Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFL8_LEIBR

TriTrypDb:

LbrM.27.1030 , LBRM2903_270016200

Length:

905

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFL8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	491	495	PF00656	0.532
CLV_C14_Caspase3-7	496	500	PF00656	0.511
CLV_NRD_NRD_1	216	218	PF00675	0.701
CLV_NRD_NRD_1	402	404	PF00675	0.554
CLV_NRD_NRD_1	486	488	PF00675	0.572
CLV_NRD_NRD_1	49	51	PF00675	0.635
CLV_NRD_NRD_1	517	519	PF00675	0.601
CLV_PCSK_KEX2_1	117	119	PF00082	0.478
CLV_PCSK_KEX2_1	215	217	PF00082	0.700
CLV_PCSK_KEX2_1	402	404	PF00082	0.554
CLV_PCSK_KEX2_1	44	46	PF00082	0.667
CLV_PCSK_KEX2_1	486	488	PF00082	0.572
CLV_PCSK_KEX2_1	517	519	PF00082	0.573
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.478
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.547
CLV_PCSK_SKI1_1	395	399	PF00082	0.544
CLV_PCSK_SKI1_1	51	55	PF00082	0.607
CLV_PCSK_SKI1_1	512	516	PF00082	0.620
CLV_PCSK_SKI1_1	714	718	PF00082	0.461
CLV_PCSK_SKI1_1	823	827	PF00082	0.361
CLV_Separin_Metazoa	680	684	PF03568	0.485
DEG_APCC_DBOX_1	529	537	PF00400	0.497
DEG_SPOP_SBC_1	522	526	PF00917	0.578
DOC_CKS1_1	549	554	PF01111	0.650
DOC_CYCLIN_yCln2_LP_2	549	555	PF00134	0.532
DOC_CYCLIN_yCln2_LP_2	729	735	PF00134	0.466
DOC_MAPK_gen_1	323	332	PF00069	0.510
DOC_MAPK_gen_1	402	409	PF00069	0.551
DOC_MAPK_gen_1	748	756	PF00069	0.402
DOC_MAPK_gen_1	762	769	PF00069	0.382
DOC_MAPK_gen_1	838	847	PF00069	0.403
DOC_MAPK_MEF2A_6	222	229	PF00069	0.545
DOC_MAPK_MEF2A_6	323	332	PF00069	0.510
DOC_MAPK_MEF2A_6	340	348	PF00069	0.463
DOC_MAPK_NFAT4_5	222	230	PF00069	0.544
DOC_PP2B_LxvP_1	725	728	PF13499	0.471
DOC_PP2B_LxvP_1	882	885	PF13499	0.481
DOC_PP4_FxxP_1	339	342	PF00568	0.560
DOC_USP7_MATH_1	23	27	PF00917	0.662
DOC_USP7_MATH_1	289	293	PF00917	0.705
DOC_USP7_MATH_1	347	351	PF00917	0.544
DOC_USP7_MATH_1	401	405	PF00917	0.556
DOC_USP7_MATH_1	495	499	PF00917	0.587
DOC_USP7_MATH_1	503	507	PF00917	0.724
DOC_USP7_MATH_1	606	610	PF00917	0.619
DOC_USP7_MATH_1	638	642	PF00917	0.706
DOC_USP7_MATH_1	794	798	PF00917	0.592
DOC_USP7_UBL2_3	766	770	PF12436	0.372
DOC_WW_Pin1_4	35	40	PF00397	0.581
DOC_WW_Pin1_4	360	365	PF00397	0.586
DOC_WW_Pin1_4	397	402	PF00397	0.619
DOC_WW_Pin1_4	534	539	PF00397	0.633
DOC_WW_Pin1_4	548	553	PF00397	0.554
DOC_WW_Pin1_4	735	740	PF00397	0.395
LIG_14-3-3_CanoR_1	123	130	PF00244	0.517
LIG_14-3-3_CanoR_1	172	176	PF00244	0.596
LIG_14-3-3_CanoR_1	222	228	PF00244	0.549
LIG_14-3-3_CanoR_1	402	408	PF00244	0.552
LIG_14-3-3_CanoR_1	422	427	PF00244	0.534
LIG_14-3-3_CanoR_1	5	9	PF00244	0.623
LIG_14-3-3_CanoR_1	50	56	PF00244	0.546
