Putative ABC transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ABC transporter, putative

Species:

Leishmania braziliensis

UniProt:

A4HFM1_LEIBR

TriTrypDb:

LbrM.27.1060 , LBRM2903_270016500

Length:

159

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HFM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFM1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	3
GO:0015399	primary active transmembrane transporter activity	4	3
GO:0022804	active transmembrane transporter activity	3	3
GO:0022857	transmembrane transporter activity	2	3
GO:0042626	ATPase-coupled transmembrane transporter activity	2	3
GO:0140359	ABC-type transporter activity	3	3
GO:0140657	ATP-dependent activity	1	3
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	1
GO:0005524	ATP binding	5	1
GO:0017076	purine nucleotide binding	4	1
GO:0030554	adenyl nucleotide binding	5	1
GO:0032553	ribonucleotide binding	3	1
GO:0032555	purine ribonucleotide binding	4	1
GO:0032559	adenyl ribonucleotide binding	5	1
GO:0035639	purine ribonucleoside triphosphate binding	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.512
CLV_PCSK_FUR_1	86	90	PF00082	0.398
CLV_PCSK_KEX2_1	88	90	PF00082	0.619
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.376
CLV_PCSK_SKI1_1	88	92	PF00082	0.361
DOC_PP2B_LxvP_1	9	12	PF13499	0.544
DOC_USP7_MATH_1	122	126	PF00917	0.401
DOC_USP7_UBL2_3	41	45	PF12436	0.574
DOC_WW_Pin1_4	59	64	PF00397	0.405
LIG_14-3-3_CanoR_1	132	139	PF00244	0.460
LIG_14-3-3_CanoR_1	148	156	PF00244	0.489
LIG_14-3-3_CanoR_1	89	93	PF00244	0.352
LIG_14-3-3_CanoR_1	99	104	PF00244	0.355
LIG_BRCT_BRCA1_1	100	104	PF00533	0.384
LIG_FHA_1	4	10	PF00498	0.661
LIG_FHA_1	89	95	PF00498	0.398
LIG_FHA_2	103	109	PF00498	0.581
LIG_FHA_2	122	128	PF00498	0.482
LIG_FHA_2	48	54	PF00498	0.398
LIG_LIR_Apic_2	91	95	PF02991	0.344
LIG_LIR_Gen_1	101	108	PF02991	0.602
LIG_LIR_Gen_1	127	137	PF02991	0.542
LIG_LIR_Nem_3	101	107	PF02991	0.451
LIG_LIR_Nem_3	127	133	PF02991	0.536
LIG_PCNA_PIPBox_1	66	75	PF02747	0.382
LIG_PCNA_yPIPBox_3	117	130	PF02747	0.413
LIG_Pex14_2	73	77	PF04695	0.389
LIG_SH2_CRK	92	96	PF00017	0.446
MOD_CK1_1	102	108	PF00069	0.366
MOD_CK1_1	13	19	PF00069	0.539
MOD_CK1_1	80	86	PF00069	0.430
MOD_CK2_1	102	108	PF00069	0.580
MOD_CK2_1	121	127	PF00069	0.468
MOD_CK2_1	47	53	PF00069	0.510
MOD_GSK3_1	10	17	PF00069	0.635
MOD_GSK3_1	148	155	PF00069	0.505
MOD_GSK3_1	27	34	PF00069	0.430
MOD_GSK3_1	76	83	PF00069	0.404
MOD_GSK3_1	94	101	PF00069	0.317
MOD_NEK2_1	2	7	PF00069	0.548
MOD_PK_1	99	105	PF00069	0.391
MOD_PKA_1	88	94	PF00069	0.355
MOD_PKA_2	131	137	PF00069	0.451
MOD_PKA_2	88	94	PF00069	0.355
MOD_PKA_2	98	104	PF00069	0.350
MOD_Plk_1	39	45	PF00069	0.509
MOD_Plk_2-3	27	33	PF00069	0.496
MOD_Plk_4	99	105	PF00069	0.391
MOD_ProDKin_1	59	65	PF00069	0.398
MOD_SUMO_rev_2	112	122	PF00179	0.382
MOD_SUMO_rev_2	147	156	PF00179	0.505
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NUW0	Trypanosomatidae	48%	100%