WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HFK8_LEIBR

TriTrypDb:

LbrM.27.0930 , LBRM2903_270015200

Length:

1039

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFK8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	37	41	PF00656	0.651
CLV_C14_Caspase3-7	752	756	PF00656	0.478
CLV_C14_Caspase3-7	763	767	PF00656	0.430
CLV_NRD_NRD_1	442	444	PF00675	0.305
CLV_NRD_NRD_1	463	465	PF00675	0.351
CLV_NRD_NRD_1	62	64	PF00675	0.399
CLV_NRD_NRD_1	741	743	PF00675	0.504
CLV_NRD_NRD_1	783	785	PF00675	0.442
CLV_NRD_NRD_1	935	937	PF00675	0.667
CLV_NRD_NRD_1	986	988	PF00675	0.493
CLV_NRD_NRD_1	99	101	PF00675	0.521
CLV_PCSK_KEX2_1	62	64	PF00082	0.422
CLV_PCSK_KEX2_1	741	743	PF00082	0.504
CLV_PCSK_KEX2_1	782	784	PF00082	0.482
CLV_PCSK_KEX2_1	935	937	PF00082	0.673
CLV_PCSK_KEX2_1	98	100	PF00082	0.515
CLV_PCSK_KEX2_1	986	988	PF00082	0.493
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.515
CLV_PCSK_SKI1_1	1027	1031	PF00082	0.510
CLV_PCSK_SKI1_1	182	186	PF00082	0.497
CLV_PCSK_SKI1_1	270	274	PF00082	0.389
CLV_PCSK_SKI1_1	580	584	PF00082	0.454
CLV_PCSK_SKI1_1	962	966	PF00082	0.376
CLV_PCSK_SKI1_1	987	991	PF00082	0.423
DEG_APCC_DBOX_1	269	277	PF00400	0.466
DEG_APCC_DBOX_1	704	712	PF00400	0.406
DEG_MDM2_SWIB_1	374	382	PF02201	0.322
DEG_MDM2_SWIB_1	746	754	PF02201	0.572
DEG_Nend_UBRbox_3	1	3	PF02207	0.639
DEG_SPOP_SBC_1	359	363	PF00917	0.485
DEG_SPOP_SBC_1	395	399	PF00917	0.486
DEG_SPOP_SBC_1	429	433	PF00917	0.351
DOC_CKS1_1	297	302	PF01111	0.405
DOC_CKS1_1	642	647	PF01111	0.308
DOC_CKS1_1	795	800	PF01111	0.534
DOC_CKS1_1	867	872	PF01111	0.377
DOC_CYCLIN_RxL_1	1024	1034	PF00134	0.568
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.532
DOC_CYCLIN_yCln2_LP_2	137	140	PF00134	0.361
DOC_MAPK_DCC_7	846	855	PF00069	0.442
DOC_MAPK_gen_1	116	124	PF00069	0.509
DOC_MAPK_gen_1	846	855	PF00069	0.442
DOC_MAPK_MEF2A_6	596	605	PF00069	0.361
DOC_MAPK_MEF2A_6	635	642	PF00069	0.443
DOC_MAPK_MEF2A_6	833	842	PF00069	0.608
DOC_MAPK_MEF2A_6	846	855	PF00069	0.394
DOC_MAPK_NFAT4_5	635	643	PF00069	0.439
DOC_MAPK_RevD_3	48	63	PF00069	0.455
DOC_PP1_RVXF_1	119	126	PF00149	0.420
DOC_PP1_RVXF_1	463	470	PF00149	0.392
DOC_PP1_RVXF_1	960	966	PF00149	0.392
DOC_PP2B_LxvP_1	137	140	PF13499	0.385
DOC_PP2B_LxvP_1	459	462	PF13499	0.313
DOC_PP4_FxxP_1	1022	1025	PF00568	0.435
DOC_PP4_FxxP_1	565	568	PF00568	0.390
DOC_USP7_MATH_1	162	166	PF00917	0.580
DOC_USP7_MATH_1	209	213	PF00917	0.362