LIG_14-3-3_CanoR_1	532	537	PF00244	0.565
LIG_14-3-3_CanoR_1	564	569	PF00244	0.589
LIG_14-3-3_CanoR_1	570	576	PF00244	0.558
LIG_14-3-3_CanoR_1	795	803	PF00244	0.698
LIG_14-3-3_CanoR_1	868	874	PF00244	0.400
LIG_APCC_ABBA_1	330	335	PF00400	0.595
LIG_BRCT_BRCA1_1	752	756	PF00533	0.455
LIG_Clathr_ClatBox_1	162	166	PF01394	0.535
LIG_Clathr_ClatBox_1	443	447	PF01394	0.561
LIG_FHA_1	157	163	PF00498	0.531
LIG_FHA_1	200	206	PF00498	0.676
LIG_FHA_1	288	294	PF00498	0.587
LIG_FHA_1	549	555	PF00498	0.652
LIG_FHA_1	631	637	PF00498	0.672
LIG_FHA_1	694	700	PF00498	0.428
LIG_FHA_1	735	741	PF00498	0.427
LIG_FHA_1	820	826	PF00498	0.491
LIG_FHA_1	859	865	PF00498	0.395
LIG_FHA_1	868	874	PF00498	0.351
LIG_FHA_2	36	42	PF00498	0.535
LIG_FHA_2	522	528	PF00498	0.688
LIG_LIR_Apic_2	337	342	PF02991	0.555
LIG_LIR_Gen_1	101	108	PF02991	0.445
LIG_LIR_Gen_1	183	191	PF02991	0.784
LIG_LIR_Gen_1	656	667	PF02991	0.514
LIG_LIR_Gen_1	90	100	PF02991	0.569
LIG_LIR_Nem_3	125	130	PF02991	0.516
LIG_LIR_Nem_3	183	189	PF02991	0.780
LIG_LIR_Nem_3	234	239	PF02991	0.657
LIG_LIR_Nem_3	32	37	PF02991	0.530
LIG_LIR_Nem_3	656	662	PF02991	0.514
LIG_LIR_Nem_3	90	96	PF02991	0.559
LIG_LIR_Nem_3	99	103	PF02991	0.468
LIG_MYND_1	728	732	PF01753	0.508
LIG_NRBOX	699	705	PF00104	0.436
LIG_PCNA_yPIPBox_3	888	899	PF02747	0.436
LIG_PTB_Apo_2	538	545	PF02174	0.526
LIG_PTB_Apo_2	94	101	PF02174	0.518
LIG_PTB_Phospho_1	94	100	PF10480	0.517
LIG_REV1ctd_RIR_1	336	341	PF16727	0.550
LIG_SH2_NCK_1	669	673	PF00017	0.599
LIG_SH2_STAP1	156	160	PF00017	0.434
LIG_SH2_STAP1	669	673	PF00017	0.599
LIG_SH2_STAP1	72	76	PF00017	0.475
LIG_SH2_STAT5	105	108	PF00017	0.528
LIG_SH2_STAT5	62	65	PF00017	0.518
LIG_SH2_STAT5	781	784	PF00017	0.374
LIG_SH2_STAT5	821	824	PF00017	0.533
LIG_SH3_3	113	119	PF00018	0.439
LIG_SH3_3	366	372	PF00018	0.551
LIG_SH3_3	376	382	PF00018	0.525
LIG_SH3_3	415	421	PF00018	0.564
LIG_SH3_3	423	429	PF00018	0.606
LIG_SH3_3	443	449	PF00018	0.512
LIG_SUMO_SIM_par_1	589	595	PF11976	0.525
LIG_SUMO_SIM_par_1	731	738	PF11976	0.437
LIG_SUMO_SIM_par_1	860	866	PF11976	0.387
LIG_TRAF2_1	133	136	PF00917	0.527
LIG_TRAF2_1	322	325	PF00917	0.496
LIG_TRAF2_1	373	376	PF00917	0.583
LIG_TRAF2_1	38	41	PF00917	0.591
LIG_TRAF2_1	408	411	PF00917	0.572
LIG_TRAF2_1	654	657	PF00917	0.511
LIG_WRC_WIRS_1	864	869	PF05994	0.448
LIG_WW_3	300	304	PF00397	0.654
MOD_CDC14_SPxK_1	400	403	PF00782	0.545
MOD_CDC14_SPxK_1	738	741	PF00782	0.415
MOD_CDK_SPK_2	397	402	PF00069	0.542
MOD_CDK_SPxK_1	397	403	PF00069	0.544
MOD_CDK_SPxK_1	735	741	PF00069	0.400
MOD_CK1_1	101	107	PF00069	0.419
MOD_CK1_1	208	214	PF00069	0.560
MOD_CK1_1	223	229	PF00069	0.775
