624
DOC_USP7_UBL2_3	25	29	PF12436	0.661
DOC_USP7_UBL2_3	57	61	PF12436	0.577
LIG_14-3-3_CanoR_1	159	167	PF00244	0.564
LIG_14-3-3_CanoR_1	178	186	PF00244	0.691
LIG_14-3-3_CanoR_1	54	60	PF00244	0.561
LIG_14-3-3_CanoR_1	93	97	PF00244	0.304
LIG_FHA_1	144	150	PF00498	0.610
LIG_FHA_1	41	47	PF00498	0.536
LIG_FHA_2	168	174	PF00498	0.645
LIG_FHA_2	183	189	PF00498	0.682
LIG_FHA_2	30	36	PF00498	0.612
LIG_LIR_Gen_1	101	111	PF02991	0.286
LIG_LIR_Gen_1	60	70	PF02991	0.580
LIG_LIR_Nem_3	101	106	PF02991	0.283
LIG_LIR_Nem_3	60	65	PF02991	0.534
LIG_LIR_Nem_3	68	73	PF02991	0.461
LIG_LIR_Nem_3	95	100	PF02991	0.384
LIG_PCNA_yPIPBox_3	184	198	PF02747	0.561
LIG_Pex14_1	103	107	PF04695	0.335
LIG_Pex14_1	71	75	PF04695	0.300
LIG_Pex14_2	107	111	PF04695	0.335
LIG_Pex14_2	72	76	PF04695	0.404
LIG_PTB_Apo_2	64	71	PF02174	0.572
LIG_PTB_Phospho_1	64	70	PF10480	0.572
LIG_REV1ctd_RIR_1	94	102	PF16727	0.383
LIG_SH2_CRK	62	66	PF00017	0.533
LIG_SH2_STAP1	37	41	PF00017	0.629
LIG_SH2_STAT5	110	113	PF00017	0.289
LIG_SH2_STAT5	153	156	PF00017	0.571
LIG_SH2_STAT5	75	78	PF00017	0.430
LIG_SH3_3	166	172	PF00018	0.655
LIG_SH3_4	29	36	PF00018	0.607
LIG_TRFH_1	165	169	PF08558	0.546
MOD_CK1_1	9	15	PF00069	0.674
MOD_CK2_1	167	173	PF00069	0.644
MOD_CK2_1	29	35	PF00069	0.619
MOD_GlcNHglycan	100	103	PF01048	0.593
MOD_GlcNHglycan	17	20	PF01048	0.512
MOD_GSK3_1	11	18	PF00069	0.613
MOD_GSK3_1	98	105	PF00069	0.267
MOD_NEK2_1	11	16	PF00069	0.658
MOD_NEK2_1	48	53	PF00069	0.563
MOD_NEK2_1	80	85	PF00069	0.308
MOD_NEK2_2	102	107	PF00069	0.288
MOD_PIKK_1	127	133	PF00454	0.455
MOD_PIKK_1	158	164	PF00454	0.562
MOD_PIKK_1	29	35	PF00454	0.643
MOD_PKA_2	158	164	PF00069	0.562
MOD_PKA_2	92	98	PF00069	0.371
MOD_Plk_1	182	188	PF00069	0.655
MOD_Plk_4	119	125	PF00069	0.590
MOD_Plk_4	6	12	PF00069	0.647
MOD_SUMO_for_1	163	166	PF00179	0.554
MOD_SUMO_rev_2	135	142	PF00179	0.607
TRG_ENDOCYTIC_2	165	168	PF00928	0.583
TRG_ENDOCYTIC_2	62	65	PF00928	0.526
TRG_ENDOCYTIC_2	73	76	PF00928	0.254
TRG_ER_diArg_1	52	55	PF00400	0.548
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCX1	Leptomonas seymouri	70%	100%
A0A0S4JB41	Bodo saltans	39%	100%
A0A1X0P566	Trypanosomatidae	53%	100%
A0A3S7X0K5	Leishmania donovani	89%	100%
A0A422N2U5	Trypanosoma rangeli	55%	100%
A4I2Q3	Leishmania infantum	89%	100%
D0A5V5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AD79	Leishmania major	90%	100%
E9AZ03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%