DOC_USP7_MATH_1	342	346	PF00917	0.609
DOC_USP7_MATH_1	359	363	PF00917	0.456
DOC_USP7_MATH_1	395	399	PF00917	0.591
DOC_USP7_MATH_1	526	530	PF00917	0.444
DOC_USP7_MATH_1	673	677	PF00917	0.512
DOC_USP7_MATH_1	760	764	PF00917	0.510
DOC_USP7_MATH_1	86	90	PF00917	0.534
DOC_WW_Pin1_4	10	15	PF00397	0.598
DOC_WW_Pin1_4	105	110	PF00397	0.634
DOC_WW_Pin1_4	296	301	PF00397	0.450
DOC_WW_Pin1_4	345	350	PF00397	0.573
DOC_WW_Pin1_4	510	515	PF00397	0.494
DOC_WW_Pin1_4	641	646	PF00397	0.317
DOC_WW_Pin1_4	662	667	PF00397	0.573
DOC_WW_Pin1_4	758	763	PF00397	0.776
DOC_WW_Pin1_4	794	799	PF00397	0.538
DOC_WW_Pin1_4	817	822	PF00397	0.543
DOC_WW_Pin1_4	84	89	PF00397	0.499
DOC_WW_Pin1_4	866	871	PF00397	0.387
DOC_WW_Pin1_4	923	928	PF00397	0.588
LIG_14-3-3_CanoR_1	182	187	PF00244	0.416
LIG_14-3-3_CanoR_1	193	201	PF00244	0.399
LIG_14-3-3_CanoR_1	288	292	PF00244	0.507
LIG_14-3-3_CanoR_1	62	66	PF00244	0.546
LIG_14-3-3_CanoR_1	701	708	PF00244	0.459
LIG_14-3-3_CanoR_1	744	749	PF00244	0.385
LIG_14-3-3_CanoR_1	81	86	PF00244	0.440
LIG_14-3-3_CanoR_1	833	840	PF00244	0.550
LIG_14-3-3_CanoR_1	856	864	PF00244	0.544
LIG_14-3-3_CanoR_1	878	888	PF00244	0.439
LIG_14-3-3_CanoR_1	900	904	PF00244	0.493
LIG_14-3-3_CanoR_1	986	995	PF00244	0.453
LIG_Actin_WH2_2	575	592	PF00022	0.389
LIG_APCC_ABBA_1	888	893	PF00400	0.346
LIG_BIR_III_4	991	995	PF00653	0.539
LIG_BRCT_BRCA1_1	254	258	PF00533	0.459
LIG_BRCT_BRCA1_1	430	434	PF00533	0.283
LIG_BRCT_BRCA1_1	86	90	PF00533	0.609
LIG_Clathr_ClatBox_1	837	841	PF01394	0.590
LIG_DLG_GKlike_1	744	751	PF00625	0.388
LIG_FHA_1	106	112	PF00498	0.595
LIG_FHA_1	127	133	PF00498	0.522
LIG_FHA_1	202	208	PF00498	0.472
LIG_FHA_1	214	220	PF00498	0.277
LIG_FHA_1	23	29	PF00498	0.473
LIG_FHA_1	245	251	PF00498	0.489
LIG_FHA_1	261	267	PF00498	0.284
LIG_FHA_1	313	319	PF00498	0.426
LIG_FHA_1	361	367	PF00498	0.515
LIG_FHA_1	397	403	PF00498	0.453
LIG_FHA_1	446	452	PF00498	0.431
LIG_FHA_1	511	517	PF00498	0.425
LIG_FHA_1	581	587	PF00498	0.340
LIG_FHA_1	606	612	PF00498	0.489
LIG_FHA_1	635	641	PF00498	0.472
LIG_FHA_1	68	74	PF00498	0.516
LIG_FHA_1	686	692	PF00498	0.481
LIG_FHA_1	795	801	PF00498	0.540
LIG_FHA_1	855	861	PF00498	0.613
LIG_FHA_1	867	873	PF00498	0.410
LIG_FHA_1	943	949	PF00498	0.501
LIG_FHA_1	976	982	PF00498	0.426
LIG_FHA_2	154	160	PF00498	0.459
LIG_FHA_2	244	250	PF00498	0.324
LIG_FHA_2	35	41	PF00498	0.669
LIG_LIR_Apic_2	1021	1025	PF02991	0.506
LIG_LIR_Gen_1	152	163	PF02991	0.421
