LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Exocyst complex component Sec6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Exocyst complex component Sec6
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HFM4_LEIBR
TriTrypDb:
LbrM.27.1090 , LBRM2903_270016800 *
Length:
940

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0000145 exocyst 3 11
GO:0032991 protein-containing complex 1 11
GO:0099023 vesicle tethering complex 2 11
GO:0005737 cytoplasm 2 1
GO:0020016 ciliary pocket 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HFM4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFM4

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 11
GO:0006887 exocytosis 4 11
GO:0009987 cellular process 1 11
GO:0016192 vesicle-mediated transport 4 11
GO:0032940 secretion by cell 3 11
GO:0046903 secretion 4 11
GO:0051179 localization 1 11
GO:0051234 establishment of localization 2 11
GO:0140352 export from cell 2 11
GO:0031503 protein-containing complex localization 2 1
GO:0051601 exocyst localization 3 1
Molecular functions
Term Name Level Count
GO:0000149 SNARE binding 3 1
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 608 612 PF00656 0.731
CLV_NRD_NRD_1 106 108 PF00675 0.512
CLV_NRD_NRD_1 205 207 PF00675 0.455
CLV_NRD_NRD_1 212 214 PF00675 0.518
CLV_NRD_NRD_1 522 524 PF00675 0.488
CLV_NRD_NRD_1 568 570 PF00675 0.428
CLV_NRD_NRD_1 700 702 PF00675 0.327
CLV_NRD_NRD_1 772 774 PF00675 0.236
CLV_NRD_NRD_1 906 908 PF00675 0.555
CLV_PCSK_KEX2_1 106 108 PF00082 0.529
CLV_PCSK_KEX2_1 212 214 PF00082 0.487
CLV_PCSK_KEX2_1 568 570 PF00082 0.405
CLV_PCSK_KEX2_1 772 774 PF00082 0.249
CLV_PCSK_KEX2_1 785 787 PF00082 0.250
CLV_PCSK_KEX2_1 841 843 PF00082 0.313
CLV_PCSK_KEX2_1 883 885 PF00082 0.547
CLV_PCSK_KEX2_1 899 901 PF00082 0.458
CLV_PCSK_KEX2_1 906 908 PF00082 0.557
CLV_PCSK_PC1ET2_1 785 787 PF00082 0.205
CLV_PCSK_PC1ET2_1 841 843 PF00082 0.367
CLV_PCSK_PC1ET2_1 883 885 PF00082 0.500
CLV_PCSK_PC1ET2_1 899 901 PF00082 0.493
CLV_PCSK_SKI1_1 138 142 PF00082 0.484
CLV_PCSK_SKI1_1 3 7 PF00082 0.792
CLV_PCSK_SKI1_1 568 572 PF00082 0.407
CLV_PCSK_SKI1_1 638 642 PF00082 0.424
CLV_PCSK_SKI1_1 701 705 PF00082 0.298
CLV_PCSK_SKI1_1 772 776 PF00082 0.289
CLV_PCSK_SKI1_1 779 783 PF00082 0.302
CLV_PCSK_SKI1_1 896 900 PF00082 0.553
DEG_APCC_DBOX_1 771 779 PF00400 0.449
DEG_APCC_DBOX_1 825 833 PF00400 0.556
DOC_CKS1_1 920 925 PF01111 0.701
DOC_CYCLIN_RxL_1 203 214 PF00134 0.478
DOC_CYCLIN_RxL_1 773 783 PF00134 0.557
DOC_MAPK_gen_1 106 114 PF00069 0.397
DOC_MAPK_gen_1 182 191 PF00069 0.412
DOC_MAPK_gen_1 250 259 PF00069 0.535