MOD_CK1_1	4	10	PF00069	0.570
MOD_CK1_1	474	480	PF00069	0.616
MOD_CK1_1	548	554	PF00069	0.591
MOD_CK1_1	566	572	PF00069	0.514
MOD_CK1_1	586	592	PF00069	0.537
MOD_CK1_1	641	647	PF00069	0.618
MOD_CK1_1	863	869	PF00069	0.412
MOD_CK2_1	130	136	PF00069	0.595
MOD_CK2_1	208	214	PF00069	0.557
MOD_CK2_1	261	267	PF00069	0.559
MOD_CK2_1	274	280	PF00069	0.547
MOD_CK2_1	35	41	PF00069	0.530
MOD_CK2_1	370	376	PF00069	0.619
MOD_CK2_1	405	411	PF00069	0.578
MOD_CK2_1	521	527	PF00069	0.763
MOD_CK2_1	674	680	PF00069	0.463
MOD_CK2_1	743	749	PF00069	0.528
MOD_Cter_Amidation	48	51	PF01082	0.529
MOD_DYRK1A_RPxSP_1	534	538	PF00069	0.548
MOD_GlcNHglycan	119	122	PF01048	0.528
MOD_GlcNHglycan	210	213	PF01048	0.600
MOD_GlcNHglycan	231	234	PF01048	0.528
MOD_GlcNHglycan	26	29	PF01048	0.636
MOD_GlcNHglycan	384	387	PF01048	0.621
MOD_GlcNHglycan	473	476	PF01048	0.600
MOD_GlcNHglycan	488	491	PF01048	0.646
MOD_GlcNHglycan	583	588	PF01048	0.626
MOD_GlcNHglycan	640	643	PF01048	0.772
MOD_GlcNHglycan	849	852	PF01048	0.650
MOD_GlcNHglycan	99	103	PF01048	0.506
MOD_GSK3_1	171	178	PF00069	0.578
MOD_GSK3_1	19	26	PF00069	0.742
MOD_GSK3_1	201	208	PF00069	0.589
MOD_GSK3_1	223	230	PF00069	0.733
MOD_GSK3_1	254	261	PF00069	0.640
MOD_GSK3_1	397	404	PF00069	0.640
MOD_GSK3_1	4	11	PF00069	0.565
MOD_GSK3_1	449	456	PF00069	0.663
MOD_GSK3_1	474	481	PF00069	0.632
MOD_GSK3_1	482	489	PF00069	0.586
MOD_GSK3_1	49	56	PF00069	0.710
MOD_GSK3_1	544	551	PF00069	0.615
MOD_GSK3_1	564	571	PF00069	0.645
MOD_GSK3_1	622	629	PF00069	0.604
MOD_GSK3_1	638	645	PF00069	0.573
MOD_GSK3_1	799	806	PF00069	0.525
MOD_GSK3_1	819	826	PF00069	0.417
MOD_GSK3_1	828	835	PF00069	0.301
MOD_GSK3_1	863	870	PF00069	0.386
MOD_LATS_1	455	461	PF00433	0.702
MOD_N-GLC_1	148	153	PF02516	0.561
MOD_N-GLC_1	287	292	PF02516	0.617
MOD_N-GLC_1	412	417	PF02516	0.565
MOD_N-GLC_1	482	487	PF02516	0.661
MOD_N-GLC_1	606	611	PF02516	0.526
MOD_N-GLC_1	693	698	PF02516	0.506
MOD_N-GLC_1	79	84	PF02516	0.616
MOD_NEK2_1	1	6	PF00069	0.595
MOD_NEK2_1	130	135	PF00069	0.471
MOD_NEK2_1	21	26	PF00069	0.560
MOD_NEK2_1	227	232	PF00069	0.611
MOD_NEK2_1	254	259	PF00069	0.542
MOD_NEK2_1	471	476	PF00069	0.548
MOD_NEK2_1	544	549	PF00069	0.623
MOD_NEK2_1	734	739	PF00069	0.396
MOD_NEK2_1	8	13	PF00069	0.541
MOD_NEK2_1	847	852	PF00069	0.488
MOD_NEK2_1	860	865	PF00069	0.374
MOD_NEK2_1	867	872	PF00069	0.272
MOD_NEK2_2	503	508	PF00069	0.569
MOD_NEK2_2	809	814	PF00069	0.454
MOD_NEK2_2	828	833	PF00069	0.420
MOD_PIKK_1	148	154	PF00454	0.556
MOD_PIKK_1	21	27	PF00454	0.657
MOD_PIKK_1	252	258	PF00454	0.537
MOD_PIKK_1	592	598	PF00454	0.514
MOD_PIKK_1	794	800	PF00454	0.573