LIG_LIR_Gen_1	203	213	PF02991	0.296
LIG_LIR_Gen_1	299	309	PF02991	0.416
LIG_LIR_Gen_1	315	323	PF02991	0.473
LIG_LIR_Gen_1	45	54	PF02991	0.522
LIG_LIR_Gen_1	480	489	PF02991	0.407
LIG_LIR_Gen_1	683	694	PF02991	0.346
LIG_LIR_LC3C_4	599	603	PF02991	0.303
LIG_LIR_Nem_3	152	158	PF02991	0.382
LIG_LIR_Nem_3	180	184	PF02991	0.345
LIG_LIR_Nem_3	203	208	PF02991	0.309
LIG_LIR_Nem_3	299	305	PF02991	0.411
LIG_LIR_Nem_3	315	320	PF02991	0.466
LIG_LIR_Nem_3	334	340	PF02991	0.422
LIG_LIR_Nem_3	45	50	PF02991	0.508
LIG_LIR_Nem_3	466	472	PF02991	0.479
LIG_LIR_Nem_3	480	484	PF02991	0.304
LIG_LIR_Nem_3	683	689	PF02991	0.374
LIG_MAD2	560	568	PF02301	0.330
LIG_MYND_1	458	462	PF01753	0.390
LIG_Pex14_2	374	378	PF04695	0.304
LIG_Pex14_2	746	750	PF04695	0.540
LIG_Pex14_2	984	988	PF04695	0.408
LIG_SH2_CRK	47	51	PF00017	0.585
LIG_SH2_GRB2like	403	406	PF00017	0.382
LIG_SH2_GRB2like	968	971	PF00017	0.308
LIG_SH2_NCK_1	155	159	PF00017	0.453
LIG_SH2_PTP2	403	406	PF00017	0.515
LIG_SH2_SRC	403	406	PF00017	0.515
LIG_SH2_SRC	968	971	PF00017	0.466
LIG_SH2_STAP1	47	51	PF00017	0.509
LIG_SH2_STAP1	481	485	PF00017	0.381
LIG_SH2_STAT5	153	156	PF00017	0.381
LIG_SH2_STAT5	174	177	PF00017	0.564
LIG_SH2_STAT5	403	406	PF00017	0.515
LIG_SH2_STAT5	925	928	PF00017	0.593
LIG_SH2_STAT5	982	985	PF00017	0.478
LIG_SH3_2	279	284	PF14604	0.588
LIG_SH3_3	273	279	PF00018	0.458
LIG_SH3_3	294	300	PF00018	0.483
LIG_SH3_3	343	349	PF00018	0.499
LIG_SH3_3	639	645	PF00018	0.289
LIG_SH3_3	690	696	PF00018	0.316
LIG_SH3_3	804	810	PF00018	0.448
LIG_SH3_3	846	852	PF00018	0.462
LIG_SH3_3	864	870	PF00018	0.343
LIG_SH3_3	89	95	PF00018	0.509
LIG_SH3_3	992	998	PF00018	0.549
LIG_SUMO_SIM_anti_2	1007	1013	PF11976	0.402
LIG_SUMO_SIM_anti_2	599	604	PF11976	0.306
LIG_SUMO_SIM_anti_2	799	805	PF11976	0.570
LIG_SUMO_SIM_par_1	262	267	PF11976	0.283
LIG_SUMO_SIM_par_1	599	604	PF11976	0.401
LIG_SUMO_SIM_par_1	687	695	PF11976	0.402
LIG_SUMO_SIM_par_1	721	727	PF11976	0.341
LIG_TRAF2_1	167	170	PF00917	0.437
LIG_WRC_WIRS_1	1019	1024	PF05994	0.496
LIG_WRC_WIRS_1	202	207	PF05994	0.319
LIG_WW_3	1024	1028	PF00397	0.462
MOD_CDK_SPK_2	866	871	PF00069	0.387
MOD_CDK_SPK_2	923	928	PF00069	0.664
MOD_CDK_SPxxK_3	866	873	PF00069	0.377
MOD_CK1_1	177	183	PF00069	0.549
MOD_CK1_1	192	198	PF00069	0.362
MOD_CK1_1	260	266	PF00069	0.392
MOD_CK1_1	290	296	PF00069	0.651
MOD_CK1_1	345	351	PF00069	0.633
MOD_CK1_1	36	42	PF00069	0.660
MOD_CK1_1	361	367	PF00069	0.431
MOD_CK1_1	445	451	PF00069	0.481