DOC_MAPK_gen_1 470 479 PF00069 0.452
DOC_MAPK_gen_1 699 709 PF00069 0.562
DOC_MAPK_MEF2A_6 185 193 PF00069 0.450
DOC_MAPK_MEF2A_6 236 243 PF00069 0.471
DOC_MAPK_MEF2A_6 253 261 PF00069 0.470
DOC_MAPK_MEF2A_6 747 755 PF00069 0.534
DOC_PP1_RVXF_1 784 791 PF00149 0.492
DOC_PP2B_LxvP_1 916 919 PF13499 0.640
DOC_USP7_MATH_1 108 112 PF00917 0.509
DOC_USP7_MATH_1 273 277 PF00917 0.699
DOC_USP7_MATH_1 295 299 PF00917 0.560
DOC_USP7_MATH_1 304 308 PF00917 0.400
DOC_USP7_UBL2_3 66 70 PF12436 0.645
DOC_USP7_UBL2_3 841 845 PF12436 0.586
DOC_WW_Pin1_4 309 314 PF00397 0.433
DOC_WW_Pin1_4 555 560 PF00397 0.524
DOC_WW_Pin1_4 624 629 PF00397 0.522
DOC_WW_Pin1_4 726 731 PF00397 0.405
DOC_WW_Pin1_4 919 924 PF00397 0.689
LIG_14-3-3_CanoR_1 212 216 PF00244 0.407
LIG_14-3-3_CanoR_1 222 227 PF00244 0.468
LIG_14-3-3_CanoR_1 836 840 PF00244 0.542
LIG_Actin_RPEL_3 192 211 PF02755 0.550
LIG_Actin_WH2_2 130 145 PF00022 0.582
LIG_Actin_WH2_2 167 184 PF00022 0.441
LIG_Actin_WH2_2 580 595 PF00022 0.443
LIG_Actin_WH2_2 625 640 PF00022 0.326
LIG_AP2alpha_2 355 357 PF02296 0.492
LIG_APCC_ABBA_1 230 235 PF00400 0.455
LIG_APCC_ABBA_1 360 365 PF00400 0.536
LIG_BIR_II_1 1 5 PF00653 0.768
LIG_BRCT_BRCA1_1 110 114 PF00533 0.395
LIG_BRCT_BRCA1_1 452 456 PF00533 0.543
LIG_BRCT_BRCA1_1 625 629 PF00533 0.593
LIG_BRCT_BRCA1_1 872 876 PF00533 0.620
LIG_BRCT_BRCA1_2 625 631 PF00533 0.622
LIG_CaM_IQ_9 205 220 PF13499 0.490
LIG_deltaCOP1_diTrp_1 563 572 PF00928 0.418
LIG_deltaCOP1_diTrp_1 656 663 PF00928 0.449
LIG_eIF4E_1 52 58 PF01652 0.556
LIG_FHA_1 10 16 PF00498 0.752
LIG_FHA_1 456 462 PF00498 0.466
LIG_FHA_1 495 501 PF00498 0.499
LIG_FHA_1 587 593 PF00498 0.453
LIG_FHA_1 671 677 PF00498 0.495
LIG_FHA_1 77 83 PF00498 0.611
LIG_FHA_1 805 811 PF00498 0.499
LIG_FHA_1 912 918 PF00498 0.726
LIG_FHA_2 174 180 PF00498 0.325
LIG_FHA_2 412 418 PF00498 0.511
LIG_FHA_2 51 57 PF00498 0.540
LIG_FHA_2 513 519 PF00498 0.547
LIG_FHA_2 680 686 PF00498 0.482
LIG_FHA_2 716 722 PF00498 0.511
LIG_FHA_2 83 89 PF00498 0.628
LIG_LIR_Gen_1 111 120 PF02991 0.393
LIG_LIR_Gen_1 200 210 PF02991 0.351
LIG_LIR_Gen_1 225 234 PF02991 0.460
LIG_LIR_Gen_1 294 304 PF02991 0.475
LIG_LIR_Gen_1 331 342 PF02991 0.510
LIG_LIR_Gen_1 501 510 PF02991 0.432
LIG_LIR_Gen_1 626 637 PF02991 0.390
LIG_LIR_Gen_1 656 663 PF02991 0.479
LIG_LIR_Gen_1 688 695 PF02991 0.534
LIG_LIR_Gen_1 737 745 PF02991 0.514
LIG_LIR_LC3C_4 392 395 PF02991 0.469
LIG_LIR_Nem_3 111 117 PF02991 0.417
LIG_LIR_Nem_3 155 161 PF02991 0.496
LIG_LIR_Nem_3 183 189 PF02991 0.459
LIG_LIR_Nem_3 200 205 PF02991 0.318
LIG_LIR_Nem_3 225 229 PF02991 0.479
LIG_LIR_Nem_3 231 237 PF02991 0.398
