XRN_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

XRN 5'-3' exonuclease N-terminus, putative

Species:

Leishmania braziliensis

UniProt:

A4HFL7_LEIBR

TriTrypDb:

LbrM.27.1020 , LBRM2903_270016100

Length:

592

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFL7

Function

Biological processes
Term	Name	Level	Count
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	16
GO:0003824	catalytic activity	1	16
GO:0004518	nuclease activity	4	16
GO:0004527	exonuclease activity	5	16
GO:0005488	binding	1	16
GO:0016787	hydrolase activity	2	16
GO:0016788	hydrolase activity, acting on ester bonds	3	16
GO:0097159	organic cyclic compound binding	2	16
GO:1901363	heterocyclic compound binding	2	16
GO:0003723	RNA binding	4	1
GO:0004532	RNA exonuclease activity	5	1
GO:0004534	5'-3' RNA exonuclease activity	7	1
GO:0004540	RNA nuclease activity	4	1
GO:0008409	5'-3' exonuclease activity	6	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.569
CLV_C14_Caspase3-7	436	440	PF00656	0.627
CLV_C14_Caspase3-7	573	577	PF00656	0.742
CLV_MEL_PAP_1	466	472	PF00089	0.513
CLV_NRD_NRD_1	166	168	PF00675	0.333
CLV_NRD_NRD_1	196	198	PF00675	0.341
CLV_NRD_NRD_1	314	316	PF00675	0.386
CLV_NRD_NRD_1	351	353	PF00675	0.621
CLV_NRD_NRD_1	421	423	PF00675	0.539
CLV_NRD_NRD_1	519	521	PF00675	0.575
CLV_NRD_NRD_1	547	549	PF00675	0.738
CLV_NRD_NRD_1	98	100	PF00675	0.262
CLV_PCSK_FUR_1	349	353	PF00082	0.663
CLV_PCSK_KEX2_1	166	168	PF00082	0.295
CLV_PCSK_KEX2_1	196	198	PF00082	0.342
CLV_PCSK_KEX2_1	314	316	PF00082	0.413
CLV_PCSK_KEX2_1	351	353	PF00082	0.635
CLV_PCSK_KEX2_1	519	521	PF00082	0.575
CLV_PCSK_KEX2_1	590	592	PF00082	0.629
CLV_PCSK_KEX2_1	98	100	PF00082	0.260
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.635
CLV_PCSK_PC1ET2_1	590	592	PF00082	0.704
CLV_PCSK_SKI1_1	108	112	PF00082	0.324
CLV_PCSK_SKI1_1	331	335	PF00082	0.473
CLV_PCSK_SKI1_1	34	38	PF00082	0.361
CLV_PCSK_SKI1_1	353	357	PF00082	0.580
CLV_PCSK_SKI1_1	444	448	PF00082	0.468
CLV_Separin_Metazoa	328	332	PF03568	0.261
CLV_Separin_Metazoa	445	449	PF03568	0.446
DEG_APCC_DBOX_1	33	41	PF00400	0.569
DEG_SPOP_SBC_1	112	116	PF00917	0.388
DOC_ANK_TNKS_1	181	188	PF00023	0.510
DOC_CYCLIN_RxL_1	351	362	PF00134	0.446
DOC_CYCLIN_yCln2_LP_2	238	244	PF00134	0.497
DOC_MAPK_gen_1	467	474	PF00069	0.497
DOC_MAPK_gen_1	72	81	PF00069	0.524
DOC_MAPK_gen_1	96	104	PF00069	0.489
DOC_MAPK_MEF2A_6	274	282	PF00069	0.333
DOC_MAPK_MEF2A_6	321	329	PF00069	0.501
DOC_PP1_RVXF_1	272	278	PF00149	0.336
DOC_USP7_MATH_1	113	117	PF00917	0.525
DOC_USP7_MATH_1	18	22	PF00917	0.533
DOC_USP7_MATH_1	204	208	PF00917	0.571
DOC_WW_Pin1_4	124	129	PF00397	0.568
DOC_WW_Pin1_4	452	457	PF00397	0.320
LIG_14-3-3_CanoR_1	108	113	PF00244	0.502
LIG_14-3-3_CanoR_1	314	318	PF00244	0.314
LIG_14-3-3_CanoR_1	352	359	PF00244	0.627
LIG_14-3-3_CanoR_1	467	473	PF00244	0.415
LIG_14-3-3_CanoR_1	488	498	PF00244	0.555
LIG_14-3-3_CanoR_1	546	552	PF00244	0.744
LIG_14-3-3_CanoR_1	98	103	PF00244	0.502
LIG_AP2alpha_2	240	242	PF02296	0.506
LIG_APCC_ABBA_1	139	144	PF00400	0.539
LIG_APCC_ABBA_1	398	403	PF00400	0.580
LIG_BIR_III_4	432	436	PF00653	0.762
LIG_BRCT_BRCA1_1	386	390	PF00533	0.491
LIG_eIF4E_1	171	177	PF01652	0.569
LIG_eIF4E_1	233	239	PF01652	0.482
LIG_eIF4E_1	312	318	PF01652	0.468
LIG_FHA_1	159	165	PF00498	0.558
LIG_FHA_1	211	217	PF00498	0.497
LIG_FHA_1	497	503	PF00498	0.475
LIG_FHA_1	509	515	PF00498	0.468
LIG_FHA_1	584	590	PF00498	0.512
LIG_FHA_1	76	82	PF00498	0.478
LIG_FHA_2	200	206	PF00498	0.548
LIG_FHA_2	480	486	PF00498	0.560
LIG_FHA_2	513	519	PF00498	0.418
LIG_FHA_2	553	559	PF00498	0.562
LIG_FHA_2	568	574	PF00498	0.483
LIG_FHA_2	92	98	PF00498	0.561
LIG_Integrin_RGD_1	360	362	PF01839	0.649
LIG_LIR_Gen_1	172	178	PF02991	0.562
LIG_LIR_Gen_1	276	283	PF02991	0.320
LIG_LIR_Nem_3	172	176	PF02991	0.527
LIG_LIR_Nem_3	276	282	PF02991	0.320
LIG_LIR_Nem_3	286	292	PF02991	0.360
LIG_LIR_Nem_3	394	399	PF02991	0.458
LIG_LIR_Nem_3	451	457	PF02991	0.351
LIG_PCNA_yPIPBox_3	526	540	PF02747	0.444
LIG_Rb_LxCxE_1	151	172	PF01857	0.569
LIG_RPA_C_Fungi	331	343	PF08784	0.512
LIG_SH2_CRK	17	21	PF00017	0.452
LIG_SH2_CRK	289	293	PF00017	0.407
LIG_SH2_CRK	396	400	PF00017	0.383
LIG_SH2_CRK	83	87	PF00017	0.424
LIG_SH2_NCK_1	236	240	PF00017	0.489
LIG_SH2_SRC	17	20	PF00017	0.404
LIG_SH2_SRC	9	12	PF00017	0.404
LIG_SH2_STAT5	130	133	PF00017	0.419
LIG_SH2_STAT5	159	162	PF00017	0.451
LIG_SH2_STAT5	163	166	PF00017	0.449
LIG_SH2_STAT5	312	315	PF00017	0.490
LIG_SH2_STAT5	388	391	PF00017	0.435
LIG_SH2_STAT5	392	395	PF00017	0.467
LIG_SH2_STAT5	9	12	PF00017	0.354
LIG_SH3_1	258	264	PF00018	0.338
LIG_SH3_3	226	232	PF00018	0.452
LIG_SH3_3	257	263	PF00018	0.545
LIG_SH3_3	47	53	PF00018	0.441
LIG_SUMO_SIM_anti_2	211	218	PF11976	0.292
LIG_SUMO_SIM_anti_2	220	227	PF11976	0.352
LIG_SUMO_SIM_anti_2	326	331	PF11976	0.431
LIG_SUMO_SIM_anti_2	77	84	PF11976	0.367
LIG_SUMO_SIM_par_1	77	84	PF11976	0.373
LIG_TRAF2_1	155	158	PF00917	0.418
LIG_TRAF2_1	400	403	PF00917	0.572
LIG_TRAF2_1	554	557	PF00917	0.735
LIG_TYR_ITAM	286	306	PF00017	0.517
LIG_TYR_ITIM	81	86	PF00017	0.463
LIG_TYR_ITSM	392	399	PF00017	0.275
LIG_WW_2	263	266	PF00397	0.575
LIG_WW_3	105	109	PF00397	0.463
MOD_CK1_1	116	122	PF00069	0.382
MOD_CK1_1	245	251	PF00069	0.493
MOD_CK1_1	316	322	PF00069	0.365
MOD_CK1_1	345	351	PF00069	0.646
MOD_CK1_1	384	390	PF00069	0.431
MOD_CK1_1	407	413	PF00069	0.523
MOD_CK1_1	508	514	PF00069	0.547
MOD_CK2_1	245	251	PF00069	0.439
MOD_CK2_1	452	458	PF00069	0.261
MOD_CK2_1	512	518	PF00069	0.431
MOD_CK2_1	552	558	PF00069	0.798
MOD_CK2_1	567	573	PF00069	0.746
MOD_CK2_1	91	97	PF00069	0.452
MOD_GlcNHglycan	108	111	PF01048	0.323
MOD_GlcNHglycan	118	121	PF01048	0.367
MOD_GlcNHglycan	178	181	PF01048	0.359
MOD_GlcNHglycan	183	186	PF01048	0.344
MOD_GlcNHglycan	191	194	PF01048	0.293
MOD_GlcNHglycan	283	286	PF01048	0.407
MOD_GlcNHglycan	293	296	PF01048	0.452
MOD_GlcNHglycan	318	321	PF01048	0.510
MOD_GlcNHglycan	336	339	PF01048	0.605
MOD_GlcNHglycan	362	366	PF01048	0.623
MOD_GlcNHglycan	448	451	PF01048	0.377
MOD_GSK3_1	108	115	PF00069	0.429
MOD_GSK3_1	116	123	PF00069	0.397
MOD_GSK3_1	124	131	PF00069	0.431
MOD_GSK3_1	468	475	PF00069	0.487
MOD_GSK3_1	487	494	PF00069	0.498
MOD_GSK3_1	508	515	PF00069	0.562
MOD_GSK3_1	51	58	PF00069	0.348
MOD_N-GLC_1	218	223	PF02516	0.322
MOD_N-GLC_2	523	525	PF02516	0.403
MOD_NEK2_1	176	181	PF00069	0.381
MOD_NEK2_1	242	247	PF00069	0.460
MOD_NEK2_1	313	318	PF00069	0.303
MOD_NEK2_1	334	339	PF00069	0.542
MOD_NEK2_1	472	477	PF00069	0.429
MOD_NEK2_1	489	494	PF00069	0.428
MOD_NEK2_1	498	503	PF00069	0.438
MOD_NEK2_2	120	125	PF00069	0.463
MOD_NEK2_2	381	386	PF00069	0.492
MOD_PIKK_1	552	558	PF00454	0.546
MOD_PIKK_1	91	97	PF00454	0.354
MOD_PK_1	423	429	PF00069	0.368
MOD_PKA_1	351	357	PF00069	0.631
MOD_PKA_1	519	525	PF00069	0.621
MOD_PKA_1	98	104	PF00069	0.356
MOD_PKA_2	181	187	PF00069	0.211
MOD_PKA_2	313	319	PF00069	0.332
MOD_PKA_2	345	351	PF00069	0.609
MOD_PKA_2	468	474	PF00069	0.396
MOD_PKA_2	478	484	PF00069	0.414
MOD_PKA_2	487	493	PF00069	0.488
MOD_PKA_2	519	525	PF00069	0.597
MOD_PKA_2	547	553	PF00069	0.523
MOD_PKA_2	98	104	PF00069	0.366
MOD_Plk_1	210	216	PF00069	0.316
MOD_Plk_1	242	248	PF00069	0.456
MOD_Plk_1	583	589	PF00069	0.741
MOD_Plk_4	159	165	PF00069	0.427
MOD_Plk_4	212	218	PF00069	0.410
MOD_Plk_4	234	240	PF00069	0.453
MOD_Plk_4	245	251	PF00069	0.379
MOD_Plk_4	75	81	PF00069	0.363
MOD_ProDKin_1	124	130	PF00069	0.462
MOD_ProDKin_1	452	458	PF00069	0.319
MOD_SUMO_rev_2	183	192	PF00179	0.320
TRG_DiLeu_BaEn_1	373	378	PF01217	0.501
TRG_ENDOCYTIC_2	236	239	PF00928	0.347
TRG_ENDOCYTIC_2	289	292	PF00928	0.382
TRG_ENDOCYTIC_2	303	306	PF00928	0.311
TRG_ENDOCYTIC_2	396	399	PF00928	0.487
TRG_ENDOCYTIC_2	83	86	PF00928	0.424
TRG_ER_diArg_1	195	197	PF00400	0.446
TRG_ER_diArg_1	313	315	PF00400	0.405
TRG_ER_diArg_1	466	469	PF00400	0.424
TRG_ER_diArg_1	519	521	PF00400	0.576
TRG_ER_diArg_1	545	548	PF00400	0.688
TRG_ER_diArg_1	72	75	PF00400	0.460
TRG_NLS_MonoExtN_4	349	355	PF00514	0.635
TRG_Pf-PMV_PEXEL_1	321	326	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	34	39	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I835	Leptomonas seymouri	61%	100%
A0A0S4ILZ5	Bodo saltans	34%	100%
A0A0S4JAK8	Bodo saltans	29%	100%
A0A1X0P557	Trypanosomatidae	40%	100%
A0A3R7RG04	Trypanosoma rangeli	27%	71%
A0A3S7X0L0	Leishmania donovani	80%	100%
A0A422N1U3	Trypanosoma rangeli	42%	100%
A4I352	Leishmania infantum	80%	100%
C9ZPR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	66%
D0A5U8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AD71	Leishmania major	78%	99%
E9AYZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
V5AT41	Trypanosoma cruzi	40%	100%
V5BDQ7	Trypanosoma cruzi	28%	96%