Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFM2_LEIBR

TriTrypDb:

LbrM.27.1070 , LBRM2903_270016600

Length:

281

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFM2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	253	255	PF00675	0.707
CLV_NRD_NRD_1	259	261	PF00675	0.709
CLV_NRD_NRD_1	35	37	PF00675	0.614
CLV_NRD_NRD_1	4	6	PF00675	0.553
CLV_PCSK_KEX2_1	253	255	PF00082	0.707
CLV_PCSK_KEX2_1	33	35	PF00082	0.614
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.569
CLV_PCSK_SKI1_1	36	40	PF00082	0.622
CLV_PCSK_SKI1_1	87	91	PF00082	0.516
DEG_COP1_1	264	273	PF00400	0.630
DEG_MDM2_SWIB_1	160	168	PF02201	0.566
DEG_Nend_UBRbox_1	1	4	PF02207	0.667
DEG_SPOP_SBC_1	117	121	PF00917	0.700
DEG_SPOP_SBC_1	197	201	PF00917	0.517
DEG_SPOP_SBC_1	222	226	PF00917	0.575
DOC_AGCK_PIF_2	68	73	PF00069	0.623
DOC_MAPK_gen_1	34	45	PF00069	0.659
DOC_MAPK_MEF2A_6	103	110	PF00069	0.514
DOC_MAPK_MEF2A_6	39	47	PF00069	0.648
DOC_PP2B_LxvP_1	135	138	PF13499	0.391
DOC_USP7_MATH_1	117	121	PF00917	0.695
DOC_USP7_MATH_1	18	22	PF00917	0.674
DOC_USP7_MATH_1	197	201	PF00917	0.753
DOC_USP7_MATH_1	202	206	PF00917	0.772
DOC_USP7_MATH_1	222	226	PF00917	0.673
DOC_USP7_MATH_1	235	239	PF00917	0.647
DOC_USP7_MATH_1	88	92	PF00917	0.769
DOC_USP7_UBL2_3	2	6	PF12436	0.529
DOC_WW_Pin1_4	127	132	PF00397	0.592
DOC_WW_Pin1_4	142	147	PF00397	0.531
DOC_WW_Pin1_4	151	156	PF00397	0.670
DOC_WW_Pin1_4	207	212	PF00397	0.720
DOC_WW_Pin1_4	228	233	PF00397	0.715
LIG_14-3-3_CanoR_1	25	32	PF00244	0.685
LIG_14-3-3_CanoR_1	260	266	PF00244	0.549
LIG_14-3-3_CanoR_1	87	95	PF00244	0.521
LIG_FHA_1	143	149	PF00498	0.628
LIG_FHA_1	163	169	PF00498	0.548
LIG_FHA_1	239	245	PF00498	0.768
LIG_FHA_1	26	32	PF00498	0.634
LIG_FHA_1	53	59	PF00498	0.574
LIG_FHA_1	61	67	PF00498	0.518
LIG_FHA_2	152	158	PF00498	0.600
LIG_FHA_2	246	252	PF00498	0.627
LIG_GBD_Chelix_1	236	244	PF00786	0.768
LIG_LIR_Gen_1	161	172	PF02991	0.617
LIG_LIR_Gen_1	264	273	PF02991	0.687
LIG_LIR_Nem_3	161	167	PF02991	0.587
LIG_LIR_Nem_3	264	268	PF02991	0.656
LIG_LIR_Nem_3	72	77	PF02991	0.709
LIG_NRP_CendR_1	279	281	PF00754	0.678
LIG_Pex14_2	160	164	PF04695	0.515
LIG_REV1ctd_RIR_1	71	79	PF16727	0.561
LIG_SH2_NCK_1	265	269	PF00017	0.642
LIG_SH3_3	229	235	PF00018	0.708
LIG_SH3_3	40	46	PF00018	0.593
LIG_SH3_3	63	69	PF00018	0.551
LIG_SUMO_SIM_anti_2	272	278	PF11976	0.626
LIG_TRAF2_1	249	252	PF00917	0.699
MOD_CK1_1	183	189	PF00069	0.715
MOD_CK1_1	226	232	PF00069	0.730
MOD_CK1_1	238	244	PF00069	0.748
MOD_CK1_1	27	33	PF00069	0.705
MOD_CK2_1	151	157	PF00069	0.599
MOD_CK2_1	245	251	PF00069	0.701
MOD_CK2_1	47	53	PF00069	0.565
MOD_GlcNHglycan	200	203	PF01048	0.657
MOD_GlcNHglycan	271	274	PF01048	0.663
MOD_GlcNHglycan	97	100	PF01048	0.722
MOD_GSK3_1	13	20	PF00069	0.787
MOD_GSK3_1	180	187	PF00069	0.626
MOD_GSK3_1	198	205	PF00069	0.657
MOD_GSK3_1	217	224	PF00069	0.486
MOD_LATS_1	23	29	PF00433	0.546
MOD_N-GLC_1	25	30	PF02516	0.738
MOD_NEK2_1	198	203	PF00069	0.747
MOD_NEK2_1	24	29	PF00069	0.544
MOD_NEK2_1	240	245	PF00069	0.777
MOD_NEK2_1	47	52	PF00069	0.684
MOD_PIKK_1	223	229	PF00454	0.791
MOD_PKA_2	24	30	PF00069	0.800
MOD_Plk_4	235	241	PF00069	0.651
MOD_Plk_4	47	53	PF00069	0.545
MOD_Plk_4	60	66	PF00069	0.495
MOD_ProDKin_1	127	133	PF00069	0.580
MOD_ProDKin_1	142	148	PF00069	0.525
MOD_ProDKin_1	151	157	PF00069	0.669
MOD_ProDKin_1	207	213	PF00069	0.718
MOD_ProDKin_1	228	234	PF00069	0.715
MOD_SUMO_rev_2	4	11	PF00179	0.622
TRG_DiLeu_BaEn_2	131	137	PF01217	0.611
TRG_ENDOCYTIC_2	265	268	PF00928	0.623
TRG_ER_diArg_1	253	256	PF00400	0.738
TRG_ER_diArg_1	34	36	PF00400	0.634
TRG_NLS_MonoCore_2	32	37	PF00514	0.451
TRG_NLS_MonoExtN_4	32	37	PF00514	0.451
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J0	Leptomonas seymouri	46%	100%
A0A1X0P427	Trypanosomatidae	35%	100%
A0A3S7X0L8	Leishmania donovani	73%	100%
A0A422N2W4	Trypanosoma rangeli	30%	100%
A4I2Q0	Leishmania infantum	73%	100%
D0A5V2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AD76	Leishmania major	73%	100%
E9AZ00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%