LIG_LIR_Nem_3 247 252 PF02991 0.454
LIG_LIR_Nem_3 294 299 PF02991 0.561
LIG_LIR_Nem_3 354 360 PF02991 0.533
LIG_LIR_Nem_3 437 443 PF02991 0.425
LIG_LIR_Nem_3 501 506 PF02991 0.416
LIG_LIR_Nem_3 626 632 PF02991 0.524
LIG_LIR_Nem_3 639 644 PF02991 0.402
LIG_LIR_Nem_3 656 662 PF02991 0.272
LIG_LIR_Nem_3 737 741 PF02991 0.497
LIG_LIR_Nem_3 789 793 PF02991 0.461
LIG_MLH1_MIPbox_1 872 876 PF16413 0.657
LIG_PCNA_yPIPBox_3 327 339 PF02747 0.306
LIG_PCNA_yPIPBox_3 699 713 PF02747 0.405
LIG_Pex14_1 659 663 PF04695 0.335
LIG_Pex14_2 226 230 PF04695 0.470
LIG_Pex14_2 572 576 PF04695 0.355
LIG_Pex14_2 594 598 PF04695 0.447
LIG_Pex14_2 808 812 PF04695 0.496
LIG_PTB_Apo_2 243 250 PF02174 0.531
LIG_PTB_Phospho_1 243 249 PF10480 0.528
LIG_REV1ctd_RIR_1 873 882 PF16727 0.568
LIG_RPA_C_Fungi 901 913 PF08784 0.630
LIG_SH2_CRK 131 135 PF00017 0.582
LIG_SH2_CRK 186 190 PF00017 0.539
LIG_SH2_CRK 202 206 PF00017 0.333
LIG_SH2_CRK 249 253 PF00017 0.525
LIG_SH2_GRB2like 600 603 PF00017 0.623
LIG_SH2_GRB2like 715 718 PF00017 0.480
LIG_SH2_NCK_1 669 673 PF00017 0.480
LIG_SH2_PTP2 190 193 PF00017 0.433
LIG_SH2_PTP2 443 446 PF00017 0.342
LIG_SH2_SRC 600 603 PF00017 0.495
LIG_SH2_STAP1 334 338 PF00017 0.484
LIG_SH2_STAP1 440 444 PF00017 0.423
LIG_SH2_STAT3 363 366 PF00017 0.447
LIG_SH2_STAT3 792 795 PF00017 0.447
LIG_SH2_STAT5 190 193 PF00017 0.351
LIG_SH2_STAT5 233 236 PF00017 0.405
LIG_SH2_STAT5 363 366 PF00017 0.405
LIG_SH2_STAT5 443 446 PF00017 0.388
LIG_SH2_STAT5 52 55 PF00017 0.538
LIG_SH2_STAT5 536 539 PF00017 0.374
LIG_SH2_STAT5 60 63 PF00017 0.534
LIG_SH2_STAT5 643 646 PF00017 0.360
LIG_SH2_STAT5 669 672 PF00017 0.383
LIG_SH2_STAT5 686 689 PF00017 0.480
LIG_SH2_STAT5 715 718 PF00017 0.342
LIG_SH2_STAT5 792 795 PF00017 0.428
LIG_SH3_3 226 232 PF00018 0.490
LIG_SH3_3 350 356 PF00018 0.437
LIG_SH3_3 480 486 PF00018 0.462
LIG_SH3_3 781 787 PF00018 0.355
LIG_SH3_3 86 92 PF00018 0.520
LIG_SUMO_SIM_anti_2 235 242 PF11976 0.514
LIG_SUMO_SIM_anti_2 518 523 PF11976 0.568
LIG_SUMO_SIM_par_1 496 504 PF11976 0.561
LIG_SUMO_SIM_par_1 931 937 PF11976 0.517
LIG_TRAF2_1 53 56 PF00917 0.563
LIG_TRAF2_1 561 564 PF00917 0.565
LIG_TRAF2_1 62 65 PF00917 0.553
LIG_TYR_ITAM 183 205 PF00017 0.529
LIG_TYR_ITIM 156 161 PF00017 0.589
LIG_TYR_ITIM 184 189 PF00017 0.541
LIG_UBA3_1 381 387 PF00899 0.507
LIG_UBA3_1 57 66 PF00899 0.654
LIG_UBA3_1 916 924 PF00899 0.501
LIG_WRC_WIRS_1 223 228 PF05994 0.578
MOD_CDC14_SPxK_1 729 732 PF00782 0.227
MOD_CDK_SPK_2 726 731 PF00069 0.227
MOD_CDK_SPK_2 919 924 PF00069 0.718
MOD_CDK_SPxK_1 726 732 PF00069 0.227
MOD_CDK_SPxxK_3 624 631 PF00069 0.566
