Deoxyribonuclease Tat-D

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TatD related DNase, putative

Species:

Leishmania braziliensis

UniProt:

A4HFM3_LEIBR

TriTrypDb:

LbrM.27.1080 , LBRM2903_270016700

Length:

379

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFM3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0004518	nuclease activity	4	1
GO:0004527	exonuclease activity	5	1
GO:0004529	DNA exonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0008296	3'-5'-DNA exonuclease activity	7	1
GO:0008408	3'-5' exonuclease activity	6	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	328	330	PF00675	0.221
CLV_NRD_NRD_1	73	75	PF00675	0.235
CLV_NRD_NRD_1	78	80	PF00675	0.235
CLV_PCSK_KEX2_1	315	317	PF00082	0.253
CLV_PCSK_KEX2_1	328	330	PF00082	0.221
CLV_PCSK_KEX2_1	374	376	PF00082	0.329
CLV_PCSK_KEX2_1	73	75	PF00082	0.235
CLV_PCSK_KEX2_1	78	80	PF00082	0.235
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.278
CLV_PCSK_PC1ET2_1	374	376	PF00082	0.258
CLV_PCSK_PC7_1	74	80	PF00082	0.315
CLV_PCSK_SKI1_1	179	183	PF00082	0.314
CLV_PCSK_SKI1_1	285	289	PF00082	0.221
CLV_PCSK_SKI1_1	308	312	PF00082	0.325
CLV_PCSK_SKI1_1	374	378	PF00082	0.258
CLV_PCSK_SKI1_1	78	82	PF00082	0.346
DEG_APCC_DBOX_1	77	85	PF00400	0.476
DEG_Nend_Nbox_1	1	3	PF02207	0.388
DOC_CKS1_1	7	12	PF01111	0.419
DOC_CYCLIN_RxL_1	90	102	PF00134	0.363
DOC_CYCLIN_yCln2_LP_2	187	193	PF00134	0.435
DOC_MAPK_gen_1	147	155	PF00069	0.393
DOC_MAPK_gen_1	78	86	PF00069	0.491
DOC_MAPK_MEF2A_6	147	155	PF00069	0.515
DOC_PP1_RVXF_1	283	289	PF00149	0.458
DOC_PP2B_LxvP_1	187	190	PF13499	0.435
DOC_PP4_FxxP_1	94	97	PF00568	0.453
DOC_USP7_MATH_1	122	126	PF00917	0.471
DOC_USP7_MATH_1	230	234	PF00917	0.495
DOC_WW_Pin1_4	228	233	PF00397	0.571
DOC_WW_Pin1_4	6	11	PF00397	0.566
LIG_14-3-3_CanoR_1	179	187	PF00244	0.448
LIG_14-3-3_CanoR_1	79	85	PF00244	0.480
LIG_deltaCOP1_diTrp_1	291	299	PF00928	0.363
LIG_eIF4E_1	75	81	PF01652	0.476
LIG_FHA_1	109	115	PF00498	0.431
LIG_FHA_1	19	25	PF00498	0.432
LIG_FHA_1	218	224	PF00498	0.510
LIG_FHA_1	81	87	PF00498	0.431
LIG_FHA_2	246	252	PF00498	0.517
LIG_FHA_2	322	328	PF00498	0.363
LIG_FHA_2	349	355	PF00498	0.482
LIG_LIR_Apic_2	93	97	PF02991	0.457
LIG_LIR_Gen_1	161	169	PF02991	0.433
LIG_LIR_Gen_1	208	218	PF02991	0.482
LIG_LIR_Gen_1	291	302	PF02991	0.450
LIG_LIR_Gen_1	37	47	PF02991	0.423
LIG_LIR_Nem_3	161	165	PF02991	0.428
LIG_LIR_Nem_3	182	187	PF02991	0.531
LIG_LIR_Nem_3	208	213	PF02991	0.482
LIG_LIR_Nem_3	296	302	PF02991	0.447
LIG_LIR_Nem_3	37	43	PF02991	0.454
LIG_LRP6_Inhibitor_1	98	104	PF00058	0.163
LIG_PDZ_Class_2	374	379	PF00595	0.453
LIG_SH2_GRB2like	370	373	PF00017	0.453
LIG_SH2_STAT3	302	305	PF00017	0.515
LIG_SH2_STAT5	12	15	PF00017	0.327
LIG_SH2_STAT5	140	143	PF00017	0.489
LIG_SH2_STAT5	176	179	PF00017	0.440
LIG_SH2_STAT5	261	264	PF00017	0.421
LIG_SH2_STAT5	342	345	PF00017	0.435
LIG_SH3_3	350	356	PF00018	0.473
LIG_SUMO_SIM_anti_2	253	259	PF11976	0.363
LIG_SUMO_SIM_par_1	150	157	PF11976	0.411
LIG_SUMO_SIM_par_1	96	102	PF11976	0.363
LIG_TRAF2_1	127	130	PF00917	0.432
LIG_TRAF2_1	248	251	PF00917	0.421
LIG_TYR_ITIM	160	165	PF00017	0.427
LIG_WRC_WIRS_1	242	247	PF05994	0.453
MOD_CK1_1	109	115	PF00069	0.524
MOD_CK2_1	122	128	PF00069	0.386
MOD_CK2_1	245	251	PF00069	0.437
MOD_CK2_1	321	327	PF00069	0.363
MOD_CK2_1	348	354	PF00069	0.458
MOD_GlcNHglycan	120	123	PF01048	0.297
MOD_GlcNHglycan	266	269	PF01048	0.228
MOD_GSK3_1	118	125	PF00069	0.564
MOD_GSK3_1	241	248	PF00069	0.436
MOD_GSK3_1	260	267	PF00069	0.339
MOD_GSK3_1	306	313	PF00069	0.435
MOD_GSK3_1	58	65	PF00069	0.515
MOD_N-GLC_1	118	123	PF02516	0.263
MOD_N-GLC_1	18	23	PF02516	0.221
MOD_N-GLC_1	245	250	PF02516	0.235
MOD_N-GLC_1	264	269	PF02516	0.129
MOD_NEK2_1	192	197	PF00069	0.463
MOD_NEK2_1	260	265	PF00069	0.463
