A small, compact tail-anchored protein related to animal TMEM222 and plant RTE1. Function unknown.. Localization: ER (by homology) / Golgi (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 11 |
| NetGPI | no | yes: 0, no: 11 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 11 |
| GO:0110165 | cellular anatomical entity | 1 | 11 |
Related structures:
AlphaFold database: A4HFL3
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 178 | 180 | PF00675 | 0.414 |
| CLV_PCSK_KEX2_1 | 178 | 180 | PF00082 | 0.414 |
| CLV_PCSK_SKI1_1 | 179 | 183 | PF00082 | 0.247 |
| CLV_PCSK_SKI1_1 | 75 | 79 | PF00082 | 0.321 |
| DEG_Nend_Nbox_1 | 1 | 3 | PF02207 | 0.668 |
| DOC_MAPK_DCC_7 | 182 | 190 | PF00069 | 0.281 |
| DOC_MAPK_MEF2A_6 | 182 | 190 | PF00069 | 0.281 |
| DOC_MAPK_RevD_3 | 164 | 179 | PF00069 | 0.465 |
| DOC_PP4_FxxP_1 | 78 | 81 | PF00568 | 0.481 |
| DOC_PP4_FxxP_1 | 95 | 98 | PF00568 | 0.584 |
| DOC_USP7_MATH_1 | 100 | 104 | PF00917 | 0.368 |
| DOC_USP7_MATH_1 | 120 | 124 | PF00917 | 0.555 |
| DOC_WW_Pin1_4 | 35 | 40 | PF00397 | 0.640 |
| LIG_14-3-3_CanoR_1 | 173 | 178 | PF00244 | 0.623 |
| LIG_CaM_IQ_9 | 62 | 77 | PF13499 | 0.549 |
| LIG_CSL_BTD_1 | 36 | 39 | PF09270 | 0.635 |
| LIG_FHA_1 | 159 | 165 | PF00498 | 0.465 |
| LIG_FHA_1 | 42 | 48 | PF00498 | 0.368 |
| LIG_Integrin_RGD_1 | 9 | 11 | PF01839 | 0.362 |
| LIG_LIR_Apic_2 | 44 | 48 | PF02991 | 0.444 |
| LIG_LIR_Apic_2 | 94 | 98 | PF02991 | 0.657 |
| LIG_LIR_Gen_1 | 105 | 114 | PF02991 | 0.493 |
| LIG_LIR_Gen_1 | 132 | 138 | PF02991 | 0.368 |
| LIG_LIR_Nem_3 | 105 | 110 | PF02991 | 0.454 |
| LIG_LIR_Nem_3 | 132 | 137 | PF02991 | 0.441 |
| LIG_LIR_Nem_3 | 44 | 49 | PF02991 | 0.422 |
| LIG_PDZ_Class_2 | 196 | 201 | PF00595 | 0.361 |
| LIG_Pex14_1 | 45 | 49 | PF04695 | 0.468 |
| LIG_Pex14_2 | 33 | 37 | PF04695 | 0.604 |
| LIG_SH2_PTP2 | 174 | 177 | PF00017 | 0.658 |
| LIG_SH2_STAP1 | 117 | 121 | PF00017 | 0.455 |
| LIG_SH2_STAT3 | 63 | 66 | PF00017 | 0.530 |
| LIG_SH2_STAT5 | 174 | 177 | PF00017 | 0.594 |
| LIG_SH3_3 | 15 | 21 | PF00018 | 0.648 |
| LIG_SH3_3 | 33 | 39 | PF00018 | 0.605 |
| LIG_SUMO_SIM_anti_2 | 187 | 192 | PF11976 | 0.427 |
| LIG_SUMO_SIM_par_1 | 193 | 198 | PF11976 | 0.409 |
| LIG_TYR_ITIM | 82 | 87 | PF00017 | 0.440 |
| LIG_WRC_WIRS_1 | 92 | 97 | PF05994 | 0.667 |
| MOD_CK2_1 | 1 | 7 | PF00069 | 0.654 |
| MOD_GlcNHglycan | 11 | 15 | PF01048 | 0.460 |
| MOD_GlcNHglycan | 122 | 125 | PF01048 | 0.206 |
| MOD_GSK3_1 | 156 | 163 | PF00069 | 0.454 |
| MOD_N-GLC_1 | 149 | 154 | PF02516 | 0.355 |
| MOD_N-GLC_2 | 139 | 141 | PF02516 | 0.244 |
| MOD_NEK2_1 | 1 | 6 | PF00069 | 0.609 |
| MOD_NEK2_1 | 149 | 154 | PF00069 | 0.415 |
| MOD_NEK2_1 | 195 | 200 | PF00069 | 0.334 |
| MOD_NEK2_1 | 65 | 70 | PF00069 | 0.383 |
| MOD_PIKK_1 | 100 | 106 | PF00454 | 0.423 |
| MOD_PIKK_1 | 149 | 155 | PF00454 | 0.478 |
| MOD_PIKK_1 | 55 | 61 | PF00454 | 0.504 |
| MOD_Plk_1 | 149 | 155 | PF00069 | 0.555 |
| MOD_Plk_1 | 2 | 8 | PF00069 | 0.638 |
| MOD_Plk_4 | 184 | 190 | PF00069 | 0.407 |
| MOD_Plk_4 | 195 | 201 | PF00069 | 0.362 |
| MOD_Plk_4 | 41 | 47 | PF00069 | 0.444 |
| MOD_Plk_4 | 91 | 97 | PF00069 | 0.673 |
| MOD_ProDKin_1 | 35 | 41 | PF00069 | 0.641 |
| TRG_ENDOCYTIC_2 | 134 | 137 | PF00928 | 0.444 |
| TRG_ENDOCYTIC_2 | 174 | 177 | PF00928 | 0.704 |
| TRG_ENDOCYTIC_2 | 84 | 87 | PF00928 | 0.440 |
| TRG_ER_diArg_1 | 177 | 179 | PF00400 | 0.625 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1I138 | Leptomonas seymouri | 60% | 100% |
| A0A0S4IX94 | Bodo saltans | 50% | 100% |
| A0A1X0P8A2 | Trypanosomatidae | 54% | 99% |
| A0A3S7X0K2 | Leishmania donovani | 73% | 100% |
| A0A422NWL7 | Trypanosoma rangeli | 51% | 100% |
| A4I2P7 | Leishmania infantum | 73% | 100% |
| D0A2W6 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 48% | 100% |
| E9AD67 | Leishmania major | 71% | 100% |
| E9AYZ2 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 68% | 100% |
| F4ITL6 | Arabidopsis thaliana | 32% | 80% |
| Q8BVA2 | Mus musculus | 34% | 97% |
| Q9H0R3 | Homo sapiens | 35% | 97% |
| Q9SD42 | Arabidopsis thaliana | 32% | 87% |
| V5DL06 | Trypanosoma cruzi | 53% | 100% |