MOD_CK1_1 173 179 PF00069 0.403
MOD_CK1_1 25 31 PF00069 0.694
MOD_CK1_1 276 282 PF00069 0.514
MOD_CK1_1 455 461 PF00069 0.496
MOD_CK1_1 555 561 PF00069 0.521
MOD_CK1_1 603 609 PF00069 0.631
MOD_CK1_1 76 82 PF00069 0.609
MOD_CK2_1 173 179 PF00069 0.403
MOD_CK2_1 409 415 PF00069 0.391
MOD_CK2_1 50 56 PF00069 0.535
MOD_CK2_1 578 584 PF00069 0.379
MOD_CK2_1 59 65 PF00069 0.507
MOD_CK2_1 679 685 PF00069 0.480
MOD_CK2_1 715 721 PF00069 0.373
MOD_CK2_1 82 88 PF00069 0.622
MOD_CK2_1 862 868 PF00069 0.543
MOD_GlcNHglycan 16 19 PF01048 0.748
MOD_GlcNHglycan 24 27 PF01048 0.719
MOD_GlcNHglycan 275 278 PF01048 0.746
MOD_GlcNHglycan 334 337 PF01048 0.530
MOD_GlcNHglycan 411 414 PF01048 0.600
MOD_GlcNHglycan 445 449 PF01048 0.459
MOD_GlcNHglycan 450 455 PF01048 0.420
MOD_GlcNHglycan 464 467 PF01048 0.468
MOD_GlcNHglycan 490 493 PF01048 0.522
MOD_GlcNHglycan 533 536 PF01048 0.511
MOD_GlcNHglycan 601 605 PF01048 0.641
MOD_GlcNHglycan 613 616 PF01048 0.775
MOD_GlcNHglycan 872 875 PF01048 0.621
MOD_GlcNHglycan 895 899 PF01048 0.644
MOD_GSK3_1 10 17 PF00069 0.754
MOD_GSK3_1 108 115 PF00069 0.522
MOD_GSK3_1 169 176 PF00069 0.461
MOD_GSK3_1 21 28 PF00069 0.714
MOD_GSK3_1 31 38 PF00069 0.674
MOD_GSK3_1 446 453 PF00069 0.367
MOD_GSK3_1 462 469 PF00069 0.498
MOD_GSK3_1 484 491 PF00069 0.529
MOD_GSK3_1 513 520 PF00069 0.520
MOD_GSK3_1 578 585 PF00069 0.497
MOD_GSK3_1 697 704 PF00069 0.442
MOD_GSK3_1 754 761 PF00069 0.330
MOD_GSK3_1 846 853 PF00069 0.595
MOD_N-GLC_1 169 174 PF02516 0.561
MOD_N-GLC_1 513 518 PF02516 0.460
MOD_N-GLC_1 552 557 PF02516 0.538
MOD_N-GLC_1 99 104 PF02516 0.619
MOD_N-GLC_2 578 580 PF02516 0.378
MOD_NEK2_1 1 6 PF00069 0.763
MOD_NEK2_1 197 202 PF00069 0.440
MOD_NEK2_1 37 42 PF00069 0.618
MOD_NEK2_1 377 382 PF00069 0.424
MOD_NEK2_1 409 414 PF00069 0.541
MOD_NEK2_1 434 439 PF00069 0.515
MOD_NEK2_1 452 457 PF00069 0.505
MOD_NEK2_1 506 511 PF00069 0.444
MOD_NEK2_1 749 754 PF00069 0.475
MOD_NEK2_1 87 92 PF00069 0.542
MOD_NEK2_1 876 881 PF00069 0.606
MOD_NEK2_1 94 99 PF00069 0.550
MOD_NEK2_2 295 300 PF00069 0.449
MOD_NEK2_2 358 363 PF00069 0.517
MOD_PIKK_1 112 118 PF00454 0.495
MOD_PIKK_1 323 329 PF00454 0.604
MOD_PIKK_1 815 821 PF00454 0.480
MOD_PIKK_1 850 856 PF00454 0.582
MOD_PKA_1 701 707 PF00069 0.479
MOD_PKA_1 731 737 PF00069 0.480
MOD_PKA_2 10 16 PF00069 0.750
MOD_PKA_2 211 217 PF00069 0.412
MOD_PKA_2 835 841 PF00069 0.349
MOD_PKA_2 877 883 PF00069 0.552
MOD_PKB_1 699 707 PF00069 0.447
MOD_Plk_1 169 175 PF00069 0.526
MOD_Plk_1 377 383 PF00069 0.431
MOD_Plk_1 422 428 PF00069 0.491
MOD_Plk_1 513 519 PF00069 0.608
MOD_Plk_1 552 558 PF00069 0.596