MOD_CK1_1	477	483	PF00069	0.376
MOD_CK1_1	662	668	PF00069	0.376
MOD_CK1_1	676	682	PF00069	0.304
MOD_CK1_1	700	706	PF00069	0.444
MOD_CK1_1	761	767	PF00069	0.588
MOD_CK1_1	773	779	PF00069	0.507
MOD_CK1_1	832	838	PF00069	0.724
MOD_CK1_1	84	90	PF00069	0.600
MOD_CK2_1	112	118	PF00069	0.516
MOD_CK2_1	153	159	PF00069	0.453
MOD_CK2_1	162	168	PF00069	0.480
MOD_CK2_1	243	249	PF00069	0.325
MOD_CK2_1	721	727	PF00069	0.513
MOD_GlcNHglycan	1006	1009	PF01048	0.543
MOD_GlcNHglycan	159	163	PF01048	0.552
MOD_GlcNHglycan	164	167	PF01048	0.507
MOD_GlcNHglycan	259	262	PF01048	0.387
MOD_GlcNHglycan	371	374	PF01048	0.322
MOD_GlcNHglycan	415	418	PF01048	0.316
MOD_GlcNHglycan	444	447	PF01048	0.420
MOD_GlcNHglycan	592	595	PF01048	0.426
MOD_GlcNHglycan	661	664	PF01048	0.406
MOD_GlcNHglycan	67	70	PF01048	0.516
MOD_GlcNHglycan	708	711	PF01048	0.467
MOD_GlcNHglycan	736	739	PF01048	0.449
MOD_GlcNHglycan	81	84	PF01048	0.483
MOD_GlcNHglycan	916	919	PF01048	0.702
MOD_GlcNHglycan	991	995	PF01048	0.427
MOD_GSK3_1	149	156	PF00069	0.423
MOD_GSK3_1	158	165	PF00069	0.441
MOD_GSK3_1	203	210	PF00069	0.334
MOD_GSK3_1	260	267	PF00069	0.295
MOD_GSK3_1	30	37	PF00069	0.733
MOD_GSK3_1	341	348	PF00069	0.593
MOD_GSK3_1	355	362	PF00069	0.528
MOD_GSK3_1	365	372	PF00069	0.341
MOD_GSK3_1	445	452	PF00069	0.459
MOD_GSK3_1	61	68	PF00069	0.544
MOD_GSK3_1	619	626	PF00069	0.454
MOD_GSK3_1	742	749	PF00069	0.658
MOD_GSK3_1	77	84	PF00069	0.417
MOD_GSK3_1	819	826	PF00069	0.596
MOD_GSK3_1	854	861	PF00069	0.543
MOD_GSK3_1	879	886	PF00069	0.427
MOD_GSK3_1	935	942	PF00069	0.679
MOD_GSK3_1	946	953	PF00069	0.414
MOD_N-GLC_1	323	328	PF02516	0.562
MOD_N-GLC_1	673	678	PF02516	0.510
MOD_N-GLC_1	844	849	PF02516	0.446
MOD_N-GLC_2	515	517	PF02516	0.357
MOD_NEK2_1	207	212	PF00069	0.336
MOD_NEK2_1	213	218	PF00069	0.308
MOD_NEK2_1	360	365	PF00069	0.499
MOD_NEK2_1	367	372	PF00069	0.432
MOD_NEK2_1	394	399	PF00069	0.551
MOD_NEK2_1	435	440	PF00069	0.298
MOD_NEK2_1	494	499	PF00069	0.499
MOD_NEK2_1	605	610	PF00069	0.381
MOD_NEK2_1	706	711	PF00069	0.470
MOD_NEK2_1	732	737	PF00069	0.409
MOD_NEK2_1	746	751	PF00069	0.543
MOD_NEK2_1	823	828	PF00069	0.598
MOD_NEK2_2	140	145	PF00069	0.332
MOD_PIKK_1	1033	1039	PF00454	0.501
MOD_PIKK_1	700	706	PF00454	0.518
MOD_PIKK_1	827	833	PF00454	0.508
MOD_PIKK_1	855	861	PF00454	0.595
MOD_PK_1	596	602	PF00069	0.343
MOD_PK_1	935	941	PF00069	0.526
MOD_PKA_1	935	941	PF00069	0.659
MOD_PKA_2	177	183	PF00069	0.424
MOD_PKA_2	192	198	PF00069	0.376
MOD_PKA_2	287	293	PF00069	0.686
MOD_PKA_2	442	448	PF00069	0.393
MOD_PKA_2	61	67	PF00069	0.530
MOD_PKA_2	700	706	PF00069	0.543
MOD_PKA_2	832	838	PF00069	0.621
MOD_PKA_2	855	861	PF00069	0.556
MOD_PKA_2	899	905	PF00069	0.492
MOD_PKA_2	935	941	PF00069	0.791
MOD_PKB_1	742	750	PF00069	0.400
MOD_Plk_1	34	40	PF00069	0.520
MOD_Plk_1	435	441	PF00069	0.294
MOD_Plk_1	742	748	PF00069	0.595
MOD_Plk_1	844	850	PF00069	0.447
MOD_Plk_1	950	956	PF00069	0.486
MOD_Plk_4	149	155	PF00069	0.480
MOD_Plk_4	182	188	PF00069	0.414
MOD_Plk_4	252	258	PF00069	0.397
MOD_Plk_4	260	266	PF00069	0.436
MOD_Plk_4	287	293	PF00069	0.660
MOD_Plk_4	313	319	PF00069	0.491
MOD_Plk_4	342	348	PF00069	0.496
MOD_Plk_4	430	436	PF00069	0.383
MOD_Plk_4	596	602	PF00069	0.343
MOD_Plk_4	636	642	PF00069	0.454
MOD_Plk_4	685	691	PF00069	0.415
MOD_Plk_4	718	724	PF00069	0.539
MOD_Plk_4	746	752	PF00069	0.516
MOD_Plk_4	773	779	PF00069	0.567
MOD_Plk_4	802	808	PF00069	0.428
MOD_Plk_4	819	825	PF00069	0.415
MOD_Plk_4	859	865	PF00069	0.405
MOD_Plk_4	86	92	PF00069	0.593
MOD_Plk_4	950	956	PF00069	0.323
MOD_ProDKin_1	10	16	PF00069	0.603
MOD_ProDKin_1	105	111	PF00069	0.617
MOD_ProDKin_1	296	302	PF00069	0.436
MOD_ProDKin_1	345	351	PF00069	0.574
MOD_ProDKin_1	510	516	PF00069	0.496
MOD_ProDKin_1	641	647	PF00069	0.317
MOD_ProDKin_1	662	668	PF00069	0.578
MOD_ProDKin_1	758	764	PF00069	0.768
MOD_ProDKin_1	794	800	PF00069	0.540
MOD_ProDKin_1	817	823	PF00069	0.548
MOD_ProDKin_1	84	90	PF00069	0.501
MOD_ProDKin_1	866	872	PF00069	0.378
MOD_ProDKin_1	923	929	PF00069	0.587
MOD_SUMO_rev_2	709	718	PF00179	0.377
TRG_DiLeu_BaEn_1	118	123	PF01217	0.517
TRG_DiLeu_BaEn_1	203	208	PF01217	0.466
TRG_DiLeu_BaEn_1	819	824	PF01217	0.463
TRG_DiLeu_BaLyEn_6	455	460	PF01217	0.308
TRG_DiLeu_BaLyEn_6	553	558	PF01217	0.553
TRG_DiLeu_LyEn_5	118	123	PF01217	0.517
TRG_ENDOCYTIC_2	155	158	PF00928	0.369
TRG_ENDOCYTIC_2	403	406	PF00928	0.515
TRG_ENDOCYTIC_2	47	50	PF00928	0.509
TRG_ENDOCYTIC_2	481	484	PF00928	0.382
TRG_ER_diArg_1	781	784	PF00400	0.430
TRG_ER_diArg_1	846	849	PF00400	0.480
TRG_ER_diArg_1	934	936	PF00400	0.668
TRG_ER_diArg_1	986	988	PF00400	0.493
TRG_Pf-PMV_PEXEL_1	1027	1031	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ23	Leptomonas seymouri	37%	97%
A0A3S7X0K8	Leishmania donovani	70%	100%
A4I2P0	Leishmania infantum	69%	100%
E9AD63	Leishmania major	69%	100%
E9AYY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%