Flagellar protofilament ribbon protein rib74

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Repeat of unknown function (DUF1126)/EF-hand domain pair, putative

Species:

Leishmania braziliensis

UniProt:

A4HFK9_LEIBR

TriTrypDb:

LbrM.27.0940 , LBRM2903_270015300

Length:

757

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005819	spindle	5	1
GO:0005930	axoneme	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0072686	mitotic spindle	6	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFK9

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0000281	mitotic cytokinesis	4	1
GO:0000910	cytokinesis	3	1
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0007051	spindle organization	3	1
GO:0007052	mitotic spindle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0048870	cell motility	2	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0061640	cytoskeleton-dependent cytokinesis	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1902850	microtubule cytoskeleton organization involved in mitosis	4	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0005509	calcium ion binding	5	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0043014	alpha-tubulin binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	69	73	PF00656	0.588
CLV_MEL_PAP_1	724	730	PF00089	0.505
CLV_NRD_NRD_1	116	118	PF00675	0.255
CLV_NRD_NRD_1	252	254	PF00675	0.334
CLV_NRD_NRD_1	29	31	PF00675	0.543
CLV_NRD_NRD_1	34	36	PF00675	0.550
CLV_NRD_NRD_1	397	399	PF00675	0.575
CLV_NRD_NRD_1	417	419	PF00675	0.268
CLV_NRD_NRD_1	442	444	PF00675	0.255
CLV_NRD_NRD_1	479	481	PF00675	0.307
CLV_NRD_NRD_1	533	535	PF00675	0.392
CLV_NRD_NRD_1	647	649	PF00675	0.617
CLV_NRD_NRD_1	670	672	PF00675	0.412
CLV_NRD_NRD_1	700	702	PF00675	0.423
CLV_PCSK_FUR_1	648	652	PF00082	0.383
CLV_PCSK_KEX2_1	149	151	PF00082	0.255
CLV_PCSK_KEX2_1	29	31	PF00082	0.543
CLV_PCSK_KEX2_1	34	36	PF00082	0.550
CLV_PCSK_KEX2_1	397	399	PF00082	0.575
CLV_PCSK_KEX2_1	417	419	PF00082	0.268
CLV_PCSK_KEX2_1	442	444	PF00082	0.255
CLV_PCSK_KEX2_1	479	481	PF00082	0.255
CLV_PCSK_KEX2_1	650	652	PF00082	0.386
CLV_PCSK_KEX2_1	670	672	PF00082	0.412
CLV_PCSK_KEX2_1	700	702	PF00082	0.500
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.255
CLV_PCSK_PC1ET2_1	650	652	PF00082	0.404
CLV_PCSK_PC7_1	30	36	PF00082	0.653
CLV_PCSK_PC7_1	475	481	PF00082	0.255
CLV_PCSK_SKI1_1	189	193	PF00082	0.431
CLV_PCSK_SKI1_1	246	250	PF00082	0.336
CLV_PCSK_SKI1_1	253	257	PF00082	0.294
CLV_PCSK_SKI1_1	272	276	PF00082	0.285
CLV_PCSK_SKI1_1	355	359	PF00082	0.255
CLV_PCSK_SKI1_1	443	447	PF00082	0.255
CLV_PCSK_SKI1_1	572	576	PF00082	0.494
CLV_PCSK_SKI1_1	671	675	PF00082	0.423
CLV_PCSK_SKI1_1	718	722	PF00082	0.494
CLV_Separin_Metazoa	26	30	PF03568	0.546
DEG_APCC_KENBOX_2	330	334	PF00400	0.509
DEG_SIAH_1	199	207	PF03145	0.585
DOC_ANK_TNKS_1	605	612	PF00023	0.494
DOC_CDC14_PxL_1	15	23	PF14671	0.660
DOC_CYCLIN_RxL_1	186	194	PF00134	0.632
DOC_CYCLIN_RxL_1	569	580	PF00134	0.465
DOC_CYCLIN_RxL_1	668	677	PF00134	0.408
DOC_CYCLIN_RxL_1	696	707	PF00134	0.511
DOC_MAPK_gen_1	115	123	PF00069	0.457
DOC_MAPK_gen_1	243	251	PF00069	0.452
DOC_MAPK_gen_1	440	448	PF00069	0.461
DOC_MAPK_MEF2A_6	115	123	PF00069	0.507
DOC_MAPK_MEF2A_6	559	568	PF00069	0.333
DOC_PP4_FxxP_1	13	16	PF00568	0.532
DOC_PP4_FxxP_1	390	393	PF00568	0.640
DOC_SPAK_OSR1_1	373	377	PF12202	0.333
DOC_USP7_MATH_1	209	213	PF00917	0.346
DOC_USP7_MATH_1	632	636	PF00917	0.674
DOC_USP7_MATH_1	685	689	PF00917	0.533
DOC_USP7_MATH_1	726	730	PF00917	0.526
DOC_USP7_MATH_1	749	753	PF00917	0.543
DOC_USP7_UBL2_3	436	440	PF12436	0.558
DOC_USP7_UBL2_3	531	535	PF12436	0.540
DOC_WW_Pin1_4	156	161	PF00397	0.443
DOC_WW_Pin1_4	228	233	PF00397	0.561
DOC_WW_Pin1_4	383	388	PF00397	0.596
LIG_14-3-3_CanoR_1	312	320	PF00244	0.377
LIG_14-3-3_CanoR_1	373	383	PF00244	0.343
LIG_14-3-3_CanoR_1	420	426	PF00244	0.415
LIG_14-3-3_CanoR_1	67	71	PF00244	0.605
LIG_14-3-3_CanoR_1	727	734	PF00244	0.426
LIG_14-3-3_CanoR_1	735	743	PF00244	0.417
LIG_AP2alpha_2	185	187	PF02296	0.558
LIG_AP2alpha_2	299	301	PF02296	0.455
LIG_BIR_II_1	1	5	PF00653	0.564
LIG_BIR_III_2	183	187	PF00653	0.567
LIG_BRCT_BRCA1_1	316	320	PF00533	0.534
LIG_BRCT_BRCA1_1	326	330	PF00533	0.468
LIG_BRCT_BRCA1_1	500	504	PF00533	0.534
LIG_eIF4E_1	684	690	PF01652	0.528
LIG_FHA_1	127	133	PF00498	0.408
LIG_FHA_1	143	149	PF00498	0.455
LIG_FHA_1	176	182	PF00498	0.450
LIG_FHA_1	186	192	PF00498	0.520
LIG_FHA_1	263	269	PF00498	0.468
LIG_FHA_1	452	458	PF00498	0.380
LIG_FHA_1	542	548	PF00498	0.482
LIG_FHA_1	632	638	PF00498	0.424
LIG_FHA_1	90	96	PF00498	0.356
LIG_FHA_2	259	265	PF00498	0.534
LIG_FHA_2	327	333	PF00498	0.461
LIG_FHA_2	338	344	PF00498	0.414
LIG_FHA_2	394	400	PF00498	0.686
LIG_FHA_2	577	583	PF00498	0.471
LIG_FHA_2	67	73	PF00498	0.580
LIG_FHA_2	76	82	PF00498	0.524
LIG_LIR_Apic_2	12	16	PF02991	0.538
LIG_LIR_Gen_1	207	218	PF02991	0.499
LIG_LIR_Gen_1	245	256	PF02991	0.459
LIG_LIR_Gen_1	271	281	PF02991	0.507
LIG_LIR_Gen_1	501	511	PF02991	0.509
LIG_LIR_Gen_1	599	608	PF02991	0.472
LIG_LIR_Gen_1	620	629	PF02991	0.419
LIG_LIR_Gen_1	662	667	PF02991	0.415
LIG_LIR_Gen_1	677	685	PF02991	0.348
LIG_LIR_Gen_1	731	737	PF02991	0.499
LIG_LIR_Nem_3	178	182	PF02991	0.455
LIG_LIR_Nem_3	245	251	PF02991	0.355
LIG_LIR_Nem_3	271	277	PF02991	0.465
LIG_LIR_Nem_3	299	304	PF02991	0.455
LIG_LIR_Nem_3	361	365	PF02991	0.463
LIG_LIR_Nem_3	377	382	PF02991	0.377
LIG_LIR_Nem_3	456	461	PF02991	0.482
LIG_LIR_Nem_3	501	507	PF02991	0.509
LIG_LIR_Nem_3	595	600	PF02991	0.477
LIG_LIR_Nem_3	620	624	PF02991	0.409
LIG_LIR_Nem_3	662	666	PF02991	0.409
LIG_LIR_Nem_3	677	681	PF02991	0.278
LIG_LIR_Nem_3	731	736	PF02991	0.503
LIG_Pex14_1	621	625	PF04695	0.536
LIG_Pex14_2	301	305	PF04695	0.374
LIG_Pex14_2	674	678	PF04695	0.416
LIG_REV1ctd_RIR_1	302	311	PF16727	0.399
LIG_SH2_CRK	379	383	PF00017	0.501
LIG_SH2_NCK_1	600	604	PF00017	0.586
LIG_SH2_SRC	600	603	PF00017	0.593
LIG_SH2_SRC	625	628	PF00017	0.592
LIG_SH2_STAP1	365	369	PF00017	0.504
LIG_SH2_STAP1	600	604	PF00017	0.474
LIG_SH2_STAP1	743	747	PF00017	0.533
LIG_SH2_STAT3	353	356	PF00017	0.558
LIG_SH2_STAT5	101	104	PF00017	0.468
LIG_SH2_STAT5	124	127	PF00017	0.534
LIG_SH2_STAT5	210	213	PF00017	0.525
LIG_SH2_STAT5	279	282	PF00017	0.461
LIG_SH2_STAT5	339	342	PF00017	0.455
LIG_SH2_STAT5	365	368	PF00017	0.550
LIG_SH2_STAT5	485	488	PF00017	0.460
LIG_SH2_STAT5	492	495	PF00017	0.446
LIG_SH2_STAT5	589	592	PF00017	0.421
LIG_SH3_3	129	135	PF00018	0.534
LIG_SH3_3	13	19	PF00018	0.526
LIG_SH3_3	150	156	PF00018	0.507
LIG_SH3_3	165	171	PF00018	0.488
LIG_SH3_3	386	392	PF00018	0.497
LIG_SH3_3	46	52	PF00018	0.451
LIG_SUMO_SIM_anti_2	285	290	PF11976	0.376
LIG_SUMO_SIM_anti_2	582	588	PF11976	0.400
LIG_SUMO_SIM_par_1	452	459	PF11976	0.384
LIG_TRAF2_1	109	112	PF00917	0.405
LIG_TRAF2_1	401	404	PF00917	0.410
LIG_TRAF2_1	579	582	PF00917	0.370
LIG_TRAF2_1	599	602	PF00917	0.300
LIG_TRAF2_1	643	646	PF00917	0.403
LIG_TRAF2_1	729	732	PF00917	0.398
LIG_TYR_ITSM	375	382	PF00017	0.444
LIG_UBA3_1	570	575	PF00899	0.403
LIG_UBA3_1	583	592	PF00899	0.412
MOD_CK1_1	212	218	PF00069	0.550
MOD_CK1_1	282	288	PF00069	0.507
MOD_CK1_1	313	319	PF00069	0.377
MOD_CK1_1	542	548	PF00069	0.419
MOD_CK1_1	596	602	PF00069	0.482
MOD_CK1_1	739	745	PF00069	0.446
MOD_CK2_1	106	112	PF00069	0.457
MOD_CK2_1	128	134	PF00069	0.455
MOD_CK2_1	19	25	PF00069	0.516
MOD_CK2_1	326	332	PF00069	0.482
MOD_CK2_1	393	399	PF00069	0.641
MOD_CK2_1	453	459	PF00069	0.485
MOD_CK2_1	576	582	PF00069	0.373
MOD_CK2_1	596	602	PF00069	0.296
MOD_CK2_1	726	732	PF00069	0.395
MOD_GlcNHglycan	108	111	PF01048	0.291
MOD_GlcNHglycan	138	142	PF01048	0.244
MOD_GlcNHglycan	237	240	PF01048	0.432
MOD_GlcNHglycan	295	298	PF01048	0.255
MOD_GlcNHglycan	315	319	PF01048	0.322
MOD_GlcNHglycan	43	46	PF01048	0.452
MOD_GlcNHglycan	464	467	PF01048	0.257
MOD_GlcNHglycan	627	630	PF01048	0.384
MOD_GlcNHglycan	652	655	PF01048	0.484
MOD_GlcNHglycan	753	756	PF01048	0.414
MOD_GSK3_1	126	133	PF00069	0.389
MOD_GSK3_1	204	211	PF00069	0.517
MOD_GSK3_1	223	230	PF00069	0.402
MOD_GSK3_1	258	265	PF00069	0.534
MOD_GSK3_1	310	317	PF00069	0.504
MOD_GSK3_1	320	327	PF00069	0.500
MOD_GSK3_1	333	340	PF00069	0.468
MOD_GSK3_1	506	513	PF00069	0.450
MOD_GSK3_1	61	68	PF00069	0.667
MOD_GSK3_1	739	746	PF00069	0.504
MOD_GSK3_1	749	756	PF00069	0.603
MOD_N-GLC_1	593	598	PF02516	0.494
MOD_N-GLC_1	617	622	PF02516	0.501
MOD_N-GLC_1	737	742	PF02516	0.414
MOD_NEK2_1	1	6	PF00069	0.573
MOD_NEK2_1	142	147	PF00069	0.490
MOD_NEK2_1	268	273	PF00069	0.507
MOD_NEK2_1	320	325	PF00069	0.534
MOD_NEK2_1	374	379	PF00069	0.466
MOD_NEK2_1	421	426	PF00069	0.517
MOD_NEK2_1	539	544	PF00069	0.413
MOD_NEK2_1	703	708	PF00069	0.448
MOD_NEK2_1	736	741	PF00069	0.418
MOD_NEK2_2	209	214	PF00069	0.547
MOD_NEK2_2	326	331	PF00069	0.473
MOD_NEK2_2	66	71	PF00069	0.750
MOD_PIKK_1	1	7	PF00454	0.604
MOD_PKA_1	650	656	PF00069	0.331
MOD_PKA_2	242	248	PF00069	0.438
MOD_PKA_2	311	317	PF00069	0.377
MOD_PKA_2	462	468	PF00069	0.468
MOD_PKA_2	650	656	PF00069	0.546
MOD_PKA_2	66	72	PF00069	0.681
MOD_PKA_2	726	732	PF00069	0.437
MOD_Plk_1	258	264	PF00069	0.534
MOD_Plk_1	320	326	PF00069	0.517
MOD_Plk_1	451	457	PF00069	0.455
MOD_Plk_1	510	516	PF00069	0.536
MOD_Plk_1	53	59	PF00069	0.649
MOD_Plk_1	593	599	PF00069	0.472
MOD_Plk_1	617	623	PF00069	0.499
MOD_Plk_1	84	90	PF00069	0.575
MOD_Plk_2-3	617	623	PF00069	0.485
MOD_Plk_4	170	176	PF00069	0.534
MOD_Plk_4	232	238	PF00069	0.630
MOD_Plk_4	264	270	PF00069	0.515
MOD_Plk_4	273	279	PF00069	0.449
MOD_Plk_4	333	339	PF00069	0.465
MOD_Plk_4	421	427	PF00069	0.534
MOD_Plk_4	43	49	PF00069	0.574
MOD_Plk_4	453	459	PF00069	0.504
MOD_Plk_4	566	572	PF00069	0.459
MOD_Plk_4	582	588	PF00069	0.266
MOD_Plk_4	632	638	PF00069	0.644
MOD_Plk_4	685	691	PF00069	0.420
MOD_ProDKin_1	156	162	PF00069	0.443
MOD_ProDKin_1	228	234	PF00069	0.559
MOD_ProDKin_1	383	389	PF00069	0.605
MOD_SUMO_rev_2	250	256	PF00179	0.534
MOD_SUMO_rev_2	433	441	PF00179	0.558
MOD_SUMO_rev_2	569	576	PF00179	0.308
MOD_SUMO_rev_2	635	643	PF00179	0.569
MOD_SUMO_rev_2	688	697	PF00179	0.426
TRG_DiLeu_BaEn_1	732	737	PF01217	0.490
TRG_DiLeu_BaEn_4	711	717	PF01217	0.484
TRG_DiLeu_LyEn_5	732	737	PF01217	0.523
TRG_ENDOCYTIC_2	210	213	PF00928	0.495
TRG_ENDOCYTIC_2	278	281	PF00928	0.460
TRG_ENDOCYTIC_2	379	382	PF00928	0.448
TRG_ENDOCYTIC_2	600	603	PF00928	0.481
TRG_ER_diArg_1	213	216	PF00400	0.537
TRG_ER_diArg_1	28	30	PF00400	0.545
TRG_ER_diArg_1	307	310	PF00400	0.460
TRG_ER_diArg_1	416	418	PF00400	0.581
TRG_ER_diArg_1	441	443	PF00400	0.455
TRG_ER_diArg_1	478	480	PF00400	0.508
TRG_ER_diArg_1	699	701	PF00400	0.396
TRG_Pf-PMV_PEXEL_1	189	194	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	398	402	PF00026	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5H4	Leptomonas seymouri	22%	90%
A0A0N1HZ98	Leptomonas seymouri	26%	98%
A0A0N1I3M2	Leptomonas seymouri	76%	99%
A0A0N1PBW1	Leptomonas seymouri	27%	100%
A0A0S4IJW8	Bodo saltans	26%	92%
A0A0S4IQM0	Bodo saltans	25%	100%
A0A0S4J8J7	Bodo saltans	26%	83%
A0A1X0NEV8	Trypanosomatidae	24%	95%
A0A1X0NLI2	Trypanosomatidae	27%	100%
A0A1X0NMQ3	Trypanosomatidae	24%	97%
A0A1X0P419	Trypanosomatidae	62%	100%
A0A3Q1N1R0	Bos taurus	30%	100%
A0A3Q8IDH4	Leishmania donovani	26%	98%
A0A3Q8IPU3	Leishmania donovani	87%	100%
A0A3R7KM50	Trypanosoma rangeli	27%	95%
A0A3R7L048	Trypanosoma rangeli	58%	100%
A0A3S5H688	Leishmania donovani	23%	100%
A0A3S7XC76	Leishmania donovani	26%	100%
A0A422N0Z6	Trypanosoma rangeli	24%	97%
A0A422NK00	Trypanosoma rangeli	28%	100%
A4HE78	Leishmania braziliensis	26%	100%
A4HQF8	Leishmania braziliensis	25%	100%
A4I1J2	Leishmania infantum	26%	98%
A4IC94	Leishmania infantum	26%	100%
C9ZJX4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	94%
C9ZPE7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	97%
D0A3K7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A5T5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E1BKH1	Bos taurus	29%	100%
E9AD64	Leishmania major	88%	100%
E9AHF6	Leishmania infantum	88%	100%
E9AI34	Leishmania braziliensis	23%	88%
E9AMI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	88%
E9AU74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AXM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	98%
E9AYY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q32TF8	Danio rerio	30%	100%
Q32TG3	Gallus gallus	28%	100%
Q4Q0C0	Leishmania major	26%	96%
Q4Q9U5	Leishmania major	27%	100%
Q4QI57	Leishmania major	23%	100%
Q5JST6	Homo sapiens	29%	100%
Q5JVL4	Homo sapiens	30%	100%
Q9D485	Mus musculus	30%	100%
Q9D9T8	Mus musculus	30%	100%
V5ASV2	Trypanosoma cruzi	26%	100%
V5D3X9	Trypanosoma cruzi	24%	97%
V5DA42	Trypanosoma cruzi	59%	100%