MOD_Plk_1 578 584 PF00069 0.393
MOD_Plk_1 749 755 PF00069 0.432
MOD_Plk_1 834 840 PF00069 0.447
MOD_Plk_1 862 868 PF00069 0.474
MOD_Plk_1 87 93 PF00069 0.543
MOD_Plk_2-3 579 585 PF00069 0.412
MOD_Plk_2-3 931 937 PF00069 0.669
MOD_Plk_4 170 176 PF00069 0.459
MOD_Plk_4 239 245 PF00069 0.395
MOD_Plk_4 377 383 PF00069 0.508
MOD_Plk_4 422 428 PF00069 0.518
MOD_Plk_4 452 458 PF00069 0.533
MOD_Plk_4 484 490 PF00069 0.574
MOD_Plk_4 517 523 PF00069 0.559
MOD_Plk_4 690 696 PF00069 0.447
MOD_Plk_4 715 721 PF00069 0.368
MOD_Plk_4 734 740 PF00069 0.319
MOD_Plk_4 804 810 PF00069 0.331
MOD_Plk_4 854 860 PF00069 0.434
MOD_ProDKin_1 309 315 PF00069 0.431
MOD_ProDKin_1 555 561 PF00069 0.521
MOD_ProDKin_1 624 630 PF00069 0.517
MOD_ProDKin_1 726 732 PF00069 0.227
MOD_ProDKin_1 919 925 PF00069 0.686
MOD_SUMO_for_1 69 72 PF00179 0.658
MOD_SUMO_rev_2 481 486 PF00179 0.468
MOD_SUMO_rev_2 585 595 PF00179 0.466
MOD_SUMO_rev_2 606 615 PF00179 0.764
MOD_SUMO_rev_2 62 68 PF00179 0.603
TRG_DiLeu_BaEn_1 254 259 PF01217 0.383
TRG_DiLeu_BaEn_1 417 422 PF01217 0.487
TRG_DiLeu_BaEn_1 423 428 PF01217 0.440
TRG_DiLeu_BaEn_2 246 252 PF01217 0.273
TRG_DiLeu_BaEn_3 689 695 PF01217 0.447
TRG_DiLeu_BaEn_4 64 70 PF01217 0.611
TRG_DiLeu_BaLyEn_6 369 374 PF01217 0.436
TRG_DiLeu_BaLyEn_6 763 768 PF01217 0.441
TRG_DiLeu_BaLyEn_6 90 95 PF01217 0.508
TRG_ENDOCYTIC_2 131 134 PF00928 0.584
TRG_ENDOCYTIC_2 158 161 PF00928 0.469
TRG_ENDOCYTIC_2 186 189 PF00928 0.463
TRG_ENDOCYTIC_2 190 193 PF00928 0.428
TRG_ENDOCYTIC_2 202 205 PF00928 0.341
TRG_ENDOCYTIC_2 223 226 PF00928 0.545
TRG_ENDOCYTIC_2 249 252 PF00928 0.416
TRG_ENDOCYTIC_2 334 337 PF00928 0.463
TRG_ENDOCYTIC_2 431 434 PF00928 0.409
TRG_ENDOCYTIC_2 443 446 PF00928 0.379
TRG_ER_diArg_1 105 107 PF00400 0.533
TRG_ER_diArg_1 211 213 PF00400 0.491
TRG_ER_diArg_1 568 570 PF00400 0.430
TRG_NES_CRM1_1 235 247 PF08389 0.470
TRG_NES_CRM1_1 72 86 PF08389 0.618
TRG_NLS_MonoCore_2 880 885 PF00514 0.514
TRG_NLS_MonoExtC_3 881 887 PF00514 0.489
TRG_NLS_MonoExtN_4 878 885 PF00514 0.493
TRG_Pf-PMV_PEXEL_1 250 254 PF00026 0.433
TRG_Pf-PMV_PEXEL_1 263 267 PF00026 0.533
TRG_Pf-PMV_PEXEL_1 701 706 PF00026 0.402
TRG_Pf-PMV_PEXEL_1 864 868 PF00026 0.479

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HY82 Leptomonas seymouri 70% 98%
A0A0S4JGX2 Bodo saltans 35% 100%
A0A1X0P4D3 Trypanosomatidae 50% 100%
A0A3Q8IE79 Leishmania donovani 85% 100%
A0A3R7M5J1 Trypanosoma rangeli 49% 100%
A4I2Q2 Leishmania infantum 85% 100%
D0A5V4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9AD78 Leishmania major 84% 99%
E9AZ02 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS