S5A_REDUCTASE domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1295), putative

Species:

Leishmania braziliensis

UniProt:

A4HFL5_LEIBR

TriTrypDb:

LbrM.27.1000 , LBRM2903_270015900

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HFL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFL5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.274
CLV_NRD_NRD_1	274	276	PF00675	0.190
CLV_NRD_NRD_1	307	309	PF00675	0.332
CLV_NRD_NRD_1	66	68	PF00675	0.516
CLV_PCSK_KEX2_1	105	107	PF00082	0.274
CLV_PCSK_SKI1_1	168	172	PF00082	0.562
CLV_PCSK_SKI1_1	266	270	PF00082	0.270
DEG_Nend_UBRbox_2	1	3	PF02207	0.441
DOC_PP1_RVXF_1	96	102	PF00149	0.363
DOC_USP7_MATH_1	237	241	PF00917	0.465
DOC_USP7_MATH_1	75	79	PF00917	0.348
DOC_WW_Pin1_4	127	132	PF00397	0.571
DOC_WW_Pin1_4	197	202	PF00397	0.532
DOC_WW_Pin1_4	284	289	PF00397	0.507
LIG_14-3-3_CanoR_1	271	278	PF00244	0.474
LIG_14-3-3_CanoR_1	67	74	PF00244	0.255
LIG_14-3-3_CanoR_1	98	102	PF00244	0.474
LIG_APCC_ABBA_1	222	227	PF00400	0.498
LIG_Clathr_ClatBox_1	179	183	PF01394	0.411
LIG_Clathr_ClatBox_1	302	306	PF01394	0.429
LIG_deltaCOP1_diTrp_1	115	124	PF00928	0.475
LIG_deltaCOP1_diTrp_1	187	193	PF00928	0.532
LIG_FHA_1	131	137	PF00498	0.332
LIG_FHA_1	145	151	PF00498	0.337
LIG_FHA_1	263	269	PF00498	0.355
LIG_FHA_1	285	291	PF00498	0.512
LIG_FHA_1	296	302	PF00498	0.497
LIG_FHA_2	164	170	PF00498	0.328
LIG_FHA_2	182	188	PF00498	0.164
LIG_FHA_2	265	271	PF00498	0.299
LIG_FHA_2	295	301	PF00498	0.491
LIG_FHA_2	60	66	PF00498	0.212
LIG_LIR_Gen_1	100	109	PF02991	0.513
LIG_LIR_Gen_1	115	126	PF02991	0.408
LIG_LIR_Gen_1	133	142	PF02991	0.247
LIG_LIR_Gen_1	229	238	PF02991	0.324
LIG_LIR_Gen_1	38	44	PF02991	0.534
LIG_LIR_Gen_1	46	53	PF02991	0.407
LIG_LIR_Gen_1	55	61	PF02991	0.215
LIG_LIR_Nem_3	100	104	PF02991	0.444
LIG_LIR_Nem_3	115	121	PF02991	0.431
LIG_LIR_Nem_3	123	127	PF02991	0.474
LIG_LIR_Nem_3	133	137	PF02991	0.330
LIG_LIR_Nem_3	229	234	PF02991	0.319
LIG_LIR_Nem_3	38	43	PF02991	0.530
LIG_LIR_Nem_3	44	50	PF02991	0.529
LIG_LIR_Nem_3	55	59	PF02991	0.215
LIG_MYND_1	288	292	PF01753	0.516
LIG_Pex14_1	56	60	PF04695	0.330
LIG_Pex14_2	137	141	PF04695	0.389
LIG_PTB_Apo_2	135	142	PF02174	0.212
LIG_REV1ctd_RIR_1	101	110	PF16727	0.532
LIG_SH2_CRK	283	287	PF00017	0.532
LIG_SH2_STAP1	218	222	PF00017	0.498
LIG_SH2_STAT3	61	64	PF00017	0.465
LIG_SH2_STAT5	120	123	PF00017	0.498
LIG_SH2_STAT5	206	209	PF00017	0.532
LIG_SH2_STAT5	61	64	PF00017	0.354
LIG_SH3_3	158	164	PF00018	0.371
LIG_Sin3_3	174	181	PF02671	0.313
LIG_Sin3_3	26	33	PF02671	0.348
LIG_SUMO_SIM_par_1	178	184	PF11976	0.379
LIG_SUMO_SIM_par_1	258	265	PF11976	0.340
LIG_TRAF2_1	297	300	PF00917	0.429
LIG_TRAF2_1	62	65	PF00917	0.190
LIG_UBA3_1	302	309	PF00899	0.464
MOD_CDK_SPK_2	197	202	PF00069	0.251
MOD_CK1_1	130	136	PF00069	0.327
MOD_CK1_1	240	246	PF00069	0.382
MOD_CK1_1	264	270	PF00069	0.298
MOD_CK1_1	293	299	PF00069	0.482
MOD_CK1_1	3	9	PF00069	0.407
MOD_CK1_1	78	84	PF00069	0.377
MOD_CK2_1	163	169	PF00069	0.411
MOD_CK2_1	264	270	PF00069	0.299
MOD_CK2_1	293	299	PF00069	0.368
MOD_CK2_1	59	65	PF00069	0.212
MOD_CMANNOS	148	151	PF00535	0.363
MOD_CMANNOS	248	251	PF00535	0.411
MOD_GlcNHglycan	127	130	PF01048	0.212
MOD_GlcNHglycan	18	21	PF01048	0.331
MOD_GlcNHglycan	240	243	PF01048	0.326
MOD_GlcNHglycan	251	254	PF01048	0.422
MOD_GlcNHglycan	272	275	PF01048	0.299
MOD_GlcNHglycan	5	8	PF01048	0.466
MOD_GSK3_1	12	19	PF00069	0.361
MOD_GSK3_1	140	147	PF00069	0.363
MOD_GSK3_1	197	204	PF00069	0.212
MOD_GSK3_1	238	245	PF00069	0.432
MOD_GSK3_1	262	269	PF00069	0.348
MOD_GSK3_1	290	297	PF00069	0.430
MOD_GSK3_1	76	83	PF00069	0.429
MOD_N-GLC_1	38	43	PF02516	0.330
MOD_NEK2_1	140	145	PF00069	0.331
MOD_NEK2_1	16	21	PF00069	0.339
MOD_NEK2_1	210	215	PF00069	0.319
MOD_NEK2_1	216	221	PF00069	0.288
MOD_NEK2_1	262	267	PF00069	0.372
MOD_NEK2_1	282	287	PF00069	0.135
MOD_NEK2_1	80	85	PF00069	0.395
MOD_NEK2_1	90	95	PF00069	0.404
MOD_PK_1	45	51	PF00069	0.330
MOD_PKA_2	270	276	PF00069	0.212
MOD_PKA_2	66	72	PF00069	0.304
MOD_PKA_2	97	103	PF00069	0.330
MOD_Plk_1	168	174	PF00069	0.426
MOD_Plk_1	226	232	PF00069	0.411
MOD_Plk_1	38	44	PF00069	0.330
MOD_Plk_2-3	38	44	PF00069	0.465
MOD_Plk_4	144	150	PF00069	0.336
MOD_Plk_4	226	232	PF00069	0.332
MOD_Plk_4	290	296	PF00069	0.488
MOD_Plk_4	38	44	PF00069	0.222
MOD_Plk_4	52	58	PF00069	0.267
MOD_ProDKin_1	127	133	PF00069	0.465
MOD_ProDKin_1	197	203	PF00069	0.411
MOD_ProDKin_1	284	290	PF00069	0.374
TRG_ENDOCYTIC_2	283	286	PF00928	0.411
TRG_ENDOCYTIC_2	40	43	PF00928	0.363
TRG_ER_diArg_1	104	106	PF00400	0.363
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.193

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZU3	Leptomonas seymouri	64%	100%
A0A0S4JVU4	Bodo saltans	44%	92%
A0A1X0P416	Trypanosomatidae	48%	97%
A0A3S7X0J3	Leishmania donovani	76%	100%
A4I2P4	Leishmania infantum	77%	100%
E9AD69	Leishmania major	78%	100%
E9AYZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
O74507	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	90%