MOD_NEK2_1	306	311	PF00069	0.421
MOD_NEK2_1	62	67	PF00069	0.507
MOD_NEK2_1	80	85	PF00069	0.421
MOD_Plk_1	109	115	PF00069	0.399
MOD_Plk_1	264	270	PF00069	0.515
MOD_Plk_1	361	367	PF00069	0.500
MOD_Plk_4	109	115	PF00069	0.525
MOD_Plk_4	198	204	PF00069	0.483
MOD_Plk_4	361	367	PF00069	0.475
MOD_ProDKin_1	228	234	PF00069	0.571
MOD_ProDKin_1	6	12	PF00069	0.556
TRG_DiLeu_BaEn_1	251	256	PF01217	0.435
TRG_DiLeu_BaEn_1	331	336	PF01217	0.478
TRG_DiLeu_BaLyEn_6	76	81	PF01217	0.476
TRG_ENDOCYTIC_2	162	165	PF00928	0.417
TRG_ENDOCYTIC_2	261	264	PF00928	0.421
TRG_ER_diArg_1	73	75	PF00400	0.435
TRG_ER_diArg_1	78	80	PF00400	0.435
TRG_NLS_MonoExtC_3	314	319	PF00514	0.515
TRG_NLS_MonoExtN_4	312	319	PF00514	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Q2	Leptomonas seymouri	31%	100%
A0A0N1IL51	Leptomonas seymouri	66%	100%
A0A0S4IY84	Bodo saltans	30%	100%
A0A0S4JNN8	Bodo saltans	45%	100%
A0A1X0NWJ2	Trypanosomatidae	31%	100%
A0A1X0P426	Trypanosomatidae	47%	97%
A0A3R7K0P4	Trypanosoma rangeli	50%	100%
A0A3R7LLG2	Trypanosoma rangeli	31%	100%
A0A3S5H6J9	Leishmania donovani	30%	100%
A0A3S7X0L2	Leishmania donovani	83%	100%
A1A4M4	Bos taurus	22%	100%
A4H6P9	Leishmania braziliensis	31%	87%
A4HV34	Leishmania infantum	30%	100%
A4I2Q1	Leishmania infantum	83%	100%
A4WFX9	Enterobacter sp. (strain 638)	27%	100%
A7MQN1	Cronobacter sakazakii (strain ATCC BAA-894)	28%	100%
A8ACY8	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	26%	100%
A8G8C4	Serratia proteamaculans (strain 568)	28%	100%
B1JP69	Yersinia pseudotuberculosis serotype O:3 (strain YPIII)	26%	100%
B2VG45	Erwinia tasmaniensis (strain DSM 17950 / CFBP 7177 / CIP 109463 / NCPPB 4357 / Et1/99)	27%	100%
B7LTZ5	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	26%	100%
B7XJI2	Enterocytozoon bieneusi (strain H348)	23%	100%
C6C4V4	Musicola paradisiaca (strain Ech703)	25%	100%
C6DI71	Pectobacterium carotovorum subsp. carotovorum (strain PC1)	25%	100%
C9XTA5	Cronobacter turicensis (strain DSM 18703 / CCUG 55852 / LMG 23827 / z3032)	28%	100%
D0A5V3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	99%
D0A7B6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D0KC77	Pectobacterium parmentieri (strain WPP163)	26%	100%
D0Z9R0	Edwardsiella tarda (strain EIB202)	28%	100%
D2TUZ4	Citrobacter rodentium (strain ICC168)	26%	100%
D4GGR2	Pantoea ananatis (strain LMG 20103)	25%	100%
D4ICL5	Erwinia amylovora (strain ATCC 49946 / CCPPB 0273 / Ea273 / 27-3)	26%	100%
D8MKW4	Erwinia billingiae (strain Eb661)	27%	100%
E0SLH6	Dickeya dadantii (strain 3937)	25%	100%
E1SKR8	Pantoea vagans (strain C9-1)	26%	100%
E3G381	Enterobacter lignolyticus (strain SCF1)	25%	100%
E6WHK1	Pantoea sp. (strain At-9b)	26%	100%
E8XYF5	Rahnella sp. (strain Y9602)	27%	100%
E9AD77	Leishmania major	83%	100%
E9ANR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AZ01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
P27859	Escherichia coli (strain K12)	25%	100%
P34220	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	91%
P37545	Bacillus subtilis (strain 168)	22%	100%
P57436	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	21%	100%
Q0SZ31	Shigella flexneri serotype 5b (strain 8401)	25%	100%
Q148G4	Bos taurus	31%	100%
Q17R31	Homo sapiens	22%	100%
Q4QGV4	Leishmania major	30%	100%
Q640V9	Xenopus laevis	33%	100%
Q6DAQ1	Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)	25%	100%
Q6GML7	Danio rerio	31%	100%
Q6P1N9	Homo sapiens	31%	100%
Q6P8M1	Mus musculus	32%	100%
Q89AG7	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	20%	100%
Q8SW70	Encephalitozoon cuniculi (strain GB-M1)	25%	100%
Q9L6M2	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	27%	100%
Q9UUF1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
V5BRW2	Trypanosoma cruzi	30%	100%