MOD_PK_1	422	428	PF00069	0.577
MOD_PK_1	564	570	PF00069	0.553
MOD_PKA_1	117	123	PF00069	0.481
MOD_PKA_1	486	492	PF00069	0.545
MOD_PKA_2	117	123	PF00069	0.516
MOD_PKA_2	130	136	PF00069	0.522
MOD_PKA_2	171	177	PF00069	0.594
MOD_PKA_2	208	214	PF00069	0.685
MOD_PKA_2	223	229	PF00069	0.585
MOD_PKA_2	275	281	PF00069	0.608
MOD_PKA_2	4	10	PF00069	0.682
MOD_PKA_2	401	407	PF00069	0.547
MOD_PKA_2	421	427	PF00069	0.527
MOD_PKA_2	486	492	PF00069	0.571
MOD_PKA_2	49	55	PF00069	0.583
MOD_PKA_2	544	550	PF00069	0.619
MOD_PKA_2	563	569	PF00069	0.553
MOD_PKA_2	626	632	PF00069	0.633
MOD_PKA_2	794	800	PF00069	0.503
MOD_PKA_2	867	873	PF00069	0.389
MOD_PKB_1	530	538	PF00069	0.612
MOD_Plk_1	148	154	PF00069	0.587
MOD_Plk_1	156	162	PF00069	0.593
MOD_Plk_1	326	332	PF00069	0.602
MOD_Plk_1	334	340	PF00069	0.573
MOD_Plk_1	545	551	PF00069	0.519
MOD_Plk_1	606	612	PF00069	0.527
MOD_Plk_1	693	699	PF00069	0.506
MOD_Plk_1	743	749	PF00069	0.445
MOD_Plk_2-3	718	724	PF00069	0.530
MOD_Plk_2-3	750	756	PF00069	0.467
MOD_Plk_4	171	177	PF00069	0.633
MOD_Plk_4	240	246	PF00069	0.527
MOD_Plk_4	289	295	PF00069	0.642
MOD_Plk_4	334	340	PF00069	0.549
MOD_Plk_4	586	592	PF00069	0.601
MOD_Plk_4	658	664	PF00069	0.506
MOD_Plk_4	694	700	PF00069	0.509
MOD_Plk_4	74	80	PF00069	0.413
MOD_ProDKin_1	35	41	PF00069	0.583
MOD_ProDKin_1	360	366	PF00069	0.588
MOD_ProDKin_1	397	403	PF00069	0.622
MOD_ProDKin_1	534	540	PF00069	0.630
MOD_ProDKin_1	548	554	PF00069	0.558
MOD_ProDKin_1	735	741	PF00069	0.400
MOD_SUMO_rev_2	230	239	PF00179	0.532
MOD_SUMO_rev_2	744	753	PF00179	0.461
TRG_DiLeu_BaEn_1	108	113	PF01217	0.427
TRG_DiLeu_BaLyEn_6	339	344	PF01217	0.571
TRG_DiLeu_BaLyEn_6	699	704	PF01217	0.475
TRG_DiLeu_BaLyEn_6	725	730	PF01217	0.538
TRG_DiLeu_BaLyEn_6	885	890	PF01217	0.351
TRG_ENDOCYTIC_2	100	103	PF00928	0.504
TRG_ENDOCYTIC_2	669	672	PF00928	0.603
TRG_ENDOCYTIC_2	72	75	PF00928	0.483
TRG_ENDOCYTIC_2	844	847	PF00928	0.350
TRG_ENDOCYTIC_2	93	96	PF00928	0.501
TRG_ER_diArg_1	215	217	PF00400	0.693
TRG_ER_diArg_1	222	225	PF00400	0.630
TRG_ER_diArg_1	401	403	PF00400	0.544
TRG_ER_diArg_1	467	470	PF00400	0.615
TRG_ER_diArg_1	486	488	PF00400	0.551
TRG_ER_diArg_1	813	816	PF00400	0.535
TRG_NES_CRM1_1	180	193	PF08389	0.645
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	683	687	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	888	892	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J7	Leptomonas seymouri	44%	95%
A0A3S7X0M1	Leishmania donovani	60%	99%
A4I2P1	Leishmania infantum	60%	99%
E9AD72	Leishmania major	59%	97%
E9AYZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	99%